SCIENTIFIC RESEARCH

• Document Type: CREST
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): CIA-RDP80-00809A000600200129-8
• Release Decision: RIPPUB
• Original Classification: R
• Document Page Count: 3
• Document Creation Date: December 22, 2016
• Document Release Date: June 29, 2011
• Sequence Number: 129
• Publication Date: June 25, 1948
• Content Type: REPORT

Sanitized Copy Approved for Release 2011/06/29: CIA-RDP80-00809A000600200129-8
l
C SIFICP.TION ': c
CENTRAL )Mff
INFORM
COUNTRY USSR
SUBJECT scientific Resourch
DATE DISTR?25' June 1948
NO. OF PAGES 3
DLTZ OF SUPPLEMENT TO
IIlORirATiON 1945-47 REPORT NO.
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STATE
ARM1
THIS IS UNEVALUATED INFORMATION FOR THE RESEARCH,
USE OF TRAINED INTELLIGENCE ANALYSTS
Documentary as indiceted. (Information specifically
requested.)
R C NTLY PUBi.ISILD &SF.ARCH OF TPPE
SARATOV :'T DICAL ,L':STITUTZ, USSR
"Mixed and Combined Action of Srx'le Barbiturates (Uedinal.
and Y.oxonal) with Chloroform, tidier, and Alcohol on
Isolated Frog,lieart,s S. P, Zakrividoroga, Saratov Ced,
Tnst
"Farmakol i Tokeikol" Vol 9 , 'lo 1, 1946, pp 534
Hewnal (I) and medinal (1I) ic, admixture with CIIC1
ether, or alcohol exert additive effects on iaolateda,
frog heart, whether given in therapeutic cr toxic
doses. Among combined efforts (one drug given before
the other), CHC13 contributes more toxicity than does'
ether or alcohol after dosage with ?.; but ether or
alcohol brings out toxicity of I more ahsrply than
done CH013. Results based on changes in rhythm,
amplitude, and tons of isolated frog heart after
5-10 minutes of treatment with single or mixed drug
solutions, e.g., 250 pm of it 500 ppm of II, 125 ppa
each of I and CfC131 or 250 ppm of I with 125 ppm of
(5!C130 A typical pair for combinad effects (successive
dosages` , wen 500 pvc, of CHC13 and 5, OGO pin of 1,
given in either sequence.
"Mimed and Combined Effoats of Barbiturate with 3.orphinei
.Pantopon, Magnesium Sulfate, and Local Anesthetics on
Isolated Frog Hearts." S. P. Zakrivido-oga, Saratov Ied
Inat
CLASSIFICATION P%S1 UC'..il
NAW ,.x NSRB --J~--~j- G:STRIBUWfONI T
AIR x RDB i xI I '.
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Tests tare reported with medinal (I), morphine' (II)I
centrations are in parts per million. ;+hen equal
volumes of II (6,250) and III (5,000) are mixed, a
white precipitate forms in 3-5 minutes in Ringer
solution, or 6-10 minutes in distilled water. This
compound is so toxic that the blend of solutions at
1/12 the toxic concentration of II and III is toxic.
Similar synergistic action is observed with I and II.
Clinical use of III in combination with barbiturates
is contraindicated. A blend of IV (2,000) and III
(5,000) forms a white precipitate, but without
III. VIII and. I$ show antagonism instead of synergism:;
and there are other instances of antagonism in blends,
or pairs given in sequence. Compounds formed by
synergistic pairs have not been identified. Effects
hen IX (0.5) was given after II (125), toxicity was
decreased as compared with IX alone; when II followed
IX, effect on, rhythm was lessened but toxicity to
amplitutes and tcnus wa_v intensified. The barbiturates,
in th4 blends, decrease bradyeardia and act as local.
anesthetics, showing direct antagonism.
Min Mod" Jul 23, No 6, l9t.3, pp 49-5rC
versed. This is explainable by the fact that anti-
bodies formed in the reticulo-endothelial calla are
modified molecules of the blood globulin.
Comparatitie Influonce and Therapeutic Range of Action
ca Some Drugs on Isolated Hearts of Cold-Blooded Animals,"
o. r. 4alcclvlaoroga, earaaov Leo ins
"Farmakol i Toksikol" 9cl8, :do 5,1945, pp 10--14
coefficients r.f taocic dosage (nafareacs CHCl33w~l(at
concentration of 1000 peal were meaeurad for 2Z drugs
by the effect on rate, aacplitude. and tons of frog
heart. The drugs include the following in order of
their concentration in parts per million: pentucaine
,
soveaine, lobelias-HC1, ouabain, heaetune, cocaine-HC1,
strychnine-HV)3, csmpho*, advanaline-HCl, procaine,
pentopon, arnpblan r:e-HBr, ^+:rnpine-H2304i ephadrinc,
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STAT
Sanitized Copy Approved for Release 2011/06/29: CIA-RDP80-00809A000600200129-8
 Sanitized Copy Approved for Release 2011/06/29: CIA-RDP80-00809A000600200129-8
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RC1, POOL-, pricrotoain, Ne barbital, UVO. .F_ e1
metrazolo, and ?tOFF, H1t;hest TD/" LD ratios wereei ~e,
own by stronirie--H2SOb 5,0^~ 1copo1a:^.1ne-R3r 6,9^n,
and atrvchnjnm-?POi ?,(^' G)efficient3 of to r5.c
dosare increa?ed In the order of drupe renp~inp from
0,01?5 for pontocnine to 66,6 for 's'tOP,
STAT
Sanitized Copy Approved for Release 2011/06/29: CIA-RDP80-00809A000600200129-8