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Document Creation Date: 
November 3, 2016
Document Release Date: 
September 13, 2013
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November 16, 1943
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PDF icon CIA-RDP13X00001R000100180005-0.pdf14.71 MB
Declassified and Approved For Release 2013/09/13: CIA-RDP13X00001R000100180005-0 '064 t k,"-; , rir,f; ar; 4. ;`. Kreigt? 1 0 0 D ED/ el E t, ;1":"-????t, 4 I , '07f, qr. CDT" ?E,,, ?44/PArlif, tIt`. 4'44 F4. ? .gati" t , +!, pip ? t a -? 01, t. ?-# h, ??-c -vt1/4, s 44 -err' ??. WrIpt? rStr s"t-' ?7" Declassified and Approved For Release 2013/09/13: CIA-RDP13X00001R000100180005-0 Declassified and Approved For Release 2013/09/13: CIA-RDP13X00001R000100180005-0 'f-15?4 Z .; .4. ;?c-'5?? 4,- s?-?55 ? .5- ? C. r 144- 3 Irs,:?4:421=- - 1 74. ? 'Wit* 11" .*3 - .443=0.,;?ii,44.41s,:. ? .# ,14,1 ' 45 : Vt. '4: 4?t1' ":* ? cf=. 3 5t. - - 5 4:1 elqty * ' r, ? 5,* "e? mvet?,,' Declassified and Approved For Release 2013/09/13: CIA-RDP13X00001R000100180005-0 Declassified and Approved For Release 2013/09/13: CIA-RDP13X00001R000100180005-0 ck, 4 fr.. 15-4 31.4, 011110413419611Momm-to,km. ik-zaft MaikUi "-c 0 0 D 11,rip 4 - - A NoV.,1 Itorivamor.c,aapw;fseurcrdoMmnimggrAlVtwow."' p. Air 14 leg !...att. p > 4 ".. 4." , ? :r; , 1;1, , ? ' ? ? ez ? 1"",*3-- ??????*,.. ? ? -?? ...It ;.? - 4.4 ? 4.s .4` 7).? ? -7.i ?; , ? ? k: , .77 Off Of the tee rets riat 4Li ? `, ? - 7 - ? '4' 4 5r e a - ? 73? Lf?:, A It ?sqr -; ? IP, 40.sto..;41 'ste, ???%, 14,1 , a4441,b-r? " X Declassified and Approved For Release 2013/09/13: CIA-RDP13X00001R000100180005-0 Ids 1 if zrjAa1-71;1 1:42Th - , 1.4,2 273), i *-4 - _ ' ? - ? 1 Declassified and Approved For Release.2013/09/13 : CIA-RDP13X00001R000100180005-0 WAR DtPol1/4R'Tpitorr sefencots o ouporty 00ePtC41 Of VU*Lt0411F001 WAII0t0PKWY0f4 MWORANDUM for - The Uirectar, Office or StrPtlo JervAci4A Subject: The use of etabrino by ths - 1. For the past fifteen months the ,Cm7 used atebrine almost e.:.olusively for til suppcf479 treatment of malaria when necessary tn troop; 41cw14(i in tropical oversees theaters. Eundrods of teloiagm:Ig of men have taken the Oeug re.;ularly fo: pg)riod; ranging from several weeks to several atontcls Although toxic reootions have boon obs4)rv?90 ttl relctively small proportion or la4IviduA11. t',117 a4744 usually been mild in oharncter, havfo oipally when the drui; was first str,rted, n.11 general have not interfered with th,) edministrstion of tho drus, 2. To a large extent mtabrin rinz suppl''Lt1,1 quinine in the treatment of ollaicai e44,02_1 ): among Army personnel. Atahrino is recommtaltIld t.J. 11 generally used for the majcv portion o: Lt.!) taorl- peutio course of treatment. 3. Experience has been that iltdriTL-1 too general, as effeotive es quinine for the sta;.prea$Iv and curative treatment of malaria. ikAALA I\ \AA40.41%ti Tes 5. Ems, leneral, entive 2:edicine A11. Cam MUNOCATIONs sHoULD 0400POSSOKO TO -THillt SOIROS0.4 0410,11CRAL, U. S. ^More. WekilliNIONIO:r0f4 Q C .1! neclassified and Approved For Release 2013/09/13 CIA-RDP13X00001R000100180005-0 Declassified and Approved For Release 2013/09/13: CIA-RDP13X00001R000100180005-0 _ . _ ? ormeewimmwmigmegfittUMOM Attached herewith 13 the or-11,e,..tnal. Atrnished you Law. Tr:rons 711i1Th,yryil :11 rmr:411 time or tho mootinc, with'Or. C. Vie also ttrteh tho o r nal or ths, 4',1 r to you on the subject nf tpn tra #,eti t I. 1:11 11. Captain ii*offrnan Arzl I am n trriftz te.) vmec the vitandns and thra atabrine, v ich nv bra heap.N.1 as well a3 the oth?ni theatres where thm sup917-1.ng t` Noise) two -); - =1, t. Release 2013/09/13: CIA-RDP13X00001R000100180005-0 I OFFICE OF STRATEGIC SERviCES WASHiNG1011, O. C. I; 1 Ellery C. Huntington, Jr. Atabrinv All OSS can do do Ls preen rIct4 this would make some more bad frtends for out of our field in this project, In-my opinIn. 