TISSUE THERAPY ACCORDING TO KRAUZE

• Document Type: CREST
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): CIA-RDP80-00809A000600400548-9
• Release Decision: RIPPUB
• Original Classification: C
• Document Page Count: 3
• Document Creation Date: December 22, 2016
• Document Release Date: August 25, 2011
• Sequence Number: 548
• Publication Date: August 2, 1951
• Content Type: REPORT

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CENTRAL INTELLIGENCE AGENCY
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Khirurgiya, No 2, 1946, pp 14-17.
REPORT
CD NO.
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DATE DIST. .2 1951
NO. OF PAGES 4
SUPPLEMENT TO
(REPORT NO.
Using chemically treated tissue, fetal membrane in particular, on exten-
sive and varied material (in diseases with manifest pain syndromes, scar forma-
tion, and inflammatory processes even of specific character), Krauze estab-
lished that on local application the tissues which are applied exert a resorp-
tive action on fibrous tissue in the process of its formation in the course
of healing that is accompanied by granulation. He also found that they promote
the resorption of scars and have a very definite analgesic effect.
In explaining subcutaneous implantation, Krauze started with the following
assumptions. The resorption of scars and inflammatory infiltrates can take
place only under participation of enzymatic proteolytic processes (cellular
and tissue), whose combination can be conditionally referred to as proteolysis
factors. The possibility of an influence of the implantations on the func-
tional state of the nervous system cannot be denied; it may be an analgesic
action, or an effect on the neurotrophic component of the pain process.
We used chemically treated tissue in 212 cases at a military evacuation
hospital; of these, seven of the cases were causalgia as the result pf fire-
arm damage to the peripheral nerve shafts in the presence of mechanical irri-
tation; five were cases of phantom pains after amputation of extremities;
53 were contractures of nonarthrogenous origin; 125 were cases of nonhealing
wounds; and 22 were cases of stomach and duodenal ulcers.
In all of the above cases, subcutaneous implantations were performed.
In addition, implantatijons were applied as fillings in 69 cases of osteomye-
litis. Chemical treatmet of the fetal membrane was carried out with a 2-percent
solution of chloramine during 7 days. The solution was changed twice every 12
hours during the first day, and only once during the remaining 6 days. The
tissue was preserved in the solution until it was used. Before use, the fetus
membrane is dropped into physiological solution for 5-7 min and the liquid
squeezed out between gauze strips. We believe that this kind of treatment
assures absolute sterility of the tissue. For each implantation, 4-5 grams
of fetus membrane are used.
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root The patient was given a month's furlough. After the furlough, he was
admitted to our hospital with a nonhealing wound in the region of the pit below
the knee, located in the center of a wide callous scar. There was restricted
flexibility of the knee joint. After two grafts, the wound healed, the function
of the joint was restored, and after 12 months the patient was returned to
active duty.
Simultaneously with implantations, fetus membrane was also applied in the
form of bandages (pieces of flattened tissue placed on the skin). The surface
of the fetus membrane is a dry aseptic bandage. If it did not become soaked
with pus, it was left in place for 12-15 days- The fetus membrane resembled
parchment paper applied to the wound; healing apparently proceeded underneath
it.
At the point of the implantation, there appear. a local reaction inflam-
mation with slight exudation of tissue fluid, with appreciable disturbance of
the general condition. The infiltrate disappears within 2-3 days. After the
implantations performed by us there were cases of suppuration, which were
attributed to technical defects and not to insterility of the tissue.
In addition to implantation and the surface application of chemically
treated tissue, we used it as filling in 69 cases of osteomyelitis which
developed after bone injuries due to firearm wounds and mainly in nonseques-
tral and sclerotic forms. The location of the infection and the results of
the treatment are given in Table 2.
Injury
Osteomyelites
Humerus
Forearm
Wrist
Pelvic bones
Femur
Shin
Foot
Total
Table 2
No of Patients Recovered Improved No Improvement
4 -- 3
17 11 -- 6
21 16 -- 5
_5 3
69 48 -- 21
We used the fillings mostly in cases where several surgical interven-
tions had not resulted in healing. After sufficient uncovering of the osteo-
myelitis cavity, removal of the granulation and brushing of iodine into the
cavity, the fetus membrane in the shape of a filling was inserted and the wound
completely sutured. We consider it essential to stress the fact that with poor
hemostasis, poorer results were obtained, since the fetus membrane usually was
expelled by the blood. We obtained better results in metaepiphysic osteomy-
elites.
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3. Lt P. -- Fragmentation wound with imbedded fragments; injury to ex-
ternal left femoral condyle. The foreign matter was removed in one of the
local hospitals and the pat~ent was operated on three times for osteomyelitis.
He was transferred to our hosrital for a resection of the knee joint. lathe
region of the injured femoral condyle, there was a fistula with a slight sup-
purative discharge, on the X-ray photograph, the cavity in the metaepiphysic
portion of the femur was without appreciable sequester. An operation for
inserting a filling was pejeformed, and the patient was discharged as recovered
after 2 months.
Tissue therapy was carried out against the background of customary com-
plex therapy (physiotherapy? massage, excercises, etc.)"
1. Tissue therapy, like other biological methods of treatment (Bogo-
molets` serum, shock therapy with blood, etc.), is a little-known method,
but in view of the effect obtained, it should be recommended for wide use.
2, Local application of the chemically treated tissue according to
Krauze has a pronounced analgesic action in causalgia, phantom pains, and
other pain syndromes and stimulates the regeneration process in the healing
of wounds.
3. Tissue therapy, contributing to the resorption of scars, expedities
the restitution of the junction of joints in cases of nonarthrogenous con-
tractures.
4. The filling of bone cavities in osteomyelitis with chemically
treated tissue aids the regeneration process of the bone tissue.
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