RECENT USSR WORK ON THE SYNTHESIS OF MORPHINE SUBSTITUTES

• Document Type: CREST
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): CIA-RDP80-00809A000700120017-8
• Release Decision: RIPPUB
• Original Classification: C
• Document Page Count: 2
• Document Creation Date: December 22, 2016
• Document Release Date: September 13, 2011
• Sequence Number: 17
• Publication Date: July 2, 1953
• Content Type: REPORT

Sanitized Copy Approved for Release 2011/09/14 :CIA-RDP80-00809A000700120017-8
CLASSIFICATION CONFIDENTIAL
SECURITY It~'ORMATION
CENTRAL INTELLIGENCE AGENCY
INFORMATION FROM
FOREIGN DOCUMENTS OR RADIO BROADCASTS
COUNTRY USSR
SUBJECT Scientific -Chemistry, medicine, analgesics
HOW
PUBLISHED Bimonthly periodical
WHERE
PUBLISHED Moscow
DATE
PUBLISHED Feb 1953
REPORT
CD N0.
DATE OF
SUPPLE
REPORT
Izveati n gkademii Nauk SSSR Otdeleni a Khimicheskikh Rauk, No 1, 1953,
p 1
RECENT USSR WORK ON THE SYNTffiIS C^ MORPHINE SUASTITUTFS
~omment~ According to the description given below, the drugs in
question are chemically related to demerol, except that they bear an
ester group instead of a carboxylic acid group in the 4 (gamma) posi-
tion of the piperidine nucleus. If the drugs whose synthesis is de-
scribed are not habit-forming, as claimed, they differ in that respect
from demerol. Some drugs of this group (e.g., demerol) exert a pro-
nounced spasmolytic effect which is both of the neural (atropine) and
muscular (papaverine) type]
Zn a report entitled "Synthesis of Analgesic Substances," which was pre-
sented by I. N. Nazarov, Corresponding Member of the Academy of Sciences USSR,
at the Joint Session of the Department of Chemical Sciences, Academy of Sciences
USSR, and the Academy of Sciences UzbeY. SSR, held on 24-2y October 1952 at Tash-
kent, the following observations were made by the author of the report in con-
nection with a description of the work on the synthesis of analgesics that has
been carried out under his direction,
Solution of the problem of synthesizing analgesics depends mainly on the
development of simple and practicable methods for the preparation of gamma-pi-
peri.dones. An important step forward in the synthesis of analgesics is repre-
sented by the work of Nazarov's group on the creation of new and simple methods
for preparing heterocyclic compounds, particularly gamma-piperidones, on the
basis of acetylene. The principal reactions involved consist in the condensa-
tion of ketones with vinyl acetylene. The next stage in the synthesis of the
analgesics is i,~troduction of a phenyl radical and of an ether grouping into gam-
ma-piperidones in the position occupied by the carbonyl group. The last step is
esterification of 4-phenyl-4-piperidols and their transformation into esters of
organic acids. The physiological activity of the compounds synthesized by Nazarov
has been tested under the direction of Prof M. D. Mashkovskiy.
The syntheses described form an important stage in the development of the
chemistry of analgesics, because the resulting compounds, on the basis of all of
their characteristics, must be regarded as superior to any drugs having a similar
,STATE NAW
ARMY
Sanitized Copy Approved for Release 2011/09/14 :CIA-RDP80-00809A000700120017-8
 Sanitized Copy Approved for Release 2011/09/14 :CIA-RDP80-00809A000700120017-8
action that are known at present (e.g., morphine, demerol, phenandon). In ad-
dition to having a high analgesic activity, they are relatively nontoxic. 4lhile
three to five times more active than morphine, they are free of many of the ob-
~ectionnble properties of morphine, i.e., they are not habit-forming and do not
produce any undesirable side effects. As a result of the availability oY pro-
medol 'substance synthesized by I. $. Nazarov7, USSR medicine ha:, been enriched
by a domestic drug that has a very high activity and an extensive range of appli-
cations. Promedol is not the last word of synthetic organic chemistry; the de-
velopment of other substesces with similar propert_es may be expected soon.
~~
Sanitized Copy Approved for Release 2011/09/14 :CIA-RDP80-00809A000700120017-8