SCIENTIFIC RESEARCH

• Document Type: CREST
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): CIA-RDP80-00809A000600200060-4
• Release Decision: RIPPUB
• Original Classification: R
• Document Page Count: 3
• Document Creation Date: December 22, 2016
• Document Release Date: June 29, 2011
• Sequence Number: 60
• Publication Date: May 25, 1948
• Content Type: REPORT

uuiaa~r~~~urv iiiSShJC:i~i; ~"~.
cErr~kAi. oN~rEUic~g ~~eRr
DATE.. D1S~2.. 25 k8gyr i RA-8
N0. OF PAGES ~ .
N0. OF EidCLS.
wsreo sno+en
SOdxRCE Doorto~ntaa??~ as indicAted, (xnlorraation apecitiaalJ.y ,
,...,,.s..._..
.b'~.AiT'1~X P(3BLISFDBD RES'fiAkOH OF TFIL~
I+DRtiCIY 1~DICAL x??S9'ITUTg, USSR
ugl~.oxen Diabotra. Dopendanoa of U~o Colrse of
O.+,xbatEa in t~ata on tho ~athod of Adr~i,tii.rtratioti
bf Alloxatt std th3 Blood 1ui8^~aoreaLi+c~7xsels,` Ya.
Aa .i,~.a*ia, T'.. S; l~ftodni}rova, Gor'k1y 6fed InaL
?8yu11 Meer, Ll Hio2 ! sled" Vol 22, 1io 4, 1946.
PP 44'53
Itzlept{nn n4 7M /~.? &.n.M-~:~ i~~
te~7. vein of xhite rata aroighing betvreon 140
end 200 g im-ariablq produced diabetes. &utr
cutaneous admittiatration of 200-300 mg/!cg of i
rawlLefi is diabetev in taoet caaeei, Ssoord 3et-
fection produced diabetes in animals reA?actory th
the Pirat dose. She leading of as much as 2,000
mq/itg of T b3 stomach tube had ao effect on the
arriffilej Lhia indiastce: a } ai d deatt~notion aP 3
in the geatrointeatinal tracts. a7mptooan~rsalrkt-
iog f=vm 3 sere tripheaic. Animals ahoxed ;Irftial
hgper83,yeeada Pollotired by hypoglycemia its 7 hours
and fSnel hyperglyeemia xithin 24 hears. I~hen I
sae given intravanonaly, it could be detected in
the blood and patecreas xithin 1 minute, and diej-
appeared vory rapddl?v theraAfter. I was daaLrvged
galcs'l,~ when it wao adced to xhole blood, serum,
or plg~a at a7c'.
"Alloxan Diaber:?ea. Caress of Initial /ariations
d!` Hlood Sugar in'~-ite iPica altar A~l.teiatratier_
of Alloxan," Ya. A. Iasaris, T, G. 9godnikova,
! Sanitized Copy Approved for Release 2011/06/29 :CIA-RDP80-00809A000600200060-4
Sanitized Copy Approved for Release 2011/06/29 :CIA-RDP80-00809A000600200060-4
STAT
STAT
 Sanitized Copy Approved for Release 2011/06/29 :CIA-RDP80-00809A000600200060-4 __~,
~'~~~iSTRIC
fated at various i.ntervale and their blood in,~eated
in white ffica. The blond sugar of the mice xaa sub-
stantially the saeye as in contralti xhen the rats w?oro
killed during the hyperg~,ytesmic phase of alloxan
poisoainp.; howover, the blood of rats killed during
the laoight of the hypnglycaZ3c phase caused a p-rtr-
noezncsed hypogly::emia :in ti:z micas ibis result andi-
eate? heat during the hyF?oglyeamAc -pY~a3e of aLtoxots
"Byull Ekaptl Binl i !!ea" 901 22, No 5,? 194G, PP ?3-7.6
white ruts were adrenAlectcaiizec under ether after n
fast. Blood sugar Rea determined it a number of them
at regular intervals Others neiP in3ected wish
elloxan and thoir blood se''rrs :yore determined. ?~ato
which had lost an]y one adrenal g'.~nnd ahawod a liypnr--
glycemia which increased conaiderabl~r after alloxrxn.
