THE CURARE-LIKE ACTION OF SUCCINYLCHOLINE

• Document Type: CREST
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): CIA-RDP80-00809A000700120532-6
• Release Decision: RIPPUB
• Original Classification: R
• Document Page Count: 1
• Document Creation Date: December 22, 2016
• Document Release Date: September 14, 2011
• Sequence Number: 532
• Publication Date: August 12, 1953
• Content Type: REPORT

Sanitized Copy Approved for Release 2011/09/14: CIA-RDP80-00809A000700120532-6
STAT
INFORMATION FROM
FOREIGN DOCUMENTS OR RADIO BROADCASTS CD NO.
COUNTRY
SUBJECT
HOW
USSR DATE OF
Scientific - Medicine, choline esters
DATE DIST./A
Aug 1953
PUBLISHED
WHERE
PUBLISHED
Bimonthly periodical
Moscow / Leningrad NO. OF PAGES
1
DATE
PUBLISHED
Feb 1953
LANGUAGE
SUPPLEMENT TO
Russian REPORT NO.
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R. S. Rybolovlev
let Leningrad Med Inst
fcomment: The following is taken from a paper presented 6 March
1952 at the 457th Meeting of the Leningrad Society of Physiologists,
Biochemists, and Fharmacologists iment L. M. Sechenov, Section of
Pharmacology .7
The dicholine ester of succinic acid (diacetylcholine), synthesized in
the laboratory of Prof A. L. Mndzhoyan at Yerevan, was investigated in regard
to its pharmacological activity. This drug was found to exert a strong action
of the curare type on warm-blooded animals. Intravenous administration of
0.12 mg/kg in rabbits brings about inclination of the head. In a narcotized
cat, a minimal curare effect is produced by 0.03-0.04 mg/kg, while complete
curarization of the gastrocnemius is produced by a dose of 0.1-0.15 mg/kg.
When artificial respiration is applied, cats tolerate doses which exceed
2,000 times the minimal curarizing doses. In other words, cats then tolerate
doses amounting to 60 mg/kg.
Succinylcholine does not have any depressing effect. It is destroyed
rapidly by cholinesterase. This makes it possible to produce an easily con-
trollable curarization by means of an uninterrupted intravenous administration
of succinylcholine (i, e., succinylcholine is applied by the drip method).
Depending on the dose, one may achieve even with a single injection complete
paralysis of all muscles for periods ranging from several minutes to several
hours. No undesirable collateral effects arise.
Froserine reinforces the action of succinylcholine by protecting it from
the hydrolytic effect of cholinesterase. Clinical data indicate the possibility
of using succinylcholine for clinical applications.
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