VEB SCHERING ADLERSHOF PHARMACEUTICAL PREPARATIONS

• Document Type: CREST
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): CIA-RDP83-00418R003000350001-8
• Release Decision: RIPPUB
• Original Classification: S
• Document Page Count: 79
• Document Creation Date: December 20, 2016
• Document Release Date: June 15, 2007
• Sequence Number: 1
• Publication Date: February 16, 1956
• Content Type: REPORT

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t
-CENTRAt INTOLIGENCe-AGENer. --T
INFORMATION REPORT
Atm. 1,s I 410
S "A"
NOFORN
432924
This material contains information affecting the Na-
rita.' Defense of the United States within the mean-
ing of the Espionage laws. Title 18. U.S.C. Secs. 793
and IN. the transmission or revelation of which in
any manner to On unauthorized person is prohibited
by law.
COUNTRY East Germany
SAW VEB Schering Adlershof
Pharmaceutical Preparations
DATE OF IWO.
PLACE ACQUIRED
DATE ACQUIRE
REPORT
DATE DISTR. '
NO. OF PAGES
REQUIPPJAENT
IIMFINENCES
16 February 1956
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THE WUXI EVALUATIONS IN ESNS MON AWE DEVINITIVE.
THE ANSAISAL Of OWEN, it PEONATIVE.
(POR UV IIIIVIIII)
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harmaceUtical products manufactured by VEB Schering
Adlershof.
A.
B.
C.
D.
E.
AmpoUles
of Calcium Thdosulphate "Schering" (Tecesal). (10 pages)
Acetylcholine - Biocatalyst of the Parasympathetic Nervous System,
Vaso-dilator, (16 pages)
Alluval - Alpha-bromisolvalerylcarbamide Sedative and Alluval Forte
Alpha-bromisolvalervlcarbaMide with Diethylbarbiturate of Sodium
Sedative, Hypnotic, Spasmolytic. (10 pages)
Supracid (Combination of Superior Sulphonamides). (13 pages)
Gentiaverm for the Chemotherapy of Oxyuriasis. (9 pages)
*TATE
F. ? Pernaemyl Forte 7 Highly Concentrated Liver Preparation (with
-vitamin B-12). (20 pages)
*OTORN
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141, 1 3Vtij 4 as I
(NOTE: Wvolkollo 40.1411111vo LedisiNd 'ert 4101.41.116010. wirok
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01 D
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?
lowl.Star *t
2 pesiaolwasolsepkossalle)-4.-eothyl-pyriaidia?
and p-eztigsbeasolsalpiiiisisuaidio.-stity1-414.341.asol
Coabias to*
of telor-inoapitteasmids
IA)
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bunt.%
The discovery of *slob maid s and ant/blotto* signified a
subverting progress at the whole medicine. Prior to such
epoch-making knowledge it had not been possible to obviate
infections with offeetive drugs. Melof previously feared
infections now loot their fright upon the possibility of
effectivo mud quick...witting treatment. While the waibiotios
kill the germs ordiseasmwthe enlOhenamitis **Tett the Wiest
of the prnincinobeasole sad existing t eV 'metering' and re-
quired for its aititaleat'lkm* paralysing the beeteriumpvid
100$ it, fall a rietinLeUtko-bodesiteeeft- of reointence.
Promoting froi-sapbtmiliaidibillis lase 'Of the sulphonamides,
the Syntheeis or numerous sulphenamides of pertially,quite
different offsets followed vary soon. Out of the groat number
-of compounds a smell'greso-of suPerior sulphonamide* turned
out promises:* 'weelities4ISINSly espesially good compatibility
end high efficieney. $ulphOnMaides Rre elimisiated through the
kidneys. In the beginning of the era of sulphonamides the
unhappy juncture of bad solubility end delayed elimination of
the sulphonamide occasionally entailed its 'erystallisatiOn
within the kidney, thud sousing renal injuries. Our SVPRAOID
excels, among others, in the impossibility to injure the
kidneys in this manner.
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It was understood very soon that the individual sulphomemides
differ in the speed of their resorption and elimination.
These two fasts ere of Miall importance as to therapeutics'
effect end sonpmtibility. Easily resorbable sulphonamides
are rioting quioker than the difficultly aboorbable ones which,
however, tote longer lasting effect. --Por any sulphonamide
a certain eemeentratiem in blood, the so-called sonoontration
level, ie required. The level ,of sUPRACID must amount at the
.least to IQ milligrams witAn 100 o.cm the bVPRACU at lower
level not poralising the bacteria suffielently; individual, .
weak baeteria, however, may go en suffering fres perelysation
but resistent OA*. will got lamas from the agent as soon as
the concentration level of sulphonamide decreases below the
required limit; in this way the drug becomes ineffectual, and
the patient is injured instead of beint-oSeiled.
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The combination of an easily ebsorboble agent of quick e11-
31inntion.with a mere diffieultly absorbable one of delayed
elimination, both, of course, of convernihato therapeutical
efficianp7, resulted ia,the diocovery of the principle of
'$ulphoetettoziTM. XJM this manner the OCnbined propa*ations
named attiring eehaidsretbly frOm giallo sulphonamides, and
that particularly ins
1) inoreama there
high levels of o
whioh rams
rived ate
2) iner"s" Ai" of effectby samPlai UP the different
effitiencies of the ihd Viduel COMOOnontei
3) twproved compatibili essonee of easy solubility
within urines to. of the danger ef formation
of concretions, and that by combining * diffieultly soluble
sulphonamide tnd en easily 001010 one. thus improviag the
solAility Of the di:neatly soluble eomponent in WW1;
4) neglected hilibt-aadiastiOn as, dae to the existence of an
agent of delayed eltainntien, also during the night a suf-
ficiently high easeentration levej in blood, liquor, and
tissues is maintained. In severe cases only a nocturnal
treatmet might be required.
Ana* a (maga of years the oombissa ton of globucide nod sul-
phomethylpyrini411* has teriled-Ont.excelIontI7; we are pro-
ducing this combination in shape of 4PRACID.
