EXPEDITIONS FOR THE STUDY OF OMSK EPIDEMIC HEMORRHAGIC FEVER

• Document Type: CREST
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): CIA-RDP80-00809A000600330562-1
• Release Decision: RIPPUB
• Original Classification: S
• Document Page Count: 2
• Document Creation Date: December 22, 2016
• Document Release Date: August 26, 2011
• Sequence Number: 562
• Publication Date: August 8, 1950
• Content Type: REPORT

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CENTRAL INTELLIGENCE AGENCY REPORT
TION FROM
INFORMA
FOREIGN DOCUMENTS OR RADIO BROADCASTS CD t:0. ST-74
HOW
PUBLISHED
WHERE
PUBLISHED
DATE
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Scientific - Medical :hemorrhagic fever
Bimonthly periodical
Moscow
Apr 1948
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DATE OF
INFORMATION 1948
DATE DIST. ~ Au$ 195G .
NO. OF PAGES E
a SUPPLEMENT TO
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THIS IS UNEVALUATED {NFORMATION
SOURCE VestL,ik Akademii Meditsinskikh Nauk SSR, No 2, 1948.
EXPEDITIONS FOR THE STUDY OF
OMSK EPIDEMLC HEhIOARHA IG C____-__~FEVEf~
Digest'
During the past few years, the Institute of Neurology aew infectiousan
expedition for the study of Omattackinghmancin the Central Asiatic regions
disease, of unknown etiology,
of the USSR.
As early as 1944, members of the inaCri~mea Wereiconductingestndieson
the Li1C11 independent Primorskaya Army
Crimean hemorrhagic fever in an attempt to define the immunological, etio-
logical, epidemiological, and serological charactiniCTimeanfHemmorrhaeig c Fe-
Results of these studies were published in 1945,
ver, and in 1947, in the series Medical News and the volume Virus Diseases.
In 1946, an expedition was sent into the Omsk regmilaroto thosesofdCri~
an epidemic disease whose characteristics were very carrier
mean hemorrhagic fever. The absence of the tick Hyaloma marginatum,
of Crimean hemorrhagic fever, in the fuana of Omsk Oblast made studies dif-
ficult. The studies were carried out under the supervision of Prof R. M.
Akhremovich and several members of the Omsk Aiedical Institute including G. A.
Sizemova, Yu. V. Veselova, V. P- Ksndtothensv~ No definitesresults w_reeob--
shin, entomologist G. I. Netskiy,
tained by this expedition, with the result that in 1947 the Omsk Oblast Pub-
ofcMedical Sciencesnorganized anspecialfexpeditionatohstudy OLd the Academy
This expedition was placed under the supervision of Prof~M. P. Chumakov,
Laureate of the Stalin Prize, and included the followingvmeusologistrand Sci-
Bilibin, Yu. S. Kleyn, neuropathologist Di.N'; Vo'Sorbkirm?
entific Associate A. P. Brlyayeva, N. S. Slaving, A. V. Gagarina, and Labora-
tory technicians 0. A. Arapova and K. D. Vinogradova. In addition, workers
were recruited~frlOZialistationsmeandathe AgriculturaleInstitutenstThetexpedi-
'Microbiology, which was
tion consisted of a total of 50 members. The virusological group,
aleo Under the supervision of Prof M. P. Chwnakov, was divided into two clin-
ical groups headed by Prof A. Bilibin and Prof R. M. Akhremovich. Three other
groups contained within the expedition included ~he parasitological groups,
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consisting oY Prof A, V. Fedyushin and entomologist G. I~ Netskiy; the epidem-
iological group headed by Docent M< V. Los? and the pathologoanatomical group
under Prof I. S. Novitskiy.
In addition to research conducted by the expedition, M. P. Chumakov and
Dr A, P. Belyayeva conducted laboratory experiments in their laboratory at the
Institute of Neurology, Academy oY Medical Sciences USSR, to determine the ef-
fects of filtrates obtained from human poliomyelitic victims on monkeys. Ex-
periments on immunity were conducted on monkeys at the Sukhumi Biological Sta-
tion, an affiliate of the Academy oK.MVoroshilovancand L~RIbyMart'yanova.~~
of the Institute of Virusology, .
In 1945 and 1946, associates of the Omsk Institute of Microbiology and
Tularemia Station, including A. A. Gavrilovskaya, Ye. D. Kushnir, and others,
conducted detailed studies to determine the microbe agent in the etiology oY
OL. The steppe tick Dermacer_tor pictus was found to contain OL virus, and
thus might be the source of infection in humans It was possible to deter-
mine a method for sero3lagno; is in isolated cases of OL.
As a result of data collected by the Chumakov Expedition it was possible
to make the following statements
1, The causative agent of OL was found to be a filterable virus, present
in the blood oY patients and pathogenic to many laboratory animals. The etio-
logical role of this virus, which is passive on animals, has been defined, in
view of the regularity of its detection in patients, the presence of specific
antibodies against this virus in RSK (complement fixation reaction) and RN
~ic7 in the blood of people previously affected by this disease, and Yinally,
OL and accid.entadelaboratoryninfectionstoc?casionedaaftereworking withcthiss of
virus.
2. Valuable materials were collected on the clinical, laboratory, path-
omorphological, and ep:demiological characteristics of OL.
3, Steppe ticks Derc~acentor pictus, collected in the OL endemic regions
contained virus and hence msy be carriers.
4. 'i~he development of an immunity to OL in those vaccinated with killed
virus established the possibility of practical use of vaccination in combating
this fever
5. In tests on monkeys, mice and other animals, it was shown that there
was an absence of crossed immunological reactions between OL and Crimean hem-
orrhagic fever as well as an absence of etiological independence oY eared only
these infections, which in clinical-epidemiological relationship appe
similar but not analogous to each other. On the basis oY experiments with
crossed immunity on guinea pigs and as a result oY regular morphological stud-
ies it was possible to diYferentiate the OL virus from the filtered; ricketts-
isl type of Q fever, or the so-called atypical virus pneumonia.
6. The possibility of practical serodiagnosis of individual cases of OL
and those suspected of OL illnesses was established by means oY reaction oY
uniting the complement and reaction due to neutralising the virus with speci-
fic senmxs.
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