PAPERS PRESENTED IN PHARACOLOGY SECTION, FIRST WORKING CONFERENCE OF CHECHOSLOVAK PHYSIOLOGISTS, BIOCHEMISTS, AND PHARMACOLOGISTS

Document Type: 
Collection: 
Document Number (FOIA) /ESDN (CREST): 
CIA-RDP80-00809A000700200123-1
Release Decision: 
RIPPUB
Original Classification: 
C
Document Page Count: 
3
Document Creation Date: 
December 22, 2016
Document Release Date: 
August 31, 2011
Sequence Number: 
123
Case Number: 
Publication Date: 
September 27, 1954
Content Type: 
REPORT
File: 
AttachmentSize
PDF icon CIA-RDP80-00809A000700200123-1.pdf184.69 KB
Body: 
Sanitized Copy Approved for Release 2011/08/31 :CIA-RDP80-00809A000700200123-1 CLASSIFICATION C_0-P1-F_-I-D_-E-N-T_-I-A-L CENTRAL INTELLIGENCE AGENCY INFORMATION FROM FOREIGN DOCUMENTS OR RADIO BROADCASTS COUNTRY SUBJECT Scientific - Medicine, toxins, HOW PUBLISHED WHERE PUBLISHED DATE PUBLISHED quarterly periodical Prague Sep 1952 SUPPLEMENT TO REPORT NO. THIS IS UNEVALUATED INFORMATION Chekhoslovatska a Fiziolo i a (Russian edition of Ceskosloven~kn FY toloFt vol 1, No , PP 339-341 - PAPERS PRFSIIITED IN PHARhL1COLOGY SECTIOId FIRST WORKING CONF'EREI7CE OF CZECHOSLOVAK PHYSIOLOGISTS BIOCHEt+IISTS AND PHARMACOLOGISTS The First Working Conference of Czechoslovak Physiologists, Biochemists, and Pharmacologists took place in Prague on ~-1'( October 19;2. The meeting was dedicated to the memory of iI. ye. Vvedenskiy. The following papers were pre- sented in the section of pharmacology, subdivision of the pharmacology of exter- oreceptors and interoreceptors. G. Raskova and others of the Pharmacological Institute, Scientific Research Institute of Epidemiology and Microbiology, Prague, presented three papers on the properties of the toxin of TSK (Shigellae Shigae). In the investigation which formed the subject of the first paper, the changes in the sensitivity of intestinal interoreceptoon in cats and rabbits were measured during the process of immunization with TSK. In the course of the experiments described, the reflex changes in the blood pressure and respiration were deter- mined. It was found that TSK produces in nonimmunized animals considerable re: flex changes of the blood pressure and respiration; for a certain time it blocks the irritation of interoreceptors with acetylcholine, brings about a gradually: decreasing reaction as immunization progresses, and beginning with the third im- munization produces no reflex changes at all. In animals immunized to the last stage mentioned, one cannot bring about even by means of acetylcholine the reflex changes of blood pressure and respiration which take place normally. pith the aid of adenosine ATP (triphosphoric acid), which under ordinary conditions removes the bloc];ing brought about by TSK, one may during the course of immunization in- crease to some extent the sensitivity toward acetylcholine, but not towards TSK. The results obtained were interpreted by the authors of the paper from the stand- point of Vvedenskiy's theory. The second paper presented by Raskova and her collaborators dealt with the influence of ATP acid on the toxicity of TSK. In the investigation discussed in the second paper it was established that there is a two-phase effect of ATP on the toxicity of TSK in white mice, the nature of which depends on the time of ad- ministration of ATP. I,/hen ATP and TSK are administered simultaneously, the STATE ARMY N SRB FBI DISTRIBUTION CLASSIFICATION C-O-N-F-I-D-E-N-T-I-A-L Sanitized Copy Approved for Release 2011/08/31_ CIA-RDP80-00809A000700200123-1 ?? Sanitized Copy Approved for Release 2011/08/31 :CIA-RDP80-00809A000700200123-1 C-O-N-F-I-D-E-N-T-I-A-L toxicity of TSK is usual]?y raised, although the doses oi' ATP are relativelyy small. On the other hand, when ATp is administered subsequent to the introduction o? TSK, the toxicity of TSK is considerably lowered. The maximum of :hc achieved by ATP is within 30-36 hours after the Detoxification tical evaluation of the results has been made, administration of TSK. A statis- The third paper presented by Raskova and others dealt with changes in the parabiotic process produced by the adenosine triphosphorec acid of TAK. In the course of the investigation reported in this paper, it was established that TSK brings about a parabiotic process in a nerve-muscle preparation of the cat in situ. As a result of the iuununization of the animals with TSK, the course of parabiotic is accelerated and reaches a definite maximum at the time of the fourth or fifth immunization. However, the parabiotic process can not be brought about by TSK subsequent to iaanunization. This is a newly established property of the toxin. The results of the investigation were interpreted from the standpoint of the concepts of Vvedenskiy and Ado. L. Vacek of the Pharmacological Institute, Brno, in a paper entitled "The Effect of the Irritation of Sensory Organs cn the Growth of Some Laboratory