SUPRACID seems
qulok action
High and *mutant concentration lei in blood, liquor,
and tissues ,
:uperior therspeuticel *Malmsey
Axbellent somplaibtlitY on tho-oarl of kidneys
Prominent, general sompatibility, also on the part of the
stomach.
effi 1.407 14 (Mick torn tion of
in bloods, liquor, end tissues
On their heights quickly sr-
VID is n combin tion of oud shpres of sulphomethylpyri-
midine acid phosthylthiodia taoh tablet of SMACID con
-
"ins 0.25 Cr aft Witt altioulle (10 0.c* Of a totally 20 percen,
aqueous solution of the corresponding aodium *alto) 1 gram
each of the two *component*.
erPL
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r-{
.'3
buiphomothylpyrimidine -(mothylpyrimal, pyrtmal-*)
Chemische Yernsidarste41=4
is, ,aee'dtbg to the constitutional formula, a 2.(p.amia00
bemse1ea1Pkonssido)-4-nethiel-Wri1Ii4flns, upon peroral appli-
esti* Itaphonstitylpirilaidine is resorbed very soma, thus quid
entailing hig* ootesntration ?f level in blood. After 291
pereral medication Or 3 grams of SVPRAOID in $ oases the
medium consentrption of blood amounted, after 2 hours, to
12,4110; and allor 4 inure the maximum of 13.6 stiot was
reached. Thin the *intent 'slimly deilaretleed oitsi* arriving*
after 24 hOurs,*in ***raga value 5,9'mgA,(aemording te
5oheifo1d741Mmig 11,)). The olimlaation of sulphomotlylpyri-
midine'is proPortionalli slew lortii this hict a longer la, Jag
'high afenatint Vied of blot d, liquor, and tissues results,
heweve*,*is ensued by reinforced aceiyiatioa
in the Wily, 5tAiiihOieniaes hre acetileted in the body in dif-
'ferent'quantitiscAbe therapeutically ineffectual acetyl-
sulphonamides, Of *Ours., Art in general of rolstivoly diffi-
cult eaubilitit eau** the fesred fOrmation 44 con-
,
*retie**, and's the t Mains in tho kidneys the organ
or eitsitairtion of4mitpuomaittist *hue entailing serious eon-
pi/cations. '
But eniphomethylpyriaidinet n- the contrary* ozool* in mg
leedItil.4.142.420t441 se that renal oomplicrtions
Must be hardly oxpeotod, particularly when sufficiomt care is
listen for athelising the urine by Ample supply of fluid,a1A,A,
if necessary, VI additional modioation of bicarbonate of soda.
Out of tut sulphemothylpyrimidins a* rem-tenpereiture
07 mg ere tieettivOi in 100 gram* a **rum*
Out of atiziog rel'homethylpyrimidins, on the contrary,
St reemmtimperalarolho renewing cuiatitios are dissolved,
*id tug to the sorresponding pesnviroaments
p4 $: 22 mg%
pa 6t 41 111.0
INA 7: 115 ragli
ps es 304 MOE
Consequently the 41134111st sulphonsth:IPYrim dins is of am-
ofillont iolubility all the more the aitent of acetylation of
sdlphomethylpyrimidine in human urine amounts to about 58 14
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The p eau, of a 20 percent uecum emambion of ulphometkyl-
pidine-Jeedium amounting to. 1c.T the edvolttege of the good
c
001UbilitY its proved* ee4reusefti1y tbere.is, in spite of 111'k-
m-it doses. net reason for trteibt **.the formation of renal con-
cretions.
Sulpheethil *Aimee
( QUemisehe orael4Iratelluagl )
For y ars pelt the 2-(41-smincbanze10ulphonamid0)-5-ethyl-
,3,4-tbiodipzol as globucide lira pronic.ently turned out in
therapy, due to its efficiency and excellent compatibility.
It is .:Ilitckly resorbe.d, too, and, on the contrary to the
sulplomethylprrimidine, also quickly eliminated agrOm. There-
fore the ezteat of ;cetyletion within the body is kept small
(see peg. 8). The ecetyl-globueide, furthermorefand ea the
cantreri to the acetyl-compounds of the major part of other
salphonamidea, being of arum, easy solubility as the above-
mentioned-salphomethylpyrimidiam also glebucide does not
entail nny formation of renal concretions.
Solubility of meaty ated sulphonaelides at changed-peva/meg
KiWM aft:roast
lubilit
Pm GA
PR Ti
pR St
.olubtiity ef.att
239 mg;.;
Aztent of sc tyletion in human, arta
de
de in
"irolan
,;,irosa
74allow
111-
Olebucide
bulphomethylpyriml-
dtne
5u1phonilamide
Allphothiesol
Ualphopyridine
different pereaueet
a
enp.temperttures
about 8 percents.
pR-velue of * 20 percent aqueous solution of the sodium salts
7.3
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31PP*91#
810buOide ant sulphasetlyriaidin ere prominently supple-
mentary one to the 0460 04 to their quollties I for this
reason the combinaTien'ef.both agents maat result in s pre-
paration which is superior in respect of effielency Pod eon-
patibility. iraotice has 04101:444 *WO Oie. 00-operation of
globucide nnd sulphemothylpyrinidtne aeaerts the principle
of suiphe-eunftwtiOno thus out:tiling Substantially increased
therapeuticIal efficiency end coupetibility. Agents of quit*
elimination (globuoide) and suoh of delayed elimination
(OUlphoisethAPYrinidine) seonre at quick 4144 steeply seeending
increase of the level of blood, itquors and' tissue, sad pro-
portionally 104g-listina taintansnoe of the conditions sohieved
Iurireadiagramm1 -)
are after Medication .*
Conditions or livel or blood upon 2s1 piroral
todiestiOn Of 3 graze of 0 RACtD
' (cp. curve Of level of blood on page 9).
? The curve distiaetli shows the 'quick rise exceeding the re-
glared?manimum level of blood of 10 mg%; the therapeutically
effective lower limit is, in spite of the single modicetiea4
Seethed, again not earlier than after 6 *ours. aftb. Pairtures
distinguish 41JRRACID es s modern, combined preparation uhiek,
of course, taxing therapy ie medicated ioz'e than Ones (op.
eurve on page 8).
Sine* both components are elim neted at di root times the
test of the kidneys is aualler then *mon usine only one sul-
phonamide. In this eennerotion import-nee should be attaohed
to the foot that, when Oombining two esposito sulAenemidee,
the conditions of solubility of the eliminated products in
urine become more adventsgetus than under use of only one of
the two components.
