A. INTERMEDIATES AND CHEMICALS

• Document Type: CREST
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): CIA-RDP83-00423R000100670001-6
• Release Decision: RIPPUB
• Original Classification: C
• Document Page Count: 10
• Document Creation Date: November 9, 2016
• Document Release Date: November 9, 1998
• Sequence Number: 1
• Content Type: REPORT

Znterrnediates and Chemicals This Un10vai&;a"t-j intormat'on for US Otfioi'g
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""PYRG -II
BIOS LABS OFFERING FINE NEW CHEMICALS
is the starting point of many pharmaceuticals.
your ana t doeS not warrant dissemil
nation b report.
Oil, Paint and Drug Reporter - 10-27-52, Page 60 25X1A2g
Bios Laboratories, Inc., New York, is offering five new chemicals --
parabanic acid, phrenosine, 2-iodothiophene, luminol and thiof ormamine.
Parabanic acid is reportedly soluble in alcohol, sparingly soluble in
water, and is said to undergo reduction, alkylation and condensation reactions
Phrenosine, described as yellowish white crystalline powder, is said to yield
D-galactose, sphingosine and phrensinc acid on hydrolysis. 2-iodothiophene is
reportedly the starting point for the synthesis of many thiophene derivatives
such as dyes, indicators and pharmaceuticals. Luminol is used as an analytica
reagent, as an indicator in plant and animal biochemistry, and as a moisture
indicator. Thioformamine is used in preparation of thiazole and thiazoline, a
ORGANIC INTER 1EDIATES, NErJ DYESTUF.i S AGENCY, FORMdED
CPYRGHT Source s
first time. A list of the intermediates is available on request to the cam an i.
Dyestuff products offered by the new company represent the output of
about thirty manufacturers, with some of the materials on the market for the
are at 120 Central Avenue, Clark Township, New Jersey.
factured by the Chlorophyll Corporation of America. Offices of the new company
Oil, Paint and Drug Reporter - 10-20-52, Page 55
A new company, Organic Intermediates, has been formed to serve as a
clearing house for the sale of dyestuff intermediates manufactured by the smaller
dyestuff concerns and to act as a sales agent for chlorophyll and derivaties manu-
Sources Chemical Peek -10-4-52, Page 32
TM-BUTYLAMINE
CPYRGHF
boils at 44 c to 50 c, the new amine undergoes alkylation., cyanomethylation,
cyanethylation, oxidatio: and a number of other reactions typical of its family.
company's series of tert-alkyl amines. A clear, colorless to amber liquid which(j. w
Rohm and Haas Company is now offering the first development quanta ties
of tert-butylamine. It's the latest and lowest molecular weight member of the j
Suggested uses are in the preparation'of vulcanization accelerators,
oil and grease additives, insecticides, surface-active agents, antimalarials and
corrosion inhibitors. It is also useful as a catalyst in certain reactions.
REILLY B'AR' S PYRIDIN PLANT REPORTED NEAR COMFLETION
S4.irce : Oil,
CPYRGHI
nt.oA fn gn nrs ct.raam_earl v 1 n 1253
Paint and Drug Reporter - 10-13-52
Pages
illy Tar and Chemical Corp. has announced that its'new synthetic
yridin plant in Indianapolis, Indiana is rapidly nearing completion and is
 Approved For Release 1999!
I
B. Dyes and Pigments
LONG CHAIN, ALKYL SUBSTITUTED DYES IMPART WATER REPELLENCY
CPYRCffrce: Chemical & Engineering News - 10-6-52
Page 2
A laboratory accident at Michigan State College has led to the discovery
that certain types of dyes will import to textiles water repellency as well as
color. In a report before the 17th Unit Process Symposium, C. C. De Witt and
P. L. Shroff told how a long chain, alkyl substituted dye which had been prepared
for some work in mineral flotation was spilled and wiped up with a white cloth.
The cloth was later found to be not only colored but also water repellent.
