(ESTIMATED PUB DATE) COMPARISON OF THE EFFECTS OF MLD-41 AND LSD-25

• Document Type: SPECIALCOLLECTION
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): 00151903
• Release Decision: RIPPUB
• Original Classification: U
• Document Page Count: 5
• Document Creation Date: January 21, 2025
• Document Release Date: January 15, 1983
• Publication Date: June 25, 1957

CatPA it Ss..N 4,,f THE Er aa...4 I AV) L. !.7).2.5
Mt).41 Is 1...methyl�dlethylemidt..if lysergic acid. Studies
on this aGent were undertaken in order IQ cbtatis data on
structure.actIvIty relationships in the LSO series., .
The purposes of the present experiments were: II/ to
-
determine If MID induced LSD�like effects, dnd 12) to estess
roughlY the potency Qf ian as eared with LSD.
WET14COS
Sol.oetts. fQurteen Nenro males aced 1.Z.4 to 45 years volun.
Peered for the experiments. Au were prisoners who were servins
sentences for viJaflen of the LC 5, nIrc,Jic laws eftd ail ha/
been abstinent fr,vn namilc dross for at leasf six moaths prior
I o servInG in these experimente. i:11 were la cp.;.04 physical and
mental health, none 'Ire psycSotic -oar all. had taken LSD 00
previous �..itc41.10fts.
nruv.ls The drug: were givem *.,re ly 14 solution, identities
� � -..-� . �
uf the drozs were unknk:.wn to both the pstlents and observers.
414nJkn,w of the our)otts of the ex;..
r tA t& end ,
furthermore, were not aware that ,3 new L57).l1ke drug was betno
-
-,e.tige 2
Oven. SolotIons of the druus Were orePored with freshly
distilled water and preserved in brown bottles; 4..noentrat1on
a stock solutions was 100 mcgm.Ac. DOSCS Ca' each individual
were measured with micro-olpeftes and drugs diluted to 30 cc.
with freshly distilled water and administered while ;)aficsfs
were fasting.
MeW04* of tbiogtsure enf. _Patients were housed lo a soeciel
ward which is reserved foi experLnentation with psychot.mimetic
drugs.. The patients entered this ward on the night before teats.
All were accustomed to the environment. Al hourly intervals*
two hours befcra and eight hours after aiministrafLn of drugs,
the pUpillary diameter was measured under conditions
controlled light and accommodation. The distance thr.-..ugh which
a calibrated her must fall to elicit-a kneejerk weivA ter.
mined. Systolic blood pressure was measured after ten minutes
rest In bed. Patients filled cut a modification of the Abramson-
larvik questionnaire hourly., and sh-4rt menfal.stafus examinations
were made by the aft nding Physician. Data on oupitlary size,
bid Pressure, and threshold for elicitation of Lneeicrk were
plotted kio graph paper and the average ,A the Iwo pre-drug
'observatLns used as a. baseline. t7ata un,Jer the cury fr the
U.hour period of observation WISS measured with a planimefer, thus
reducing all data on these particular measurenents f.. a tingle
figure. 1-uestions were cwnied, eliminating any that were also
scored positively prior to insestion of the drug. Clinical
gra.ie was assessed accurdtno to the method of Isbell, at
described in the attached reprint.
Dusec4". Patients received, In randomized order' placeb4
LSD 1 cGm./kg. 110 subjects); IS1 1.5 mcgm.Ag. (10 subjects);
end LSD 2 g. /k9. ES subjects); and various doses of )4X1,41.
In order to ascertain the 4x)rox1m4te di:sage range, prellminery
runs.wcre done with 'AI.D..41. rilth doses of .25 cc./kg.
patient}, 0.5 mcgm./Itg. II patient', 0.75 mcgm./ig. El patient),
or 1 mcgm.Ag. II petientl, no objective Gr subjective effects
were observed. However, when 1.5 megm.,h0. 13 patients' or
2 mcsyn,Ag. Et patient) were given, definite, but mild,Ln.like
mental symptom Were- observed, It was,. therof.rel deeld4d that
elcperlmental 43zses would be hicher than 2 ratm. of ME.D.41 per
�
Sia patients received f ML)-41, 10 received 4 mt
4nd 6 received d mcgm4As.
%:,SULTS
'7,Istilfs are sh4)en In the fable. In rea4ing tNe fabte,
ficures represcrt mean f=r the pdrticular rleasurc7ten 4. the
standard err,Ir.
Tht data however, art *sufficient f* shz.ve thlitt
1.11 ereat4s aute;n1e LIisturb4nces slmllar causi!,1
by L3; 121 1.4.177) ercates.plychtt dlOurb4n,zes
caused by 1.71;t. 1-T1 Is fers potept than Lsn. Thi? et1 PeErit
a rough es41rnat.c that LSD la vtv.ititrA I. Ainc.half c f:7nt az
LSD. Such a figure Is only an appr,ximation since true d,.:32.
response curves canna be cc,nsfructed because number of -afients
at each (14ise was two mails some .;ationts did not receive all
dies, and, 42o4rently� fief ;)ortion a the dcte.respcmse curve
had already been reached with the 4.cocm.Ac. dose in cote of
kneejerkso Pupilltry size, and blood pressure.
Subjective phenomena reported after ingestion of MLD.41
Included anxiety, feelings of unreality, confusion, haptic sens4.
tions� afferatt-fts 1-44etile, visual, 3nr4 ac(tif;ry
the
preitrtco! er:A-JtIr.xs.rfrt7e!
;he k..:1�re&c.ft P bZZAA MCre
I h.) 1.0 hours as cared tu 30 minuf t after LSD)
dI ncf i'.0:rs;st 14.nre
' 1410.41 is,. psychotomimetic drug which induces nevtal effect:,
similar to those of LSD. it Is roughly one.third to Gag.hisif as
pctent as Ls).
oat
�
A-343
You....11�������������10.1�Air,
1 crit
!acetic,
4.38 k 0.2
40.94 k 0.4
40.0 0.10
Ci.APAZIS.,14 +.)F Eff CC TS kJ Ian .41 Arn
LSI Mcgm.A1;*
2.40 L0.34 .).60 4 0.38 '.39 0.54
4.42 0.34
4.53 4 0.52 4.82 4 0.47
2.!10 4 04% 2.�',3 4 0.39
1.5 4 0.4
OW.
3 k 15
"
11:1 LCVM.O/KGO
3.0
4 .0
3.04 4 0.35
0.7.����
6.0
3.10 4 0.20 2.4'6 4 0.49
4.55 4 0.60 1 0.47 4.0 4. 0.5
If �
2.83 4 0:37 4 0.41 3.10 4 0.5
19 4 22 34
1.3 k 0.37 1.0 :/4. 0.55
42 J. 13
1.3 0.3 2.0! 0.32
wellial�II.P41������.la
Number of subjects at uerl;us &Atilt L50 1.0 metn./1(v. (19 subjects);
LSD 1.5 mcgs./4. 110 sublet:103'1.5D 2.0 mcgm.Au. 10 :ubj/etslil /AD 3.0 mcom.A0.
16 subjects); MID 4.0 mcem.Ap. tIO subject,); IND 6.0 ncm./r. 46 subjects).
floures are mars istand4r4 errors,.