In animals losing, both adrensl glai:ds Lh9 blood sugar.
was eeeentfally normal, but Sniection of alloxan~lod
to a saeeere and often Total hypaslyrc~aia. Thus it
was aonfi.rm?d that the initial hyg~:glycosia rafter
inseotion of alloxsze is the reoult of interaction of
the letter rrit;~ the adrenal glands. . In a second ax-
~rlmeaet, rats An,~ected with slloaozn xsre latflr decapi-
Gor'kig ,aaee~ Ins?t
diabai.ae thaws is s large a~bunt o* instil. n in Lhe ,
blood ehieh eauxes the catastrophic fall of the
blood sugar.
"Al`loxstt 01eHetos. 'Influence of F'nt-rich 1~'ood on
the Course of Diaixtes in :tihite bets?" Ya. f+.
diuresis dioreaead sharplq and glucos? v;as osaentielly
absent frown the urine. Ftetubn to normal ai~t did izot
see a return of Elucose escc*etion. In s.~other Reries,
after diabetes yeas induced, the animals were fad a
diet of hog tallow, lean beef, vitamins, snd minerals.
The fat level was increased slowly tip to 700. Diuresis
xae small end glucose level in the urine was very low.
ketnrn to normnl diet led. to increased diuresis and
glucose excretion. N1th tho high-fat, loft-protein
diet, ketoAe bodies ceere absent Prom the urine; with
?e high protein intake Lhey were always present,
alai dontaining 'rvp bog taiioa and ~vp normt'I irad,
Immediateiv after initiation of 4he+ IstLer?dieC,
"9yull Ekaptl Hiol i bled" Vol 22, No 6, 1946, PP 36-9
White rate in which dYabetes wee induced i;5? rllosw:a s:
ware kept on a normal diet for 20 days and tree on a
"Determination oP Potrcxidase Activity in Blood,"
~'. V. Simakar, Oor'kiF Nets Inst.
?Bfokriimiyn" Yol '!0, 1945r FQ 3Ga3
From O.0]33 ind3.go carmine a 0.001N solution is pre-
pared jest lntore use. The titer i-? determined by
Sanitized Copy Approved for Release 2011/06/29 :CIA-RDP80-00809A000600200060-4
STAT
 Sanitized Copy Approved for Release 2011/06/29 :CIA-RDP80-00809A000600200060-4
I
fteS7P.ICTED" ~~~ ~ I
"F3~.11 3oc'Chirnn Yo2 12, 1945~ PP 77;?-9?
F~vior o! amilas in elecc.raraductloa 1:~ studied to
detsx~r.3.ned phethe- ogollc and open-chain Peptides can
be distinguished in pre+te;.na. ;l"rn electro6o5 era pure
,?bp tbA1 anado aoltation i~_ 2(7J6 G;z80~, iao cathodo aulu~
short L?tut aramtio amides are reduced only nYwr. Ph ie
in direct eombirra~iion v~ith thq C of CO. Fiperarin~v hao
the same effect ae 1'G, .Fatty acid aad.dos aro not ~-
?du4ed anises !~6 or Ph replccos the H in HCC'NH2 or
AoN&2. The reduction of hippuric acid is an exeegtion.
Th?r .greater ease oP red~~stlo.> rf aroaeotie oompoer~ds is
3
RSSTFilCB~
Sanitized Copy Approved for Release 2011/06/29 :CIA-RDP80-00809A000600200060-4
aoidilyi~g 0.001 iodigo osxeitnc solution with
fZl'1 8Q8QF~D sod f:itsetEng vii;h O.OOLPT 9Bn0ly an-
t31 the color changes ifrom ~c:sen to a pure ye:t].or+.
The wcidation is conpS.derrd ~t an and as ~cc?at as ~i,N
blue hee changed to a rose-~llo~: colcr. the t:ihs
neceaeary for the oxidation o.C the indigo carmine is
n measure of the pa:rxiaaae activity. The method i;:
eec??irate to 5;8, Since tt,a peraxLdaue action oP the
bi,ood is rolated to the araou?~t ~f horraglobin, and the
3Attrr roariee with diYfernnt people, for purposoa o4
conparfeon, the sroxtdaoe activity ie divided ts; the
percentage of hoaoglobin.
"F.SSbctroraduction o f t're Peptide i+roup in Cyclic .and
Open-chain Compounds. Fieductiom oY Certain Amides and
Substituted Amides,~~ N, 1. G.errilov, B. V. Koperinn,..
3d? L. K]yucttareva, Cor'h3y 1~'sd .Ir1a
probeb~y due to thEir greater easo of hydrolysis and
the solubility of the compounds prcduusd.
STAT