PAPERS PRESENTED IN PHARACOLOGY SECTION, FIRST WORKING CONFERENCE OF CHECHOSLOVAK PHYSIOLOGISTS, BIOCHEMISTS, AND PHARMACOLOGISTS
Document Type:
Collection:
Document Number (FOIA) /ESDN (CREST):
CIA-RDP80-00809A000700200123-1
Release Decision:
RIPPUB
Original Classification:
C
Document Page Count:
3
Document Creation Date:
December 22, 2016
Document Release Date:
August 31, 2011
Sequence Number:
123
Case Number:
Publication Date:
September 27, 1954
Content Type:
REPORT
File:
Attachment | Size |
---|---|
![]() | 184.69 KB |
Body:
Sanitized Copy Approved for Release 2011/08/31 :CIA-RDP80-00809A000700200123-1
CLASSIFICATION C_0-P1-F_-I-D_-E-N-T_-I-A-L
CENTRAL INTELLIGENCE AGENCY
INFORMATION FROM
FOREIGN DOCUMENTS OR RADIO BROADCASTS
COUNTRY
SUBJECT Scientific - Medicine, toxins,
HOW
PUBLISHED
WHERE
PUBLISHED
DATE
PUBLISHED
quarterly periodical
Prague
Sep 1952
SUPPLEMENT TO
REPORT NO.
THIS IS UNEVALUATED INFORMATION
Chekhoslovatska a Fiziolo i a (Russian edition of Ceskosloven~kn
FY toloFt vol 1, No , PP 339-341 -
PAPERS PRFSIIITED IN PHARhL1COLOGY SECTIOId FIRST WORKING CONF'EREI7CE
OF CZECHOSLOVAK PHYSIOLOGISTS BIOCHEt+IISTS AND PHARMACOLOGISTS
The First Working Conference of Czechoslovak Physiologists, Biochemists,
and Pharmacologists took place in Prague on ~-1'( October 19;2. The meeting was
dedicated to the memory of iI. ye. Vvedenskiy. The following papers were pre-
sented in the section of pharmacology, subdivision of the pharmacology of exter-
oreceptors and interoreceptors. G. Raskova and others of the Pharmacological
Institute, Scientific Research Institute of Epidemiology and Microbiology, Prague,
presented three papers on the properties of the toxin of TSK (Shigellae Shigae).
In the investigation which formed the subject of the first paper, the changes in
the sensitivity of intestinal interoreceptoon in cats and rabbits were measured
during the process of immunization with TSK. In the course of the experiments
described, the reflex changes in the blood pressure and respiration were deter-
mined. It was found that TSK produces in nonimmunized animals considerable re:
flex changes of the blood pressure and respiration; for a certain time it blocks
the irritation of interoreceptors with acetylcholine, brings about a gradually:
decreasing reaction as immunization progresses, and beginning with the third im-
munization produces no reflex changes at all. In animals immunized to the last
stage mentioned, one cannot bring about even by means of acetylcholine the reflex
changes of blood pressure and respiration which take place normally. pith the
aid of adenosine ATP (triphosphoric acid), which under ordinary conditions removes
the bloc];ing brought about by TSK, one may during the course of immunization in-
crease to some extent the sensitivity toward acetylcholine, but not towards TSK.
The results obtained were interpreted by the authors of the paper from the stand-
point of Vvedenskiy's theory.
The second paper presented by Raskova and her collaborators dealt with the
influence of ATP acid on the toxicity of TSK. In the investigation discussed in
the second paper it was established that there is a two-phase effect of ATP on
the toxicity of TSK in white mice, the nature of which depends on the time of ad-
ministration of ATP. I,/hen ATP and TSK are administered simultaneously, the
STATE
ARMY
N SRB
FBI
DISTRIBUTION
CLASSIFICATION C-O-N-F-I-D-E-N-T-I-A-L
Sanitized Copy Approved for Release 2011/08/31_ CIA-RDP80-00809A000700200123-1 ??
Sanitized Copy Approved for Release 2011/08/31 :CIA-RDP80-00809A000700200123-1
C-O-N-F-I-D-E-N-T-I-A-L
toxicity of TSK is usual]?y raised, although the doses oi' ATP are relativelyy small.
On the other hand, when ATp is administered subsequent to the introduction o? TSK,
the toxicity of TSK is considerably lowered. The maximum of :hc
achieved by ATP is within 30-36 hours after the Detoxification
tical evaluation of the results has been made, administration of TSK. A statis-
The third paper presented by Raskova and others dealt with changes in the
parabiotic process produced by the adenosine triphosphorec acid of TAK. In the
course of the investigation reported in this paper, it was established that TSK
brings about a parabiotic process in a nerve-muscle preparation of the cat in
situ. As a result of the iuununization of the animals with TSK, the course of
parabiotic is accelerated and reaches a definite maximum at the time of the
fourth or fifth immunization. However, the parabiotic process can not be brought
about by TSK subsequent to iaanunization. This is a newly established property of
the toxin. The results of the investigation were interpreted from the standpoint
of the concepts of Vvedenskiy and Ado.
