PHARMACEUTICAL APPLICATIONS OF ACRIDINE DERIVATIVES IN THE USSR

• Document Type: CREST
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): CIA-RDP80-00809A000700080083-0
• Release Decision: RIPPUB
• Original Classification: U
• Document Page Count: 3
• Document Creation Date: December 22, 2016
• Document Release Date: September 9, 2011
• Sequence Number: 83
• Publication Date: August 27, 1952
• Content Type: REPORT

anitized Copy Approved for Release 2011/09/14 :CIA-RDP80-00809A000700080083-0
~ D y __.. O rf G
CUI~:SIflCATl~C ~c'&~ ~~)~ ~ G
CENTRAL.INT_L!I~~G NCY REPORT
ONFORMATION FROM
FJRFrIt3N DOL"Jh,'ENTS L~F2 RAD9U BRbAD~ABTS CD N0.
DATc. DIST. 7~ Al.lg 195?
fiUPPLEh1EPdT TO
REPORT N0.
f~au~iv~W~a ~m11~ic~iunq~o~ucwweE?n~u
E. r.'a ~I ~n a,, ul pEE9n. m mxuuax of TEE EEYEtJi19E
w-In ~ Tnln m iwc. wlw EE ao cs~mwEmE rates a Eco-
YN1aE it.lAR mEYC6tE1t0Y H iW nay Ia Maala111E.
into eosi~o'nndA of thin type and increaslag the riza of the molecule by snbeti-
tntioa of hesavier groups into the 2 or 6 positicn h=ve a deleter;uus often az
the ohamotherapenbie activity of the drug. Tile nuaaeraue analogs of atebrin
THIS i5 UNEVALUATED INFORMAT!Oh:
SCOW 4r~14MfA1 KL'IL4ZCM yV1Y~J VJ: NrS1~J.1W ~~~A~YOfiJ 1tf 1LU VVVA
A. itii' arigorovekiy
l~4oacae
YRie follarittg eoridine derivatives are iSportaat therapeutic drags: ac-
;fqu:ime `gnineerine or atebria~: flavxcridine (acriflavine or trypaflstivine),
eitich is need both in aedf.cal &nd vetnrin~ry practlce and has acquired partieu-
.lar layryortansa in the iatter? rivanol; and the bacterial drug eeptoflavine (3,
6-diaalnacridine ev]Sate) (1~ Atebrin, is the principal therapeutic and propby-
lmetl_ sg~at for tmlaria.(P) 'fhs rapid 3cral~~..it urnd nY?plicatian ofi c~li-
cotnd oheaical processes, 15 resrs ago, which formed the basis of as esrtensive
prodnetloa oP atebrin east be regarded as a great achi?vem~ait of the~yonag So-
viet pharmcentical iffiustry at that time. (3-8)
Coll,rition of rosults obtained. by Sovfat:seieaftsts oa theeetiviiyr~.. stebr4u
ai~a3og$ ($=11) led to the conalnelon that~lintrodncing additio~.enbdtlLnentn~
aynthesis~d during tine Bast 1y years, both in the DSSR and abroad, are almost
ezeEusvely cam~anrls tmt are disu6c;tituted ~n the benzene nuclei oP acridine
(34 anbsti'~ntion With the a2lSgleaiao group in the 9 paeitioa, which' id: aleaya .
mYBe, is disregarded). II9 'rankers left unchany~ed the substitution of the 2 and
6 poaitioae xith a chl?x~o and a mothozy group, re tively, beceuee theq ap-
parenl.y regarded this enbstituRion ae opiiasl.(12). In the iavastigations in
quaet.on, ths.eearEh Pox compounds esh'.biting an activity granter than t~itr, of
atebrin ran coadncted Dy modifying the nature of the enbotitneat is the 9 posi'-
Lion.
oath nipplea~entary~snbatitntion of the ~aolecule of atebrin or one of ice aaa-
loga by a beaic group in the 7 poazition; e.g., aminoquinacrina (2-methoay-6-
chlorw7-emis~o-9-~-diethylaaino-~>?eethylbutylaminoacridine). CaaponaQ.e of
_ 1 _
~~~ a~F~c~~~. use ~~~Y
DlS4RIBS1SiDN
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COUNTP.`P tY3s~
~L!(a,it~C'~ Scientific - Cheai.atry, medicine, zEV drsgs
Haiti=~
~'i1~U~HED tionthly ~ricdicn.l
..WHERE. .
PUBLISHED t=ozcrna
OAO'k
ist IgLISti~~c ~r lg~ .
STAT
 anitized Copy Approved for Release 2011/09/14 :CIA-RDP80-00809A000700080083-0
8h~~*ype do-sot yialdyin nctivity to atehrin en3, in addit-Jan to that; cra rnn-
?.v.~c.~i~~ l~.noquioacrina also proved to be ass effective reaedq
Soz t4m11eriaala sad ot@er diseases caused by pmtozaa.(14)
8lrtof)~ariae is a Ptighiy Dative satieaptic: its solutions hsve a bect?.erio-
atwtlc ~elYect oa pathogaaic org:a..aiama, even in e, dilution es high a: 1;4tYJ C00.
