(SANITIZED)UNCLASSIFIED SOVIET PAPERS ON BRAIN RESEARCH IN ANIMALS(SANITIZED)

• Document Type: CREST
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): CIA-RDP80T00246A018300450001-9
• Release Decision: RIPPUB
• Original Classification: U
• Document Page Count: 14
• Document Creation Date: December 22, 2016
• Document Release Date: January 6, 2012
• Sequence Number: 1
• Content Type: MISC

Declassified in Part - Sanitized Copy Approved for Release 2012/01/06: CIA-RDP80T00246AO18300450001-9
Next 1 Page(s) In Document Denied
Iq
Declassified in Part - Sanitized Copy Approved for Release 2012/01/06: CIA-RDP80T00246AO18300450001-9
 Declassified in Part - Sanitized Copy Approved for Release 2012/01/06: CIA-RDP80T00246A018300450001-9
STAT
,KIPHA/7 6'b1CWtrt ta~~rTE76Noc7-0
IrTTERACTION OF A'WwYSERS IN TTD1 FORMATION VD / / 0
OF :MOTOR FOOD CONDITIOT' = .,ILEXES ILEXES 44
Z44 G R NA ~- V)/y510 S Adryanov
Institute of Brain, USSR, Academy of 'Medical Sciences, Moscow
Complete bilateral disconnection of the cortical territories
of the skin and optical. analysers was carried out in dogs, foilowing
t'-ie e&.aboration of motor and secretory food conditioned reflexes
to sine e and complex stimuli. The operation did not prevent the
possibility of joint activity of the disconnected analysers; the
positive conditioned reflex to a complex of cutaneous (mechanical.
stimulation) and optical. (an object or light) stimuli was preser-
ved. After tli.e operation, the stabi' ity of the conditioned reflexes
to sing' e and 6omp7_ex in-ibitory stimuli was considerably l.owered.
Pilate al frontal lobotory in dogs with disconnected nuclei of
the optical and skin analysers produced a prolonged serious dis-
tiirbance of conditioned fef exes both to sine e and complex stimuli.
The lowered stability of positive and particul.arl y of inb3.bitory
reflexes may be due not only to the disconnection of analyser nucl Ai,
but also to a 7esion during the operation on the central projection
pathways of the anal.ys;;rs and secondary changes in the cortex and
subcortical formations.
INDIVIDUAL PROPERTIES OF aECTRICAu PROCESSES IN T'IE Sou Gv "-"
CORTEX AND T BPAIlT STE."" STRrCTTTRES IF DOGS j' //
T S Yaumova y0 ~"
Laboratory of r_ectrophysiol.ogy, Institute of Brain, USSR Academy
of Medical Sciences, Moscow
Electrica,7 processes were studied in the specific auditory (med-
ical. genicuuate body corpus quadrigeminum) and non-specific
(reticular formations structures of the mid-brain and the cerebral.
cortex in ten dogs. Changes in electrical activity in the specific
and non-specific system of the mid-brain level in the course of
habituation to the experimental_ conditions and under the influence
of external. stimuli have common features in each anima (wide
irradiation). At the same time differences were recorded in the
electrica7 activity of individual. anima's. In some dogs the amp-
"Itude and frequency of el.ectrica"l oscih ations in the cortical and
particul ar'yr the brain-stem structures, varied in a wide range, whi1.e
in others the c?'anges were s'ig)t'y pronounced under the sane con-
ditions. The similarity of elec3trical processed in different brain
sy ttezls of the given animal. prolte s that the individual pecul iar -
ities of the nervous system are inherent in all the brain structures.
Elaboration and stabilization of defensive conditioned reT eyes is
attended by a redistribution of activity in the specific and non-
specific systems of the brain with a gradual concentration of the
processes in the specific systems of the brain-stem. The concentration
Declassified in Part - Sanitized Copy Approved for Release 2012/01/06: CIA-RDP80T00246A018300450001-9
 Declassified in Part - Sanitized Copy Approved for Release 2012/01/06: CIA-RDP80T00246AO18300450001-9
sets in individual dogs after a different member of pairings and
proceeds at different levels of the processes.