Concentration of 34phonsnide inarua upon One Medication
of 4 grams:
(- Kurvendingrammt -)
arange ;;;K:,Air
Red alebuside
2revai :iulphomethylpyrimidine
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A
YreeJI CI la rum larid st am-taztperAture soluble
in mJa at .296 2ut
is spproximrttely corresc
zethylpirimidiae the a
portant (GP* pate 6)?
p Of a 2 p.reeait sqUeous olution of enprecid-
sodium is 9.4. The low*. /mit of %he therapenticallj required
level of blood is 10 age
Upon only ett vedieetta0 ?f 4 gr par Oa this value is
ree.ebed rinsed:1 after sue bow isoi a half. After 24 hews
still 3 aci could be proved. (aosording to Schwerts (16))
(cp. ourve 04 pep 9). La hAsson. arias .42AACID La eet:fisted
to thc extent of 32 percents,
solUbility of acetyleted SUPRACID
adiat to that of acttyleted sulOho-
of acetyl gobuoide no% being i2-
4.ti adi
range = AIITACID
Crewe . f!ulphothiesol
Blue . 2.4-di:Aethy1pyr1nidiu4
5u11hon.edds-16ve sera* tipm p oral medication of
4 smote,
(- r:urveadi
1rt nd3 4flt5th. 6th 7th
,U1IV:a1)-level of hlood lane medication of 63 grans within
7 davit, aoa that 12 grams on the flret dai wbioh doe. than
,vss r7tduo11.y reduced by 1 grim p4r day. Repeated medications
Ru1 phoiaend o trererore,tremendeuoir lemmass the level
of bloOd.
(Irs2hi -)
anent at sOlubi
04 aerum at roam-
fire d ssolvied3
Brown
Red
o bLXstlon.
rture the following qn-ntities
methy inidins ST ate
?buctde 2,9 me
Orange# lajaltaf4 4LAUti
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NOEORil
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tM? 4001
;4umerous.pubilcations ve the imel efficiency qied (ma-
potibility Of the combIntion of globucide end sulphomathyl-
pyrtaidine e$ preeent in 513211P,III,.
Jlataer (9) reorte that.the combination es preeent in 3UP3A-
CID excellently turned out in the line_ Of measeelogle Where
other sulphonamides had failed SUPRALID resulted in unobjeot-
ionable successes; in this coal:potion the treatment of 112
,
feverish abort,ione left special impression. Onig (12) saw
-
firms the viid suoeenees in theitlii of gin.aecology. Se points
out the gn14 Oompiiibility'at a dostge of 115 grams per day
'which were medicated in single dosesry four hours without
increasing the supply of fluid. ltspeoisll,/ good effect he was
able to observe fano when treating feverish abortions and
pyelitis. Inflammations of the endometrium wore not infix, *di
the spreading of .erms, hoiever, wss grev-intited..
Beyond tho tiard month of life coAilentions-on the part of
the liver, kiAneys, or the formation of methaemeglobin with
severe opines's, es mey occur when :ediceting other 3ulphon-
amides, were not observed in any case.. (the special oare to
be tpten darint the first three months of life is disoussed
in details on page 13.) The new oombinstion 3UPRAC1D succeed-
ed sleo in the ;meat of other sulphonnmides being incompatible
on the part of the etomaeh
In the line of kate*a; medicine the new oombinatien-drug
excellently stood its test of eondirmation to largest eAtk,..tf.
mums (a) reports on succeeaes when treating 20 lobar
pneumonias, 13 bronchopneumonias, 5 cases of otitis, 2 soar-
lstinel anginas, 2 oases of scarlatinal otitis, 15 mutes of
soarlatinel lymphadenitis, 4 cases of coli-pyeIltis, 1 Urals-
bophletbitie, 1 erysipelas, severs" suppurative shin-diefasses,
9nd 2 eft0.8 efectli-ehelineitis. rn this oemnectiem,importame
should be ntteched to the feet that globucide is concentrated
vithin bile in such e way thet glebuoide and, consequently,
ZUPAAOID may be desigmod as drugs of seleetien for bile-
infections.
Uhlmn (1) brings into special pro4linence the good success
when curing lobar pneumonia. He points out that even at high
dosage any alkalizine of urine wns,aerleeted without envy
denwmat for oonsiderv0
Zi 3
*Reed anpply of fluid. [either
911111t A AIM
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hOrOfity
AT
ifhh' ';;;cy? ign
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onothorapy of COWOriosto
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OBITIAVEN
Far the Chemotherapy f Onyuriasis
The pismworms, also namod thread "worms, (ozyuris vermicularis
or *steroids* vormioularie) are prevalent in the small and
the largo Westin*, particularly is the terminal intestine,
frequently is the appendix.? The female leaves the anus, d."
posits there 10000 to 12000 or., and dies. The male dies *1..
ready in the intestine after sopmlation. if the ember of
ozyuris misting in Westin* is very smell the plovers* are
always Protruding', to the *entre or bulk, saying that they
never can be proved by examining the stools merely from opk.
cid.. is gush wait* the easimeakille of the bleid-pieture
may be considered as important indication*
Any *nal avagisal iSehing.erouses t suspicion of ozyuriasis.
The microseepie emminsties then will clarify the matter.