L. Vacek of the Pharmacological Institute, Brno, in a paper entitled "The
Effect of the Irritation of Sensory Organs cn the Growth of Some Laboratory Ani-
andsguineappigsdwereesub~ectedsduring110 weeksotoganfincessantrirritati ncof these
sensory organs with sound and light. During this time, the growth of the animals
was determined by measuring the changes in weight. Animals whose sensory organs
wasefoundithataonlywinsignificartt changes were prodmueedwin male miece,~ewhile the
weight of female micE dropped constantly beginning with the 4th week. No changes
were observed in male rats, whip the growth of Female rats was stimulated.
Eighty percent of the male guinea pigs which had been irritated with light and
sound perished, while only 2C~, of the female guinea pigs died. A reduction of
weight was observed in the guinea pigs that did not perish.
E? Lecian and E. Iecian, Jr, of the Pharmacological Institute at Brno, gave
a paper dealing with the effect which irritation of sensory organs has on the ac-
tion of strophanthin and digitalis. They founrk that rats which had been irritated
by means of sound and light survived otherwise lethal doses of strophanthin or
digitalis. It was established by them that the hearts of rats whose sensory or-
gans had been irritated exhibited a lower content of cal=ium than the hearts of
control rats that had not been subjected to any irritation. The increased resis-
tance to the toxic action of the drugs is explained by the reduction of the cal-
cium content in the heart brought about by the sensory irritation. The authors
conclude that during a period of great excitation, particularly in cases when
cardiac patients are treated, one should use doses of cardiac stimulants which
are higher than those administered ordinarily,
M. Gava, I. Jelinek, and L. Sirucel: of the Pharmacological Institute, Scien-
tific Research Institute of Epidemiology and Microbiology, pr e
paper on the dynamics of the hemolytic action of streptolysin 0. They investigated
the action of streptolysin 0, the toxicity of which in mice xeighing ~U grams com-
prises 2.5 to 1+?5 units of DLSo and in rabbits approximately 40 units per kilogram
of weight. The results of the measurements carried our on II5 rabbits by means of
the modified photometric method, proposed by V. G. Karru and F. V. Cornok, showed
that when the dose of streptolysin 0 is increased in a geometric proportion, the
hemolysis increases relatively slowly, which is contrary to the results obtained
by Bernheimer. The maximum ?aas achieved more rapidly with higher doses. With
low doses the curve of hemolysis has a single, sharp maximum, whilr. with high
doses the level of hemolysis remains at the highest point during a relatively long
time within the limits of a definite oscillation wave of 'the curve.
- 2 -
C-O-N-F-I-D-E-N-T-I-A-L
- -
Sanitized Copy Approved for Release 2011/08/31 :CIA-RDP80-00809A000700200123-1
Sanitized Copy Approved for Release 2011/08/31 :CIA-RDP80-00809A000700200123-1 ~
I. Vanechek, M. Tronickova, and L. Sirucek of the Pharmacological Institute,
Scientific Research Institute of Epidemiology and A}icrobiology, Prague, also pre-
sented a paper dealing with the. properties of streptolysin 0. In the investiga-
tion reported in this paper it was established that streptolysin 0 often produces
a fall of blood pressure in cats which are in a state of chloralose narcosis and
rabbits which are in a state of urethane narcosis: In other cases streptolysin 0
has no effect on the blood pressure. As a result of the action of streptolysin 0,
the reaction arising in response to the stimulation of interoreceptors by acety-
choline is blocked for a short time. Afcer prior sensitization by intraperitoneal
administration of streptolysin 0, there is a characteristic blocking of interore-
ception, a condition xhich after a certain time passes into a paradoxal stage.
Then the animals perish after a violent reaction, because their }iearts stop.
Z. Votava, I. Sramkova, and M. Chvatolova of the Scientific Research Insti-
tute of Pharmacy and Biochemistry, prague, reported on suli'onium analogs of spas-
molytic substances and on their pharmacological properties. According to this
paper, a group headed by Dr Protiva prepared three sulfonium analogs of antihis-
taminic substances a?id eight sulfonium analogs of spasmolytic substances, in
which nitrogen was replaced with sulfur. The replacement of nitm~en with sul-
fur did not change the spasmolytic effect o t~e..?substances ir. gnPrsion.but
raised their toxicity, particularly on intravenous administration. Only sub-
stance 3-1216 (2-phenyl-cycloherylacetoxy-ethyl-dimethyl-sulfonium iodide pro-
duces a high spasmolytic effect. This effect was 50 times higher than that of
stropine on the isolated intestine and approximately the same as that of atropine
in vivo. ifie effect on salivation and elimination of tears after stimulation
was approximately 20 times lower t' n that produced by atz~pine.
-3-
C -O-Id-F-I-D-);-PI-T-I-A-L
Sanitized Copy Approved for Release 2011/08/31 :CIA-RDP80-00809A000700200