A detailed study of this and related dyes followed. The basic dyes
used on wool included: octyl malachite green hydrochloride, octyl rosaniline
hydrochloride, malachite green hydrochloride, and parasaniline hydrochloride.
The dye bath is made up using acetic acid, boilinb water, and a small amount
of sodium sulfate. To fix the basic dyes on cotton, tannic acid was used. 'York
on azoic dyestuffs such as nonyl and undecyl azo-N also revealed the water re-
pellency property.
GENERAL DYESTUFF OFFERS COLORS DATA
C y' P1HTOil, Paint and Drug ieporter -11-10-52. Page 55
General Dyestuff Corp. has published a brochure describing the properties
and uses of its line of "Heliogen" colors. The booklet gives full information
on the powder brands, paste and presscake brands, water-dispersible powder brands
and water dispersible paste brands of "Heliogen" colors. A free copy of "Heliogen
Colors" may be obtained from General Dyestuff Corporation, 435 Hudson Street,
New York 1L, N. Y.
C tR HTAmerican Dyestuff Reporter - 10-13-52, Page 691
Arigen Pastes, stabilized azoic dyes emulsion form, have been intro-
duced by Interchemical Corp., for the fast-color printing of cotton, spun rayon
and other fabrics.
Although Arigen Pastes were developed specifically for use. in printing
by Interchemical's exclusive Aquadye Emulsion system, they are said to be equally
suitable for use in conjunction with conventional gum thickness.
Among the advantages cited for Arigen Pastes when applied by the Aquadye
emulsion system are sharper marks, smoother blotches, better hand,and greater
ease of application. Because no starches or gums are present in the emulsion,
this system is claimed to be particularly valuable for printing flannels, suedes
and sheers. Arigen Pastes are also recommended for printing draperies, upholstery
fabrics, tablecloths, handkerchief, dress goods andother materials.
Arigen Pastes reportedly approximate one-fifth the strength of the
corresponding arigen powders. They produce prints of the same depth, shade,
and fastness properties as are obtained with the corresponding Arigen Single
Solutions, it is stated.
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SOLUBLE %7A- OYES
RYrReHTkmerican
Dyestuff Reporter - 10-13-52, Page 687
The Anold, Hoffman and Company, Inc. has begun the production of soluble
vat dyes at its plant at Dighton, Mass. The dyes will be sold under the general
name of "Ahcovat Soluble' dyes. Currently in production at the Dighton Plant
are the following colors:
Ahcovat Soluble Green IB
Ahcovat Soluble Olive Green IBL
Ahcovat Soluble Pink IR
Ahcovat Soluble Indigo 0
Ahcovat Soluble Golden Yellow IGK
Ahcovat Soluble Golden Yellow IRK
Ahcovat Soluble Biue IBS'
DYESTUFF PRODUCTION- JAPAN
(JPWGH -lanufacturing Chemist = August 1952, Page 351
Production of dyestuffs during the year ending March , w
11;,720 metric tons, an increase of 2,300 tons over the previous year. Exports
were only 899 tons, and present unsold stocks in Japan are estimated at 2,200
tons, of which about 1,000 tons are sulfite dyes.
J :y U11PERZ.) NET, ]~UT!1112 DYE
QR,YrRGHTournal of Commerce - 10-15-52
A new, bright red acetate dye, Eastone Brilliant Fast Red 2B-( ,F, will
be offered to acetate textile finishes by Tennessee Eastman Company within the
next few weeks. The dye is claimed to possess a combination of fastness
properties and dyeing characteristics unequaled by any acetate red dye now on the
market.
H. L. Ford, assistant vice-president of the company, stated that tests
in the development laboratories and evaluations in the field failed to disclose
a single weak spot in the over-all characteristics rf this new red dye.
"An analysis of the properties of Eastone Brilliant Fast Red 2B-GLF",
he reported, "shows its resistance to atmospheric gas and light fading to be
oTua] to rm 1+.+.pr than any nt.her acetate red or pink available."
