TREATMENT OF TOXIC DYSENTERY WITH PERISTON N

• Document Type: CREST
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): CIA-RDP80-00809A000700150105-7
• Release Decision: RIPPUB
• Original Classification: R
• Document Page Count: 2
• Document Creation Date: December 22, 2016
• Document Release Date: September 13, 2011
• Sequence Number: 105
• Publication Date: November 26, 1953
• Content Type: REPORT

Sanitized Copy Approved for Release 2011/09/14: CIA-RDP80-00809A000700150105-7
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CLASSIFICATION,
INFORMATION FROM .... .. -
FOREIGN DOCUMENTS OR RADIO BROADCASTS CO NO.
COUNTRY Germany (USSR)
INFORMATION 1952
PUBLISHED Monthly periodical
WHERE
PUBLISHED Moscow
DATE
PUBLISHED Jul 53
LANGUAGE Russian
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DATE DIST. ; (p Nov 1953
NO. OF PAGES 2
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REPORT NO.
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Zhurnal Mikrobiolo ii EpidemioloRii i Immunobiolo
TREATMENT OF TOXIC DYSENTERY WITH PERISTON N
Ye. S. Geronimus (Editor)
.Lomment: The following is the complete text of a Russian ab-
stract of an article by J. Dieckoff, in Ztschr. f. d. Gesamte and
Innere Medizin, No 15, p 682, 1952, a periodical which is published
in Leipzig_
After mentioning the high lethality among patients suffering from toxic
dysentry, the author ff. Dieckoff7 emphasizes the necessity of developing an
effective method of treating this disease in view of the circumstance that
administration of antitoxic serum does not yield good results. The author
cites published data in regard to the mechanism of the action of periston or
collidon (polyvinyl pyrellidone), which is a nonbiogenic colloid, and points
out the capacity of periston to bind endotoxins and exotoxins, to exert a bene-
ficial effect on capillaries, and to bring about elimination of toxins through
the kidneys. The action of periston has been demonstrated by the application
of this substance in diphtherial infections both under experimental and clini-
cal conditions. The author has treated toxic dysentery with a 6% solution of
Periston N, which has a molecular weight of 20,000.
Experimental investigations carried out on rabbits show that administra-
tion of periston within 10-20 min after administration of a lethal dose of
dysentery toxin prevents death in the majority of cases (out of 16 experimental
animals, 14 survived). Seve.iteen children suffering from toxic dysentery were
treated with Periston N. The histories of these cases are described. Sonne,
Strong, and Flexner dysentery bacteria were isolated from these patients.
Periston N was injected intravenously in doses of 15 milliliters per 1 kg of
weight twice a day for 2-3 days. A single injection was carried out in 20-30
minutes. Yn 15 cases an effect due to Periston N was apparent. This effect
could usually be observed 24 hr after the injection.
CLASSIFICATION
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Sanitized Copy Approved for Release 2011/09/14: CIA-RDP80-00809A000700150105-7
 Sanitized Copy Approved for Release 2011/09/14: CIA-RDP80-00809A000700150105-7
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of the walls of capillaries-tojbloodCplasma Landethat then severe dcollapseiwhi h
occurs in this disease is due to a reduction of the quantity of plasma that
circulates in the blood vessels, the author, describes a series of physicochemi-
cal investigations of the blood which he carried out. According to his data,
filling of the blood vessels, an increase in the total quantity of blood, a re-
duction of the viscosity of blood, a rice of osmotic pressure, and some other
effects are observed after the administration of Periston N.
The author concludes that Periston N exerts a beneficial tberapeucic ef-
fect, bringing about cessation of the :ever in 24-36 hr (usually after the
second injection), a rapid disappearance of the bloody and mucous stool, im-
provement of the general condition, and amelioration of the blood circulation.
For these reasons, Periston N is an effective agent for the treatment of toxic
dysentery.
Sanitized Copy Approved for Release 2011/09/14: CIA-RDP80-00809A000700150105-7