1 Declassified and Approved For Release 2013/09/13: CIA-RDP13X00001R000100180005-0 Declassified and Approved For Release 2013/09/13: CIA-RDP13X00001R000100180005-0 ".'??' ? "9.. t? . ? ? _ OFFICE OF SINATIEGIC SOIV4VICE111 ?h. attachod memorandum wns prepared at th* r..1144et of %altar O'Meara. It is a sequel ti his momortArnthalk ta you, of March 29. I understand that it wns OiNeara-s lat4ntioo that this memorandum Os forwarded for your aossiliorAti4n, A 1 1 Declassified and Approved For Release 2013/09/13: CIA-RDP13X00001R000100180005-0 Declassified and Approved For Release 2013/09/13 CIA-RDP13X00001R000100180005-0 OFFICt OP IIITRATtOIC StRVICtili INTE OtOrriCit 04040 TO: Wa Otilears FROM: J. A. Hamilton SUBJECT: Atabrins Pursuant to your rsquost I am herevitN hriaging the atabrine situation up to date. 1. $ome time ago, at the request at the Naar last Division of the Stete Departmeat, we made ea tafe'etai examination of the Iaternational Red Cross requirement, for Greece, and made various reeme-Jeadatilne with re- *pact to food and medical supplies. Z. On March 24, 1943, lir. Foy Kohler of the State Department informed as that this teternational aad :rood had been forbiddes to purchase atabrine beoause oC alacat complete absorption or present and an lolpated supolide by United Nations military needs. 3. Examination of the atabrine Rrodueation sLtuati,At revealed the following* a. The armed forces, traditiozally depom-ent on quinine, had made no strategic aver-all sstlmate of atabrine requirements. As ictormati:a from amtaan and Guadaloanal began to trickle in, their require. meats were slowly but gradually raised. U.S. armed roroes were not very sensitive to the shortage, since they had first priorities on what- ever amounts of atabrine w!?re produced. b. Lend-Lease supplies, hawcArer, were reduced to 47% of the absolute minimum requirements for troops, with no provision for United Nations civilians cutai.* the Western Hemisphere. There was no alloy:Peace for such countries as Greece, whore 2,600,000 will'oe ta- footed with malaria this summer, and 200,000 will die, if antimalarial treatment is not begun at once. n.,incQifipd and Approved For Release 2013/09/13 CIA-RDP13X00001R000100180005-0 Declassified and Approved For Release 2013/09/13 : CIA-RDP13X00001R000100180005-0 c. Despite the fonts thtt. atabrine oloodurrtion requires relgtivttly gmill quastltbes stretoKle materials, and that U.S. produntion la ",noorelins;Py unlimited, expansion of prnduntl:,n h144a 1,1*. sistently held back. d. Basic patents for *tabrine ***** ciamelocivi by Farbenindtistrie, and wAre hold in thls lemultry by Winthrop Chemics1 Company. Contr*1 of the latner company, 00.% German-ownd, WMA 40quIrei 67 thol 4/144 Property Custodians when he vitsted lenoral Antlino and ?ilia Cott oa April 24, 1042. *Lathrop, hawe-rer, 004 pormitted to Continue to holci the *"ins **-,ente, with the understanding that Winthrop woqit 4xoan4 production to swot atabrine needs. Winthrop did expand productio .0 and iater ii- censed Merck and Coapany to produne atebrice for the duration or the war plus SIX menthe. e. A large share of the responsloitity for reetriatLon of production lies with the blvision RequLr4ment4 Committee on Drugs, of W.P.8., dominated by Mr. J. Stook and Major John A Purtnton. Thes4 awn wocv formerly minor executives In the Prescrption ;epar-.019nt of Walgreen Drug Stores, ari Parke-L:3411s. reso4ett7ely. They have consistently lisregArded civIllan *a. brine needs throughout the world, ,And assumed ree,00. sibility for