S A---,A wo Prt.eo~t ~/ ~'C / /j NO 3, /f 6 l
ELECTROEIdCEPHALOGRAPHIC ATTALYSIS OF T.7 E ACTIVITY
OF DIFFEPENT LAYERS OF THE CE? +ERP1 CORTEX DURING
COiWITIONED MMEXPS
E' ectrophysi8.-. ogica'. Laboratory, Institute of Brain, USSR Academy
of Medical Sciences, 11oscow
Defensive conditioned re'f-_exes elaborated to r'hyt'hmical acoustic
and photic stimuli were studied in dogs with 30-40 diam. electrodes
chronically implanted in different layers of the cortex of the acoustic,
visual, cutaneous and motor analysers. It has been found that during
the formation of defensive conditioned reflexes the process of exci-
tation unites the neurons of all cortical '? inks of the reTtex into
one functioning system; the process is predominantly localized in
the II and IV layers of the analyser, where the signal stimuli are
addressed; in the II and IV layers of the cutaneous analyser and
in the III and V ' ayers of the motor analyser. Internal. inhibition
(differentiation, extinction), like the process of excitation,
simultaneously envelope cortical structures of those analysers,
between which conditioned connection has been elaborated, predom-
inantl.y in the sane layers of the cortex.
YPNAn 86{C w i7 rr
AE~'T~flbNac76~ Voc /o
INDIVIDUAL ,AYERS OF TQE CEREBRAL CORTEX IN CHRONIC
EXPERIMENT S
Institute of the Brain, USSR Academy of Medical Sciences, Moscow
1959
Declassified in Part - Sanitized Copy Approved for Release 2012/01/06: CIA-RDP80T00246AO18300450001-9
 Declassified in Part - Sanitized Copy Approved for Release 2012/01/06: CIA-RDP80T00246AO18300450001-9
Ce~yR 6h07vrN yecKa;- Ala 3
8, 313
A STUDY OF THE CONTRACTIONS OF AN ISCE,ATED NUSQ.F PIER
Laboratory of Cell Physiology, the Leningrad State University
A study was carried out of the change in the character of res-
ponses to single condenser discharges of an isolakied striated frog
muscle fiber surviving in Ringer sa'ien. The effect of some chemical
substances was also tested, viz. of different concentrations of
potassium chloride, ethyl. al.coho1 , Ringer saline without Ca-ions,
sodium citrate and -dinitropheno'.
All the above agents call. forth substantially similar changes
in the contractility of the fiber. That is to say, with aggra-
vation of its functional state the fiber does not more respond to
stimulation by only non-graded contractions which propagate along
the fiber, but begins to exhibit local- graded contractions which
at a certain stage of alteration become the only kind of response
of the muscle fiber to any strengtht and length. of stimulation.
After the disappearance of propagating responses the plots of
the magnitude of 7_ocal_ contraction as a function of the strengtht of
stimulation acquire a smooth S-shape their position in the system
of coordinates depending on the functional state of the fiber., At
earlier stages of alteration the smooth course of the curves at a
definite strength of stimul.ation is disturbed owing to the appear-
ance of non-graded propagating responses.
The c..istence of two types of muscle response, their dynamics
as associated with a change in the functional state of the fiber,
the S-shaped curves relating the magnitude of the local contraction
to the strenght of stimu' ation--? 1.1 these data justify the appl_ i-
cabi' ity of the principal statements of the gradual theory of
excitation as suggested by Nasonov, to the contractile reactions
of the muscl.e tissue.
