(ESTIMATED PUB DATE) ATTEMPTS TO BLOCK LSD REACTION WITH BOL GIVEN SIMULTANEOUSLY WITH LSD

• Document Type: SPECIALCOLLECTION
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): 00173491
• Release Decision: RIPPUB
• Original Classification: U
• Document Page Count: 3
• Document Creation Date: January 21, 2025
• Document Release Date: January 15, 1983
• Publication Date: April 10, 1957

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ATTEMPTS TO BLOCK LSD REACTION WITH SQL GIVE
SIMULTANEOUSLY WITH LSD
These experiments were carried out because the
close chemical similarity of DOL and LSD suggested that
SOL might block the LSD reaction by competing with LSD
for receptor sites.
Subjects used were IS nontolerant former morphine
addicts, all Negro males who were in good physical con�
dition who presented no evidence of major psychoses.
Most of these patients had had considerable experience
with LSD. They received, in randomized order, the
following drug combinations: SQL placebo plus LSD placebo;
DOL plus LSD; and DOL placebo plus LSD. The combination
of DOL plus 'LSD placebo was not studied because of the
shortage of DOL, and also because the results should be
Identical with those described in the report dealing with
the acute effects of DOL.
The dosage of BOL was '2-4 mg./70 kc. of bodyweighf
and was given with the LSD. Nine patients received- the
higher dose. The dose of.LSD Was 0.5-1.5 mcgth./kg.
Smaller doses were used'in the first patients tested,
because of the possibility that the drugs might synergize.
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Methods. Measurements Included threshold for kneejerks,
pupIllary diameter, systolic blood pressure, the Abramson�
...
iarvik questionnaire, and grading of mental effects using
the scale previously described. The results are shown in
the fable, a copy of which was tent with my letter of
8 March 1957. It Is obvious that there was no significant
blocking of the LSD reaction and no accentuation of it.
Conclusion. Administration of 801. simultaneously
with LSD does not block or accentuate the LSO reaction.
There is no reason to believe that giving BOL after LSD
wouldigive any different results, since GInzel and Mayer�
Gross have reported that Intravenous administration of BOL
does not reverse the LSD reaction. These results suggest
that the attenuation of the LSD reaction observed after
two days pre�treatment with LSD is due to the development
of cross tolerance.
� ".
Discussion. Because of the inconclusiveness of
eir
the experiment it will have to be repeAted. Foriunately
We have succeeded in obtaining an additional supply of
'BOL and will repeat the experiment using a larger number
or subjects, all of whom will be tested with LSD prior
to Initiation of the formal experiment in order to
eliminate nonreactors or to establish a dosage which
will create a significant degree of reaction.. We
intend to give Bel for three days prior to LSO, two
days prior to LSO, and to do another experiment in
which a single dose will be given two hours before the
LSO.