SCIENTIFIC ABSTRACT BELITSEV, V. A. - BELITSINA, N. V.

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December 31, 1967
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owl I" VIOVINT-li W041 6ac/ *00 ell -to ago '-r see 31K' bh. Utter' remse -a** Gold (10do. t coo of colls In OL An. (P) 000 00 Fee see woo WOO ago 241ALLOW"A4 LM"TWM C16A"WwAlnw Woo iii-fte its 0 a 14"49 1 lVit 4wv to I Ir 9 k I . . . . . . FA U At 10 a I o o o.* I's 000000 Ot 00 00 a 0 0 &0-9 to 0 0 000000 - _04 0 0-0 0 -0_0 0 ja BELITSEV, V. Ae "Problems of the how scheme of Fermentationus (P. 709) by BeIttsev, V. A. SO: A&_W_ceg in ContenmorAC& Blolggy_ (USPEKKI SOWMENNOI BILOGTI) Vol. V0 No. 4 1936 M BELITSER, V. "Recent work of the meyerhof school", (P. 921) by Belitserp V. SO: . Advano.es :,~ bo'atemorArv BigloM (USPEKKI SOVR.IPZMTiT.OI BIOLOMI) Vol. 5, No. 51936 I 1 .0 '1111SUSm I" Half a a IF a 40 ay A J. it V I )I a b -P 01 P f- I a -A "10A A -11-x F. 4 4 IAN 1014frelsuall of respiration and famentatim in the Uvingirel IL Domstlacelysispnserve the respiratory of thit dame CS11? *6 9 tu S. R.) 40, .40 -Th,, (a. Pill :iota r of tAvtkmx of the birain mcm of tht! rat swi vat An-t -410 it i's 141MMS were tA),wt,,%4 in a wartottric app. with Luld *h)"11 pmvkxa anarrubioals. in The perv ncr and al,,tjx-r of Slurow in the Medium. H. corw1wh.,l that lucwylix ildumts the anatirame inwtivutitm of the rtspita - lotmy M-ArM Of tiSSM Cliffs,. It i5 PoWhir that 00 -tv" to rtstom or othrywisc to pirm-m the chent. tons. imments of the mpirmory itystein. W. A. Perli%vic w -OG 00 0 pCfA%JjjOGKAL CITIRAY&OC CLASSWKITIC. too- sl~fflolll 0 9 C-v a.. Lit 0 An& so two viWiwim S As 4 1 1 V U AV So AS ic Ra A 0 0, 0" 6, or' 4, 4" 0, 0, 0 0 a 0 0 0 8 Ce 0 04 0 e 0 0 0 4 a 0 0 0 0 * 60 A 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0-0 6~45 0 0 0 0 0 9 0 0 0 & 0 * 0 9 0 0 0 0 W1,94 0 Seef 0 go, *a as 00 so 44 ,3 it go. go a It it ii it m I I a 22 : : 0- 9 - 0 A I I OA X-9 lob 9~ at. N;4#1 plocisla$ 4.0 0 rl .00 Rw*adm of w swAd so Nw. (U. S. 114. R.) ZkWimPf"ta. 19 3944: d. C. A. 32, zwo; A -2,691, 64171.-A M. G. 16fame f9TA&LmKA1. OTINAT09 CLASUPICAMN u jg AV 00 Lsli a a,* 0 a a so 0 0 0 a 4, 9 ;;100- 00 ***'.a *00 4 Sao 0 0 0 0 & .09 coo ,go we* SICNO: Ail I#AWO **IMF& 0 a 0 3 a r 0 0 0 9 0 0 0 9 a 0 0 0 a 0 0 a 0 0 '1051A 0 0 0 At a 0 0 a & 9 & 0 0 0 0 *,a 0 0 004 bell oor 0o:: oo* 009 .002 **a oov so- 00- go. 00, 00- 0 6 0 0 0 & 0 0 0 * 0 0 0 Ole 0 0 0 0 1 u Off, a 1, 12 13 x x x v x 45 41 42 43 a is ! It X I, a It a pa It S I W , IT am AT 9 ?1 - A I. a L-J- . d t I . -14- 1.0taffill Ift, &.0 if" 000101 61C.0% -!!-1 0-0 WMe Aw AT , &I well Poll MWO ROMPOPUll IT.Ms. I 'It" Tjj 'ry be a-ma.) 11 wwn luapwdv it P- so a32wqdwqd 10 SUMHAV Aq px!uvduxON 1! "Irlusm, 10 salua!334 aql sit aix"11, be 10 4qvi UMTJ!&.u bql in ama-L" vy-audow --,g A*jI1ktvv-9 Wj -It -V puff v-qtkAZ 09 "L 'Y'A 09 IF 00 go 0o 00 !.7 00 . 