drastic cuts (to 47%) ur United Rati.)ns minimum military requirements. f. As of March 29, 1946, the estimated totak pro. duotion of atabrine for 1943 was 2J0,000 poqn.ls. 4. When the vurious persons and a,;enc.es corwerned oftth atabrine were canvassed, a remarkable sltuatiaa was re7,c.vd: In at least ten t,overnmental and quasi-governmental sgencLg. there were persons who were u1 Liar with one or more aspActs of the &atter, and who were literally exploding with rags. Yet, for one reason or another, they were not able to take definitive action. Examples: a. The Justice Department after aocumulating lo,)0L documents relating to German-American chemical indus- tries and patents, was called off the case because of political pressure. Persons concerned with the matter were so disturbed about it that we were able to ootain pertinent bits of information as a private citizen, wIth- out OSS idcitification. -?."" ? ???.? ??? ? ? ?;;? i " ? . ; .,717 norinccifiad and Approved For Release 2013/09/13: CIA-RDP13X00001R000100180005-0 ? Declassified and Approved For Release 2013/09/13 CIA-RDP13X00001R000100180005-0 ' ? ri4 -? *fp e40. ? b. Various *omit-Wm of the Watianal Reseso a Council were quits &Imre of the Ootiouotot* *0 kb* situation, hut their *honer apsoilise that tAwy are to furnish reports at the request of grA,Jornrayat agencies, rather than to Initiate oOtion* 6. la the light of the facts ',Lich ieveluped, t4 00t,Tmme anparent that pressure fro sourooa *mad hiti, te 1* exerted to effoot any appreelabl, chanot La tto eituati,n. Furthermore, every day lost worsened no already ivolottely situation* The following &talon* were taken' a. A memorandum was forwarded to iff O'Veartt oula *arch 29* 1943* with recommendations for J.C.S.act1411. b. The State Department put us IA boanoll *1th (r8r 4 Of Governor Lehman's Office of Foreign Reiter. This group was surprised and iisturbed* as *ell they might be, Limo their relief requirements would * filled only after Lend-Lease needs *are mot. we suggested that they request an independent anaiyeke of the matter by the National esea-ch Council. c. The National Research Council, Camilittmee an Kedicine and Drugs, (moo activated, not Phlia- delphia and within three days submitted a rgport to the Lehman organisation. (Annex 0 d. The Office of Foreign Relief, in the person' of Messrs. Osborne and Xanthaolcy* made aa aggressive representntion of their oase to the DivisLan Re- quirements Committee. e. Gradually becoming aware of incrtmz.ag pressure for production, the Division, Req4roments Committee began negotiations leading toward licensing undtnr pharmaceutical companies, including Abbott Labora- tories, Eli Lilly and Company, and E. R. Squibb alad Sons. As a result, the anticipated production Cor the calendar year 1943 was raised to ,;00,000 [manage (from 290,000 pounds on linrah 29? 1943). It should be noted, however* that this anticipated increase is largely on impe, end that volume approskching 80,000 pounds per moall willnot be reached before December, 1943. . - . - LL?e-4.e. 1:`??;1.-r 2 ": ? ir?ke _ - - Annrnved For Release 2013/09/13 CIA-RDP13X00001R000100180005-0 Declassified and Approved For Release 2013/09/13: CIA-RDP13X00001R000100180005-0 b. Various committees of the Saeml Reseerdh Couneil were quite aware of the seriousness f tWe situation, hut thair charier rpilcIfise that they aro to furnish report* et the giequest of talksrame t agetoiee, rathor Oats to 1)11%9A-tee aetion. 6. In %he liKht of the foots which developed, it boowno anparent that proseure from many sow*** 'mold hate exerted to effect any appreelabie change In the situat,Son. Furthermore, every day lost woreened the already lopiorttble situation. The following .tions were tokkoat a. A memorandum was roreatded to X. COlicArs on Maroh 29, 1943, with recommendations for 4.