1.958
14)4~~17of rat y ,v y
THE DISTRIBUTION OF A VITAL DYE (r-TUTPL, RED) MiIiEN M
GIANT AEON OF SEPIA AYD SEA ':TATER
A A Vereninov, N N 1Tikol sky and D L Rosental
Declassified in Part - Sanitized Copy Approved for Release 2012/01/06: CIA-RDP80T00246AO18300450001-9
 Declassified in Part - Sanitized Copy Approved for Release 2012/01/06: CIA-RDP80T00246A018300450001-9
;KYPMA)7 CbJCLFN
I1 PROVED STEOEOTAXIC DF71rAT" FOR 6MALL ATTI2-'UAu S
R 11 I.1 e she r sky
Institute of Tligher Nervous Activity, USSR Academy of Sciences,
1!o scow
1960
Oil 0 [-AIR
C0P ATION EEMMEEIT =z IPTTENSITY OF L I GRT SCATTERING,
CONCENTRATION OF SOME AGEi'?TS AND DURATION OF T72IR ACTION IN
NERVE CELL S
47ROTO P'0 -4 3, A/a $4 i s 4
CQANGES OF DISPERSION DEGREE LAS1MA CQ i OID PARTICLZS OF
NERVE CELLS UNDER T1IE ACTION OF THE SCL.,UTIONS OF QUININTr
SCLPTATE, EGG ALEMIN AND ETHJ1URETW
ItCTHHk /'JrHtfHrP4aCK0rO YNNdEPcH7 -r4
-
sh itl.e
No_~ Eng
Na /S
/ersq
The change in the excitability of the isolated striated musc'.e
fibrg in Ringer solution, wh.il e mechanica" y injured, under the
action of Ringer solution without ca' cium ions and of different
concentrations of KC!., natrivm citrite, -denitropheno'. has been
investigated. The investigation shows that the character of changes
in fibre excitability depends both on the duration of the employed
stimu7i and on the kind of fibre contraction (local. or propagating)
taken as the criterion of the threshold. Tinder the action of a1.
the test agents a number of common properties has been observed in
the change of the muscle fibre excitability: sudden disappearance
of excitability determined by propagating contractions; at a cer-
tain stage of the alteration an increase of rheobase excitability
extimated by the '.oca. contractions at simultaneous decrease of
excitability to stimuli of small duration; at the 'ate stages of
the alteration gradual. decrease of the lhoca7l' excitability to
stimu'. i of any duration.
The change of the excitability proves to be in a'.' the cases
closely connected with that of the magnitude and the character of
muscle fibre contractions, thus a"owing us to donsider the ob-
tained data in the light of Nasonov's gradual theory of excitation.
Declassified in Part - Sanitized Copy Approved for Release 2012/01/06: CIA-RDP80T00246A018300450001-9
 Declassified in Part - Sanitized Copy Approved for Release 2012/01/06: CIA-RDP80T00246AO18300450001-9
& 1044 ETFf/b 3KCVC'PHMC-W7.4Abif v`'f SkWAbrIlh
TTY EFFECT OF 7XTIRPATIOiT OF = VAGUS COF.TICAL
REPP.ESEITTATION Z07773 UPON INTEROCEPTIVE COT*DITIOfl
P JEXES PRO?! TAE STOMACR ATD IT'TESTITTE
A N Sovetov, V N Chernigovsky
From the Institute of Norma''. and Pathologica'. Physiology of the USSR
Academy of Medical Sciences, Moscow
Experiments were performed on 3 dogs. The state of extero-
and interoceptive conditioned reflexes was studied prior to and
after the renova' of the vagus cortid-0 re-presentation zones.
Extirpations of these areas was associated with the dist=bance
of conditioned reflexes from the stomach and had no effect upon
those coming from the intestine, innervated by the sp'anchnic nerve.
Extirpation of a parietal lobe area control operation performed in
one of the dogs, caused no changes in the exterointeroceptive con-
ditioned ref'.exes. Removal of the afferent vagus representation
zones in dogs with denervated stomach was associated with pro'.onges
and fluctuating disturbance of the interoceptive reflexes from the
stomach.
