SCIENTIFIC RESEARCH

• Document Type: CREST
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): CIA-RDP80-00809A000600200101-8
• Release Decision: RIPPUB
• Original Classification: R
• Document Page Count: 6
• Document Creation Date: December 22, 2016
• Document Release Date: June 29, 2011
• Sequence Number: 101
• Publication Date: June 14, 1948
• Content Type: REPORT

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I
U.ASSIHCAIION RESERICT1i1)
P$'0', CENTRAL INTELLIGENCE AGENCY)-
CoUN1W us=
SUBJECT Soieatifia Reaeazob
PLACE
ACQUIRED
VATS OF
IWC13PWEN
1946-47
7$11 OOOf00*1 00078100110000800$ 8011011110 I*108000" 00r0000
or 700 0011*000700 111111 1110 0110100 00 700 0000000 00* 00
?, 0. c" SO 010 00 00 8*1*000. 17112'.09000100 00 0*0 08110.0000
000 110 0007/070 A. 000 080000 m 00 8.0110090800 000700 10 000.
$101110 m Y.. 00 ,.o.c 19$ or THIS ro00 H 000010700. 000.
070$ 1119w87000 000r"te9 Jr 00000 or 700] 0000 .000 01 n04:tan
0* 000090 1100000007 m 7000 000m7*00 000007
REPORT
DATE DISTR.14 June 1945
NO. OF PAGES b
NO. OF ENCLS.
(LISTED BELOW)
SUPPLEMENT TO
REPORT NO.
THIS IS UNEVALUATED INFORMATION FOR THE RESEARCH
USE OF TRAINED INTELLIGENCE ANALYSTS
SOURCE as indicated. (Xntormati-m opocifical]y
.
R TT4T PUBLISHED RESLABCU (7 T
LCAZ T Or =D=L SOMMS, UM
"ffeot of Protracted IKs]nutrition (Predominantly
CarboI drate) on Acs: ation of Geac:bio Acid in mare,
L. K. Hremmner, B. A. Lavrov, Aced Iced Sol tioaooor
p1 Ekapar Biol. i Med" Vol 23, 1947, pp 43-5
In guinea pigs on aoorbutogania diet for 15-18 de's,
followed by an essentially carbolrate diet, growth is
ehthrply retarded. Attar 61 data the saimala ware di-
waded mw z groups,, one or wi+iah was given a eharpiy
reined aao~art of hay, the other receiving about 30 g
deilyf the latter group shaved gradual loss of sovrvy
but 11 ddle In the 3At mnliwaas tame an autopsy in
liver, klftere, and supmerrmsls were cnbetant3a1]y baler
narmsla eampamble with initial earn vy levels.
"lotion at A to on Blood Veaeelo' A.G.
Phgaobco. A415 Med Sot 1(baoow
"I,Q1 14cspe MAI i Nod* Vol 23, 1947, pp 35-7
mgatrlta+acwas with isolated frog leg and rabbit ear in
peloa wi solutions of adeaoslaetriphosp~hate at
204 .2.3t1C am blood vessel ocntractian, save Sutton
sL e u th ha.~ .TP oanoestmWo w, or ojenvim at
2110'-1:10 .
e1aflummor of Lostlo, Aoetoacetio, and A 7
-1IS
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Acids on the 8yntbeaie of Amino Acids in Liver and
Zidn S1icee," S. Kaplanakiy, Zh. Shmerling, Aced
Bied Soi Dtoec~eat
void and ammonium salts, Is further studied. Accord-
ing to Slooh, the pavbgbh metabolic products of
Janine an ieovelerio, a.:atcaoatic, ,B 4owybut 7=
rio, and aoet9o acids. or these produota, only Be
OLhas a stimoisg effect an the formation of amino
acids from Wruvio acid. and,smaomium alto. in in-
hbiting effect is profted by aoetoacetia any,, P-
h$ ybutyrto acids. Another new + no of amino
acid formation tV liver slices has been observed in
the pzeaeaoe of acetoacetic and a 4~y,Jyrcagburis
"BSc aimiya" Vol 12, 1947,'V 2734
An earlier finding that leucine stimulates the egn-
thesia by liver slices of amino aeids from pyrwiie
acids and sumomivo alto. The N of thie amino sold to
not liberated by the Van 8]y.?lo reaction in 3 minutes
as in the case 'hen pyruvic sold is the s ate,
but O x1wAw are required. This indicates the for-
erutixm not of on Q - but of a ,8-asmino acid, most
probably f -irainobustyrio acid.