(S. action. b. The *tato Department put us La touch eith ofrl$01r1 of Governor Lehmaa's Office of Porelgs rhis group was surprised and lieturbed, as ttehl they might be, &IMO their relief recolremenes would be filled oily after Lead-Loase needs wee, aot. suggested that they request an Inuopectieint analysis of the meGter by the National Research Council. C . The Sational Research Council. Committees on Vedioine and Drugs, once activated, met in Phlia- delptia and within three days submLtted a report to the Lehman organisation. annex 0 d. The Office of Foreign Relief, La the persons Misers. Osborne and Xanthazky, Mk40 an aggressive representation of their case to the Divislon Re- quirements Committee. e. Gradually becoming aware ot tucc-143.aK prossare for production, the Division Requircoonts Committlo began negotiations leading toward liceoslng undor pharmaoeutical oompanies? including Abbott Labor*- tories, Eli Lilly and Com/pa/on and E. R. Squibb and Sons. As a result, the anticipated proohotion for the ?slender year 1943 was raised to 40.000 pounas (from 290,000 pounds on March 29, 1943). It should be noted, however, that this anticipated increase is largely on paper, and that volume approachini 80,000 pounds per moal will not he reached before December, 1943. 4 ? ? eitf:-.0"-t.'"' .nrnr4 InnrnvAd For Release 2013/09/13: CIA-RDP13X00001R000100180005-0 Declassified and Ap roved For Release 2013/09/13 : CIA-RDP13X00001R000100180005-0 64 The expftndiod produatAen whitth holt 0*** 0411004 dwitut the past fortnight right be loOed tra sottt ellseniJNIty. loirs it not for the following (0/41.A4U* fe-te, a. The plannsd expensidn witl not protwo itiftlf:Leolt atabrine in time to supply teed* foe thl ouiv,de, stimotor. Rvou it a few tone of etebrine el,. fru litesi to gtoakog*, this quantity will have to a* outarected Cram an4 aleedy reduced roquiromat* or United NAtt(14 trow*. bo The companies licensed Or Innthrlp Kft * to Otintive to push produetioa et the expense of ilk** essential eammodities? since thole ilooba* to 44o the German patents expires six towtAs aftoir the' wte, o. As was the as** with the Merck pleat* thft mew producers will have to wait for prioriql** en le* 0/TAtp- malt. This required equipment it not large* LA lastOkty, but proouring some of It conflicts with othor ornevg*noy projects, cuob as the rubber prograft. ror example,, to reach a rats of 6.000 pound* per moath? 46bott e,-. quires liatoou worth or now aquipmpat, Inol,4dIng speotei kettles, glassware and filters. With 4A1 priorttAo$, they gilt get this in 3-4 *oaths d. With the same psrsoas la ocratrol of tho Nirlaton Requirements Committee on Drugs of W.P.d., thore 4s ood reason to believe that, once a substantial Incrsase is planned and the immediate pressure is eased, these por. sons will not continue to push production, la the past they have put off claimant agencies Croix moth to month, with continuous promises of abundance wust around the corner. e. Malaria has been inoreasinc by leaps said bunds R3 a result of the breakdown af sanitary facilities and the increasing movements of troops and populati,:as throu4sh- out the world. f. The attached Ratioaal Resecrob Council report estim- ates that the present world requirements for atabriae ars "more than 9,OOO,OOC pounds per year", or lb times tha .hped for production in 1943. rIc,ifirand Annroved For Release 2013/09/13: CIA-RDP13X00001R000100180005-0 Declassified and Approved For Release 2013/09/13 CIA-RDP13X00001R000100180005-0 SECRET PIVen if India and oerhein other ikr4n4 *eo Nriti*.4n Oft as non-essential, present antloietoft ,?)roduatL)h for 1943 is still only 1A, to L/10 ,5f too fl000k144r7 50q04r0, without provision for spread of the 41seeme, g. The seriousness of the melArlii, problem is qrymal4tey out of proportion to the teahnoLc4ical prc,oleut 1r incroesin tabrine production. Mew prodiwtoo ment to raise pro.Wotton one mIllion Dn4n4a ;).3r (i.e., more than double the ho ad-for clApsto,?1 3C Deoember, 1243) would cost lees trnn ode Lt This is less than 0000 GI the 'oat o07 the ribber program for 1943. 