SCIENTIFIC RESEARCH

• Document Type: CREST
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): CIA-RDP80-00809A000600200218-9
• Release Decision: RIPPUB
• Original Classification: R
• Document Page Count: 7
• Document Creation Date: December 22, 2016
• Document Release Date: June 29, 2011
• Sequence Number: 218
• Publication Date: August 6, 1948
• Content Type: REPORT

RI NTLY PUBLISHED RESEARCH CF THE ALL-UNION CHELaC0-
P1W &CtlL06ICAL SC37NTD'IC RESEARCH INSTITSE USSR
eCbsaiatry of Aydrosyfuohsoneas I. Eupittono and Rubro
pI0ms " I. !a. Fbatoveddy, A.N. Eydlln. All-Union
Chem harm Soi Res last, Svw&ovek
eZhua Obahah iim" Vol 36, 1946, pp 2043-52
K ,w syntheses of eupittone (3,3',Y',5,5'o`a-hearamethasq-
4,4'?dibydroxyoiuoheone) (I) and rubro eae (3,31,3"-
trimethaxy. 1,4 '?di2ydeo3+Psuhaono) (II) are described.
Both I and n etimulato blood prodnation in guinea pigs;
cinder affect produced by actin.
!Cleavage of } oagfnohaoOe," I. Is Pbetovskly, A. N.
Eyd1in, A21- tan Chen Pharm Sci Rea Fast, Sverdlovsk
"Zb !lbeheh Shia" Vol 16, 1946, pp 2053-64
Since enpittone (I) and rnhropbene (II) have been re-
parted as having soar t?beromtlostetic properties, the
poceibility of ant's aotl-7ity reaidirig in tr nta of
I and n prasepted the etu ly of the cleavage of t?
to hoonss uaderr a variety of conditions. Amain (III)
me also Included in the at*. Shaking I, II, or III
In 5% AaCH >mder about 3C0 a p caste of 0 and deter-
aluing the u',.11ioed 0 gage 0-utilisation across rmioh
are presented. III is essentially completely cleaved
in 32 !somas, II requires 15 bows, chile I is mmcbanged
in 15 boas, Siedlar oxidation of bBnsoquinene, tol-
ugniavne; and nathoVq dnos a led to caaplation of the
reactich vithi,-% 2 hours; FhOH yea mmohaaged in 3 ho=,
CLASS yATION }'J:-ZT-IICTI:D
CENTRAL INTEL r ~p
INFORFIIATi8" 'Ff T
COUNTRY USSR
SUBJECT Soientif+c Research
PLACE
ACQUIRED USSR
DATE ti''
IIaWCRlIATION 19,45-46
of we 55105 "Stff 111515 sus 0or. TOt UMO*Mt efe so
a? L.O.. ft as pl. Y N155t0. M=6 tl1551 US"A" M
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`DATE DISTR. 6 "August 1948
NO. OF PAGES 7
NO. OF ENCLS.
(LISTED BELOW)
SUPPLEMENT TO
REPORT NO.
THIS IS UNEVALUATED INFORMATION FOR THE RESEARCH
USE OF TRAINED INTELLIGENCE ANALYSTS
Spin Docomentory as indicated. (Infornation specifically
NAVY
as
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CLASSIFICATION PICM
z
Z
OuSnu)aunON
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Rotative stability of the iB6a0 derivatives to oleavs?eT
Derivativee,e G. A. Qarkuahaa A11-won Chem Phaam Rea
crude msoadie acid; further-llltration and oooiiig gave
"Zhur Obehch ?wdm" Vol 16, 1946, pp 2025
decolorization with biealtite gave 2-iodo-3-hydroo4,
gave what appeared to be bsnaoxy-l,4-pyrone. Pyrone was
from EtOA to give 3-ttvdroi~-1,4-Phone; it melts at
of its !V -Substituted Derivatives of the Alkyl Carbwg1tc-
"Zhur 0bahch Khim" Vol 16, 1946, pp 1933-40
toward pnemeon?a and dyaentery approximately equivalent
derivative howed some activity toward dysentery, but had
dine nucleus. None of the produote showed appreciable
properties indicate a pyridonimiae strrctura, i.e., the
derivatives were prepared by condeneation of Na aulAspyr-
at physiological pA level., a number of carboxylic acid
Available evidence for the "normal" and the 2-pyridoni-
butylandno) Quinoline," Y. V. Rubtsov, M. V. Lt unova,
"Zhur Obehch Min" Vol 16, 1946, pp 1873-6
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with oo2lectiom or the diatflUtee; the sublimed pc14d,
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Two methods are explored for the synthesis of the 4Piso?-
mer of plawooohin. Syntheses procedures starting with 6-
methosy-4?ehloroqutinaaine-1C1 and with 6-meth -
q tnoline are, described.
