A SOVIET REVIEW OF GEMORRAGICHESKIY NEFROSO-NEFRIT

• Document Type: CREST
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): CIA-RDP80-00809A000700240014-8
• Release Decision: RIPPUB
• Original Classification: U
• Document Page Count: 3
• Document Creation Date: December 22, 2016
• Document Release Date: July 11, 2011
• Sequence Number: 14
• Publication Date: September 1, 1955
• Content Type: REPORT

Sanitized Copy Approved for Release 2011/07/12 : CIA-RDP80-00809A000700240014-8
STAT
Sanitized Copy Approved for Release 2011/07/12 : CIA-RDP80-00809A000700240014-8
 Sanitized Copy Approved for Release 2011/07/12 : CIA-RDP80-00809A000700240014-8
A SOVIET REVIEW OF "GEMORRAGICHESKIY NEFROSO-NEFRIT"
UrOlOaiVa No 1, 1955. pp 94-5
N. I. Chuchelov
(Comment: This is a review of the book Gemorraaicheskiv Nefroso-
Nefrit (Hemorrhagic Nephroso-Nephritis) by A. A. Smorodintsev,
V. G. Chudakov, and A. V. Churilov, Medgiz, Moscow, 1953, 126 pages.
The review was published by N. I. Chuchelov in ER12alya, No 1, Janu-
arY-March 1955, pages 94-95.1
The book by Smorodintsev et al, describes a disease of virus origin which
is transmitted to human beings by blood-sucking mites. This disease was first
discovered and described in the Far East by Soviet workers. It was earlier
confused with various other diseases, such as toxic influenza, meningitis, etc.
Cases are known of operations carried out under the mistaken assumption that the
patien'.s suffered from perforations of the.stomach or duodenum. The authors
should be given credit for carrying out a detailed study of the disease, es-
tablishing the fact that it is of virus etiology, and clarifying the mechanism
of its transmission.
The question in regard to the name of this disease is very controversial.
In the opinion of the authors of the book, the kidneys are the principle site of
the infection in the human organism. According to them, the changes in the
kidneys typical for this disease are not encountered in other diseases or poison-
ings and constitute a special form of an affliction of the kidneys which is a
distinguishing mark of tb+.s disease. One may advance several objections to this
assertion.
It follows from the description of the clinical aspects of the disease that
the patients develop oliguria and sometimes anuria on the 5-7th day of the disease.
Protein appears in the urine and a considerable number of erythrocytes and modi-
fied renal epithelium are also found there. Azotemia develops in the blood.
When an autopsy is carried out on patients who have died from the disease,
extensive changes in the kidneys are observed, to which the authors refer as a
bilateral acute interstitial serous-hemorrhagic nephritis, pointing out that the
changes in the cortical matter of the kidneys are especially prominent and that
these changes resemble those found in necrotic nephrosis of the kidneys resulting
from mercuric chloride poisoning. In the opinion of the authors, specific changes
in the renal tubules and in extensive regions of the cortical matter are typical
for hemorrhagic nephroso-nephritis. the changes are caused by interferences with
drainage produced by destruction of parts of the collecting tubules as a result
of their obturation with cylinders. It follows from the description of the
clinical aspects and of the preparations' which have been made, as well as from
the figures which accompany the text of the book, that the changes in the kidneys
of which the authors speak are characteristic for a cortical necrosis of the
kidneys (a necrotic nephrosis or a nephrosis of the lower nephron). This is a
condition the etiology of which may be vE.:y diverse. A kidney affliction of this
type occurs not only in the Far East, but can also be encountered anywhere in
the world.
The changes in the kidneys which are typical for this affliction can be most
frequently observed after shattering of the lower extremities by a traumatic
compression, in complications following birth or abortion, after transfusion of
incompatible blood, or in poisoning with antifreeze or mercuric chloride.
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 the cause hlsch the which develops as a result leads to anoxia and the latter ie
the uand he dying off of the renal cells. Particularly sensitive
for 4-6 hours initial parts of the tubules, that
the kidneys is sufficient to cause the phenomenAn a iofsthechemia cortical nes crosis ofd
Against the background of the renal affliction the c
picture of the disease develops. This picture comprises vomiting,
clinical oliguria which changes into anuria, and az,temia, so that death often results;
as the authors point out. 8i
lital There are no reasons to assert, however, that the
aspects and the pathological phenomena described by the authors are
characteristic only for the disease under consideration.
The data cited in the book indicates that there is a primary acute af-
fliction of the nervous system, a fact which the authors recognize b
the disturbance of the nervous system is,very extended and shows traits specific
for this disease. Y saying that
The affliction of the nervous system is very
important es clearly expressed
in disturbances of tho mesodermal apparatuses of the nervous system, the most
vessels thatparesof awfocalaedematicedestructivedorinecrobiotictty e. T blood m, In ctoxicentraleffectnervouofs
authors, The
whithechopfunctionsinion of
factor of the disease.
as the causative
It follows from this that the disease must be interpreted somewhat differently
than has been done by the authors. The primary factor in the disease is an acute
affliction of the central nervous system with the virus. After the expiration
of only 3-5 days, reflex action leads to the described affliction of the kidneys
as a consequence of disturbances in the renal blood circulation. Thus the
changes in the kidneys, described as a cortical necrosis of the kidneys or an
interstitial serous-hemorrhagic nephritis, represent only one of the s
of the disease. These changes are not typical for the affliction of the central
nervous system in symptoms
conditions question but can be observed in connection with a
bring aboutwischemia,, anoxia,tandhnecr sisal circulation in the kidneysaandlthueal f the
e di in rejectingtheirthedisnovocaincussion
method of treatment in this disease, sense, the authors are mistaken
ofetheyrenalhregion which
catheterization of the renal pelvis andhrinsi of mehe pe s with haure yal
ological salt solution in order to bring aboutg a reflex action.or application
of carbocholine (0.25 P~si-
mg subcutaneously) and other spasmolytic drugs. The
authors are right in emphasizing that it is necessary to avoid a rough
of the renal region or sharp knocking in the region of the waist in order to
test for Paeternateki 's a palpation
estt, which a tskiy symptom. The method of investigation by means of the
firs is occasionally applied in because detection of a sensitivity oftherkidneys toopain bandblocation ofithe
foci of pain is , fingers. quite possible by a careful testing of this region with the
With the stipulations made above, the book that has been reviewed must be
regarded as a very useful contribution to medicine. It describes one of the
reflex afflictions of the kidneys which can originate from a number of different
causes.