7. In the light or the situation an o4tithed elo-Fed N4e$i t olarifioations and actions moos to be af utmofC! ttopn-tsato.e? a. The Natinnal Researoh Counci L hes d#t triswt adequate produotion *OSA best be achl4v4dy th* lisnment or oentrallAed sAthorLty s4ch its Ls eiholq in the oontrol of rubber". Very pointedly, the ohole-41 Is between oermittimf, the Wmision Requirements Committee to continuo; Ito incompetent management of the situatin on * pmton-eorit basis, or denoting the job to some ,)tAlor *4thortty with sufficient over-all $;rsisp or the siutil.,torx an4 trol over production materials to uarantAo the praauotA.1!k of an adequate supply of atabrine. One of the advanta es of such *n authority youtd Je its powmr to secure the unoonditi nal release or the ,;ermaA patents, to the end that the private InitlatLve of ?harm- oeutical oompanies would be stimulated by post.war ,)43LAOS4 prospects. This would probably airect Lamadlately * flon- siderable productive maohinery from leis vital pharma- ceutical manufacturing. In addition, rese4rch an awe variations of the atabrine molecule olow only a ,air anti- malarial) would be stimulated. Another alvIvta6, bf an over-all authority would be its power to mobi.itl olutp merit now in existence outside the pharmaoeutioal ind,J,atry. For example, the most oritical piece of tl.p,tratus ls the Pfaudler kettle. Many or tho$0 miotht pt* obtained from breweries. ; ? / itrATZ4,2 - ???'' ? .0 0")???5 ?"Er' f, .0 ? .4*- ; 4.2y .-"^?.^es?nri Fru- Release 2013/09/13 CIA-RDP13X00001R000100180005-0 Declassified and Approved For Release 2013/09/13 CIA-RDP13X00001R000100180005-0 41% b. The Nationel Researeh Ceunati rukit flinalamontod "That antimalarial& must be cetiti4arad in or of munitions of este. 0. Some military sanitarian-a, hold tm4t tn cclitloy164 army's antimalariel proivam is relktively indopInden1 or the degree of Infestation in the civilian ocioulAttan. This conteution may tot be valid. Other 41ftetal$ss 44oh as plague, typhus and yellow fever tend to increA411 Un a malaria-infested populQtion, and U14,7 tow conetitute a threat to occupying troops. The reduntion efiwm in a civilian population may reduce the number of Infootiod mosquitoes, end thug reduce the frequency of trlop trIfecOtion. Within the lest ten months the stated military requirements of the U.S. and otter J;ITaiiallattons have been raised over fifteen times. The stated military requirements may continue to Increase. d. A final example of U.S. 'awkwardness Ls thu tan. agemout of malaria Is seen IA the high, proportion of our troops which have been incapacitated by taie ciismese. In some theaters tais as ranged from 10 to 16% and tool.. By contrast, there is rairly ocirvi1tcta6 evirleace Mitt the Germans, in heavy endemie North African areas, rarely lost as much as 1% of their offeotive strength to talmria. 8. Insofar as OSS is concerned, our activitles d4rin4 the past fortnight hey* boom carried out an SA informal 'oasis. 