NEW SOVIET SEDATIVE PROMEDOL

• Document Type: CREST
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): CIA-RDP80-00809A000700100495-0
• Release Decision: RIPPUB
• Original Classification: C
• Document Page Count: 2
• Document Creation Date: December 22, 2016
• Document Release Date: October 25, 2011
• Sequence Number: 495
• Publication Date: February 10, 1953
• Content Type: REPORT

Declassified in Part - Sanitized Copy Approved for Release 2011/10/25: CIA-RDP80-00809A000700100495-0
CLASSIFICATION CONFIDENTL4L
SECURITY INFORMATION
CENTRAL INTELLIGENCE AGENCY
INFORMATION FOREIGN DOCUMENTS OR RADIO BROADCASTS
COUNTRY USSR
SUBJECT Scientific - Medicine, new drugs
410W
PUBLISHED Monthly periodicals
WHERE
PUBLISHED Moscow
DATE
PUBLISHED Feb, Aug 1952
LANGUAGE
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unor or in .11r4 ro ar? W rasa. ~n r Yy,..q, mr ex .crc?
.uur* .r ?r v.. rV.owco ru.ar i.
lumbers in parentheses refer' to
append ed sources7
_ The Presidium A
the workers Pnddinstitutionc de tof Sciences USSR expressed its appreciation to
development of the new Soviet sedativeiPr~ted in the research which led to the
omedol.
Credit for developing this highly effective drug, which
follow clo~titprooerties all previously Imown sedatives, is surpasses in shared by then
The Laboratory of Unsaturated Compounds, Institute of Organic Chemistry,
Academy of Sciences USSR; The Chair of Organic Chemistry, Moacow Institute of Fine
Chemical Technology imeni M. V. Lomonoaov, Ministry of Higher Education USSR; the
A11-Uuion Scientific Research Chemicopharmaceutical institute imeni S. Ord.hoai-
kidze, Ministry of Public Health USSR; and numerous medical institutions of the
Ministry of Public Health, USSR.
A thorough clinical investigation of Prof) of was made at medical inatitu-
tiona of Moaccv, Leningrad, and Sv--rdlovsk./I
1
Promedol is a white crystalline powder which is readily soluble in water.
When dissolved (in water) it produces a transparent colorless liquid with a
slightly bitter taste. It can be easily sterilized by boiling, does not deter-
iorate, and can be preserved for an indefinite period of time. The initial
peroral dose is 0.025 g, which may be increased if necessary. Subcutaneous in-
jections of a 1% to 2% solution may be started with 0.01 g to 0.02 g and may
Possibly be increased, though larger dosage for hypodermic administration has
not been attempted. Effects of the
30 minutes after administration, with a you Ping se ti Patient in dbsle 25 as
ing 2 to ) hours. Observations revealed a slight drotine he not and lodp r--
sure
sure (approx tely 5 MM), pulse, and respiration of the patient the normal blood pres-
of Promedol. It has been noticed that in case tofnt erteains ad
systolic and diastolic pressure dropped more sminutes followingh
the injection of Promedol and maintained the new low level forr quite a whiling
Dime not specified7. This decline in blood pressure was accompanied by pain in
the cardiac regiou and some buzzing in the ears. In cases of hypotonia, Promedol
caused a slight increase of arterial pressure. No toxic effects, nausea, or vom-
iting have been observed. No pathological changes in the blood or urine have been
found.
Declassified in Part - Sanitized Copy Approved for Release 2011/10/25: CIA-RDP80-00809A000700100495-0
Periodicals as indicated.
REPORT
CD NO.
DATE OF
DATE DIST. /,9Feb 1953
SUPPLEMENT TO
REPORT NO.
THIS IS UNEVALUATED INFORMATION
NEW SOVIET SEDATIVE PROtiEDOl
 Declassified in Part - Sanitized Copy Approved for Release 2011/10/25: CIA-RDP80-00809A000700100495-0
The new drug is apparently not habit-forming. It is expected to replace
morphine sulphate and pantopon in surgical practice, as well as in therapy re-
quiring relief from acute pain. (2)
Morphine and its derivatives should be discarded, because they are highly
~niaed.~ I~gdol (Demerol; ethyl ester of 1-methyl-4-phenyl isonipecotic acid) and
(hydrochloride of diametbylamino-diphenyl-heptanone) are synthetic drugs
with highly toxic properties and low effectiveness. Promedol represents a defi-
nite improvement in the field of sedative drugs. It exhibits a low toxicity and
is highly efficacious. Practically no changes in blood pressure, pulse, or res-
piration were observed on administration of Promedol fonder normal condition) to
patients. Some slight reaction was noted after injections of a 2% solution, the
use of which is recommended only in cases of acute pain such as that encountered
in renal colics or in connection with malignant tumors. Promedol is an effective
aid in obstetrics, reducing labor pains and increasing the rate and strength of
uterine contractions. Further research and experimentation on this drug are
recommended.
PubliThe
HeaalttDh USSRthas authorized wide use of Promedol in Council
practice.(3)
1. "Development of a New Sedative, Promedol" Editorial Release7, Vestnik Akademii
Nauk SSSR, Feb 1952, No 2, P 115
2. "Study of a New Analgetic. Promedol, in Surgical Practice." V. V. Izosimov,
student of the 6th Course. Surg Clin, Faculty of Pediatrics, II Moscow Med-
ical Inst imeni I. V. Stalin. Kliniches ya Meditsina Vol XXX, No 8, pp 63-
65, 1952
3. "The New Sedative Drug Promedol," Prof I N Nazarov, Corresponding Member
of the Academpr of Sciences USSR, Prof M. D. Mashkovskyy, V. A. Rudenko, N. S.
Prostakov, and V. I. Ishchenko (Moscow). Klinicheskaya Meditsina Vol XXX,
No 8, pp 60-63, 1952
Declassified in Part - Sanitized Copy Approved for Release 2011/10/25: CIA-RDP80-00809A000700100495-0