HUNGARIAN PHARMACEUTICAL INDUSTRY AT THE BEGINNING OF THE FIVE-YEAR PLAN

• Document Type: CREST
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): CIA-RDP80-00809A000600370208-0
• Release Decision: RIPPUB
• Original Classification: C
• Document Page Count: 5
• Document Creation Date: December 22, 2016
• Document Release Date: September 26, 2011
• Sequence Number: 208
• Publication Date: January 4, 1951
• Content Type: REPORT

Sanitized Copy Approved for Release 2011/09/27: CIA-RDP80-00809A000600370208-0
1
CLASSIFICATIOt.1 CONFIDENTritinfilEIMMirt6/1'.2.
COUNTRY
SUBJECT
CENTRAL INTELLIGENCE AGENCY
INFORMATION FROM
FOREIGN DOCUMENTS OR RADIO BROADCASTS
Hungary
Economic - Pharmaceutical industry
REPORT
CD NO.
DATE OF
INFORMATION
50X1 -HUM
1950,
HOW
PUBLISHED.
Monthly periodical; daily newspapers
DATE DIST. 4 Jan 1951
WHERE
PUBLISHED
Bucharest
NO. OF PAGES 5
DATE
PUBLISHED
Jun - 28 Oct 1950
SUPPLEMENT TO
LANGUAGE.
French; Hungarian
REPORT NO.
TRIG DOC NNNNN COMMIS INFORMATION AFFECTING TNT NATIONAL DEFENSE
OF TER UNITED STATES WIThIN INS IMMUNE IF 111140NAGII ACT 1111
IT. 1: C.. SI AND ALAI ITS TRANSMISSION OM TIN IIEVELATION
OF ITS CONTENTS IN ANY NNNNNN TO AN 1111AVTIIONIZED MINION IS FI10.
IIIIIID ET LAW r NEFRODUCTION OF THIS FORM IS INON11111111.
THIS-IS UNEVALUATED INFORMATION
SOURCE Periodical and newspapers as indicated.
HUNGARIAN PHARMACEUTICAL INDUSTRY
AT THE BEGINNING OF THE FIVE-YEAR PLAN
gumbers in parentheses refer to appended sources./
The Five-Year Plan gave the pharmaceutical industry, along with all other
industries, a new impetus. The development of the pharmaceutical industry was
aided by the creation of a Central Institute of Pharmaceutical Research and the
formation of special groups, charged with solving certain difficult problems.
A brief description of the more important pharmaceutical establishments and
their main products follows.
Chinoin
This house, founded in 1910, has become the most important pharmaceutical
plant in southeastern Europe. Numerous raJearch specialists are working inces-
santly on the solution of problems of pharmacology and organic chemistry. With
the collaboration of leading chemists, Chinoin has succeeded in preparing many
specialities which are used in human and veterinary medicine.
Human Medicine -- Novurite, Novatropine, Bilagite, Medobis (all have been
on the market for 10 years); Ultraseptyl (sulfamethylthiazol); Vitaplex P (ru-
tin); Hexalgone (a synthetic with the characteristics of morphine); and Tebam-
inal (antiphthisic with a p-aminosalicylic acid bake).
Veterinary Medicine -:- Distol (antidistomiasis); Neo-Todorit (for the pre-
vention of piroplasmosis and cocidiosis in cattle); Ultraseptyl ad us. vet.;
Kebal (antiascaridic and antimacracanthorhynhyque gic%);.Vermitan (antipara-
scaridic, vermifuge); and some new preparations, Septrol (antidysenteric for
calves and new-born pigs), Ultrabor (elastic bougies to prevent the retention
of fetal sacs), etc.