tomes of too.wevea is fuehso ee attributed to the forma,
tion of an intermediate samiftwhoom. Possibility of a
ev m niaction between the reduction-oxidation potential and
biological activity corroborated by the finding that the
fueheones studied have the same ability to promote hamo-
gllobin production in guinea pigs.
the quinone series, the potentials are progressively, shifted
to more negative values. Velma are given at 250 in the
absence of Etas and at 600 after addition of 30 aeigme4
Ball? Fuheones produced two waves, values of which are
given at 600 in the pdresence of 30 voles of Et(L Padn-
phenoass and ftobsonss, Lie Me, and two Me0 groups (1n
2 sitions) give almost no potential variations. In
toted Qttinonee, Thence.., and Fuobeonee," A. G. uSteombng,
L. H. Rayne, All-IDodon Chem Therm Rea' Inst, Sveerdlovsk
"Zhur ataboh Dim" Vol 16, 1946, pp lI31-42
"Pblarigraphio Study of the Hell-Weve Potentials of Substi-
"Alkaloids of Tsachalanthue Norolkovis M. Structure of
Tina , the Amino Alcohol Porwed in the F4-
dmlrsie of the Alkaloid ':raolulasYthamine," G. P. Men,-
"ZMar Crmbcb Ebim" Vol 26, 1946, pp 1311-16
similar to heliotridane, and that the difference in the
cawzoe of the Bofeenn degradation is the two cases 10 due
to . Since the ?grorop is primar9 In
Saes a base, , identical with Prelog'a pyrroliaiaine.
It is cowl=d= t peeudchelletridans (source of trap-
holantham1o"no)?has the structure of 1-matbYlpy aMm,
facidation of traohelanthaeddine with CrO. in dilute H2A04
Sava an amino acid, C , which ar sus as a
saoaohydrate. DeearbCV3 t an by means of Ca0 hydrate
Results o' vapor oonposi+ion and dateraination of sixtures
of beams and CIZ:l3 are gins in tabula.* form at 25.050,
34.6x, a4 44.550. CNunges of free energy and entropy are
P. MOM, All-Odon Chem Pharm ass Inst, mown.
"9 Mahah Ihiae Vol 16, 194.6, pp 972-82
argy and Entropy of Their formation," $. A. iiteyeu-, I.
"het~slmtion of Pressure and Composition of Vapor 111w-
tures of Hansen. With Cblorofosm and Changes of Free M%-
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'Neutral Eaters of Sulftnic Acid and Ia01yatomic Alcohols,*
U. Na. Ereft, All-IImism Chem HUM Res Thatt Moscoe
'Zhtn Mahoh Ehim" Vol 16, 1946, PP 677-d4
Neutral esters of HI30 and polyatomic alcohols may be
prep red by the reae of chiorocarbonate eaters on acid
U230L eaters. Most readily preparable and most stable are
tt~aa~~ eaters rdroae P-C atom does not have an H atom. Prep.
aration of derivatives of an alcohol with a secondary CH
(glynerol) failed. Syntheses prooederos described.
*Sesltanilamide Derivatives of Aromatic Arsonic Acid: I.
