USSR RESEARCH ON FURACYLIN AND ITS APPLICATIONS

• Document Type: CREST
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): CIA-RDP80-00809A000700050643-1
• Release Decision: RIPPUB
• Original Classification: S
• Document Page Count: 2
• Document Creation Date: December 22, 2016
• Document Release Date: September 22, 2011
• Sequence Number: 643
• Publication Date: April 16, 1952
• Content Type: REPORT

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CLASSIFICATION F-E_C-R-E-T
SECURITY INFORMATION
CENTRAL INTELLIGENCE AGENCY
INFORMATION FROM
FOREIGN DOCUMENTS OR RADIO BROADCASTS
COUNTRY USSR
SUBJECT Scientific - Chemistry, therapeutics;
HOW Medicine, infectious diseases
PUBLISHED Biweekly newspaper
WHERE
PUBLISHED Moscow
DATE
PUBLISHED 13 Mar 1952
LANGUAGE Russian
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REPORT
CD NO.
DATE OF
DATE DIST. 1k Apr 1952
SUPPLEMENT TO
REPORT NO.
THIS IS UNEVALUATED INFORMATION
i9Sk RESEARCH ON FLTtAC'fLIN AND ITS APPLICATIONS
Prof S, Giller, Laureate Stalin Prize,
Corr Mem Acad Sci Latvian SSR
Prof A. Iepukali, Riga
Since 1947, the Academy of Silences Latvian SSR has worked on the clinical
application of nltrofuranes. About ~,- 'ocncundo of this class were synthesized
in the course of that work and new methods for the preparation of nitrofurane
derivatives developed. In the bt-ginninf. of 1948, the valuable properties of
furacylin (synthesized by . Giller and E Gud-in:yetse) were established.
Furacylin has an extensive range of action on both gram-positive and gram-neg-
ative bacteria. It has a bacteriost.st!c effect, at concentrationa of 1100,000
to 1:200,000 and a bactericidal effect. at higher concentrations, acting on all
species of streptococci and staphylococci, intestinal and typhoid bacteria,
gonococci, Flexner's dysenteria, brucella, bacteria causing gas gangrene, etc.
Prof I. I. Kazanskiy and V. F. Novinskaye of Moscow found that furacylin also
has a strong t.rypanocidal action Furthermore, the effectiveness of this drug
in the tree?tment. of coccidiosec of unimale snd of various virus infections
was noted.
An investigation of the enzymotoxic properties of furacylin disclosed its
selective action on enzym.,.s which are present both in the microorganism and the
bacterial cell. In therapeutic concentrations (1?4,200), furacylin does not
suppress the physiological activity of the majority of enzymes, encountered .in
the living organism. An exception are dehydrogenases, which, even at high
dilutions of furacylin, lose their capacity to participate in oxidation-re-
duction processes. Dehydrogenases participate in the metabolism of pyruvic
acid. 1. e., aid in the process of carbohydrate metabolism. It is possible
that this specific activity of nitrofuranes endows them with the ability to
suppress the growth of bacteria,
Furacylin acts selectively on enzymes, i. e., substances which are very
sensitive to the action of chemical agents. Consequently, it is not very toxic.
This conclusion has been confirmed by pharmacological data and clinical obser-
vations.
1,4 NSRB DISTRIBUTION
FBI
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S-E-C-R-E-T
the USSR 1950, the Pharmacological Committee Ministry of Public Healt~ of
admitted furacylin to general use for external application. In the
same year, the Riga Pharmaceutical Plant No 3 started production of this drug.
In 1951, the Academy of Sciences Latvian SSR held a meeting at Riga, in
the course of which an audience of 400 physicians and scientists. In a report
by Prof A. Kalnyn'sh, Acting Member, Academy of Sciences Latvian SSR, and S.
Giller, the connection between the chemical constitution of nitrofiranes and
their physiological activity was clarified. These authors also pointed out
that substances of this class affect enzymatic oxidation-reduction processes
of macroorganisms as well as of microorganisms. However, macroorganisms have
many Ways of compensating this harmful effect, so that the toxicity of these
substances to higher organisms is negligible.
S. P. Zayeva, Doctor of Medical Science (Institute of Experimental Medicine,
Academy of Sciences Latvian SSA), reported that nitrofuranes (including furacylin),
as distinguished from sulfonamides, preserve their effectiveness in the presence
of paraaminobenzoic acid. This property permits the use in surgery of furacylin
solutions combined with novocain, which is of great practical importance.
Zayeva further stated that parentheral administration of furacylin has no appreci-
able influence on the morphological indexes of peripheral blood or the resistance
of erythrocytes.
Prof A. F. Lepukali, chief of the Hospital Surgical Clinic, Riga Medical
Institute, and Prof F. I. Stradyn', Corresponding Member, Academy of Sciences
USSR, presented data obtained by observing 5,000 instances of the clinical
application of furacylin. For therapeutic purposes, they use a 1:5,000 solution
of furacylin or an ointment having a 1:500 concentration of furacylin. In oto-
laryngological prac'ice, a 1: 1,500 solution in 70% alcohol is occasionally
used.
A study of reactions of the organism to pareutheral administration of a
furacylin solution showed that this drug stimulates phagocytosis considerably
and raises the phagocytary capacity of the macroerganiem. Externally, fu.- ?,y-
lin is used for the initial treatment of wounds, in cases of burns, carbuncles,
nhlegmons, osteomyelitis, suppurative pleuritis, and suppurative processes of
various localization. The application of furacylin, as well as of any other
chemotherapeutic agent, cannot
to place gery, of course. On the other hand,
prophylactic furacylin operations in the abdominal and thoracic regions, contributesetoianlowering,or
of lethality and of the rate of post:-operative complications.
Furacylin has the following valuable properties capacity to stimulate
phagocytosis, lack of inhibiting effect: >.c far as maintenance of the com-
position of the blood and hemopoiesls are concerned, absence of hemolysie,
lack of harmful effects on the urinary secretion system, capacity to ex-
pedite granulation and the healing of vounda.
At present, surgical clinics of the Latvian SSR use furacylin extensively.
A report presented by Dr F. Niburg at, the meeting mentioned above states that
excellent results were obtained with this cheap and }highly effective
the conditions of medical prac';c a in villages. According to data reported byer
V. Ferber, furacylin was also found very useful and effective for ophthalmolog-
ical applications.
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