- 1 - CONFIDENTIAL
CONFIDENTIAL
? DISTRIBUTION
A
Sanitized Copy Approved for Release 2011/09/27: CIA-RDP80-00809A000600370208-0
Sanitized Copy Approved for Release 2011/09/27: CIA-RDP80-00809A000600370208-0
CONFIDENTIAL
CONFIDENTIAL
50X1 -HUM
Besides the above, the plant also produces a great number of fine chemi-
cals, alkaloids (Chinoin is one of the world's largest producers of papaverine),
vitamins, and hormones.(1)
The plant also produces acidum acetylosalicylicum tbl 0.5 g; acidum
phenylaethylbarb, tbl C.015 g; acidum phenylaethylbarb. tbl 0.1 g; acidum
phenylaethylabarb. tbl 0.3 g; allylbarbamidum tbl F. N.; amidazophen tbl 0.10 g;
amidazophen tbl 0.3 g; barbamid tbl 0.4 g; Chlorogenium tbl 1 g; demalgon tbl;
Deseptyl tbl 0.40; Domatrin inj; Domatrin tbl; Domatrin inj. mite; Domopon inj.;
Domopon tbl; ephedrin hydrochlor tbl 0.05 g; Ephrit tbl; Hvngaronal tbl; Isto-
pyrin tbl 0.5 g; Istopyrin tbl 1 g; natrium sal. tbl 0.5 g; natrium sal. alkali-
solvens. tbl; neomagnol tbl; Neotroparin inj.; Novurit inj.; Novurit supp.;
opium cone. inj. 2%;opium conc. 4%; opium conc. c. homatropinum tbl; opium conc.
tbl 0.01 g; opium conc. tbl 0.02 g; papaverin hydrochloric. inj. 4%; papaverin
hydrochlor. tbl 0.04 g; P. a. b. sulfamid tbl 0.4 g.
Also, phenolphtalein tbl 0.2 g; Perparin mu.; pheaphtalein tbl 0.5 g;
Purgo tbl (bed patients); Purgo tbl forte; papaverinum comb. tbl; Purgo baby tbl;
Purgo chocolate 0.2 g; Purgo chocolate 0.5 g; Sevenaletta tbl; Transpulmin inj.;
Troparin tbl; Troparin combinatum tbl; Ultraseptyl inj. 20%; Ultraseptyl kup.;
Ultraseptyl tbl; Ultraseptyl B tb1.(2)
Gedeon Richter
Established in 1901, this plant has become one of the best-known pharmaceu-
tical houses of central Europe. There are departments of biological and pharma-
ceutical research, chemical laboratories, and a section to study the therapeu-
tically active principles of plants. The most modern methods of manufacture are
used in this factory. The efficacy of Gedeon Richter products is recognized by
international medical and pharmaceutical publications. The factory has made
great progress since the end of World War II and the construction of new instal-
lations has permitted the production of a long list of very important prepara-
tions.
Products: Only the most recent hormones and organotherapeutic preparations
are listed here: Glanduitrine (standardized extract of the posterior lobe of
the hypophysis); Syntestrine (propionate of diethylstilbene); Glanducorpine
(synthetic hormone of the corpus luteum); Glanduantine-Ch (gonadatropic hormone
of the chorion); Perhepar (standardized liver extract with proteins removed);
and Thrombofort (isolated thrombin, local coagulant) which is the latest Richter
preparation.
Other pharmaceutical specialities of Richter include Ergam (the total a).-
kaloids of barley ergot), Bellafite (the total alkaloids isolated from bella-
donna, with a high hyoscyamine content), and Atriphos (sodium adenosinetriphos-
phate.)(1)
Also, acidum diaethylbarbituricum tbl 0.5 g; adrenalin inj. 0.1%; adrenalin
inj. 0.1%; burow tbl; calcimusc. inj.; calcium acetylosalicylicum tbl 0.5 g;
calcium chlorat. inj. 10%; calcium gluconicum inj. 10%; chininum hydrochloricum
tbl 0.15 g; chininum hydrochloricum tbl 0.25 g; chininum sulfuricum tbl 0.10 g;.
chininum hydrochloricum tbl 0.50 g; chininum sulfuricum tbl 0.25 g; chininum sul-
furicum tbl 0.5 g; codeinum hydrochloricum tbl 0.01 g; codein hydrochloricum tbl
0.02 g; codein 'hydrochloritum tbl 0.03 g; Coerulamin dgr. tb1;. coff. natr. benz.
inj. 10%; coff. natr. benz. inj. 20%; dextrose inj. 10%;dextrose inj. 20%; dex-
trose inj. 40%; Dolor tbl; Etovaletta tbl; glycerin supp. 2 g; glycerin supp. 3g;
glycerin supp. 5 g; Haemorrhoidalia sunp; hexamethylentetramineltd. 0.5 g;
Also, hyperol tbl l globylus 3 g; ichtyol globulus 6 g; kafalgol
tbl; Kafalgol tbl forte; KalmopyrisApl; Dithescop I. inj. mite; Dithescop II.