11960
1Ypjtitr Bb lcWE11 H '0161'-0/' 4F-9P reAt6 HocrH Vv-~ /O
STUDY OF TTTE RCLZ OF ITTTFROCEPTIVE SIGITALIZATION ~v 3
IN T' I'E.?'DIITG BE?TAVIOUR OF ATTIMALS
V IT Chernigovsky
Leningrad
In experiments the dogs had a choice of several solutions
containing milk and various amounts of sodium chloride (7.0, 2.5
and 3.5 per cent). The anima's readily drank the so' utions ?gassing
on from the 'less concentrated to more saturated ones. The infusion
of 300 ml. of a 5 per cent sodium chloride solution into the stomach
through a fistu'.a caused the animal in a few minutes (3-8) to re-
fuse to tape the most concentrated milk solutions of sodium chloride.
`INen the sodium ch' oride solution was removed from the stomach, the
former attitude to milk sodium chl. oride mixtures was restored.
The change in the attitude to such solutions was not a result
of thirst or mechanical stimulation of the stomach recept&rs by
the infused solution. The choice of the milk sodium chloride mix-
tures disappears or is disturbed, after the section of the vagas
nerves under the diaphraghm, which testivies to the reflex nature
of the phenomenon in question. If a 27 per cent glucose or sac-
charose is substituted for the 5 per cent sodium chloride solution,
the choice of the milk-sodium chloride mixtures is not disturbed.
'960
Declassified in Part - Sanitized Copy Approved for Release 2012/01/06: CIA-RDP80T00246AO18300450001-9
 Declassified in Part - Sanitized Copy Approved for Release 2012/01/06: CIA-RDP80T00246AO18300450001-9
Qi
i tvoilr tl (Ill file .Urf?,e
I
The In)ttlll p(,srtlce potential reIJ,. ?ts local 'xcitatiou of tilt neurons
r}tit fly the p\ranurl:li tunes) rl' 01e 11 Ind 111 lavets. 'ari?iu'~ ur tl n
. - ?. i,''?`'',~t- flowed by an alpha like Wave and Ii). In the Intervals br?tN'ren
be stimuli slow oscillations of tilt' 11411 1itial predoulinat~d (F'i 1).
An analysis of the given facts Nas based on the following theoretical
aumptions-
w
1. Changes In the latency nt. the ltr'nlu:,l't r sport es !te n '?yltne~s to
:changes in the excitability of the neurons of the ,nbcortitrll relays.
rogresaneli on the other hanil the l,rilu;lr\ resl,una'c were bitter r
ressl't1 (Fig, .5. B). With l'onlplt'tr' e\Ilt1,t1t)11 it the iITI tacit stilllu
,tlmulus. the ueta-rhythnr evoke,I I,\- the tnuditinnt,d stimulus weakened
to gradually increasing Meta like nc~tlrn ar.,sr tPit~. 41 the prinulrv respnn
fts were weakly expressed: lilt' initial p?citiv. putterrtiai as often reduced
quirk oscillations of snutil aulplltn,ir .
1?. x 1111 e t I n rl. In the cotlrst' o, :1(01,- it xtiJlr'tiotl fit' a Cuhllltton,-il rt'tlt?\
P. When the conditioned reflex was flit reinforced ht an uncou,litiont?t1
Declassified in Part - Sanitized Copy Approved for Release 2012/01/06: CIA-RDP80T00246AO18300450001-9
 Declassified in Part - Sanitized Copy Approved for Release 2012/01/06: CIA-RDP80T00246AO18300450001-9
256
-ers decreases. then under the tnfluenc:? of tlt se saint. intlutl-o's I,i.al (.xci-
tation dt velups in them to the full rxteut and theft dies away.