REVOLUTIONARY PROCESS SPEEDS DYEING OF CLOTH
Cg&uY Hfjournal of Commerce - 10-10-52
What its inventors claim to be the most revolutionary and efficient
dyeing and scouring machine ever invented was unveiled this week in Philadelphia
at the Hussong-Valker-Davis Company plant, wet, process dyeing machine manu-
facturers, and producers of the new equipment.
If this new machine lives up to the claims of its inventors, it will
indeed be revolutionary and one more long step will be taken in the direction of
loti l~l 'V `b~li 'el`e` L 1f?69t/b Hbe$ CIA-RDP83-00423R000100670001-6
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~'GRY PROC ,SS SPEED, DYEING OF CLOTH (cont' d)
It was created by Boyce C. Bond, sales manager of the fine chemicals
ivision of Pittsburgh Coke and Chemical Co., and is called the Bond machine.
According to Mr. Bond, the new device will be able to run from 20 to 120
ards of cloth through per minute, depending on the type of construction and the
ind of dyestuff employed. It is planned for everything from elastic tapes to
8-foot carpets.
Features of the new Bond machine are its unusual versatility in the
ypcs of dyestuffs use flexibility of short runs, better and speedier diffusion
If dye solution throughout the fabric and economy offloor space, says its inventor.
A :ontrol panel allows an ope_atcr to operate it completely aut,-)wj tic al'_' y,
rorn speed, tension and temperature through to the thickness of the fabric being
yed. It is so versatile, he said, it can be used to apply a fix solution to
my one side cf a carpet. It can be used for finishing fabric or for application
f waterproofing or mothproofing compounds.
Explanation of the exceptional uniformity and speed in dyeing, it was
xplained, lies in two metal plates through which the fabric passes in the process
he plates are perforated in a p? ecisely calculated pattern which enables the
ye solution to be squirted under pressure evenly on both the face end back of
he fabric. The many streams form to make an almost continuous sheet of solution
hich meets the fabric, with equal pressure on each side. The dye liquor is thus
orced instantaneously throughout every fiber.
Mr. Bond said the secret of his machine is that the process is a liquid
pressure process and not mechanical. It operates with an unusually low volume
Of dye solution, resulting in considerable savings. Fabrics dyed on the pilot
odel include cotton, wool, rayon, nylon, orlon, dacron, and blends. On the
atter, the results are as uniform as on a 100 per cent fabric.
Pile fabrics, such as velvet, plush, corduroy, carpeting; have also been
yes with a minimum of crush or pile distortion. A simple adjustment in the
'dth of space between the plates adapts the machine for the type of fabric.
The Bond machine can apply all the various classes of dyestuff, including
at, direct, acid, sulphur, acetate and naphthol. Colors can Le mixed in the
achine without regard to exhaust or affinity rating with uniform results. Even
old dyeing vat colors have been mixed with hot dyeing vat colors successfully.
Sounds like a pretty good machine but the model has not yet been tested
omnercially. 'ae must, wait a while before its qualities have been confirmed.
NEW :R'ZINFORCING PICX :ENT IS OFFERED BY HUBER
buY-c HTournal of Commerce - 10-17-52
Commercial quantities of L`eolex 20, a new white reinforcing pigment,
are now available from J. M. Huber;Corp.'s chemical division plant at Havre
De Grace, Maryland.
Zeolex20,,~ app~~calcium zeolite, has wide reinforcing applications in
Carrie PIYc~eh`t G S eJ c''ftc~&It 4cp coati 42ir~, varie 66'o 6O~-6r
industries are also under study.
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RUTILE EXPA14SION GOAL FIXED AT 25,000 TONS
cRYRGHTil, Paint and Drug Reporter - 10-6-52, Page 3
The Defense Production Adninistration last week set a goal for U. S.
supply of rutile from both domestic and foreign sources at 25,000 tons per year,
to be achieved during 1954. This provides about 6,000 tons new capacity over
that existing in 1951.