The fuadamental Condition for * suceessful worm-cure is the
interruption of ike way from as to the mouth* Per this pur-
pose the affected patient has to wear, at the least during
sight, waterproof slips or knickers, and to keep the anal
region, covered, up to finished seventh year of ego, with *
paste of aluminium aeotete, and, beyond, this age, with a paste
of 5 percent, white precipitate.. Up to no... have demisted
from the us* of such -pastes our GENTIATNEK beteg an absolutely
end reliably, eating vermifugs. The patients. however, not
treating the matter seriously ammigh we have decided to mot
this indifference by recommending a paste. - The great number
of vormifuges and treatment propagated up to now proves their
**trustworthiness. Aluminium acetate as formerly used nearly
everywhere is according to Ehrhardt (2) (Heidelberg) hardly
eating on azyuriasis. ES-dicks (5) Pointed out the high offi-
eieney et **atlas (crystal) violet ea other sorts of worms;
This agent, therefore, was used for amyuriesis, and excelled
in conspicuous evocessee.
oi,dutoloty
Wok () found, in course of 1000 autopsies, an affection
with emyuris in vein* of 43.2 percents. Even this high figure
is too low inssmuch as Hesnak 43) Etated that 90 percents of
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aU ohildroo
isitit ozywrito, sot lottopt irooa tooroasoo *la* figure up
to 9644 persists*
post or -*air iUe aro iatoote4
Ma lei te
Pres each female *boo 1
*bloat oolourloao, tk1skaa4
lenitim 40 to 60 pi, sidtki 3O*'
12 mime length,
mat Owe oblong-ovete,
ir........"...,,,.....,,,,....,..-E,..........,-,-.4,4.--,------.T
40111". lisoloost UAW . I
Dikair4sterritoOt i
i 'Matto lolott Pagotabplool of.- I
1
ih000sairt I - (?iolot) *-0,----- T
If
anal re
Ovum (al14001
growing up, under Winnow
moisture, to ovum with mature
slipping.
Meieros'opio Prowe
Adult persons tete, ot might or .r1y in the morning, 30 grams
of Glauber's selt ?si en empty sth and dissolved in weter
in order to dischar** the intestine at the lest four times;
SECr,
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U eery, eill-be roved la ed andAtai always liquid
dipsuiripp? Owistig tortiss ,sbeervoitairthat the recto* may be
boo tressaynris whiehi,AisMatteat-thial,'St the same time
are eboadently ezistiag is the amen iatoetise grow* uP
people bopped the 1416 year of their Wei any proof cannot
bit VOW* *041111M401Osive relief of the bowels as
dimwit*, -hertsbeve?
tit ts cies* teat
torts tio be
sod bs *tans of Glauberis salt
imsbei or similar*
Wanirina-batie
Ikea adhowlini **me wee mu the moderns sioresoopio
;ultra of stools will sever faits As to altildren a light
smear. from exterior seal skin is aieroseepieelly examined
ter eve Of ezyurisi Vat same sou too dens; vrith a slightly
solved snob pot et Wisht_ ea the eat* and realised to it re-
isblY by sues of a stripe of etieklastiaseter? The most
Lteble proof ilea be Oren by thi Malt of aellephane?
ties Of thie eiwbremeest Or phyeleal speptese
imesissphilia also vsimably: Man -101 tateetdnal parasite.,
The asthant thipraier or 011010.414.- MOP* Arefatidtre obtained
from eethyl-derivatives ofpolossallise Sepeeially peat*
and beinnothyloop.oresectl$ja. ere goyim* an imperteat part.
The aixture of both esbeen it in,Oemittry sailed gentle*
.violet, respay srpostsaiss La VA took. ism violt
is emael. ten. 01001114444441.7 vailtaa violet, anyetel
prostaxime, sad maihetiO'vlOtot ir0 atimitattlit liras of a
aiziore Of pests *ad haammethyl.."-remaleimo*
eh* ilasbaeldarotenabti
Attested children *sy have a high Geiser, frequently, however,
they are hollaw-eyed, pole *ad esotteds ellealkmtempered, i?e?
fisiarveses The 1141011 tteldair impairs the aosimury attention,
La sehoe34 egyerieois may eves revolt lan west.? The appetite
of the eland serferias free-woras deeressost the sleep ie un-
easy* due- to the anal itehimg, th94r..stng the swirl
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swatt*blsaess. In this way the affeat
a vicious caroler upon "on ofwhi
newish Like erten sowimas rnums.
? ehild will
Latent parasite
the lire or ono
days latest. But
Wilmer. grows
ly biologioal
? Porthoftoro the stor0000pioally
sir together
in the morning.
*rap-clothing.
with ONSUAYERM. **re-
title avoidance of
reinfeeltionsi
1) to Week th0100.17 Ak*
to 0MY 44111**t* aM**1100.1"11,1 at
aU141* e moils mat be el4ene4
iStialt ***biol.
to ouori for r
slips shish hove to be
hot water aduo.,40.0. W
in additime
sorted into the
weaves.; oat the syripofti
ui
stools, prior
up in the leer-
Mau water i.e.
by bedy-linen, tight
4*7 111, dmy, and soaked in
(14) vereemmends to mar,
a small extent in-
migration of the
with this is prevented,
of Ohs mattering stars
3) to 000lvolthaotortromest
4) to avow, ova odkorftg to
br washiAS this f
the ova swimming on Ah* we
stances may *dhow* to the rood *
toad vase-tables
et otherwise,
in eireum-
Imilamillit
Wootton: cans
vermionlaris).
41,0*tillogs
All &teems accompmmi
perticalerty pylori* ot000sio, geetropteet., gastric Onaesta.
(enterobins
ad rstitf of the bowels,
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miring sof distotie pro-
Asatiens-mer att./time the 's pestossienal astiviti
such OW fax ver#140/0tiali *MO paleitived so extremely agree-
ighla siodiosawataip floo, so sAlionwate aoithor larsittrao nor
ememate sr. ,044,404 sa00,66 011111AVON-Pilia ere pre-
i410,04 tres-Abo, 4406100 aatildAY at gestrie Juice hp a
00040 PreP00110$ 04, Pri?14111" 441"1"4"4" of
ism.* 411444?.41440141 *pen
tiy sbserb WA, dye,stnef is re-
smell emteat, and-eliminated
at lesseaaselk The etizi ted
Vale** Ifs* 'treatment 0
theAds*e sitlisoldliamilOSOMit sad- theretere, it is net
Siteatemeemittyit il?t the Whole quantity of
Woostaly** smemia, is thelmftstimeitteintag the worms in an
latsmsive, vielet miaow Illai-Iban at the same time.
atroroartoo at **ropy rfrogitootty contest this
art Athol* todasir "salt 4to the part the cossintration of
47.401hift tho'hilloot vitt*" la playing, at course, is
this ,00maeottoo. o410**** Of 41101MAYWRII eamsating to 0,06
-wow per pill otoolokoo Ihistoosatioally 0reetivs oenesstra-
lies if I?j is paM t the feet that
dye-stmtt, however,
ES AIM are
ilth stool.
retiens whoa treat
tats Is preid by the .zariitustiais of Sehmidt and
lemitham Mahe aitlide4 *4 Okiliron* and report on their
smeeesselt. As found tikr caatrala aaaalata4 **or use of the
diegnOetiaally vary fagot stieting-tepsefeellephane after.
