ANTIBIOTICS - XANTHOCILLIN

• Document Type: CREST
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): CIA-RDP83-00423R000800420001-6
• Release Decision: RIPPUB
• Original Classification: C
• Document Page Count: 4
• Document Creation Date: December 23, 2016
• Document Release Date: July 24, 2013
• Sequence Number: 1
• Publication Date: June 1, 1953
• Content Type: REPORT

Declassified in Part- Sanitized Copy Approved for Release 50-Yr2013/07/24:CIA-RDP83-00423R000800420001-6
.A111:13N
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Country: Germany (Soviet Zone)
Subject: Antibiotics - Xanthocillin
Place Acquired by Source:
Date Acquired by Source:
50X1
Date of Information: May 1953 50X1
50X1
50X1
1. Xanthocillin is a new antibiotic which is obtained in crystalline purity
from the mycelium of a special breed of penicillium notatum. It was discover&I
In 1948 at Friedrich Schiller University in Jena. The chemical analysis
of the substance has not yet been completed. On the basis of favorable
hypotheses, xanthocillin is preferred for local treatment of bacterial
infections of various sorts, whereas it is not suited for enteral or parenteral
general treatment. The following characteristics may be mentioned:
2. Polyvalent Effect, Bacteriostatic and Bactericidal
cf. Efficiency Spectrum of Xanthocillin in vitro (at end of report).
In addition to staphylococci, streptococci, diphtheria bacteria, and other
gram-positive germs, highly diluted xanthocillin arrests also such gram-
negative germs insensitive to penicillin as proteus, pyocyaneus, coli, among
others, as well as tubercle bacteria and such anaerobic spore producers
as tetanus, gas-gangrene, and symptomatic-anthrax bacilli. Thus, xanthocillin's
antibiotic effect can be extended to practically all germs which cause local
infection or which can be seized by prophylactic wound treatment. Not
only does xanthocillin arrest germs, but in considerably high dilution it
even kills germs.
3. No Resistance Development A serious and constantly increasing danger to the
reliability of sulfonamides and antibiotics is presented by the fact that the
pathogenic germs are developing resistance to these medicaments. The
experiment to accustom 50 different germs in vitro to xanthocillin through
_daily treatment with subliminal doses has to datebeen unsuccessful.
Whereas hemolytic staphylococci doubled and quadrupled their resistance
to sulfonamides and penicillin on the 6th-12th day, these same germs showed
no increase in resistance to xanthocillin even on the 100th day or later.
Against sulfonamide and penicillin, the germs had developed total resistance
on the 50th-60th day. Those germs which experimentally had become resistant
to sulfonamide or penicillin, fully retained their sensitivity to xanthocillin.
On the basis of these results and considering the experiences with other
antibiotics, it may be concluded that also under clinical conditions develop-
ment of resistance against xanthocillin may practically be ruled out.
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4, Natural Retarding Action ffepotWirkuhe Xanthocillin is relatively not
easily soluble. On the one hand, this characteristic is an obstacle to
the production of injection preparations with sufficient absorption capacity
suitable for general treatment; on the other hand, for local theraphy,
however, this characteristic has the advantage of slow absorption and natural
retarding action.
5. Stability Xanthocillin is extensively stable toward chemicals, and is
entirely thermostable. In watery suspension, xanthocillin may be heated one
hour to 1200 without adverse effects. The preparations may be stored for
an unlimited length of time without any loss of effectiveness. Even when
other remedies, e. g. disinfectants or chemotherapeutics, were used during
xanthocillin therapy, there was noticed no unfavorable effect on the antibiotic
action of the xanthocillin.
6. Therapeutic Effect Clinical tests on 17,000 patients to date have shown that
all xanthocillin preparations are very well tolerated. The therapeutic effect
of xanthocillin is based not only on its antibiotic characteristic, but
clearly also on its capacity to cleanse wounds and promote granulation.
7. Xanthocillin's Therapeutic Significance Because of xanthocillin's extensive
polyvalent effect, therapeutic success may be expected for xanthocillin preparations
principally in all cases of bacterial infection which can be treated locally.
