SCIENTIFIC - MEDICINE, INFECTIOUS DISEASES, PLAGUE, VACCINE

• Document Type: CREST
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): CIA-RDP80-00809A000600150033-8
• Release Decision: RIPPUB
• Original Classification: S
• Document Page Count: 3
• Document Creation Date: December 22, 2016
• Document Release Date: June 15, 2011
• Sequence Number: 33
• Publication Date: September 26, 1952
• Content Type: REPORT

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TEXT U USSR IEBTRUCTIO 8 IN COMMON WITH
E UBC Q IP UE d CC17B
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MsINIBTRX OP PUBLIC BYALTh USSR
IIIXLT1 STATE ANIPLAOUE IEBTITVTB FOR SIMIA AND THE FAR EAST
Temporary Instructions on the Application
of Dry Living EV PLccis.e
1. The dry living NV vae:oine vhioh is supplied by thi Irkutsk State Anti-
plagui lnetitute for Biberie and the Far Best r,p:osents a suspension of aviru-
lest plague microbes which have been dr.ed in high v,-euum (yhey are absolutely
harnlsss to humans).
B, laccuiation with the above vaccine "eats* imxuaity against plague for
a period up to one year.
3. Vaccinations are cerricA out by specially trained medical personnel.
4. The vaccine is effective for a period of 1* years ;roe the time of its
r least, if it 4" been storeA at a tesgsoi4t%re below Go C, .,)r betvesa plus
i U asd lue ri` C. Whom stored at room t-eraturs, the vaccine is effective
for a period of 45 days. If the vaccine has been kept for this period, the
dose indioatsd on the label is increased by one tird.
R. Prior to inoculation, al: persons vho are inoculated are subjected co
medical eseaiaation according to general rules.
co oL/ CLASSIFICATION s-4-C-R-E-T
U5? OFPICIAI8 ONLY CENTRAL i1 .t~NO
COUNTRY
SUBJECT Scientific - Medicine, infectious diseases,
50X1-HUM
1948 1950
DATE DIST. Seep 1952
NO. OF PAGES 3
SUPPLEMENT TO
REPORT NO.
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 Sanitized Copy Approved for Release 2011/06/16: CIA-RDP80-00809A000600150033-8
6. The following conditions contraindicate inoculation: acute diseases
accompanied by high temperature; subcompensated and decompensated heart con-
ditions; tuberculosis in as active form; acute chronic diseases of internal
organs (kidneys, liver, etc.); pronounced hypertension; swelling and tender-
ness of lymphatic glands; recent recovery from a dissaee; pregnancy (second
half).
Note: Chronic malaria is not a contraindication, provided that qui-
nine or atebrin have been administered previously.
7. Inoculations are carried out in a room which is protected from duct.
No more than two or three persons are admitted to this room Let the same
time.
8. Preparation of the t'n.ccine for inoculation is carried out in the Pei- .
lowing manner: After the tip of the ampule has been nested over the flame of
an alcohol burner, a drop of water is placed on the hot glary, whereupon the
glass cracks and breaks off. After the ampule has been opened, one cubic me-
ter of a physiological solution is introduced into it by means of the needle
of a sterile syringe. The ampule is then shaken in order to obtain a homo-
genous suspension. The microbe suspension formed in the ampule is then taken
up by mews of a sterile pipette or a eyringo with a long needle and trans-
ferred into a sterile flask or bottle. The suspension is thereupon diluted
further with physiological melt solutio:., so as to obtain a suspension con-
taining 1.5 billion bacterial bodies per one cubic centimeter.
Note: The quantity of sterile physiological solution which should
be used for diiuting the contents of the ampule is indicated on the label.
9. The inoculation is carried out once. The dose is one cubic meter of
diluted vaccine.
Motet Children younger than 10 years receive one third of the dose
adminlstesod to adults; children between 10-15 years, one half of the dose ad-
ministered to adults. After the age of 15 years, the full dose is adminis-
tered.
10. Before dilution of the vaccine and after, the ampules are carefully
inspected. Papules exhibiting the following conditions are -object to re-
Jeotioas (a) cracks in ,,he glass; and (b) presence of uniissolved lumps, films,
or extraneous occlusions,
Notes Anpuler which have been rejected must to returned to the in-
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11. The vaccine is diluted on the day on which the inoculation is carried
out. The prepared (diluted) vaccine, under ordinary conditions of storage, is
effective for a period of 8-10 hr. Vaccine which has not been used is destroyed
by ordinary disinfectant solutions or by boiling for 30 sin.
It. The vaccine should be inoculated by scans of a sterile syringe. Boil-
ing out of the needle of the syringe after every inoculation is indispensable.
13. The vaccine should be introduced under the akin at the back at the
lower carom of the shoulder blade. Prior to the inoculation, the skin is
treated with alcohol and ether, thea swabbed with iodine. After the injection,
ad absorbent cotton ball moistened with iodine is applied to the site of the
injeetioa is~d_`ately after the needle is withdrawn.
a-z ?C-2-1-T
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S-E-C-R-E-T
24. After the inoculation, a local and general reaction may occur.
15. A general reaction expresses itself in indisposition, headaches, and
a rise of temperature -- most frequently to 37.50 C, more rarely to 38-39? C,
and in individual cases to 390 C. In rare cases, nausea ansl vomiting are ob
pear within 24-148 nr.
16. A local reaction occurs in almost all cases and is expressed in ,:.
swelling, redness, and tenderness at tine site of the injection. More seldom,
the regional Llocal glands swell. All these symptoms begin to develop 6-10
hr after the inoculation (rarely within 2-3 days) and usually disappear within
- n
17. If the reaction is strong, the persons who have been' inoculated are
freed from occupational acti.vitiess.
Neither in cases of a local or gex.eral reaction is any therapeutic
interference necessary. If there is a strong general reaction, the person
placed in a stationary hospital.
18. Whose who have been inoculated are kept under medical observati.n.
The registration of persons who have been inoculated must be' carried ' out ac-
cording to established procedure and is obligatory.
19. In organizing 'no,ulations with EV vaccine (as far as iadicat;ouF,
execution, etatist,cs, etc., are 'oncernad), one should be guided by "Regula-
tions and Instructions for Antiplague Public Health Establishments," 1937,
1946 50-52,-- Confirmed by the Scientific Council of the Institute, 22 September
B-s-C-R-S-T
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