Most trivalent 71A percent., esd Otter second trowilmeat
94 percents if the children were fro,frem stems,
tuz,licstjen find 0,asts_
oftespeity 4113 asie trealgoirnt with fianiniiMM,is provided.
1*40aPaataitr **Maims eases the therapy may No elartimmed
ter some farther days, or the treatment is repeated after en
interval ata fortnights
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Upon the ? iskieal-teste serried tait ess 'MATSU tho
toiletries sohoao?of denies as to rine= for * 3 days'
tree taint
Children Amp . 4F 4I * I pill,
Children aged f . ? ? IMViale dey I pill,
Children Aged so than 10 row* ? ? *riot, a day I pill,
i5 ? ? *trio* a day 2 pills.
Admit end obildroa amid as
It is of .utliest inportenee e our
latx.to_roarALAstihi.er AAL.A.Artaksttif.ith "lee state it
will talk* its 'Optimal fitfoot UAW/ lattoirAkino if net thinned
by olives.
If the gnawed pills are ot, tsken nutii in tho end of repast,
and if, in the event of fatty toot, they remain in the stomach
for a perio exeeedin 2 ha?a the ptlle are decomposed resilt-
lag la symptoms or part of stomeoh
*kink sill appearmest dis dity while *
oathartiri or yeasid atotwoh, floes, does
no* =ma* phaneate= trritation. It,.Ste event of exist-
ing ityperealdity, therefor, o eielosas to medicate from
the 'vory beginning and et the see. tile* =all quantities of
Neutral= es es to bind the ettetrattivo hydrochloric acid. Drage
ontatning bicarbonate of sada mad tiler a11al1atngEojez,
zatigeuztaxt_natkket to,tipagLinnest as they would even
ace *lora*s the dareempo.Aitibom of the pills within stomach.
henadharinp; strictly ti the treatment,welos nnY eYmPtoms of
incompstibility ars olostointely exaluded the *oat soluble in
the small intestine preventing ouch troubles.
?artioularly when medicating the smgarad tlla te ohildren
specie/ =re shoOld be. tisk= for the driqr being swallowed
80;1444 sod astinsli? Any 'intakies shold be avoided as the
saliva ie subj,eet. to **tended del/y saria)ions showing O-
vals= from SA to 84 so that ecoasionaIly p*-figures of
the int.ettai1 enviroament soy be reFtehed. Iii this manner
the PTatootilo
too.
reful adherilas
oeutiems, no alreod
importance fore snot
oaf bs somotinoo diasplIrod in the mouth,
11, 2044red general pre-.
details, is of fundamental
ant Of osynriasis. _
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Ta spite of this a-etre may rseetn without uecese, too.
'11,4**r (11)104444-410.011000xyhrbisis sof the appendix
arse:PA* 401)0 cemaiderWal iam/gaifiesate secondary stets
sine* the sppiadix iii**Aie of disordereCoaavvenee of stool
may become. et,t4e,eago Use. e ressavoir of wows* In such",
ii:o.nqueoly...T.4..plithqueseiwrikoses:ofter treatsento of oouxe.,
!to*. Are Peqt 404hargad frau the OPeedits, time
pretoading, a *is imeetiridoi.auct asses JavAst occur
also, *ben using other px ..eparottioas. Sven ferment-drugs must
fill in math eeenitt
I* Pins at V0014 0440041004.1.100014,4* thought of. r.a. this
*00401011 is further to he noticed that-.warma in the appendix
OS7 (4114, eilePtame 1011ar te_sppeadieitie; even larked, taxis
friss ofrern-eppea Savable otteveXoPiee even
ii ci&tto
(*roved*
It is 441,tat. th0104041k 4ss Ossee oaa*ot he remedied but
hi 461 :014***14401 Pt *otiose i.e. by appeaddletenn
eleveriliotelle, SOO 0:.teier macheiresia *me treatments sift
alSIWAVVIXtre eliit WelEMW440 Oommlnelleme the ideal patient
141V4tolk-**1:10603***-4*-41iVe, his eaisris.ta without any
medioettea of drsgmt-h04:stmee we have to realm with the
um afpw)OOMOORM *ko*id be takes far treataent of
vermigetlemo
Original *watt*
Pill* it %Of grams *sob*
? pills
0.06 peas each.
49F9RU
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ATTACHMLNii
1, ii
Hisiall Cone tvi 4v.r 'Mere *Van
Ciorataining Nor fit sat 12 /sir Mapoull?
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Approved For Release 2007/06/15: CIA-RDP83-00418R003000350001-8 ?
PERMASMYli PORTE
Highly Camoontrstod Wet Preparation
oontsining 20 of vitamins 112 per anpoulle
Phrtilokogy Permitaess ARalmis
Our liver preparation PERVAIgil. PORTA is elosely connected
with peraleieus or Siormer's anaemia. Prior to diving into
partisulars as to the drug itself we hay, to thrash out in
detail the features of this illness.
Dimmer's diem* ts sharacterised by 4241EVII&9
eLtri-kinit...1011-Ititftr....4aAten124.E12.436-04.151E0
11.1111-2911.a.tieltilarin resulting in an advanced and dan-
gerous redustim of ihe circulating quantity of rod blood
cells. This is why is slim* of this disease a reduction c
the abOollito analibrrikt344 iMood-ielle is found **tailing
10,04141 oonoiveenOiat "MAW hipad the qiimslaty of oxygen re-
mitred does not moot as longer the body's demand, on the
other hand the bilirabla of serum is increased, due to in-
tensive splitting of haemoglobin, bilirabin, the bile pigment,
being the final predust of reduction of haemoglobin. Besides
stercobilin is elininated in *novae*. quantities. This matter
senses the typical colour of stools; it is elosely akin to
the urotilia, eliniastion of whisk is increased, too, entail-
ing a dark colour ef urine.
