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December 22, 2016
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October 27, 2011
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February 25, 1952
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Declassified in Part - Sanitized Copy Approved for COUNTRY SUBJECT HOW PUBLISHED WHERE PUBLISHED DATE PUBLISHED LANGUAGE INFORMATION FROI+. FOREIGN DOCUMENTS OR RADIO ROADCASTS CD CENTRAL INTECIGENCE'AGENCY v REPORT CLASSIFICATI R Scient.lfic - Mfedicino, tick encephalitic 1:50 'tussinn DATE OF INFORMATION 1950 STAT DATE DIST. ol.5' Feb 1952 NO. OF PAGES b SUPPLEMENT TO REPORT NO. THIS IS UNEVALUATED INFORMATION n11 TOCY,T,f TY m.. O, T? ?IT? IUUT rn811 uno~ UUNT, n lO,? O,I,11? TI 11w1N 0/ ffO,q, ACT ul 1. e. C., a, lull U. U A1nn1? m TYul1UYOa OS T? ff,YTg1 OF rtT Cnin?, 1, YT win TO Y SUIThOMU, null, tl PRO? 1101? ,T U,. UTTONOrM1 U T,l$ n,1 I/ nO,1MTn. i.evropatclogiya i ?sil:htLtri_;;, 'i,l YIX, 'fo 2, 1950, pp 19-21. TIC{ rKETIl/II.IriIS I`I N(Lk-froV OIcIJ.ST I. 1948 N. V. Samovich :submitted 19 Aug 1919 CJh Icsl. ;itu:y cf t c. -ce dti;?.: in o1 7?:;v `0 OSt Ins said, uui,Iue and cleorl, Jefira.c; ,i'alit ,r?- lished a J ' poison with the cliaicol picture of ""cefh:aitia es dencri} 'd It, the :-- ast (SCr.:i', Shapoval, Fanov, and th, ulna Kazakhstan .; t?'=1uv ;-r': ':andryko). niuti cc ciiairr:i nFerript!;,:, of cues rf. ?;;riouo seasons of the year ar? .:I:.;:r: the prrsance Of n:,r,)on,,'7 'part fro:, loc 1 peculiarities. In T','/, : n'. o\' ch's "IR:e State of the Spi-~a1 _'luid in S,rr n;-.iuWn=r EncepL.ilitis," in the u:.rk Gtate of the ;.plan, laid in Tic: Encephalitis, n,blished in Trudy )blotu? s , o atonetolovirhesYo o S:stitute, Yol T, 1^143, Which was based on , aterial hoe the yearn 193r' to 19.1, we 'ere a? le to ricte the presence of .local mud seasonal differences In changes in the fluid, with a repetition of thr, }:uric type cha:?acteristics. "-'h^ p;c,'liarities of tic:- encephalitis it, i.olotov 0hlnst are clearly revealed by observations as to the course of tick encephslitis in 1548 In the data of the nerve diseases clinic of the Xolotov ::edicel. Institute. Suring the summer :..o:,ths, 4'( patients .rith acute forms of tlcl. encephalitis were admitted to the clinic from various rayons of the oblast. All patients had, before developine. the disease, been in the woods, but only 42 percent had picked ticks from theaselves. The first case of the disease dated from 13 Jay and the last from 1 August. In slay, nine persons becore ill; in June, 25; in July, 12; and in August, one. STATE NAVY ARMY AIR 40 Declassified in Part - Sanitized Copy Approved for Release 2011/10/31 CIA-RDP80-00809A000700040541-5 Declassified in Part - Sanitized Copy Approved for Air STAT p3?;m.r:aeon , .rcerirgeal forms predominated, without pronounced focal sympi.ms. ^.he rePhalitic form was myel:itic in , the not+_n.~;~rcpha'.o myelitis in bested in 24 persons, the polin- 4, er,d th'- =ncephalit.- Jr, one. , the plrne in detected in four Forms xhich were not c cleaearly lyd defiefined were xere poraars. A -?peon;. Croup wee forri by seven patients with tree presence of s thal,-ia an reurovascutar dernai reactions which had not been described earlier th in e works of local r,europathologists. It was possible to detect forms which were not clearly definer] ir. only the Mulyansk center, where all cases nese were submitted to scrutiny. of ii_- ithou', touchirr- on t.a:_ ch'3-acteristics of sufficiently well-known type manifeseRf the of tic': e::cecir,lit aspe-te of the case is, It is still necessary that individual ur a;n,?as occurring Burin shool7 C the season under consideration r.. -,. ?i she cases, a hr ,_1 course of the high-temperature pod '?''L c"y 'in:r ti temperature, the temperatureefell to6 nee.7 :':,:? 7.2 dty;, ?_?i`,lc again. ;;cd~.r?,,;.:_ .tr. J el. i;. ,. ^:aerc in the patient's condit and risr., i_ scc: cases, the neurological symptom's hadn air 'y r?:[:ctv'. -,Ile Whose wh?,n r;... airy. ,.y ,1 n, ;?,T .;J. f,. i,.,; patient was placed under the observa_ ti r,.,amre;(' , Chile the primary period was revealed on the basis :rr2tic^ a::d Was c;LL)rc influen;:c, inC of i.,;.,1, .? ofoten than not diagnosed of typical as infln. r t ;, i E reveal the presence of typical to of c su y 1.: "3imary period. It had also been as i ..r.r h,,r possibl t t. tr(.nd in earlier seasons 1939, it one f :11; - ., ... , in 1J39, it -_ i:)~ ? Yu,tt:,rn is r ,,, er-t ?,.:,= :. re b i :.:;i ;!1e e.m o^ rrr.:,our.