(ESTIMATED PUB DATE) REPORT ON C-5 (TETRAHYDROCANNABINOL, NITROGEN ANALOGUE)

• Document Type: SPECIALCOLLECTION
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): 00151830
• Release Decision: RIPPUB
• Original Classification: U
• Document Page Count: 2
• Document Creation Date: January 21, 2025
• Document Release Date: September 8, 1976
• Publication Date: October 1, 1958

Report on C-5 Page 2
Drugs. C-5 was dissolved in alcohol in appropriate concen-
tration so that patient did not receive more than 30 cc. with
distilled H20 and was drunk. Placebo consisted of starch
suspension in water to simulate appearance.
Initial dose of C-5 was 0.1 mg./70 kg. This was increased
in stepwise fashion in subsequent trials until last patient
received 100 mg./70 kg. Forty-two trials were carried out on
the 15 patients. In 15 trials dose was 10 mg. or more (to 100 mg.)
per 70 kg.
Results. No distinct effects were. observed or reported with
any of the doses used. Changes in measurements were indisting-
uishable from those of placebos. Because of the negative results,
no comparison with c-9 was made.
Conclusion. C-5 appears to be a relatively inert drug in
man.
Future Plans. None.
H1:tkh
_. October 19se
REPORT ON C-5 (TETRAHYDROCANNABINOL, NITROGEN ANALOGUE)
Experiments were designed to determine the dosage range
required to obtain effects with C-5, to assess type and quality
of subjective effects, time course, and to compare with effects
of C-9.
METHODS.
Subjects. Were 15 Negro male former addicts in good
physical and mental health. All were experienced marihuana users.
None knew type of drug being given or effects to be expected.
Measurements. Following observations were made at hourly
intervals once before and eight times after administration of
drug:
1. Pulse rate ) After 10 minutes
) in bed and after
2. Systolic and diastolic blood pressure ) 1 minute standing
3. Rectal temperature
Pupillary diameter
5. Threshold for elicitation of kneejerk
6. Questionnaire containing items reported after marihuana
and LSD
7. Notes on behavior.
General Conditions. Patients entered the ward on day before
and remained overnight. They were awakened at 6 a.m., and drug
was given with patient fasting. Patient remained in ward through-
out observation period; free to mingle with others between
observations.