inj. forte; Nautisan supp. mite; 1Witimbolax tbl; morphinum hydr. inj. 1%;
CONFIDENTIAL
CONFIDENTIAL
Sanitized Copy Approved for Release 2011/09/27: CIA-RDP80-00809A000600370208-0
Sanitized Copy Approved for Release 2011/09/27: CIA-RDP80-00809A000600370208-0
CONFIDENTIAL
CONFIDENTIAL
morphinum hydr. inj. 2%; morphinum hydr. inj,3%; morphin hydr. inj. 4%; mor-
phinum hydrochlor. inj. 2% c. atropinum fulfuricum 0.05% inj.; morphinum hydro-
chlor. inj. 2% c. atropinum suffuricum 0.1% inj.; natrium Ivomatum tbl; natrium
chloratum inj. 0.65%; natrium chloratum inj. 10%; natrium citricum inj. 3.8%;
natrium hydrocarbonicum tbl 1 g; ol. camphorat inj. 20%; phenamidum tbl 0.5 g;
phenylum salicyl. tbl 0.5 g; scopolaminum hydrobromicum inj. 0.05%; scopolami-
num hydrobromicum inj. 0.1%; Tannocarbon tbl; Tonogen sol. 0.10%; and Veropyron
tb1.(2)
Also, camphor globulus 15 g; camphor globulus 25 g; caps. gelat. ol. ri-
cini 5 gr; caps. gelat. ol. ricini 3 gr; Emplastrum diachylon Ph. Hg. IV.; Em-
plastrum diachylon comp-Ph-118.1V.; Emplastrum hydrargyri Ph. IV.; Emplastrum
minii adustvm; Emplastrum sapunatum Ph. Hg. IV.; Emplastrum saponatum salicy-
latum Ph. Hg. IV.; pilulae fern i carbonici Ph. Hg. IV.; pilulae fern i jodati Ph.
Hg. IV.; pilulae ferro arsenici FN.; pilulae kreosoti Ph. Hg. IV.; pilulae lax-
antes Ph. Hg. IV.; pilulae roborantes FN.; and sebum saliculatum Ph. Hg. IV.(3)
Dr Wander
The house of Dr Wander was founded in 1910 and originally made only dietary
preparations (flour, etc.) for children. After World War I, the manufacture of
pharmaceutical products was started; since then, the Theosan preparations have
become world-famous. Synthetics were started in 1930, and the first product was
Vestine, an azopyridine dye, which is used even today. The study of sulfona-
mides resulted in the production of Dicalmine which is used for rheumatism. In
late years, the research laboratory has been ekperimenting with sympathomimetic
substances (Sympathomine, Broncholyeine) and in the related field of chemistry
and biochemistry (methinonine, glutathion, ergosterone, etc.).
Under the Five-Year Plan, the factory is increasing the extraction of al-
kaloids from native plants (chelidonine, etc.). The installation of new ma-
chinery will triple production by the end of the plan.(1)
Dr Egger
When the house was founded in 1696, the number of products was very limited.
