DIISOPROPYL FLUOROPHOSPHATE IN THE TREATMENT OF GLAUCOMA

• Document Type: CREST
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): CIA-RDP80-00809A000600280516-8
• Release Decision: RIPPUB
• Original Classification: S
• Document Page Count: 4
• Document Creation Date: December 22, 2016
• Document Release Date: October 12, 2011
• Sequence Number: 516
• Publication Date: January 26, 1950
• Content Type: REPORT

Sanitized Copy Approved for Release 2011/10/12 :CIA-RDP80-00809A000600280516-8
COIINTRY IJSR.
rI ASSiFICATION SIsCl"tEi 3~~~E~
FOREIGN DOCSJME+~iTS OR RADIO BROADCASYS CU
~;Et`!TRAL INTELLIGc.NCE AGENCY RE
INFURMATIUN FROM
SUBJECT. Medical - Diiaopropyl fluorophosphate
iiOW
PUBLISHED Bimonths..y periodical
WHERE
PUBLISHED Mosco~r
DATE
PUBLISiED Mar/Ape 1949
LANGUAGE Russian
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50X1-HUM
UATE DIST. a b Jan 1950
THIS IS UNEVALUATED INFORMATION
V.:stnJ.k Oftalmalo~ii, Vol &YVIII, No 2, 1ry49. (Informstiaa reouested.)
DIISOPROPYL FLUOROPHGSPHATIS IId TR$ TRk:A3TMEZiT OF GLAUCOA7A
s. R. P.~luaer
Eye Clinic, Acad 1~d Sci USSR
Firs~i Order of Lenin Moscow Mad Tnst
Two years e.go, Yrof !:. Ya. Ssmoylov puNlic.~ed a report on a new myotic
preparation ]mown ae dlisoYropyl fluorovhoath4te (ik'P). This article pre-
sents t;=A results of ea-periN}ents conducted at th~~ :~{.: Clinic, Acadeatiy oY
Medical Sci.eaces USSP..
DFP belongs to the c1e~s of alkaloids of the choline aeries, acts on
the cholinesterase, aad is a media~or of nerve activity. At the same: time
it causes spasms of the nonstriated muscles, nesiccates weasels, and de-
cx?esaes the flow L~f body flnid.s. It is very active; data shoxs that it is
five times more active than eceriar,, produces prolonged siyoais is man and
animals, and !:~usas spasm of accoa~odatior+ and pains in the ciliary tissues.
Same of the manifestations are headaches, and prolo:ged infection of the
conaunc~tiva. A DFP solution with avegetable-oil base is more stable and
leas toxic than a sclution with an aqu;ous base.
gxgeriments stare conducted on 21+ patients (30 eyes): 14 eyes with
chronic E-,laucoma, seven with decompensation, three with acute parwgsms,
an3 five with absolute glaucoma. Tieatmeat began with two drops of
0.1-percent solution oY DFP in a vaseline base, but due to many undesirable
effects it ?sa changed to as 0.05-percent solution with simultaneous padding
of the eye.
We attempted to determine the quality of the DFP and Its place in the
general classification of myotic aubataaces by simultaneous complex tests
oa the dynamics oY intraocular pressure, variations is the diameter of the
pupil, and size of the blind spot. It ass possible to conduct campimetric
studies on only 12 of the eyes. It was impossible in the other cases due
to the presence of atrophic scotoms, acute or~chronic glaucoma.
C[ASSIFICP.TI~N
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OlSTRIBUTION
Sanitized Copy Approved for Release 2011/10/12 :CIA-RDP80-00809A000600280516-8
S~G6ET
 Sanitized Copy Approved for Release 2011/10/12 :CIA-RDP80-00809A000600280516-8
50X1-HUM
Use of the above concentration (0.05 percent) of DPP. produced very.
significant results. After only one hour, in scotoms-patients, there was.
ofVthe scotoma rem2.3.ned stable for the first 4 days (24-hour.. periods ), .but
dsy thF scotom:. decreased to the original site of the edema. In samePoYL^
peters of mercury) during the next L days. After the third. day the'?e was
ny other myotics) for a period cf if days: In isolated cases it was possi-
was observed on the second or third. day after the 'pests w:Lth a peep-hole
light. This reaction was not observed until after tr_ third or forrth day
when utilizing ronvr;ntional light. Instillation of an 0.05-percent solution
of DFP in most cases accomp2.nied a decreased or more clearly defined con-
junctival ini'ection, and this condition persisted fur a gario3 of 5 to 7
days,. while the intensity of the ^olorii.g gradua7.ly increased tcward the
end of the first day and during the Fecond day of obbervation. There was
sub jecti,re desiccation fros !:he thi. i `.o firth da}?, arid in all cases there
w:ss sc+m.:. pain iu vhe areas ?here desi_:;:ai:~.r1 was indicated. 1.n ,one cases
ci:_iaz^,/ pains, accompanie3 by s^ute static cont:-action of the ciliary muscles,
ti~:re indicated. 3imultaaeously there was a disappeKrauce of tac irri