LETTER FROM HARRIS ISBELL TO NATIONAL INSTITUTES OF HEALTH RE SUBMISSION OF PROPOSED BUDGET FOR FISCAL YEAR 1958 & RESULTS OF 1-METHYL-LYSERGIC ACID DIETHYLAMIDE TESTING

• Document Type: SPECIALCOLLECTION
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): 00151896
• Release Decision: RIPPUB
• Original Classification: U
• Document Page Count: 2
• Document Creation Date: January 21, 2025
• Document Release Date: January 15, 1983
• Publication Date: April 25, 1957

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HEALTH, EDUCATION, AND � ,Olic Hearth Screicz,
NATIONAL INSTITUTES OF HEALTH
25 April 1957
ft/ ACIMMII4 *000(3* TFIC
NA1107141. 111112TUTI OF fa cant. NM?*
ADoscriase itasimpcm CINTV,
� U.S. PUSUC UgALTM SERVICJI Masmut
P. 0. Poi z000
Limsrori. ItiNtucitt
i am enclosing copy of proposed budget for fiscal year
1958 which has already been sent to Mr. Robert E. motley,
Administrative Assistant for 3as1c Research, National
institute of mental Health. He will submit it shortly
to the Office of Naval Research. Also enclosed is letter
to mr,. motley asking him to increase item 3, under travel,.
by Viggi,
The material i have been using is designated as 1-methyl- -
lysergic acid diethylamide. it bears the Sandoz code
number uLD-41, Lot No. 06000/ 27300/.
Anima/ pharmacology indicates toxicity is about equal to
that of LSO in mice. The material is 3.7 times as active
as LSD in inhibiting serotonin. it is pyrogenic in the
rabbit, but less so than LSD: in mice it is said to prodace
only minima/ excitation and no mydrlasis. in. the cat, -
effects are a little different than. those produced by LSD
� but studies are not complete.
� EvRitiation here, although incomplete, indicates that the -
material produces effects in man somewhat like LSD, but
that uLD Is less potent. It induces mydrlasis, elevation
In blood pressure, facilitation of deep tendon reflexes
and the usual constellation of LSD-like subjective symptoms.
The dose required to Induce a Grade 3 reaction is prcably
on the order of 4-6 mcg./kg. as compared with 2 mcg./kg.
of LSD.
Other materials i have are 1-acetyl-lysergic acid diethlamic:c
bitartrate (ALD-52) and Pyrrolidid of d-lysergic. acid (L13D-824).
Hi:rn
Enclosures
^
-Sincerely. your,
0
% / � �
Harris iSh?Ill M.D.
Director
�
�
to the.Abramson�larvik questionnaire, and assessment of
the degree of the reaction by the clinical gradi-ng system
previously-described. Mithods,of handling these data have
been previously, reported.
Results. The results are shown in the accompanying
table and are suggestive of a reduction in the intensity
of the.. ISO reaction. They show a reduction in every aspect
of the LSD reaction measured. The differences bet*een
the response- seen after NDL plus LSO and those seen after
801�placebo plus LSD reached statistical significance in
the case of effects on the kneelerks and on. blood pressure,
but were not significant on measurements of pupil lary size,
number of questions and clinical grade.
The experiment actually was unsatisfactory for several
reasons: (I) The number of subjects was small because
of the shortage of 801; (2) Six of the subjects were new,
and 4 of these proved to be non�responders (had no mental
symptoms with the dose of LSD used) with resulting skewness
In the statistics; 13) the resull-s of Ginzel and Mayer�Gross
suggest that cross�tolerance to LSD Is developing which
likely 'would not be complete in 2 days.
In the only 2 experienced subjects available, the
LSD reaction was almost totally blocked by pretreatment
with 801.
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