~ed atrophic paresis of upper in cn:j; rt ,-r+h "`~ht p+'-?sona (17%), two of they. exhibiting ethe 'e n c re", occu ' 11'c ' er cnusclen. In six patients parFS,rr oC ? . - E ;?accles of , there Uc? the humeral belt. Atrophic noteed i- 1,0 ? ;tr`;,1 -; , y1c - sct In. Cerebral hemiparesis was 1. l,ar::a Bit ,-.; Cal inrervation was exhibited by + c?' ? " P ' ,' hile I 1C was able during :) U? .1;: chr, t nB the acute period, the banc.2 0? i..- craria: :)i patient, the f"'Ictlnral distur- the ivnd,;r ha eeco:?.: ? ,?r i:< ir:r. of Paresthesia (the ,:l? ,r edge of the difior1cr: i s?r roc! of the neck, oral cthers) end The ]at t.?, ,ri cc, i VJ ;icy;" her'L t pep' . aia) of the i .eental type. lower neck, no 1__. i,? t),, "?,,?--_izr_tion in the segments of the et the rotor c;isturbance6 which hen' cr i of ti. 're female patient, who uc:derwent to ho:.; f~:cc tlona, Upon dischar'c 6 't a "el`t .. Lire fir from of sec ,'t,rt:; with a unique Fol.lo?,ring a 4- to 7F,-, ?- +. , _...._ hyt-- ,r3 thr. n e. The ,.;;, ---- ..- _ ::r L: unit or th _ r,,-cn y , the annular hy;?err , t i c peri- of inv .; ie7. - 8, 't a distance of 20-,,, , -- ._* ,y, . ronlia of the skin th?:rc , -,r, :V, Declassified in Part - Sanitized Copy Approved for Release 2011/10/31 CIA-RDP80-00809A000700040541-5 Declassified in Part - Sanitized Copy Approved for STAT general malaise, high temperature, headache (sometimes with naus ingeel symptoms and sharp pains of ea), mild men_ , a burning,u npleasant nature, situated en the ortremity nearest the Bite of the bite. band of this extremity were painful to the touch. The muscles and the neurovascular In one female patient, who had not been receiving serum treatment, there appeared, as the local dermal reaction subsided, individual + elements over the entire b of neuroinfection (genera' -Y. In the cases cited above the gen annular-rash ROE ~eecti of e malaise, headache, ,accel ratio of rythrocyte sedimentationhigh temperature, comleaedP symptoms indicating that the regional a ' etic elelemesen)nts were affected oy of pain neurovassyndromecular of sympathalgic character, change elements ( (local skin reactions), g in sensitivity, and disturbance Recognizing the great importance phalitis, we sought to do of spinal-fluid diagnosis of tick ence- everything in our Power Measurement of the pressure of the spinal fluid b to study the spinal fluid. nostic lumbar tape revealed i nteresting data, The taps were opt mediedlwithgthe patient placed in a reclining position. An initial pressure of the water col- umn of from 40 to 50 mm was established ten times; from 50 to 100 mm from 100 to 150 mm, 13 times; and higher than 150 mm 180 34 times; pressure of the fluid was repeatedly observed in ( in the enpe. A reduced clearly pronounced meningeal s Patients in t period cases, simultaneously with ameliorationmofethe patientpsa condition, a noru of zation of the pressure of the fluid was noted. tappings in such Ali_ - In investigating the fluid, lymphocytaI pleocytosis was established in the majorit of cases, ranging from tens to the first few hundreds of formed ele- ments /loud corpuscles? in one cubic millimeter. The amount of protein od not exceed 0.h5P in positive protein reactions. In inve the leucocytosis ranging frnm 9,000 to 12,000 was encounteredtina2 % o of those blood, examined. ROE, as a rule, was accelerated and was normal only in t ie cases. In the second month of sickness, a moderate eosino d quently quently noted. Phih ia was s not not nfre- infre- The carbohydrate-salt metabolism was investigated in 45 cases and the Potassium-calcium metabolism in 12. Carbohydrate Metabolism A normal amount of super in the blood was observed in 79% of thous examined. In 11.7% of those examined, the absolute sugar content of the blood was reduced 52 to 79 mg %. The coefficient of nnnetret-r e examined. A pronounced "" sugar was increased in 62. Sp increase in bWPerglycorrachia vas noted in 35% of cases. those penetration of the hematoencephalic barrier for sugar was unevmy pronounced at various stages of sickness: in the first 2 weeks, in three fourths of those