Its well-equipped laboratories now produce a long list of very remarkable spe-
cialities. The main preparations are Revival (an arsenobenzol of high spirio-
olcidal efficiency and low toxicity), Dynarsen (a compound of five-valent ar-
senic for treatment of all stages of syphilis), Eggosalil (an amide of salicylic
acid), and Hydrocodine (a derivative of codeine, with multiple effects, for se-
rious cases),
The Dr Egger plant also prepares products for radiology: Cholumbral (for
choleocysticologY), Litbudbral and Neo-Renumbral (for retrograde and intravenous
pyeolography), etc., and also Afungil (antimycotic) and Relaxil (a synthetic re-
laxant for muscles, used in surgery).(1)
Magyar Pharma
This firm manufactures a long list of preparations used in human medicine,
including Polybe (a mixture of B Vitamins) and Lostazote (an agent used to com-
bat lymphogranulomatosis). The production of the firm covers the domestic needs
and permits large export of Vitamin C and efficacious untisyphilitic drugs.(1)
The plant also produces pyramidon tbl 0.10 g and pyramidon tbl 0.30 g.(21
50X1 -HUM
- 3 -
CONFIDENTIAL
CONFIDENTIAL
Sanitized Copy Approved for Release 2011/09/27: CIA-RDP80-00809A000600370208-0
Sanitized Copy Approved for Release 2011/09/27: CIA-RDP80-00809A000600370208-0
CONFIDENTIAL
CaFIDENTIAL
Phylaxia
Phylaxia is the name of the State Serotherapeutic Institute which was
founded b-r the fusion of all serobacteriological laboratories and plant:3 in the
country, some of which have been working for over 4o years. Phylaxia produces
all serobacteriological preparations which are employed in human and veterinary
medicine. Many new preparations have been produced as the result of the ex-
haustive work of the research laboratory. The .section for human medicine pro-
duces sera, vaccines, diagnostics, common lysates of bacteria, and also precip-
itated diphtheria anatoxin, Typhylax (precipitated antityphoid vaccine) precip-
itated tetanus anatoxin, and scarlet fever-whooping cough and diphtheria-whoop-
ing cough vaccines. For some time, Phylaxia has been producing Meinicke, Kahn,
and Citichol antigens as well as an Anti-D serum (Anti-Rho) prepared from human
blood to determine the Rho factor.
The most important veterinary products are sera for fighting hog cholera
and erysipelas, Carre disease in dogs, anthrax, poultry plague and cholera,
sheep pox, rabies, and also produce bovine and poultry tuberculin.(1)
Alkaloids
Janos Kabay, a Hungarian pharmacist, succeeded in extracting raw morphine
from poppy stems. His process was adopted by the Alkaloids Factory, estab-
lished in 1927. From the outset, the factory was able to supply the domestic
market with all needed alkaloids. The plant was enlarged in 1937. After this
date, it was possible to export 90 percent of its production of crude morphine,
pure morphine, hydrochloride of morphine, and sulfate of morphine; pure codeine,
hydrochloride of u.deine, and sulfate of codeine; pure eth.imorphine and hydro-
chloride of ethylmorphine; and pure diacetylmorphine and hydrochloride of diac-
etylmorphine. All products are tested several times in the laboratories of the
plant. Alkaloida now exports to 24 countries. The factory follows minutely
the dispositions of the Geneva Convention and the formulas of the pharmacopeia
of the importing countries.(1)
In addition to the firms listed above, the following are also engaged in
manufacturing pharmaceutical preparations.
E. Gy. T.
Pro-acts: Atropin sulf. inj. 0.05%; atropin sulf. inj. 0.1%; atropin cult.
tbl 1/3 mg; calcium lacticum tbl 0.25; carbo. med. tbl 0.25 g; Eucarbon tbl;
Germicid kup; Hydrocodin tbl; Karil kup.; Karil tbl; Meristin tbl; Meristin kup.1
Lukulin dgr.; phenacetin tbl 0.5 g; theobromin jodeti drg.; and theobromin jo-
dati c. papaverino drg.(2) The firm also manufactures Vermifuge candy.(3)
Medichemia
Products: Enterosolvens natr. sal. tbl 0.5 g.(2) Medichemia also manufac-
tures chocolate vermifuge.(3)
Gyogyert
Products: Sulfoguanidin tbl 0.5 g.(2)
All Hungarian pharmaceutical factories check their products in their own
laboratories before offering them for sale, and, in addition, the specialities
, are tested quantitatively and qualitatively by the Hungarian Institute of Pub-
lic Hygiene. The institute also takes samples from the preparations which are
on the market and tests them. The preparations are also checked continuously
by a clinic.(1)
- 4 -
CONFIDENTIAL
CONFIDENTIAL
50X1 -HUM
Sanitized Copy Approved for Release 2011/09/27: CIA-RDP80-00809A000600370208-0
Sanitized Copy Approved for Release 2011/09/27: CIA-RDP80-00809A000600370208-0
1
CONFIDENTIAL
SOURCES
1. Budapest, Bulletin de la Chadbre de Commarce de Hpngrie, Budapest, Jun 50
2. Budapest, Magyar Kozlony, 28 Oct 50
3. Budapest, Tervgazdasagi Ertesito, 3 Oct 50
- E N D -
- 5 -
CONFII!NTIAL ?
50X1 -HUM
Sanitized Copy Approved for Release 2011/09/27: CIA-RDP80-00809A000600370208-0