Increase of exeitahilitN of neurons of I\' lair
Nernhutal Nat:1ral 1:~tinrtinn \\-akin, t ~~n~litiuue~l
of conelitio- retlex ~ro,itIv1.
narcosis sleep 441 reflex state aetcricv
Peripheral stimulation cause rhict'ly Peripheral %tinutlation
local excitation of the nt uron~ of causes chiefly a di,ehar
I\' layer ge of the neurun, of I\"
layer
The process of inhibition lies at thl? basis of the sharp dter,a.e in,
excitability of the neurqus of the I1' layer in the focus of conditioned sti
mulation during acute extinction.. An analysis of the bioelectrical phenomena
makes it possible to conclude that inhibition of the activity of these neu-
rone does not take place directly under the action of iucpul~ws much are
caused by conditioned stinialation. It is eonueetetl with tho arising of Alpha.
like waves evoked by unreinforced conditiune,l rtitnuli. mav be as a result
of the excitation of neuronic circuits: cortex. reticular formation of the
diencephalon.
r ? T
Declassified in Part - Sanitized Copy Approved for Release 2012/01/06: CIA-RDP80T00246AO18300450001-9 .-
 Declassified in Part - Sanitized Copy Approved for Release 2012/01/06: CIA-RDP80T00246AO18300450001-9
He116y?UO' Ecrerfl9l Otipm rt'a_ (;Otpt rB H )'JUHII'1(SP1bJtKTOpHaK
Nt)t? CtN'ltt8. IIU'.It1AiNTl?abHal)
rY~ rKPLUB tlYll CON Call NP
NOI'U PRO
BMW-
IIEpr4epN'tPlK(e pl>l,lpaxl'NNC ItNdIJ Itr1lNt,tt'pN9/'''I:tr(S paallral:''H11M
p 1 HcA-
taeT tlpe,NyltttvTrl?HNU YPPTNUi 11nt ~' tt;tcr Potion IV ,Jlljt
6yntPNNr Heltpolloll IV r-1011 ?
?,JlfIUtTU HP,~(-trA" '' H
Nl'!. h ; .tt lt'M'IUlll (1 N.1
~!V!?Dlllt -tlpbl YU4 l (Ix.. 1l -10.6
' gbiUt'HHe Huafi~,1H)1u+ IH t.
>Imo , a-5 latt Y H IV H 111 FiN1jN)H11H t'.WrH C -;U(-lrT1-NY xs''"FIOY (CN. ~P_
TopHuJ:t'AUt HN'18.I6H01'u uyHEIa N(N`Yi!HHI4' ''1111
pu~TUNb. j11. 1'. U.
s H tovlpul'u t't'fl;'aHIt51 W.1011-
94 ye.1mill uro (-t'1~-.lt'1-'?'e. '1'aKu l 1-u(Ix.tvM. 1t uCHu11l
Imil. 1/i-t~l;lt'I::`i- .Ir;F:H'1 H(Ntlltt, l''Ip)1tt:lt HtLil 14Th Me Iatl-lu V+?'Ial(H.IPH')
?,l'rHhIII 1. Iht, t'nl'ait,'ll+l ,t1'on I'Mlit,it`'.tr, I,t(IYttil:t'HUP .le TcabHtt 1It Ht ti(NtHuH
1t? 1+'THeHHu 1141-k 14.11ONWA 111H
i. N ((( c,luC? 11(tnll;.~'t 1111' H i' H r li'r ~. ( aril ,16b1qHit n(rt',ulU txrxr'r cit.