14 have only suggested lines of action to other orgaaLizationa. such as the Office of Foreign Relief and the National Research Council. We have not presumed to express or imply any p,.1loy or special interest of OSS. 9. Summary and Recommended Action: The proposal of March 29 prftsented the atabrine situation principally as it pertained to Cresco/. Developments since thmt date indicate that the matter is muoh more serious, &ad thAt its ramifications extend through military as well as civilian organ. izations. In the light of this, and in view of the necessity for immed- iate action, the need for Presidential examination and directive is apparent. It is therefore recommended that the atabrine sitamtion be submitted to the President. Enclosure: Annex I Natimal Research Council report Declassified and Approved For Release 2013/09/13: CIA-RDP13X00001R000100180005-0 ? F or Release 2013/09/131 CIA-RDP13X00001R0001001 Declassified and Approved 80005-0 CONFIDENTIAL STATEMENT OW MALARIA AND ANT1M4LARtALS N1TH PARTICULAR OFgRAICg TO AtilAR-14t4 IWPARED AT THE REQUEST OP THE OFFICE OF FOREIGN RRLIEF nHASIttifrtne:5 Z?tA3 OP THS DEPARTMENT OF STATE BY THE COMMITTEE ON MADICUM o TiSATI6NALgRIMAARrat OIL IN COMULTATION WITH THE CRAIRMAN OF THE DIVTVO; Of CiftrANTRY CAP In 7hTi: 446 RESEARCH COUNCIL AND THE CHAIRMAN OF TUR cottxtrrn ON lEtqCAL itg.M/ACR OV rtilg w7;:r1 OF SCIENTIFIC RESEARCH AND DEVELOPMENT. Malaria threatema allied military *waves A '1 hemith- it many parts of the world. Most estimates place the inoidet?oe of matAria tn the *r l4 at 3O0000,000 cases a year, although, &pools plows, the figure 44 htgh as 700,000,000. Malaria is the cause of more deahhe than *my other infectious disease. The mortality every year from malaria Is esti mated at approximately 4,000,000. War has lost to the allies more than 00 per aant or Nainine production and has increased the danger of malaria by eterveitiml, debility, and disrupted sanitation and by sending millions cf sol- diers into malarial areas. Also malaria and secondarily other demi? diseases will certainly increase as war *prowls and now 41.044 will be infeoted as soldiers return to spread the disease. The qutntity of quinine now coning from South America is so mlaate as to be wholly inadequate to meet the needs for antimmlarials as phylaotic and therapeutic agents. If malaria is to be kept within bounds dependance must be placed on other antiaalarlais. Search for new *.ntimalarials, natural or synthetic, isbeinc enere,t'oally pur. sued by appropriate research groups of the National Researoh Co4not1 and the Committee on Medical Research, 0.S.R.D.; howevqr the dis- ?ovary, evaluation and production of any new antimalarial caznot De predicted in ti mo to meet the immAiate urgent need. Reliance ror the time being will have to be placed on Atabrine the only efficient antimalarial other than gJinine known today. Malaria is endemic in the area* in which our largest armies are fighting. In these areas antimalarial& are Imperative for sup- pressive treatment for every man every day six to twelve maaths or the year and additional amounts are needed for those who develop symp- toms of malaria and require active treatment. 0-, Ile the quinine stockpile available to the United States X707 and Navy is reserved for treatment only of the acute cases and for pressive therapy in the small pers,entave that may act tolerate Atabrine it is obvious that enormous amounts of Atabrine are needed :or thera- peutic and suppressive treatment in our Armed Forces. If in addition Atabrine is to be supplied to our Allies only for their military forces the required amount immediately is . . . .....: : ,.. ; ...:, ?-, ',...., ;,- . -... ? , r Release 2013/09/13 CIA-RDP13X00001R000100180005-0 ?.. Declassified and Approved For Release 2013/09/13 : CIA-RDP13X00001R000100180005-0 If, however, it is desired to eAtend the distribwtian- of Atabrine to the civilian populations of Allied or reoocupled er)unte144 the amount of Atabrine required enormoutly exoelde the emount$ mow being produced or whioh will be produoisd under present piens. (i* production figures Page 3 and attached table). If civill?n cooperm tion with the Armed Forces ih 000upied oouatries is to 41 Inff41444 suppression of malaria among the olvillans is essential. 