06 1 r *0 -t4 -10; -91-0 -4 ;1-4 r, I " # -I iA t TW 7--A 90 it 9 a Me fir', OF w IN w w -1-k ad -1, 61 1, 0 a it m to I it v 'm R X IN AS a v IX m X to " " ot to L 17, *,Joy wo AD## C"k of dwakal Vudwmj~w Is* tauscle dwft agreblot6t, V. A. lklitorr. M. A. Zyukova and A. Va. -00 it vekxity of the .00 phowbacgot hyd"Ya") ideroml to be to obe initial during aftobifth is com -00 ygWlyoflhvw m, P unders-crobiatio. Thislaitial 'elocity Im mwu"d during the 2nd ball hm of N- -00 after the "Physitiany-dimmulvv4" 0 In the .00 =beettutilised. It was ammunted that an "Cherni. mUy_bowW'1 () w1w lkvwl". The valme (of The initial 600 a 3velocity of pbmpbftm splitting is 1.4 mg. of phosPfutgra per C. muscle per bour, at 20% the ittil W vrloriSY of W-lic jil - I acid F"n1he initial vdochy 11. v.. velocity during acrablosix) of the lactic wid famatina and The MPIMto(Y Value in the stationary conditim. of mt aerobimio. the oxidation P L40 0 qw1jent of the lactic WO is fountl to be IA. Sit- the real jobw velocity of lactic a.cid is ap"tly evvA low, The oxidation quotKul njust be of a still lowrr ,an., ow should sormat to about unity. The larik M formed in remiag mouscle is lb"dore ac or almooe quantitatively burned up. 'Tbe Wk in 11"CIAC it abnom * vchw I ' the ftaof MW VOILIAS C u% Z" spontaneum - WW osmative wut=.y a&.. suntripbosploom acid and cmtlm p"hate. The vah" Cotrempood to the bighem phoo Oman rowents. A t a - I L A BEIALLUSMICAL UMATIM11 CLASIMPICATIC9 -s 1111,34o .&v Q%v Got .1-31 Dot a- All ,P's U a #0 "Is' a Or a of or Aft L S I Cm 0 P v I v a 9 a a 0 v 11A 0 '80 Joe so a a 0 9 0 0 Ill 0 0 0 * 0 0 a 0 0 0 0 0 * of it 0 it W to 16 'r It 12 iN At jb a A jpj" Pit job "'ll to It 1-1. -A 31 0 1 v 1 0 R tout.$ f. of Ali! --4o o * a!: i -00 iiW4-64da. oft 'the' rtiontlift of auade ti". C V. A. Ilefitw. DWAimiya 2. 332-430W# I .--A synthe- -00 'iUWAWP1WM is atmerved, and respiratkni ii hicirst%rd, as go gE whelk crelatkina Is ml&d to chopped muscle in pboophair .3", ialn This takes Ptacv even whrn &K-Wr4s, 6 c%q:itkkd zoo It. 00 of .00 its@ I VAA11J XU4,-~d use too A I a S L 41TALUIP60CAL LITIROUNI! CLASUFKATICS, Uz.. like 0 NO* 44C int 'i; U U A, toodc wit 199 ptiger ICKKWM j a S a ad a a I IF 3 1 0 00 :0 0 o 0 o q J * 0 0 0 0 q * o 0 0 o q 0 o v o 0 0 0 0 o a go lei 0 0 * 10 0 0 0 0 00 00 0 fee 000*0010 ***_a 0 0 * 0 0 0 0 0 0 & 0 0 0 f II Ills I t 913111.1111"m Is 11 11 POOCIssit ..a 01color'll .Let 0 - , 4 1 0. Ok it and M. A. ZyuLova. HaU, 4a 0C - IF. R. X. S. 3, T3-7(I%Kj7)jiI1 CWgIllan,; 11 C. A- if. FeAsirAlkill &A j.441VII ff.41 IlItISCIcA svow% a 1110i I it.1voisc Its Itir plu-6,114SCIS 11) NmIt,art sit Ol. klilluir, Ill Ow 44 muma IF all sit Allsi.