Prom this diserepansy between raprodnetion and destruction of
erythreeyte the pernielome aspect results. Remarkably *pp? -d
to the small quaatity of retioulocytes within circulating
blood the anatomic state of bone-marrow shows extended
erythroblaatio centres appearing oscasionally also within
milt and liver.
Instead of anclens-less, normal (normoblastic) erythrocytes
at times of fully developed 4isesse the type of abnormaly
large and frequently molested megalobiasts is regenerated,
i.e. big cells rich in issmoglotin which, afterwards, are
f.ad as buttvalgujimmatt within peripheral blood, too.
Therefore the colour index is more than 1. Per this reason
the illness is called kuuluggp_Amme. too.
The megaloblasts the marrow of hallow bones is filled with
show a remarkably low tendency to differentiation and ripening.
The bone-marrow is at inferior.hypeeplastic and simultaneously
SECh_, - 2 -
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UiN
2 -
eating qu1tt7. iron this the
that, the poorer the periphorm
mere the bome-merrewis filiod
HU'
.
doxioal feature results
eedila in? red cells, the
blood*rormins particles.
PA.F.L.beisnAttitak ttstkt..4.10rAttatiemMg
vntue.2..stritit,ngpitiLstile_trA
VAttstitt.stItig.10.1 _ItilAattIts_ItAstse:
Ltda.
Besides this hindrelts*
La case of Yornieienm awl
globin is wafering frem
serum, furthermere,
(wo remember thet hittereglObin SOnelete or 14/400-All the alba-
*At, tk?, Orem toPhore.) The Music,-
emmll qnantities of porphyrin,
together with iron, the
or haematin ars celled haslet's.)
appear within stools and
of serail erythrocytes
so the metsboliem of hasmo-
tiro disorder; within blood
-
b also hoemetin in found.
einem* body,
blemits, furthermore,
a reildovielet
hasaini (In general
Lmereaeed quoin
urine.
This whole an4 sever* pathel ommiltims of disordered
ripening en& laistafiLstassmanne inereased heemelysis
and qualitative disorder of notebeism of haemoglobin is re-
medied at ense by the Amply of frisk liver er liver extract.
Sine* its public ti imp,- I* yOiros Castle's theory
Isoneernins the nature at peratsis 84.01lie has been aeknow-
letiod4 swims that the patient sarterias :rem this disease
is not 01144 any 'anger to form by bigkoolf the Intrinsic
'meter developed within the staheah sells adjavent to the
pylorus, amdisitain aranneris sells of the &madonna. Besides
? gamma leek Of ferments owes to be existent; even hydno-
chloric acid and mein are missing: Histnan-refraetory
*chili, appears prior to or in Walla with the outbreak of
pernicious anaemia: the atrophy of stomach lining encroaches
also upon the lining if deedeams ani oesophagus. Occasionally
pelipous deteriorations -et gostrie moose are found tending,
in the event of existing pernicious anaemia, more than other-
sus to mengmant degenerstimn.?
The intrinsic faster is formed by aver preparations which
synthesis the sound body but not the patient's organiam is
able to carry out.
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Is Whim ?le,
by 110$12.0ollis
*
ea porsielous asasois 111 shape of
0.414,40,1*.14 elahltriAlkdo mess ethers,
Ile; seesSisg to Oastle the
*grins b the lamOntopoietie vitamin
txus feed* Pernisioie.Apainia is an avita-
'gnosis *wising in um, of stopped.gastrleseeretion* This is
or the netatiltal of *AM *Min Airsiowis disorderedi the
othi befis b* to difforatelitte thentely'es -sad to ripen*
is iiiek of Anattionit* drYthrOaytes sesenohysal
korni-sharrovir soli* iir4 Lista? lsoada, Mao oleo resulting in
the Ottkdlogiell'eaiiiiiie Pieter* of reeneriows, the hyper-
tssis of isriust;. Saki usionolokiet, etalliiOnt hone-narrov
*alit aiitivirs it* iortsbia44 do to their unripened condi-
ann., proisturity,'4**s-b4l4-ist ii1104100 it neromPiiiiii,
The sole 4344044,7-is'simattaigoiiity trills 's. is the sualeusless
losasdioarrow eali1444Poiesie.ehi throlkoptiesisY* There-
fore it is se-twiny a kind of pasairsloOKtblists. with 14240Pond-
*Ns* 007000$61?40460-Voi M* The -.Oats it interior quality
' toe Vora/UM .1W01014111434 oreAtiniailio4.. sow oversegnonted
.lintonsytem, are osaliastrely *Id* urn '11bir lbseldootwais *Waits
lhailialinhesiew*isk*eirbeAleesatemally fogad en timer'.
grounds,- but also on the skin*
SaidSZALititieititialt
la general *pia** ithirlivot Therapylmes.been discovered
*toot sold Netrithi.11* aisvpropersd toAmboosliodge that these
two reoaw*Wher* beveaado vallmknommtAholiivier therapy, thus
puttims *ebbe the 'fright at hiermer's anaemia (se
salted to thei.oasOurAit'Ahs Ohysistasitiesser of tailing, Wt. *bet-Um, aserliellwarta-fatai sullesse,
or therapy it seems
teOkserds fres our flays.
In 1934 the Sobel'orise 440, 1114* carried eft by mina**
Murphy andlthipplo ir 100r tiblkraPY of pernioi-
OM anaemia.
is 1912 Pietro.Castolliso and Plans* cured peratotious *wee-
vil* Wow. Therefore the LoSasienale adjudged
is this Priforiti?Ot liver %Oran' et perateious anaemia.
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PofO RE EL
In 1911 the apoll.kammma Germin pediatrie Osamu: retoommends,
RN .
on-oesssion of a podiatrists' meeting in Paris, the treat-
sent of ammele with liver tad reports *VOA on remedial
summemees.
In 1S98 Angel reoommends in the
toeheneehrift* teen** ammenia with. 11~4,
weekly 6"Dentsche Med.
1040 Sir Patrieh Wasoes?
medicate liver
his therapy to th
ploovorior of eprue, used to
Re reports that he owes
it upon Confucius.