6efore the war the world's annual producti_t 0; InIte was estimated at 2,240,000 lbs. (Tim* Atabrina equivalent st the emtablished ration of 6 to 1, ill 448000 lbs.) This peacetime peodum tion, because of the Cartel, was far below the need. The ?ciao cf quinine made it entirely unavailable to lsege MA4Ses of tho poula. tion where malarial infection is heaviest. For long distance plan ing, the present small stookpkLe of quinins in this country can best be ignored as it must be sa-7.4 by the Army and Navy for special 1A3.1 in special oa.es. and the portation of South Amerioan bark at its prAment rte will not materl- a14 affect the overall picture. If Atabrine is to supply the antimalarial needs 4rLsing from war conditions more than 9,0)0,400 lbs. may be required. The estimated production for 1943 is allocated 1,31 fOlkOWSI Existing quinine stockpile - allocated for Armed Forces . Reserved for special cas,ss. Totaquine allocated to U.S. oivilittax Quinine to be allocated to U. S. Armed Forcos. To the United States Amy and Navy 150,000 lbs. To Allies through Lend-Lease 425,000 lbs. To the Board of Economic Warfare 55,000 Las. To the United States Civilians 12,0 0 lbs. Little is left for any distribution whatever to reoccupied countries through Offices of Foreign Relief, or other federal abencies, to occupied countries through Rad Cross. tV:411. .if !izr 17:4 ? Pr -7:frr.11;5_fr;I?;; 't ? - -? w 4.? The attached table gives in very rough figures the nalaria problem in various oountries with npHaRsified and Aooroved For Release 2013/09/13: CIA-RDP13X00001R000100180005-0 Declassified and Approved For Release 2013/09/13 : CIA-RDP13X00001R000100180005-0 the &mounts of Atabrine which might be unefully miloo4 effort was to be made to costbat malaria there. The following aro the current figures OA AtAbrine pre (a) At present the rat* or pdtk Is 257, i41 1*01, per year in U. S. A., 36,600 in nti,lienti (b) By the end of 1943 the capacity le olpooted to reach 957,000 lbs. per year in U. B. A.,. 110,000 In England* (c) Total anticipated produotion Cor 1944 Is in U. S. A., 66.000 Ix imgland. The inevitable conclusions ares 1. That antimalarials must be considorad in munitiuns of wsr 2. That groat y increased production or ataDeLne is immodiataly lapor tile.* aId a substantial stockp.14 must be es- tablished without delay. 3. That increased Importation of South AMMCLCSA cinchona bark is urgent. 4. It is the opinion of this group that these can best be achieved by thn establishment of centralised as is functioning in the control of rubber. Approved by the Committee on liedloine, National Research Council in consultation with* Dr. A. 14 Richards, ChaIrman of the Committee on Medical Research of the Office of Scientific Research end Development Dr. W. Mansfield Clark. Chairman of the Division of Chemistry, National Research Council 0. H. MO FTPFER Chairman. Committee on Medicine. N.R.C. A40W7fi-W-44244W,104Wit--,- - a _ Declassified and Approved For Release 2013/09/13: CIA-RDP13X00001R000100180005-0 ; --`41111111MIE"'" Vt-r. Estimate of annual . Incidence of Malaria Vicent of *maw of Population Cases Annual Atabrine requirement in Pounds For a 5 day for 3b week* sup- Treatment alai Course of Treatment presAve tretttment Suppressiom 4Wv..71): 0-90008 1-0001 1-0000X? dCI 1-V10 /6O/O eSeeiei -10d panaiddv pue Pe!PsseloeCI ha, oliddns cur...T1u4e'0 1an-PT:2 ucri:Itir;ur 44n12 uviAolloc Toaomoo ol mnpuvaowni 0-90008 1-0001 1-0000X? dCI 1-V10 /6O/O eSeeiei -10d panaiddv pue Pe!PsseloeCI