OtiiIlU' 6 1111)1 ttMIl .1h?:U? M'I.th ,K.U'1-i1N. G;1{i
C ~l-MHUi~ TU41tU .i(1. HIIN .1P1'KU o0-I'A IIHtTCN H NH.Iri11r 1t101IH'IHttru \"iaca-
Irt(-\z1tiIHH Nil H (1t1.IhIltlt vilacTUK veresH,IHUre
)Ytl: u>jIH U~1(IA,ibNllNr H
pYgUlliHHf1 T*.lal%eS, itCt' 6U.li U4 i Jtl:'IHIai? TeppHTu(IUH 6)'.i. T . ai t* leuli
Q*eCCOY Tl)p lOilA 01*. i tT1'Ht?Tlr? rOH{co t,r(1tl.Fi11U'r l1arP HttHrll
NMI, Ye'rNYU*1131il 11epi1U'IOUX
p:t6y$;IWt'hH fit-A, tonion IV Y III 4'.1404:1t i,t(IN: via 0,1101111111111 CTelli?NU NUa-
(II t?UIPit 1r11~CY tI ('I HbIP i~IN3HUiUFlI W.KNP CO?
Me'TYIr NIIt?N4HYI 'ITBCWI
W Ht4 pt)HUH H t'uuTLt' I. 'H~'NIIUPY \''iarIKt 4Hil.llt3Nt'trpa. Hit t iut I NC till', 'At' 1,
t.iH. (.1''.LC'1'NN' H JPul'(, Hl IHt 1'C)f
mad; ~ir.lt6 }U'{1 llul'i'HTIHN.IN THIIU 3.1143-H
? H'I'PYbI uM1aIH.1Hb1Y He*poHoli .UHHtII'! aIIiT.IH-
NNet 4INatIO.t H,I 11. t' IBeptIT:l19II1(JN, 4. 1. 1441
1. Beprror, W C. Tp. ,. .Ago, TrrH.IHrH, 15114-
`2 Fi e p N r m I.1 N, Fl? l'. T trp, tau. r?? ,? ta, r I, . rjt'?.t. (,TO-1. N Nt t. H3YK ktryt-,tl-
g. [; i? p H T a HI It n .1 I . 11. X111 wt ?'nrut 1I$
Na\'C ('!1 1 1 1', CT" :L 'l'(ti . T1 10, :i..ISKTIi
HH,?T ((ItL'.tl; ).1 Htl. 1I. 1 &t'pHTaIyUYJN,
4, h p p N i it Ili 11 d N. It TI,
?'p N T'S N. }t 1.. it 1J ti 11 r u it I. A. l1 tll~ 1'11 i:Nt'tIt ut'pB 1. lt'gT.. S. 1 ta. 15x113.
H K sla H it a It C lI Tp Oil ' gt.t tu...t it I1 t 1'', 9. 11., 1!Ra.
6 H s { t;t tt,, , I(t, .l. ta:~.t n ae.t Nays -Kat? Hayv rPys-
7, I' a ii t , .t s. , .\ II \ l l l H.I
't A1.
1.1.1'. ,, t, ;,"-. ?},1.;.n1"Y
~' [' u t 1 r, a s.. -A 1! t. a ,:?iu..1h., Il.t', t,c ; t t'1' IS, 1V~x~al, nun m'.inual,Nt1 K. 1:
SF. ~' n tt' !, .I I. \ II l;pu.+5,?+:+t~;tv??+'tat~ ltl+.U 11141 w gl,l"' .
1'+:n.nt n 11?In t 1,. 1'Ht.uttMH.tu. 10, ,at . 1`irti
1I ''IiHr I It. Too'-
It. I' U it r ;, ,t c .\ .IcH.-pol1.
nl- tt i! :dt. ~,?n'.,, ..tit-,'u! S -11 ). I;li~3.
12 .1 to a i .. ~' h.. EF;I; ,:Ii1~ I' 18. l 1! it_
. 11 1. I ki.'?
IY R i?
't:ult. Blot
,
`vni
h
I
l,
.
u d t .r w 11 l "I'1 Apr Iliit
14. B
-- ' .t Ua.iUI Y'IH&14 'Ni-a''HNtl Nte Y'....,91' ?t 1111, II
pe4l.PKCa.
HM.IHRNY,, ,'l'.' is iii "Ulit 111 H1'OIUis tlU ro
Declassified in Part - Sanitized Copy Approved for Release 2012/01/06: CIA-RDP80T00246AO18300450001-9