7mma 551 to 474 1140:41,,, COnAmius UVO, the earliest, proved
. author Of the liver therapy. Yrehehl: tbi* th*T*PY is amok
older.
thereat Silt UN* by Algot **d
of 44. Asouriesa Whipple
o O4osidarohle acceleration
mg liver. Minot and
Petisnit suffering from
sir striking successes
at the 4010 welts bleeding ane.
only due to the fact
treat. The nest year,
rOdueed in Europe.
Tor had to be given per
**on the radiate' dislike
livOre thus prelepting
3), therefore, recommended
perniciods one
miss and Whipple *arta
that raw liverlhappeas to
in 1927, the liver thoranr?
In the beginning 2
anch high 4
resulting in vomiting
any therspentioal 'nooses*
a recital therapy eith liver squash* AlthOugh be Whirls in
successes achieved IA this canner this eon be hardly thought
of since, as we know to-day, the vitamin Al2 is not resorbed
within the lower intestinal sections. end, therefore, the
effectual suhetnnee of the livero.due to whisk the action ea
pernicious anaemia rosily tehoo Moo** AO sALute ted again
without any utilisation* In spite of Sonsidersble quantitiem
of vitamin 112 sintaised oolor MO AS stools Pernicious
anaemia may "rise.
hiPAk 14troltil
Sow the development e
ettbeteasie Tam the 1 .e in sedir to medieete them pareater7
soon into obtaining the aotivf
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5 A*
ally Di wag tho liver ...streets* and consequently also
ux'.Peree.17 bar. bow dokv.lepod addedt* leter-one hos been
oonstderably rePetforsedi inrther puritioation in .reepeet
to its *outside of effective netters swaying then the am
PERIABIttli ?OM,
ism= sod javoliC14 zftworis. already La 1928 in the weekly
*MUmohoSor MA44, lothenichr4ft on a.liver extract for treat-
ise** of 'perninier'se:,abaeula *444 Pernaluesna* The first
Study coa*Oralmg, 4.40111aomyl was pliblish. 44 in 1933 by atosa
(2?)._in the weekly 4Ptionege kiln* Weelleaschrift"* Zn 1934 the
weekly .nentseho niedisintioolie gediencrehrifts published a saes-
eery en am OW liPtetisig ?too*
The dry residue of the *streets used 'now nearly azoluslye7
ommisim0 50 poroviato4r earboo* tholleree*/* of hYdredem4
IS pertimati it sitropeto tram or ilia *a& *toper* no fats,
- *es pyrbildinemetirele*
prOVita actrset setters 000110 of _00440444 pep ttde,
of. my Liver
t of *bent 10 srams of
as_ the isediention of 250 grins
leash. end Sharps discovered
pretrial: produced ft
ass as liver preparations*
(15) shookea this otateseat end reported in the seise
ser in the " .coltenschriftw on successes
sehleved aloe
of pigs for therapatt
s theripyt however, "odd
organic *Osten*e of stomachs
ent of pernicious *Anomie/
t pass through*
es tesdcw rather szs,tli why' pig's stonsok
ead also the steiSish lining of other beasts mist sot on per-
*total,. essenia* the stoseek'llaing mutely sonteins the so-
? **lied intrinsic teeter developuent of whiek fells in presence
of pert:deities eneenia* Therefore the pettent, suffering from
this disease is not *14e to resorb PAT longer the extrinsic
Agate.* Supplied- together with hod* This is why the intrinsic
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factor st.
faotor rea*
however, the
onterel oodles
pained. On perms'
umlaut *pea a
5?4g.
be td
... 6
rerally,is
hUtUtild, Rau: ,
order to get the extrinsic
motive traeti en the other hands
t be fed, of **arse by par-
if enecessfal effeete are ax-
e fleeter is not effective
resorption promoting matters,
?& c :04
'!Ithia recent years the thorn of perniotaud a4seis has am,
aidarably progressed Amos fella* 444 has been diccOverod to
contain a couple
too.
Othe;i MM* tees acting antiansomically,
Iliagn-M42
In 1940 the vittuataN
of a red, crystalline
haemetopoiesise It coatis
4 trios-liver in form
agreeable effect on
cobalt and withetands, vithout
betas destroyed, temperatures of 120.C. this matter is water-
**table and found ik livers, fresh filth* white and yolk of
aggas IstbAy, soyflour, horae-sAorements, eow-droppinga snd
0184 in 5t0313 *f 410Ual men. A study reporting on the possi-
bility if treat:mint of pernicious anaemia with human *zero-
meats is actually knew*.
The vitamin B12 is called e'*neoba1eia, too. It is identical
Ath Castle's dietetic or extrinsic factor.
"??rdiag to iltmittr=i1MINI and OW (11) this vitemin. B12
hinay sentitive *0 elsotric light. This knowledge is, it
is
proved, of enorm0041 i*Pertenco sorely colniaing in many
events the se-waled Luefficieney of the liver entreat.
In case of pernieisss stsemis this vitamin entails e remission
of eynpmkoms e this disease; se* only dotafterstione of blood
and memos timappeer WS also the nerwese phenomena of doge-
noratima ere sea44444441* 5 tO 15 #041/10 per da p are medicated
by intrasmseslar:injeatioas,-Per tuutooler myeloid.. firstly
40 gammas later-Roe 20 'gamma are.setemmandets
Lately vitamin B12'10 obtained from the substratum of oaltures
of strepteeKress arisesse?
Dyke fad his ?co?cparators m
of B12 from horee-escrements
to isolate ample quantities
exanining it after the
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?
7..
Wartag 'seised the t3e000.cel Tail, A. to human beings
they orrived at the an estsbliah*eat assaludiag that vitataia
liz reeuitelsem gke beoteriel flora existing in lower inteo
tine; that weans the existease of a bacterial syntheais which,
however, is Mt at any physiological Importance sines this
vitamin ikt2 tetierteeetety is not resorbed by the reetan.
Otherwise sey leseintena anaemia woad, be quits Impossible
as even could be proved that lho imporlaudi vitamin 312 is
arising in the intestine of patients suffering tram Parldailnia
anaemia, tee.