About two-thirds of the current U. S. supply of rutile is imported from
Australia. One-third is domestic. DPA stated that while rutile is not now in
short supply, its use: has been increasing, and because of its defense-connected
uses, a larger supply is considered desirable. DPA said it is expected Florida
will be the principal source of domestic rutilo expansion, and benefication
plants are planned for extraction of the mineral from the sand in that state.
PIGMENT I: uR EXTRU ;ION
CP?3H'Iodern Plastics - October 1952, Page 208
. Natural color vinyl compounds can be colored for around 1? per pound
with R-B-H pigments, as compared with the usual premium of 5? or 6? for pre-
colored compounds, according to R-B-H Dispersions, Div. Interchemical Corp.
Company literature states that vinyl dry blend compound can be efficiently
and uniformly colored by the new R-B-H plastic powders, which are pulverized
masterbatch dispersions of pigments in R-B-H Resin 510. Resin 510 is a thermo-
plastic, friable, hydrocarbon resins with good dielectric properties; it is
completely compatable with vinyl, as well as other thermoplastics, including
polyethylene, polystyrene, cellulose acetate, and ethyl cellulose.
I
C. Pharmaceuticals
SULFAATHIALOLE PRODUCTS NC BARRED TN PERU
Q,PX13 Hai l , FS -nt and Drug Reporter - 10-20-52, Page 65
The Peruvian Government has -barred the importation and manufacture of
ulfathia`zoley:tab~e:ts, injectable solutions and other preparations containing
Ingle or compound sulfathiazole under a decree issued last May, according to
'nformation received by the Department of Commerce,
y other products with less toxic effects.
Tie American EmbassY.-at Lima reported that officials of __the Inspectorate
neral of Pharmacy said that the use of sulfathiazole tablets and injections it
o loncrcone,d red necessary and, to the contrary, can be replaced advantageously
C"RGHWrug Trade :dews - 8-L-52, Page 59
Burroughs Wellcome and Company, Tuckahoe, N. Y. , will market "~1ax prem'~,
i new antimalarial in use in England. British investigators reported that
roducts cleared 10. of 32 patients with falciparum'snd quartan malaria within
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VITAMINS -POULTRY GROWTH
Clq~wbs it;mical Week -8-30-52, Page !rO
Drug Trade News - 8-18-52, Page 42
Page 6
25X1A2g
USDA scientists report discovery of a possible new vitamin that promotes
growth in chicks. The new factor is found in fish solubles, fish meal and meat
real. These animal by-products have been recommended for use in feeds for growing
chickt.ns even though, in recent years, it has been possible to supply all the
known nutrients without them.
TB DRUG SEEN HELPFUL IN LEPROSY TREATUENT
our eY'Journal of Comm rce - 10-23-52
An official of a Japanese leper s reported favorable result s
erc has
fn the treatment 3r1 F_. c.osy with the rw a sanatorium
osis drug, isonicotinic
Professor Kazuo Saikawa said tests were made,,_.on_14_pat.eats_..since_ last
rch. Five off` them have recovered com Zetely and the di~se.as _been stopped
in the others, he asserted.
The germ ^f leprosy in some respects resembl.e_s that .off tuberculosis.
Other TB meH_cines have been tried against lepresy .,iith varyin; rc
su.ts.
ISONICOTINYL HYDs'.2IDE
(SSWRGH1Phemical k7eek 10-11-52, Page 10
A report by Britain's Medical Research Council will crimp use of iso-
nicotinyl hydrazide, the new TP drug, in British hospitals. Reasons too much
chance of developing drug-resistant strains of TB bacilli.
Such strains were found in 11% of the trtated patients after the first
month; 52% after the second, 71% after the third month.
THREE EXPE77I1INTL1 i.NTIBIOTICS
(DIHDhe s.ical reek - 10-11-52, Page 32
Three experimental antibiotics are research news from Sharp and DohnL,
Inc. They have been dubbed Cardicin, rhodocidin and thioaurin. All possess
highly desirable attributes, but therapeutic value in each case is yet to be
determined.