Such polyvalent effect is particularly advantageous in the treatment of
mixed infections and in prophylactic care of wounds. Should in certain cases--
e.g. not easily accessible seats of infection -- the xanthocillin be ineffective
or fail, there is no fear that during continuous treatment the germs will
develop resistance through subliminal doses, as is known to be the case in
treatment with penicillin, streptomycih, or sulfonamides. Local treatment
with xanthocillin instead of local applications of penicillin, streptomycin,
or sulfonamides also counteracts the multiplication and spread of breeds
resistant to penicillin, streptomycin, or sulfonamides, and thus furthers
the reliable effect of these medicaments so important for general treatment.
This applies also to the development of allergies to penicillin, streptomycin,
and sulfonamides -- allergies which are traced to the application of the
listed medicaments in great quantities, expecially on the skin and mucous
membranes. It is this supplementing quality to the antibiotics and sulfonamides
suitable for parenteral and peroral general treatment which gives xanthocillin
Its importance as a specific local therapeutic.
8. Commercial Forms and Indication:
Xanthocillin Ointment
10-gram and 30-gram aluminum tubes
100-gram glass container
Xanthocillin
01. pedum tauri 0.2
5eat's-foot oilg 27.0
Nonirritant ointment base 100.0
For treatment of infected wounds and sores, expecially ulcera cruris, phlegmon,
impetigo, folliculitis, pyoderma, infected eczema, pemphigus neonatorum,
burns, rhagades, mastitis lactantium. The ointment is to be applied once
or twice daily, and is to be covered with a bandage.
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8. (continued)
Xanthocillin Wound Powder
10-gram and 50-gram shaker containers Xanthocillin 0.5
7-gram glass flasket Sacch. lact. ad 100.0
For wound care and infection prophylaxis in small and large surgery. For
treatment of dermatological, otological, and other infections (cf. indication
for xanthocillin ointment). In the treatment of wounds, abscesses, sores,
and burns, the powder should best be used in combination with the xanthocillin
ointment; in ease of heavy secretion, use xanthocillin powder. The powder is to
be applied once or twice daily, and is to be covered with a bandage.
Xanthocillin Wound Powder Forte
7-gram glass flasket
For treatment of spatially limited,
dental and jaw surgery.
Xanthocillin Wound Cones
50-cone tube
200-cone glass container
Xanthocillin
Sacch. lact, ad
highly infected wounds,
Xanthocillin Wound Cones with Anaesthesin
50-cone tube
200-cone glass container
5.0
100.0
4pecially in
Xanthocillin 5 mg
Sacch. lact. with
2% swelling agent ad 50 mg
Xanthocillin
Anaesthesin
Sacch. lact. with
2% swelling agent ad
5 mg
3 mg
50 mg
Microstyli for insertion into the alveoli after extractions, in case of
surgery, dental root resection, osteomyelitis; for insertion into fistulae,
furuncles, carbuncles, abscesses, ulcers, and panaritia (possibly after
puncture). 1-3 xanthocillin wound cones are to be inserted, depending on
the size of the alveolus or operation wound.
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8. (continued)
Xanthocillin Eye Ointment
10-gram glass container
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Xanthocillin 0.2
Special eye ointment ad 100.0
Xanthocillin Eye Oil
8-gram flasket Xanthocillin 0.4
Vegetable oil (purified)
with emultifier ad. 100.0
To be used in case of blepharitis, conjunctivitis, keratitis including
corneal ulcera and cornea infiltrations, blennorrhea, infectious dacryocysts,
injuries and burns; also for prophylaxis and postoperative treatment. The
ointment and the oil are to be applied once or twice daily.
Bibliography .5ee original document for authors and German titles7
Efficiency Spectrum of Xanthocillin in vitro
Tested Exciter Xanthocillin Dilutions Nourishing
Solution
Hemolytic staphylococci
Hemolytic streptococci
Diphtheria bacteria
Coll bacteria
Proteus group
Pyocyaneus and
fluorescence bacteria
Tetanus bacilli
Gas-gangrene and
symptomatic-anthrax
bacilli
Gonococci
ubercle bacteria
Proved extreme value of arrest
V2222:2711 Bacteriostatic mean value after 18 hours
simmill1111 Bactericidal mean value after 18 hours
B - Test in bouillon
KB - Test in coke bouillon
goksboui11on7
S8 or S33 - Test?in 8 (or 33)% serum
VEB Medicaments Plant Dresden
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