Net
Oasis *A gonia
endothelial
vessel-wall
4444,
Illoreel flood
Nemo- Itettosio- Sarno-
blast cytes *rtea
t itagao-
ogalsorte art*
logs---.). suAribit
\et
oftot0000sit Moro- torat-
'1Storstrto orto stow
Ammo-
0 ado
partially Poikilocytet ;
The elm* r.latt sf ntsai to the prinsipld of the Oati-
perniOions liver effiset is Mew proved. It is a feet tkat the
*Moloney eflivWr extract increities acCording to the in -
esoaaing *entente at vitamin kir thins supporting VA* pre-
sumption ths* pownistolosiinotata is? ectiotter of avitaminesis.
LI this reflood the setter of quostia ay hos
1) Of S food to ii44ts tuvitooliiito
2) Taek?f etipslinity
. I,-.
3) Damorderld
4) Amnesia. A
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wg vita
bt.t.4(4
BOOPATIMULETIAMMEIJAKILL
The i1i* athemeohrOM the-iftelialdnel red bloodaorpuscle is
*harmed 'with is higher then the Orme,- figarso
thrW aoofe+ redOced very much
.....,?reduced not so much
0.? increased
lan166*
%Get*
Yikro- Paleilosoitosic
Pbbildungt ? 204.744realeeis
21)**181 feature:
Hyperehromie meoracytosis
Hee o "in CLILIL.,-.
)
ATINLJAALAM002 --- -- --
quite loag-leeting therapies 4ith vita-ain 12 which in any
see took excellent effect on the blood-picture itielf, and
nver caused, en contrary to liver preparations, any by
effects or sllergic symptems; butftacitst...11,m1
ElagmEt_treLlk,. tupz....Ettixt, pits of all pood success
SAMSIOA-Ult d the_ seau_DimuLt_bl cod
kteelf,, thtsfltamis tenot_zet te own sans
effect en curtjalttejaastinjg mYeltajAmtems and sons
untems as liver witkits convenient efasiency.
The study by Aegtkessu and ?tartest!. (2) proves, after all,
thet_tkl_lixtr_extrao te-coetetht-boxidee-vitSalS.112a_ht_l east
one furkair_hamatekeletla factor. and that the B12-molecule
must contain two physiologically different f-,ctors one of
which can be replaced by methioaine. The experiments were
given to rats. Ihe research for vitamin B12 already resulted
ia fiading four different vitemines B12, namsly Bi2a)to d),
ench of them owning different properties.
PerStatna. forte
Now kiv,,1 come back to our apeciel subj,ct: MYL 170 PE.
Lallailt22101CUEWL
1) ritek.orAna. Pt any treatment of aneemie iron, of course,
in playing an import-at part since it is in any cnoe required
for the formation of hemachrome, the haemoglobin. If, however,
Ahen curing pernicious anaemia, the iron-store within the
orpanism is completely exhausted and no care is taken for the
supply of iron naturally even the liver therapy must remain
SF,
FORN
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ineffectual. It must be thought* on any condition, of the
LtaMilakii8011iaLgAntsquirtAgittiAAVIALIf
prelligum_eauda though the natter in question is * re-
coiled hyperohromio anaemia in ogee of whioh, when untreated,
the iron-level is abnormally high* This is due to disordered
erythropoiesia; therefore prior, to treatment the demand for
iron is lo*. The serum level of iron, however, intensively
decreases very soon after the beginning of the liver therapy
the iron nbw being used, to a larger extent, for synthesis
of haemoglobin. The_hessultkUrillues art..fresue492_normal
already durteittIstatql.Wle,the_serumjicaree g iron
still_retain_12*, indicnting that the iron stores of the body
are not yet completely filled up and, therefore., the iron
therapy must not be stopped too early.
2) Lack _of _ elbumis. Of course also the albumin required for
formation of blood is playing.* certain, part when curing the
pernicious anaemia. Neeller (18) was Rble to prove that in
the event of longer lasting malnutrition a distinct oriaia of
reticulocytes does- not set in in spite of liver medication.
He interpreta this failing, regular criais of retioulocitos
as a lack of albumins required for erythropoiesis.
3) e?ik of vitamin 812 _ The insufficient
aae
efficiency of liver extraots mainly reaulto from other reasons.
oiltn hes reported on this fact in 0 comprehensive study.
In 1950 he found that in America for perwnant trentment of
?ernicioue RAPOMilt a liver extract quantity of 2 0.om per
zIonth WS sufficient while in -England considerably higher
extmot relired then at the snme time in 113,f
Rad also during the prewar year* in.Lagland. (Even in our
country simUar conditions were prevailing!) In series of
tests 51 Patiente were treated with different :Alglish liver
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e
gni-0 iikownpise with viihusia 142 WAtisb, in any
Gam, toa *at .Met sin 'Oa blood?piwintii) itself, and
never **mood. ?h. contrary to ltvor prijuktationat any by-
-,
efforts nor allorsto Vtonolosnai but ?tar\ the preopont, of) do not
as d outlooks se
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extrieta,-and 29 is
treated' with gUa SpttOasdid isit,shOw any sufficient
hoillet(014441.1 and ?tntcel rembision in spite of the cireum-
eVaise that itnee'1,43 thi Modiiettom or -increased doses had
bogus, Mille -kb. Anstiooki drUg'ilAti2let.thrOughout optimal
resissi4as? ImItioalso worit Siailar a* r t. Skourissinient, ago,
sad social that * oplOsa the ron for
this toviittioak- is prskbsbir lissiakedii. a saaller contacts of
vitamin 5.12 of the tiglilds: CalkPlirialla with the
American cues. The English drugs however, being subject to
oontinnons-oiimical teats. toe. fres. Soft Shots the inaUffi-
aiency of the olinical testing Of liver =tracts resulted.
Now such testa are unobjectionable.
Considerable reactions can be already achieved, at low level
of erythrocytes, with proportionolly small doses which, how-
ever, will not entail full remiseion. asall.drit! of wrest:
unt essauttse tht_fgrestigi_d_1120d1
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One Amerieeadrug. The group
.4.1eastras.:It sitkiinsith
;Anne the pernioious anaemia, in Qeruny described for the
first time by Anton Siermer in 1866, has lost its fright by
discovering its causative factors and introducing the liver
therapy mRny researchers aimed at replacing the peroral fresh
liver therapy yrith all its disadvantages by an effective and
well compatible injeotion drug. lho PEAMASMIL brought out in
1930 by the German Association for Scientific Organ and Hor-
mone Preparations (Degowop ? beutsche