REFLEX EFFECT OF CHOLINOMIMETIC SUBSTANCES ON BLOOD VESSELS OF RABBIT'S EAR

• Document Type: CREST
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): CIA-RDP80-00809A000700120545-2
• Release Decision: RIPPUB
• Original Classification: R
• Document Page Count: 2
• Document Creation Date: December 22, 2016
• Document Release Date: September 14, 2011
• Sequence Number: 545
• Publication Date: August 13, 1953
• Content Type: REPORT

Sanitized Copy Approved for Release 2011/09/14 :CIA-RDP80-00809A000700120545-2
THIS IS UNEVALUATED INFORMATION
REFLEX EFFECT OF CHOLINOMIMETIC SUBSTANCES
ON BLOOD VESSELS OF RABBTT'S EAR
~omment: The following is taken from a payer ?resented
14 March 1952 at the 95th Meeting of the Section of P1Jnrmacology,
and Toxicology, oscow Society of Physiologists, Biocnem>,sts, and
Pharmacologists
The role played by the vascular receptor apparatus in the nechanism of
drug action vas investigated, In view of the fact that the blood vessels
of a rabbit's ear have a high sensitivity to impulses from the central nerv-
cus system, it vas assumed that these blood vessels may also act as a sen~~
nitive reflexogenic zone. In the investigation, M. P. Nikoleyev's method
vas used: perfJJaion of the blood vessels of an ear connected to the body
by means oP. a nerve. Perfusion of the blood vessels of the ear with acetyl-
choline the brings about a reflex drop in the blood pressure, an increased
frequency and volume of respiration, and contraction of the muscles of ex-
tremities. Prior anesthesia of the blood-vessel receptors vitkJ novucain
eliminated the reflex actions produced by acetylcholine.
Furthermore, experiments were carried out with the aim of clarifying
the effect exerted in connection with reflex reactions to acetylcholine by
reactive groups (i, e., sulfhydryl groups) which are present in the proteins
of vascular interoreceptors. After perfusion of the ear with a solution of
mercuric chloride or of cadmium chloride in a dilution of 1:1,000, S.e.,
after chemical binding of the sulfhydryl groups of receptor elements, the
reflex reactions to acetylcholine with respect to blood pressure, respiration,
anal sl;elet~l musculature are absent. The reflex reactions of the organism
are restored after the ear has been perfused with a solution of cysteine and
the sulfhydryl group; have been thereby liberated. The sensitivity of the
receptors to acetylcholine is also restored by guanidine or urea solutions.
RESTRICTED -T
DISTRIBUTION I I
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Sanitized Copy Approved for Release 2011/09/14 :CIA-RDP80-00809A000700120545-2
RAR 1952 01-YC
1
CLgSSIFICATI~N RF.STR "'
SECURI ~ INFORMAT~IQ
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i+uuvu
CENTRA ~~.~~~ ~ i'v
INFORMATION FROM
FOREIGN DOCUMENTS OR RADIO BROADCASTS
REPORT
CD N0.
COUNTRY
SUBJECT
Scientific - Medicine, acetylcholine,
ciiolinomimetlc suostauces
DATE OF
HOW
PUBLISHED
Bimonthly periodical
DATE DIST. 1.3 Ang 1953
WHERE
Moscov~Leningrad
PUBLISHED
DATE
N0. OF PAGES 2
PUBLISHED
Feb 1953
SUPPLEMENT TO
LANGUAGE
REPORT N0.
STAT
 Sanitized Copy Approved for Release 2011/09/14 :CIA-RDP80-00809A000700120545-2
These experiments have demonstrated the presence of sensitive reflex-
ogeaic zones in the vessels of s rab131t's ear and the significeace,for the
functional activity of interoreceptora, of complete retention oP structure
3y proteins.
To clarify the afferent and efferent means of impulse transmission,
experiments involving removal of the +ipper sympathetic ganglion and sec-
tion of the vague have been carried out. Experiments have also been con-
ducted on atropinized animals. The reflex reaction to perfusion of the ear
with acetylcholine was preserved after ell these interferences. It was
found to be absent only after section of the spinal cord below the medulla
oblongata.
Sanitized Copy Approved for Release 2011/09/14 :CIA-RDP80-00809A000700120545-2