IMMUNOLOGY IN THE LIGHT OF BOSH'YAN'S DISCOVERIES

• Document Type: CREST
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): CIA-RDP80-00809A000600360734-7
• Release Decision: RIPPUB
• Original Classification: S
• Document Page Count: 2
• Document Creation Date: December 22, 2016
• Document Release Date: July 22, 2011
• Sequence Number: 734
• Publication Date: December 11, 1950
• Content Type: REPORT

Sanitized Copy Approved for Release 2011/07/22 : CIA-RDP80-00809A000600360734-7
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CLASSIFICATION SECRET SECRET 1
CENTRAL INTELLIGENCE AGENCY
INFORMATION FROM
FOREIGN DOCUMENTS OR RADIO BROADCASTS
COUNTRY USSR
SUBJECT Scientific - Medicine, immunology
HOW
PUBLISHED Monthly periodical
WHERE
PUBLISHED Moscow
DATE
PUBLISHED Sep 1950
LANGUAGE
THIS DOCUNINT CONTAINS INFORMATION AF-CIINI -9 NATIONAL DEFINER
or THE UNITED STATES WITHIN ?MR NEANINI or 1OIONASt ACT SO
?. S. C.. SI AND NO. Al AISNOEO. ITS TIIANSIIISION OR TNA ETELATION
OF ITS CONTENTS IN ANT ^AMNRE TD AN UNAUTNONI110 PERSON IS PRO.
NISI TED ST LAM. NIPNOSUCTION OF ISIS FORM IE PROHIBITED.
SOURCE
CD NO.
DATE OF
INFORMATION Sep 1950
DATE DIST. /I Dec 1950
NO. OF PAGES 2
SUPPLEMENT TO
REPORT NO.
THIS IS UNEVALUATED INFORMATION
IMMUNOLOGY IN THE LIGHT OF BOSH'YAN'S DISCOVERIES
Docent R. F. Sosov
Candidate of Veterinary Sciences
[Digest7
If the bacterial form of the causative factor plays a decisive role in the
pathogenesis of the disease (for instance, in anthrax or swine erysipelas), the
therapeutic serum is highly effective, because it transforms the microbes. into
the phagic or virus form. On the other hand, it is known that hyperimmune sera
are therapeutically ineffective even in the early stage of the disease, i.e.,
before the effect of the nervous system on the pathological process has become
of pronounced importance.
This phenomenon can be explained on the basis of Bosh'yan's theory. While
the causative factors of virus diseases exist in the bacterial form, the latter
has a pathogenic effect on the organism only as a result of the changes produced
in the organism by the virus form. The virus form has a predominant pathogenic
effect in diseases such as swine plague, but a hyperimmune serum would be use-
less if applied in the therapy of the disease. Sera still are of benefit in
the prophylaxis of virus. diseases, however.
Hitherto the preparation of antivirus sera has been connected with great
difficulties. G. M. Bosh'yan's discovery resolves these difficulties; because
it now becomes possible to hyperimmunize animals with the bacterial form of the
causative factor which in its virus form produces the disease.
The new results also explain the failure to treat virus-caused diseases by
chemotherapeutic means. Furthermore, the fact that chemotherapeutic remedies
are effective in certain virus diseases (novarsenol in contagious equine pleuro-
pneumonia, sulfa drugs in human venereal lymphogranuloma), leads to the conclu-
sion that the bacterial rather than the virus form of the causative factor has
a decisive role in these diseases.
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CLASSIFICATION SECRET
Sanitized Copy Approved for Release 2011/07/22 : CIA-RDP80-00809A000600360734-7
 Sanitized Copy Approved for Release 2011/07/22 : CIA-RDP80-00809A000600360734-7
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Although some investigators hold that antibacterial immunity is distinct
from allergy and independent of it (cf work by V. M. Berman and collaborators
on tuberculosis and brucellosis), no such distinction can be made: a heightened
sensitivity of the organism must accompany immunity. A. T. Kravchenko and A. G.
Galanova, who investigated, on isolated organs, a condition produced by infec-
tion which undoubtedly affects the whole organism and is not restricted to indi-
vidual organs, came to the conclusion that there is a fundamental difference be-
tween allergy and anaphylaxis. They stated that the question of interrelation-
ship between the allergy produced by infection and the immunity of cells must be
left open for the present. Work of this type is based on Virchow's conceptions
and makes the problem unnecessarily involved instead rf clarifying it.
SECRET
Sanitized Copy Approved for Release 2011/07/22 : CIA-RDP80-00809A000600360734-7