Cardicin inhibits several yeasts, molds, bacteriophages and gram-positive
bacteria. It has also shown some activity against influenza virus. Toxicity,
however, threatens its usefulness.
Rhodocidin, isolated from an unidentified species of actinomyces, is
effective against widely differing types of bacteria. Its activity is apparently
undiminished, by serum.
Thioaurin boasts broad-spectrum activity, is relatively non-toxic in the
bargain,
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CALL FOR CAREFUL DRUG TEAM USE
gFuYr HTourna1 of commerce - 10-22-52
Two San Francisco researchers report that promiscuous use of antibiotic
combinations may result in one of the drugs deterring the effect of the other on
a disease causing organism.
They stated that antibiotic teams should only be used if an organism
proves resistant to a single antibiotic as shown by laboratory tests or adequate
therapeutic trials.
Dr. E. Jawetz and J. B. Gunnison, ad.A. divided antibiotics into two
groups: (1) penicillin, streptomycin, bacitracin and neomycin, and (2) aureomy-
cin, chloramphenicol, terramycin and possibly, sulfonamides. They said that a
combination of drugs within either group willnot antagonize each other and that
simple adaitiva effects from their multiple use are often cbs?rvt,d. R.ur&ver,
the combination of a drug in one group with one of the other group may interfere
with the effectiveness of the drugs.
MAGNAMYCIN, A NEW DRUG TO BATTLE BACTERIA
GR R H1all Street Journal - 10-13-52
A new antibiotic, Magnamycin, which the company says may prove effective
against bacteria which are immune to such antibiotics as penicillin and strepto-
mycin, has been discovered by Chas. Pfizer & Co., Inc.
The new drug is now undergoing extensive clinical tests, according to
a Pfizer spokesman. Early reports indicate that these tests will confirm test-
tube results showing that bacteria which can live in the presence of older
antibiotics, cannot survive attack by this latest drug.
In other tests on animals, 'Magnamycin was found to destroy bacteria,
such as the pneumonia germ and streptococci. Laboratory animals such as mice an
rats have been given large doses of the new antibiotic without harm to their
tissues, the company said. These doses were given by injection into veins,
muscles and the skin.
I
D. Plastics, Resins, and Rubber
3$IN
Source: Now Products Development Department - October 1952
The Minnesota Mining and Manufacturing Company is greatly impressed by
the adhesion qualities of epoxy resins and would like to obtain epoxy compounds
suitable for resin preparation.
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RUBBER CONSUMPTION - SEPTMBER
CPYRGHTsource: The Rubber Manufacturers Association - 10-30-52
Page 8
New rubber consumption during the month of September increase 13-72% to
06,533 long. tons from the 93,676 long tons consumed in August, according to the
onthly report of the Rubber Manufacturers Association, Inc.
Consumption of natural rubber during September increased 21.27% to 39,629
ong tons from the 32,678 long tons used daring August. Use of snythetic rubber
mounted to 66,904 long tons, an increase of 9.68% from the previous months'
otal of 60,998 long tons.
Consumption of reclaimed rubber by the industry was estimated at 23,459
long tons, 14.73% above the 20,447 long tons used during August.
CPYRGHT VULKOLLANS - NEW RUBBER
Sources Chemical & Engineering News - 10-27-52, Page U57
Latest to comp\ete with natural rubber are, the so-called Vulkollans.
Originally developed by . Bayer (Germany), these Elastic n terials are made
by reacting ethylene glycol and adipic acid to yield a polyester which in turn
is treated with a diisocy,.nate to form a sirupy mass. Material is then treated
with water or ethylene glycol. 'eater treatment liberates carbon dioxide yielding
a foam sponge rubber; glycol yields a solid product. Similcr products have been
studied by American companies (Du Pont-ICI's Vulcaprene and Bell Telephone's
Faracron). Advantages: high elasticity and tensile strength, good abrasion
resistance and structural strength, resistance to ozone and oils. Drawbacks:
affected by concentrated acid, alkalies, and prolonged exposure to steam and
hot water, and unsatisfactory properties below 20?C. and above 130?C. Vulkollans
are workable only during a limited period and lack adhesive properties unless
modified. Present use: rubber heels with eight to ten tiros the wear of
natural rubber. Potential uses: insoles, cable covers and fabric coatings.