$ .11 ill 41tv liscus: a, lit ftwo" 6A an ush-clift'llace if 4,41SU111411 11-4 U614 nd 11h. I Ft m is W. s xviss llOI S6 of I % r i A f C v% S; w y AS all. IS an %,Yvb&nV of d i l d t TI f l 1 9; litIl -IM11114 e tlkV%Slll. tt 1CM1114 tC 4V$.1 il ) OkIl O liltssVIV M11111 A11141W V%N111111i'lli Is Still jIlY.Ovitid AM alysolsu by snIstall-4s. Wit Site ispiltilikic a else I If alld 114,nItIAlm. It-yellb"ic S. A. Xa iAu 00 a I o 4p !c- m it 'llsilli 4w a-- lot 3 low u a 4, -0 it IS, p 0 ?V~T~ j a a it 4 It III a 0 0 0 _Ist 0 0 0 0 0 0 0 0 0 0 0 0 o * o * 0 ego 0 0 ** Ot 'Or 0 0 0 0 0 * 0 0 41111111111 91111119 Of 00 so -00 -00 -4114 -90 -90 .00 as* goo a 0 600 goo to o BELITSE-~t V. A4 "New data on the mechanism of fementation." (p. 182) by Belitser, V. A. SO; MYSBC21 In -WgWrp~7 P121W (Uipekhi Sovremennoi Biologie) Vol. VI, No. 1 1937 BELITZER V. A. "The respiration of mscles" (p. 235) by Eelitzer V. A. SO: Advanced in Contemrorary Biology L - .(Uspekhi Sovremennoi Fiologie) Vol. VII No.,2 19~7 Wit 0 0 0 0 0 0 0 v 111111tittLA Ilia itmills Dion .4 Lima )a it );u )a6 Jai? 90411 Ud)bdgo V1. . 1 1-9 -L-1- AL 00 'eftest4t ..v !.rot-rf, .Oo to 00 9 -00 muldf- 46 d. C. A "00 to Went CIPM. of 00 wbkb k Wobw" Unt PbMpbWn d, muscle. .00 00 h-I& Fit -, -- U M "Punnuou '4 the 600 ~00 ruiadw1w An I IN APPILM11Y " char. Arttrind by IthifiIii -40 ti=". tbe gatt wan Only to 13 U a rMve Ono"", 00 goo 3 go 0 00 moo to -,3 9d 00 to 0 0 i 00 'r, v00 8 1 low 4~ 4 t iswell it 041 rot 1*0 U 0 A, 10 311; 1# & jC K a 0, W It IN a It 0 0 0 0 4 0 0 0 0 * 0 0 0 0 0 0 0 a 0 0 0:0 0 0 0 0 0 0 a 0 0 0 0 0 0 o1 Soot '0 too* 0000 0000*0000.0't 0#4 *000000004 too:T t a 4 00 la A to 13 IS A;i; JIM j6fu lem Ism jI3r4I 61 49" $9411 f to n6walull lvgum. IWM. V. A. lkhtwr. "'WL4)- C- A - Sr. ---A~r Ul been provW P"e"May to ths MIC Of trot mawk, the Mo. of cm,im 16 rat muscle lodoms iarrmacd rts*a,km and the 1 ksis Of Pbo~Pbsvn. AA'thoUlth lb* "COV860II Of FCSPVU. lkm Is Quite buteper cat Of the 61mvirlic mcchaa Wg "rot 1`1101100 call a1w. to is certain extent. Owlivote obscesIvi., of iwvg. piltmohd(eq. vt,,(,tw ~Au. 1,114tuffl. I L Cohen De-PT. FA GDL I s m 9 1 R. It I- y-,S- a I IN to I a 4 a 9 " , ""0 U 19 10 it 9 of tl MAD 000 0 00000.6 I,;SO 0 0 0 a 0 0 0 0 0 0 0 0 0 0 0 0 0 0 a 0 0 0 0 9 0 * * 0 0 -00 .0 ip .00 see r*0 190 see U00 I I I S I A 0 0 11 a uld big Via job D a v a 0 a 16 0 b v is x 0 a a 43 is a to. 8-.90414% 0.001091t6 ...q. .1 It- r 713 ~ 00 S I - " I W hi W a w .4 42. t d 00 tiv* denArboxylation of The pyrocammic (Lkwkum l. u k f b -00 a asta Ity to tut amuf l. its whih the bytbqmmlk- o t1w flyrwbv estrysts". protahly cakc,4 p1- at the quafff- itaty N ottma ol Ow- thustie FWg. 0 .3 N . CKIII Cl- see 0 1 +2H 00 CNII N so* A 0 .1 . , W cl ~ OI N Cu see 00 9 w w -- - J- c coo I I +IICI i mm N-CII C11"S cHiawif so* W. A. IfMat - - k- &- I L AMITALLUIPSICAL LFTINATION CLASSWiSTIMS S 9900 view 11.1alk.. slow Paws" - 4.. t told" .40 *still 4w 4.0 &it u 11 AV Of 0 a 1.9 ,L a a a 4 a a *000000000000009 0 o 0'0#000600009000000 0 P 1 10 TA 0000000000000000 00 0404#094049690909900, I BELITZER, V. "Pasteur-reaction." (p. 416) by y._R,~k:L~Aqr _v Biolo 0 SOt Advances In ContemDorar (Uspekki Sovremennoi Diologn) Vol. VIIT, NCF. 3, 1938 o"; ; ; '9v 'OF ; ; ; :0 0 t 0 6 a 65~11 a lost to 11911utlun b It is jo is is v 0 w a V 4 0 0 'L.A-f-m 9 IF LI-Im Isl MAX .6 L 0 os~ -~ i ".400 41- a AimproWe sboud"I romcdaus to causcis. PA nW, W. S. S, R.) :4. 