Ani- andsguineappigsdwereesub~ectedsduring110 weeksotoganfincessantrirritati ncof these sensory organs with sound and light. During this time, the growth of the animals was determined by measuring the changes in weight. Animals whose sensory organs wasefoundithataonlywinsignificartt changes were prodmueedwin male miece,~ewhile the weight of female micE dropped constantly beginning with the 4th week. No changes were observed in male rats, whip the growth of Female rats was stimulated. Eighty percent of the male guinea pigs which had been irritated with light and sound perished, while only 2C~, of the female guinea pigs died. A reduction of weight was observed in the guinea pigs that did not perish. E? Lecian and E. Iecian, Jr, of the Pharmacological Institute at Brno, gave a paper dealing with the effect which irritation of sensory organs has on the ac- tion of strophanthin and digitalis. They founrk that rats which had been irritated by means of sound and light survived otherwise lethal doses of strophanthin or digitalis. It was established by them that the hearts of rats whose sensory or- gans had been irritated exhibited a lower content of cal=ium than the hearts of control rats that had not been subjected to any irritation. The increased resis- tance to the toxic action of the drugs is explained by the reduction of the cal- cium content in the heart brought about by the sensory irritation. The authors conclude that during a period of great excitation, particularly in cases when cardiac patients are treated, one should use doses of cardiac stimulants which are higher than those administered ordinarily, M. Gava, I. Jelinek, and L. Sirucel: of the Pharmacological Institute, Scien- tific Research Institute of Epidemiology and Microbiology, pr e paper on the dynamics of the hemolytic action of streptolysin 0. They investigated the action of streptolysin 0, the toxicity of which in mice xeighing ~U grams com- prises 2.5 to 1+?5 units of DLSo and in rabbits approximately 40 units per kilogram of weight. The results of the measurements carried our on II5 rabbits by means of the modified photometric method, proposed by V. G. Karru and F. V. Cornok, showed that when the dose of streptolysin 0 is increased in a geometric proportion, the hemolysis increases relatively slowly, which is contrary to the results obtained by Bernheimer. The maximum ?aas achieved more rapidly with higher doses. With low doses the curve of hemolysis has a single, sharp maximum, whilr. with high doses the level of hemolysis remains at the highest point during a relatively long time within the limits of a definite oscillation wave of 'the curve. - 2 - C-O-N-F-I-D-E-N-T-I-A-L - - Sanitized Copy Approved for Release 2011/08/31 :CIA-RDP80-00809A000700200123-1 Sanitized Copy Approved for Release 2011/08/31 :CIA-RDP80-00809A000700200123-1 ~ I. Vanechek, M. Tronickova, and L. Sirucek of the Pharmacological Institute, Scientific Research Institute of Epidemiology and A}icrobiology, Prague, also pre- sented a paper dealing with the. properties of streptolysin 0. In the investiga- tion reported in this paper it was established that streptolysin 0 often produces a fall of blood pressure in cats which are in a state of chloralose narcosis and rabbits which are in a state of urethane narcosis: In other cases streptolysin 0 has no effect on the blood pressure. As a result of the action of streptolysin 0, the reaction arising in response to the stimulation of interoreceptors by acety- choline is blocked for a short time. Afcer prior sensitization by intraperitoneal administration of streptolysin 0, there is a characteristic blocking of interore- ception, a condition xhich after a certain time passes into a paradoxal stage. Then the animals perish after a violent reaction, because their }iearts stop. Z. Votava, I. Sramkova, and M. Chvatolova of the Scientific Research Insti- tute of Pharmacy and Biochemistry, prague, reported on suli'onium analogs of spas- molytic substances and on their pharmacological properties. According to this paper, a group headed by Dr Protiva prepared three sulfonium analogs of antihis- taminic substances a?id eight sulfonium analogs of spasmolytic substances, in which nitrogen was replaced with sulfur. The replacement of nitm~en with sul- fur did not change the spasmolytic effect o t~e..?substances ir. gnPrsion.but raised their toxicity, particularly on intravenous administration. Only sub- stance 3-1216 (2-phenyl-cycloherylacetoxy-ethyl-dimethyl-sulfonium iodide pro- duces a high spasmolytic effect. This effect was 50 times higher than that of stropine on the isolated intestine and approximately the same as that of atropine in vivo. ifie effect on salivation and elimination of tears after stimulation was approximately 20 times lower t' n that produced by atz~pine. -3- C -O-Id-F-I-D-);-PI-T-I-A-L Sanitized Copy Approved for Release 2011/08/31 :CIA-RDP80-00809A000700200