Selfaniludde Compounds of Para dnobenseneareonic Acid,'
S. V. Vasiloyev, All-Uoion Chem Pharm Roe Inat, Moscow
'Zhur Cbsboh Mdm* Vol 16, 1946, pp /.51-4
Na Neste in water was treated with para-AcNAO6H00 l
to yield, on oeoling and partial concentration, pare-(N4-
*eetyi(snltanilauaido - acid. The As oopetnd
was l by with lit1 to yield pare-eulfanil-
ansidobe areenie acid I) the constants of which ere
not, given. I in %Q and 3 N NCS was treated with Na2S204
to yield 4,4'-disuTTfanilemidoeremwbensone. Howeverwhen ;
the reduet4on was performed by 802 in MOM solution toe=
obttainsd4/ -(parrs-aroeaosopheny+l) sulfanilamide. The acid
was Inactive against spirochetes or trypanosomes, while the
last taro ocmpoucde were 24 times less active than nmvar-
semoi.
*Allewiao Ee+,ars of T iao-l-Naphthoic Acid;'
3. S. -%W94evekaya, A. A. 3ropechevat, All-Union Chen Mere
Fes last, Moscow
'Zhur Cbsheb Pmts' Vol 15, 1945, pp 996-1000
Fo31owiag nw altaedac esters were prepared, all of which
were found to have definite anesthetic properties. Et
Pet a~aphtr+aoate (I), Me~ pOH, Na,
and abaroluto Um were boated; after removal of the
LtOH
and aaovaos smash alcohol in waouo, the residu? ins poured
Into water and mtracted with 0 m o f
to the dried extract ga gave
ar-%4-snie -l-ne Toasts-2 l1. Treatment of the subject
acid, NQI, ItCE, cad C 6H~0 by heating tc Lot tom,
filtering, and oonceutra it ohs fo lowed by solutica in ab-
solute XI sod addition of alcoholic HGL, gave 3-dlethyrl-
asfnoprap,'J. 1-naphthoate-2}C3.. I
eel tswatsd with 4-diatby'lemino 1-butanol and Na, and the
mixtwee es heated on an oil loath, after which the excess
swiss Wankel is removed in iacuo and the reddws poured
in Sister and extracted with M20. Treatment of the ex-
tract with O-U01 gain 4-die bylamivobutyl tetrab7dro-
~ tboete-2hC1. I, Na, 3't0&, and 1-'iet3>yl-
satm-3-bntonol heated an an oil bath, and treated an
ab , gwe
3-diutbyiamiao l aeElylprolgl ~r-.6
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m rat contain
aaete mat ion of Quinine Alinloide ftich
a Nethoaygl Oro in a Matte of Quinine ii woii,e N.
Z. Z eon, A. t. 8in*loov3kaya, 111-B on Cbaa There
Inst, Noscoc
Win" Vol 15, 1945, pp 957-61
fslfoh 6hia" Vol 16, 1946, pp 1077-d6
ditlon of WI. tba aria WAD aotoraotOC wawa M20, xxvm ' ?
brae were obtained ceverel oompawda, all of ehioh anco.
1)-Pa~oPlonia said. It
wsa ebowes.het two of the oompowide were iaeividusicon-
pWMU, while the third we. a mixt we of the two. Siailar
Con9enastion in Oft led to a aiwtura of the above cub-
stanoei. the produste are separated by orystellim tion
from IW and identified as: 6 1,2,3,4 'tetr
7(er 8)-oaphtba7IpropiowdC acid (1) and the 8(or 7)-ndpia
t c t iaoro (111. 1 fares an cmdme which neelte at, a
hi~hear teaperatmr than the oxiae of U. Clemuneen re-
&wtdoe- of I pave the corresponding, butyric acid, which
net heating with P205 in PbNe, gsee 1,2,3,4,5,6,7,6-oCta-
dmoeQ with aaelgemsted
r
thr
are t
e
d hstoe oo~yp eoaa
an in Wi-P6No to
anthreno (Us). OZeaoenea redrootion of n nave the Corr
responding bctrio aold, which an cio3iuatIon with P205 in
WIG FAb, gate an ir!ser of the M .V dexivh-
ative reared dth e-1gemsted Zn to III, ttma she ing
that and w we 7- and Eriseaers. hmther iseatmeet of
I is dese 4W in the grepsration of the lac one of r -
(6-otbaaq .1,2,3,b-~ D1). mo ybutyeia
actor n, i. It. Fsdaeow, A121 or Chen Thar lest, Noacow
?Zbwr Obrbeb Rhin" Vol 15, 1945, PP 96"
to1loidn proo,dme recd: diluted magi, and the tolme were
d
wigom&V stirred can d;A treated with ooma:atratw
RAIft and tbG ; the reaction arse um then dilated, fii-
washed, bmd nepraaipitnted from alkaline solution
by Wi or %#4:%. %WO, 2,4?C]23619te, IbO2 cad oaswreial
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concentrated HZ90 gave 2,4-dicblorobensoia acid. 02$04
a-o2~lc wit neaa MnOg and commercial trated
$2004 gars 2-ohioro-4-nitsobensoic acid. Treat nt r4th
peya-nitrotolweme gave per -nitrobemsoic acid.