"Alaleids of Treehelantbuo Norolkovi 17. Strmotrme
of Tsschelantamine," 0. P,? Wa'ehibow, Acid Tied Sol
MAW Cteheh lOrime Vol 17, 1947, pp 343-6
Bydma2Tsis of ttracbe2a a gives the pa~sviavsr5
ehavsoterrised and identified tseobe1antamid ae (an
aei-* alcohol.) and ts+aoh Until acid (I), trl04,
--- trant re is shove to to C6311(OH)ZCOg6. two
reaetiooe with I are described. It is oonciaued that
I is 2-Mtbyy1-3,b-dtb irony-3-peetaasoarbcsylio sold
8. L. Berg svebaya, I. U. Lipovich, Aced lied 84i
SNOW
MR= Cbehoh Thin" Vol 17, 1947, pp 347-%
4,1-oe t+il l l in crude CaHJ treated gisdosli7
dth Beq y1+18ed benaoata. TM in CItreatpd
"laud sift Br yis'ded ernes, and to a anovet
pules 44Womoae4245e~ bemuonfe, WbAs infested
with at room toperat4p ti, atlr-
r ? @M ir- beaghaetsyl-
asiao)noot 1.T-1-uni-htbri bessoate as a dark oil, sod
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MI salt. The ACl salt In me= Ael L heated with Or,
on a steam bath, concentrated in vaouo, shaken out with
IK.
ON and the, dry 3t20 eatraot tr%ted with
tbo3 . 91milar result was obtatnedda I alyeSa
of the orada free base by Er in AoOH. Lgmally efeot-
attaogrts to Isolate the reawting Sooner of I, either
as the free base or MI salt, failed duo to Instability
of the aqueo w ao1 *ticn; the solution gives a bxoam
admen with Pool3.,; pberweoolog~iaal evaluatima of the
sa1ttian felled to show a4y s tboadmatio action.
I was lass effective than adrenaline or ai athol In
svppostIng hoar action; it no also poorly stable in
agueoso .
at atwouft press an and tasgeature to give
1?( -1~mptathyl)-~Oathanol-1~1
W. Ss DD1 salt we ogenated with 4% Fd an C
at roes tospematne and stacapherle pressure, but
.w 1 U. ~- W ..fv I va q/J. CLAVOW&i{i AYi.
To ( 'LWslna)a 1-na1htbal in Zt?
V" a $ 8d an C, and the mixturo was hydrogenated
The Medboadm of Potentle of Asino Acids In Senor iv-
Isg AnImal Tissues free Ppuvate and Aeoania,' V. 0..
1 tciem, Acid Ned Sot Yosoow
'There DID] og 1ml 44s No in, 19147, pp P17sb00
sate as (1) fo~se.a** n of amalaostots and
-n P aa18 felts l production of a.---
r
bito4ataria sold tires i the t
Scarbw io acid
a e; (2) toehaatdoa of aspartie said (or
uteSc'
'
maid) free amalaaatic (or 4L4bto9Latearo ss-
dodos; 3)
aow (U)? me an a dirt ifie4 W New
foocsatioen at sl else by ttwmariasJon between I and
as iat C (car~,~de ) acid. Tar role of trans "-.
tiara u?tau dual step it aLaisa gntbssia W' A car-
timed by (1) the andal eaavuptdaa of aapartla sold
into ai s In the omtcee of swim & VU forsatdcs; (2)
ties eats actSarlt" of the Rio wide its
seine sold synthesis; (3) the "M 1161 decrease or the
antis at radnsti.-M indention and of transasinatios be-
teem sapvric acid and I with dilation or purifias-
tics of cell-free liver preparations, and the coinot-
dest partial reactivation of both processes by a supple-
not ofalbs eoaoga of sspartie adnopbesase. Allbwa h
poatedeted I1,? oth era, the present study appnrantly
olYYas tbs first direct m eel or an indirect biological
ante acid sOmtbasis.
'Nate' P 159, 1941, Pr QA
'La$lisstios of toe Q.? sn of Anion Acids in the
PeMea of Atdsepas e0A.S Kanthwav N. N. Dobbert,
loscow
A. S. Soo tqn, Amid
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oacura 097 with gluuaic acid, and simalar reautts
oaemr with heatinaotivated aminaphernse. Pros data
presented the authare oonolude that L$ dissodation
(a) and Uv= tar of?lH2- (b) are two distimot ansr io
stops of tmanatutdog. Stapp (a) is an ,
relatdse17 Aonspseifia and best stant Ametian of
1, 1 s e rayuisite for, but not necessarily
fo3lnwsd by, (b).
leuoine, and glycine in the presence and absence of
(t.kehn snide. Dlaanotetinn withnnt. lrptn Anirlm
Dissooietion of dL-K was studied n D-L*beled Y
glutamic and -P-uepertlc sells, fp elaclnP; .(-
"The We Acid Vetted for the PI"lficatirn and Conn
of Viruses," V. 1. Tooasemits1eiys Acad led
Sol Doseaw
carried opt with phosphate batter or acetate bolter.