Dnating with a AJature of aulfcnsoi.de drugs end aeptoflevinc has received recog-
~iS?ion es: a good aethod of enpediting *-he hcaliug of sounds.(15)
A mbar oS' othzr aeri?in~ de'r1-?ativee has bean proposed for use as thcra-
neutic sgeat8. "D:~ flr_vargin" is effective for tan treatment of septic corcli-
tiona. Tina drug contains bactericiballg acting aiirar and has the c~:ositioa
Sf a.flouble salt conalt.iag of ?,6-d7nmsnoAorld+~~ methyllactate sad uiivar iac-
Lmte.(16; 1'7) Dry Pleva,:gin fcnnd acct-ptance 1n medical and veterinar
ti
y prae;
ce
on.tht heals of good resul4s sahieved with it.{IS-20) "beutral f?.avaerldine" is
a cowbiaation of 3,6-fliaminoacridiae awnohydrochlorlde an3 3,6-disminoacridine
chloroaethylate.(21) Application of neutral flavacrid.ine together eith anlSacyl
sodium as a preservative, prevents complications fisiaiag after bloat trana~fusion.
?he tollaving aubatancea }rave bean groposed abroad for use ae antiseptics:
9-aaiaoacridine, 2,7-diaaiaaacridiae, sad 4,5-dimet'191-3,6-diaminoacridine.
?ltuteaol" has bctti proposed Par use na a r~dy agaiast tynhna. rhis do+~ ie a
azlt oY y-glycoiylaainopLsnyl araonic acid and 2,3-dieethcry-6-nitro-y-g_
,di~thylaitiao-beta-hldrosy-propylaminoacrisltca.(22)
2. ~ Pi=_+iscopoais, pg 41, 413, 549, VIII edition, itladgiz, 1946
?.. 9. 2. AsLbe1', A3aikhia 1 Yego Lecheaaoye Prluneaiya Psi ?la].arii 1 L~a-
h7loze (Qainacriae sad Its Z'herepentic Apylicetioa in malaria and Lamblio-
aio), 1947,. (3or'k1y 3Red Tnat im B. I+.. Sirov
3? ~. Yu. 14agideon, A. M. Grigorovakiy, Shim Farm Prom, 80 4, p 187, 1933
4, fb. n. Cheliutaav, I. L. San~gnats, Z. v. Beaevolcnakays,'DAB 31388. 1, 63.
1934
5? I. L, ICanny[uita, f}, V. Chelintsev, Z. V. Benevolenskaya, Ye. D. Oestrous,
A? I. 1Curaanova~, Izv.Aft 8S3& (chegical Series), Ao 1, g 165, 1934
6. d. Fn. 39egidaon, A, !9. Crlgorovskiy, V. I. Ma3:simov, 8. a, mgrga17,na~ Shim-
Farm Prop, ?1o i, p 2b, 193$
7? Q. Yn. lfi0.gidcon, A. M. Grigarovskiy, V, ft. Aiel'aikova, S. Sleyu, POSh ~~
nol 1, p 586, 1936
8. A. lf. 8rigorovakiy, t)'.8A Autl~or'e Certificate 90 50660
9? 0? [u. i~iegidaon, A. M. Grigorovekiy
Zh Obahch Khim
Vol BI
806
1
4
,
,
, p
,
93
1Q. I?` L. Smmyeats, Z. n. Benavolens3ntya, Zit Obshch Shim, Vol 3C, p 1415, 1940
i1! Y JVf yy.~
12. A 8nrvey of A~+?~~M+-+A1 Drnga, 1941 - 1945, Vol I, II, wiseloglr. (editor),
1Ddwax~a, P.aa Arbor, 1946
13. A. V.. fitoTmaova, Zh l9ly:robiol, Rpidemiol, i ;r~nnol, Fo 9, p 2~, 1940
14. A. IQ. 6riporovskiy, A. I. Bbsnlevich, ft. A. Baboehina, m. A. Ali-Zeds, IISSB
Auti'~_r'.s Certificate fto 82331
15? n. 3a. Agxaaoviah, Snl'far.Sleaidaaya Terapi5s
(Thera
K1th 8
lf
il
id
_
py
u
aa
am
e
DivBa)s P 183s tea, 1949
lb. A. 14. Qrigo.r.::ay, ;? A. Veedliteanyn, Farmataiya, 11a 6
p 15
1946
,
,
17'? A. ld. tirigorovalciy, A. I. 8h!iulevich, T. A. Veaelita3saya, 0888 Axthar'a
Certlficate ~0 65873
18. 8. I. Mh~el', Blia !(ed, Vol XS, 1-2, 89, 1942
'19. A. I. Shrualavich, neterinariya, fto 4, p &3, 1941
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STAT
 STAT'
!~.' .p. ~boslnia~; ld. A. Ali-ZaQe, A. i. ?hmaZeaich, detezinarlyrt, Ilo 5,
6 ~'tr 151k9
A :~ 42~sii(Yko~+r, 7c. 35. ~o'ok2ein, UEI~4 AuthorYg Certiffeata ~o ~63E~
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