eT -1(and 2)T6ionaphtboic Acids and Their De-
rivativwa," S. I. , 8. G. ISkhem>dna, All-
!eparation of subject acids and their exters described,
Peters Include It, N. 2-chloroethyl, 3-chloroY PyL,
est4ms, 2-distbylaminc;sth2+1 aster-901, and 3-diet yl-
amincpaop l aster-ML Th eioal properties are given.
The alumina eaters are not effective .
"Zhnr Obaboh Shim" Vol 15, 1945, pp 98?-95
'T*txsb7ftti-~1-(and 2)-Naphthoic Acids and Their Dex v-
stivee,w S. I. , H. G. Nlkhank+++?, All- on
Chem Phara Inat, Moscow
"Zhur Obehoh Rhin" Vol 15, 1945, pp 940-6
Syntheses for the preparation of subject acids and their
derivatives from ar-l-Aminotetralin end 15;1 described.
Phfei al properties are also given.
"Alkaloids of Cacalla Hastata," V. S. Honrovalbv,
gem'ehilcov, All-Union Chem Thins Res,Inat, Moscow
'Z6ta Obaboh Shim" Vol 15, 1945, pp 328-31
tbo udit wetted bW 10% W QH and extracted with C2H4C12i
extract as earEreoted with % 8280G1, __and the latter aaee
alkaline with 25%1Q9g0H and ewtracted with CH015. After
The sib leAd is h drol red by boilii in 7% alooiolio ICs
to yield a dibasic H0 acid, C8H13W-(C02H)2, *doh ma
a awed bsstanseinio acid, and an amino glyool, 01.51,
deieb as named hastanecias. The alk0oid possesses ex-
"Ar+eoolins N-axida (Cwmreoollne) 3" U. N. Mcbikina, A.
Ya. Barlin, S? D. Oasanova, IV -Obion Chem Ram Piss That,
B%% awtriniag 0. Q5 atom of active D. ?!h-+ ntxw s is*,
tbst satod with Fleric acid and allowed to stand, to
rent with ssttaatod . The 0 eatrsot of the wlx-
"Zhta; Pritlad Rhin" Vol 18, 1945, pp 634-7
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yiem exe?ellme /V/ -=we pdrate. The mete .as' further
UwW with Wi zad several por bone of CM-1 to yield
areoollu. N-*dde-El. Trsatne nt of thin th 1C
gene the rue bees as a ?ellawiak oil.tewemt of the
El mat with sag in water on areeol1ne anifesate 99
d ausGes. The gather tiger ooataied ersooliae
% nas isolated as the oxalate. The 9ndioatlons are
the 8 .Rests the emotion of the oxide to the free
bees, thm nplfedo eater beisg as laet.rmsdlate.
the *aOO ass awwwad In xaona, and the residue was cooled
~ep.d tre*t.d with ocudentnted M M. The pe?.eipitated
1 1e is0oa8,004 fIlt red off,' eeesbed, and dried$
with oMmuWated M. folinwing by eehing with
VajpN weep the I l salt. The El salt is um b -
ted in the preeaee of ltenW ltl to, yield dil~~rlrol~ 9ra.~y-
ePlteap.ration of From Tbebaim,e
1. Eh. Fe1 *deran, A. I: I rb~g, on M >
am not, swam
5Zha Prlklsd lpeise Vol 18, 194, pp ?15-1?
W NW= wee treated with ?s stirred = U solution
and the Me rented with H2GG. liset of
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