NEW ROSIN TYPE RUBBER DEVELOPED
CYsHTJournal of Commerce - 10-30-52
Greater tire wear -- longer, in fact, th,~.n the rubber industry thought
possible a few years ago -- is a distinct probability in the near future if a
new type of GR-S synthetic rubber, now in the pilot plant stage, becomes a
production r:,ality.
The new rubber was developed by scientists of the Naugatuck Chemical
Division, U. S. Rubber Company.
Laboratory tests show that the new synthetic gives 30 to 50 per cent
more abrasion resistance than standard "cold" rubber. It also has good resis-
tance to heat, cracking caused by rapid flexing, and the deteriorating effects
of aging in air.
The new rubber is made possible by the addition of rosin chemicals,
by-products of turpentine manufacture, to an extra tough "cold" type of tit-S
synthetic rubber.
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NEW ROSIN TYPE RUBBER DEVELOPED (corrt'd)
The rosin chemicals ?rake the rubber easier to fabricate into products
and improve its end product of quielities.
The chemicals are. added to the rubber when it is in the latex or liquid
form. Carbon blrick may be added at the same time.
I
E. Miscellaneous
SURFACE PRINTING INKS
`?oXA9.TModern Plastics - October 1952, Page 210
Solvent System surface printing inks based on polyvinyl chloride resin
for wallpaper printing machines are being offered by Claremont Pigment Dispersion
Corp., 110 lallabout Street, Brooklyn, New York. The inks dry thoroughly at
temperatures of 125?F. in from five to ten minutes, and have no after-tack or
pick-off. A complete range of non-crocking, non-bleeding, light-fast colors
are available.
II
Ncw Products and Types Aproved for Manufacture
Date
10-28-52
71002-23
Calcogene Black SCCF Solution
10-28-52
71016-09
Calcogene Black RBCF Conc. Solution
10-28-52
71016-10
Calcogene Black RBCF Solution
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III
Publications Committee ApFr ovals
1. "Textile Resins in 1952" by K. H. Barnard. For oral presentation
before the Ontario Section of the Canadian Textile Chemists' Assocation at
Hamilton, Ontario on October 3-
2. "Piperazines. I. Derivatives of Piperazine-l-carboxylic and -l,l,-
dicarboxylic Acid" by H. W. Stewart, N. Q. Quinones, E. U. Lee and J. J. Denton
for publication in Journal of Organic Chemistry.
3. "Piperazines. II. 1-Heterocyclic Piperazines and 1-Heterocyclic -4-
carbcthoxy-piperazin?s" by K. L. Howard, H. W. Stewart, E. A. Conroy and J. J.
Denton for publication in Journal of Organic Chemistry.
4. "Pipe"razifes:I ~-Mete"roy'i"ic-ia-guan'arbanyl, and thio-
carbancyl-piperazines" by E. A. Conroy and J. J. Denton for publication in
Journal of Organic Chemistry.
5. "Chemistry of Azo Dyes" by N. M. Mack~.nzie. Lecture to be prt-zsentad
as part of American Chemical Society Li.~cturc Serics on October 21, 1952 at
Summit, N. J.
6. "Studio,s in Textile Printing" by R. D. Greene and F. Fordenwalt.
for presentation before the fall meeting of the Providence Section of A.A.T.C.C.
and for publication in the American Dyestuff Reporter.
7. "Textile Resins in 1952" by K. H. Barnard. A speech to be made on
October 3 at Hamilton, Ontario before the Ontario Section of the Canadian Textile
Chemists, Association.
8. "Two-Sidedness" by F. 0. Sundstrom. A-paper which will be presented
to a number of closed meting between Calco and mill personnel.
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