examined; in the third and fourth weeks, in one half; and more than one month after the beginning of sicknes,, in only one third. "Salt f oflam The absolute sodium-chloride content of the blood increased in 30.3% of the patients. The coefficient of penetration of the hematoencephalic barrier for sodium chloride was reduced in 65% of the cases, due mainly } .. )rrachia (85.' ), The coefficient of penetration of sodium chloride in _rst 2 weeks of sickness was reduced in more than three fourth of thosed examined; in the third week, in one half; and after more than a month, in one third. -3- ftm*WMNW nwAaapapm. Declassified in Part - Sanitized Copy Approved for Release 2011/10/31 CIA-RDP80-00809A000700040541-5 Declassified in Part - Sanitized Copy Approved for Release 2011/10/31 STAT Comparien of the carbohydrate and salt metabolisms for tb, period of sickness agreatestn them. In the early phases of coefficient of sugar penetration was observed, the penetration of sodium chloride proved to be low- ered in the same proportion. The inverse relationship between them remained also in later phases. Potassium-Calcium Metabolism The coefficient of penetration of the hematoencephalic carrier was within normal limits in 6o,>; of the cases. Tn 40 cases, the Lange reaction with colloidal gold was performed, with a normal type of curve being obtained in 21 cases and a change in color toward violet being observed in 19 cases in the third, fourth, and fifth test tubes. Of them. these changes set in eight times with meningeal. forms in the second week of sickness ar.d 11 times with forms exhibiting local symptoms at various stages of sickness. The type of curve obtained shows coincidence with the syphi;itic bend in the correspording curve and with the curve for polio,nyeli- tie. A men!nEit!c curve was not obse: ed. The data obtained in performing the Lange rea^t.io- agree with the fluid --pressure indications, i.e., with the absence of a n>-n1.,.6itlc curve and of increased pressure. Completely differc,,t data were obtained by A. B. Nandel'boym In investi- getir.g the spinal fluid and blorsf o^ patients sick with tick encephalitis in aze.khsian. These data are fundamentally different from ours in the following respect.: prelominsr.ce of high fluid-pressure values, different morphological composition (,.f the cellular elements, presence of a usually meningitic curve in the .onge reacti?cc:, absence of changes in the salt metabolism, and lowering of the cce_fficier of' penetration for sugar. The data cited clearly indicate dezided differences In the laboratory characteristics of tick encephalitis in Molotov Oblast and Kazakhstan. J n' -a*~:at^r data differ In smaller degree, and in individual instances appr,;;:ars;e the investigations by V. V. Kartasheva of patients in the subacute stage cf tha --stern variant of tic): encephalitis. The author notes the pres- ence, in the / final' fluid and in the blood, of pathological s hli'ts in the biociem-cal equilibrium of both the carbohydrate and salt metabolism (In the majority of )8t.terlts, therF was an increase in the coefficient of penetration for sugar a.;d pronounced hYp'--'1-?rrnchia) .-,._ . Pasically, to the treatmer.? ,f our patients, together with supplementary met thods, he antiencephalias serum of hyperimmune goats was used. The serum prepared by the Molotov 7irusulogical laboratory on the basis of crOf Pshenichnov's mot od. p?,r_i_..: .. _ firmed the diagnosis, the patients-were! diagnostic lumbar tapping, which con- redko, with 30 cc of serum which had been slightly heated. with,thetordinary method of injE,ting the serum, an unusually high percentage (up to 58) of uerum sickness was observed in 1918 in the form of skin eruptions of the urticaria type, with painful skin itching and sometimes with edema of the eyelids, gums, and ever, of the larynx. The pretence of aphonia, together with edema of the larynx, could simulate the appearance of bulbar disorders. ' The general scral symptoms, which usually set in or the sixth to eight:r day following injection, were usually preceded (for 2-3 days,' by e local reac- tion in the vicinity of the site of inject--.n (in the buttock). A lethal outcome developed in only one case of the encephalitic form. - END - Declassified in Part - Sanitized Copy Approved for Release 2011/10/31 :