go coo mentratioa of the Thos in thus Increased 150-200
tats with the adsorbed Thus Is o~strifiWsd. Rtution is
red Insoluble irate is obtaiasd which no longer dissolvac
moor 4 +tmce 3sja alt reached. A anspsmsiam of
to wrap is obta. ssd by tritmeatdng the tieens in a
neater with the solution of x Lusts. After oentrittzg--
the a],aar surg s of the viraa is Room in the
rsle3~ea+Rtpa~ oasralghb. The following hey the solution
is the ied to room tespirat o and the iwate p0soip1
wDiothimiya" Vol 11, 1946, pp 247-32
Weak alkaline solution of K orate is prepared by tri-
tawbft said with normal , to which is added
Toiling aeid. This is erred to stead land is filtered
tram imelvhls coaterial. Hltrate. Is nwaftillsod with
neraaZ Ml to a pH 7.848o emb a solutiam is saturated
at roam $emperatere, ash actor fi?0 gag and tbaRing, a
"Coadaopher~ase, Codeoarfieop sae, and Pyridoa l,R A. $..
&+ame6teyn, M. G. sritsmmn, Acad lied SaL Ibaoow
"liattams No 158, 190, pp 102-4
iths t (from or awe amplax than pbotpboij ri-
damal; the system to present in the codeonrboxylase prep-
aration Gals and Tomlinson. This is ocofirmed.
?nsometru E.timmtien at small Qsntitisa of Asparkle
Aedds" A. N. D amehtayn, V. L. Teso1 ' ypas 0. Ya.
Asparlie sell in a voi* of 2-5 ml, is mwk _acaord-
DDss,a~, and 1$. Theroiot.9on adxt is aanheallssd
to`tk o led with 83P00, and the fteario acid then reduced.
Mad kin, Lead Dad Sei besar
"ffisldialga" yol 11, 19s pp 901-,16
The deludes which contains se lass than 0.20.3 ng
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to aueo aio acid, ebiob in deterairmd to a Tarbtwg appara-
tne tdth the aid of eamolaie ease, using the method
at Knobs. The method is accurate for the fttendmM= of
separtia acid in pure eolutSone, deproteiniesd tissue ox-
treats' and proRedn ydro3 iatea. ?sparagine T.d be
absent.
*A SUbMamm in Brsia Mich Seneitiaes Hassle to Acetyl-
' i! and a Mological Method for the natisn of
? in. Nero Tiuuo,* N. B. Babek yl. P. P.
ltleayew, Load Ned $oi Moscow
*BraU Nicsper WI I Ned* Vol 22, No 4, 1946, pp 5.4
it sore found that emuleiou of rabbit or gubm pig baaiu
in whiph the aaetgltaboU.ue (I) was 4, -rayed increased the
rotioo of bdded I on the rectos abdadinim of the frog.
Safe of the increase is not ltnowQ, altbcvgb it we fommd
that the I ion Vmftmed a eiedlar affect. It is
that the difficult' in the eses? by
this factor oda be avoided it the total activity at the
fib tissue oindil a is ocuper?ed with that Rommel after
the add'ttiwms of a bft godaltitr of I to the V&Wwatlm
after' the com eta dsetnn uom of the I original?y pel t.
'Speeitia ?ltatatioms of Mn Protoine," V. N. Gre&boviob,
Arad Ned doi lbsoow
* N Bid I Ned* Vol 22, No 4, 1946, pp 57-d0
Snbc chansons iatraduoticm of 50400 ag of anltidiae (I)
aide the dQ3n of rats moa'e saeoW4b1e to the action of
oatbypsl1 I.A vitro as brad with the in of utreated
aai~elRy Tue hundred mX pt I bat the opposite effect.
agiinld applied in the sane x--mw ironwood the
d#"stibdItW of t 1w d dm. No of ects ware Obeerwid as a
r11/mt of the triaiaent sdhm the proteo11tia amd- ea em-
were "pain or trjpein. It is suggested that the
spsoitio cootigoaetiamal altas-
at the *ft.
Al" abide of 'heabellvhe Lor'olbo'vi3 V. Synthesis of does
pod misfiles of i N. L. 0or svioh, 0. P.
N oddoloVV, Load red $ci Memo
*Zhne .h 10mini3* Vol 17, 19t7, pp 1714.17
A nueber at dertntlvee of tMOMAINtOddim (I) nose P*+'
Trssd for e.eoPogioal study. Reaction of I in dry
Ms b din I m son coolsn, and alsed with 0, gve
b ~ ; It in apt call .maths
and is a-faebb. anesl W+o. I sad pars-tv
bedlid is dry no am psze.eitrobedd:dyl
dUW4011 WS is LcM tested with Pe filings am PM-
MaomUft. This treated
with t2C0~ give the free base, *lob is dtT With 1
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~quivi1 t an Sm, Us A10 1 matt. n U is can
Aw to oc i e I 1 d b ~ ft Otemw to aocdzie and aMrealO-
21 with . 38`r.ft at pa pea't3m. ftmw re et'Jo a
IMMM to t" pvftMdm of
til' ? / qmIwHnm.,M am ibe& TbU 3e.
mg+ WA1' atieb as so antImUrW.
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