47,%-601 vNith OX mIt"Ibm. S. A. KWISIA 00 T 90 00 vi 04 a : j ~ 741 i IN-ItA 61 VAL L~AL ultmakof aAW KAT)ON $A I a Cho 0 IT 0 u 14 41 pp a rf to 0 At a 41 411 0 Mgt" IIN K604 1;14 0 0 0 0 & 6 0 0 * ~ 0 0 : ito 'b 0 0 4, "o 9 0 0 0 0 0*000*00009*vowo :;o 0 0 0 0 0 #*of 00 1 0 0 00900 06 goo goo roe ;so 0 boo -7-11-111 logo a a 1 6 9 0 0 0 000000 mile 0 it 0 it Ar ft 16 r, S a 34 x a p a a Is a IS v a 0 a 0 a 1 A ' AAAM-11.0- _a__L_A__I_ A t_&_ _ ,_& 0 &_1L. AkfAlf. M MI -00 00 .4 of 1060nUou thrmah phospbegen trandor li C. A. JY,-gTr,'rl"- '~-- Previi4i4ly it W been shown t , that dectimpa. of ph-phagen "it to an increaw in rv~ .00 p4fAikm. resynthesis. to A J,-,Tyhw. Thin i-. ctpLtin~t h i b ~64 m tht a n t at the dec-anrn. MvImIs 0 ptimphagn; 00 air mpiTat4wy Imoulatim 11W *hIn 0 An 1141. CILI. 1-1 .00 roobbit kidney vg Imi (whi%-h cv,nuint 1,6-plulgrn 41c. VIMIPW I)f.MIUCtg) nMIW)y MU-TV111" The fI-q)irAJtWY ti- feet .4 "Tatinc. I'viettIfy 40 4 zoo 00 see 00 it so* 00 do 8 00 goo 00 00 00 fig. 019,11~ inaii a a' 06614, do _I -- , " low 0 v j jj j m a AT of* 44 tu mm A I IVA 0 e 1e 7 to IT adore Man I It 0 00 go 0 0 01 00 000000000:::1o 0 0 0 0 0 45 r& 0 o it 0 0 9 it OS 9101 o m it 0 0 o 4010 0 * it 0 0 0 00 006 00.00 0 0 04 0 0 * 0 a 0 0 41 0 0 0 0 000 F- *secItul A60 !IM11441 Moll A C, *0 A NPI A. d- ~by w-sWd at ,p of are Inie fee A* Acm W, Okla, t en fog hat m-M.Aft-0-14- 4". fis Ommatkm a I- CO mad' 409 so voe vo a .1 &.4f- ptl,&LtUv4K&t %'I~ so* 7Tdo~jjjt A I'MOO if Oki 041 U X~&T.10 a Am A %a Iwo APINS1944 I i-V a .19 it, t9 o9 RM 0 0.010 e. 41 000040 9 0 *4 0 0 0 0 0 a 0 0 0 m U3 71, -.:1 Is U U Is 4 It j- 0 M x a W 0 40 at 1; At At 6 2 0 t Z M-N. CC, -W U !:j A_A 1 -6 i 4 The mtcbawm of It- &P aw, J!:r I i T:V do in vinialle. V. -00 . 021V of mimed itmWit diew. after WaAhinS -Ii~hlhollbol All phosphate soln. at 0'. in a voln. contS. citcatint ), pluss -00 ph,\ 00 1 phate. cogymake (11). Mt Ind cophospbarybut MI) c (alkali Inactivated cosymase) lields 0.92 mg. of phospha. (Wed. as PAI in 30 win. anaterabiosis. The 11-00 W.V11mallic acid (V) am lactic UM (VI) caw" an in. crem of IV to 2S3 wid 3.12 mg.. resp., in -%) min. A '0* suspension of 2130 mt. of muscle tissue. 0.2 ins. of 11. 0.6 -00 Mg. of US sail'12 m#. of I in phosphate 4 1 h.H- in the prrsrutv of (N with 11.06M b p di-VI yields 'I.A 1114, of V i"M min. I V (0.1mi-tioll M) have no rlycet on I- cot . ..... when 0.001 U V Is added to the above on of Aff-VI 3.44) ms. of IV art obizined. V An washed tvilk distd. 11.0 instead 4 pbriq formatioatiflVitiobsenvil. Pipts.willimuscivest.ob. takied at go-W indicated that the factor resportsible for V0upIlpF respirstitm with pbosphorylation is not an rx. tractable coenzyme. It b probably a very labile crtsyme. 00 Careful dialyab followed by the &Mo. of known theritto 0 stable comityin" save a soln. wkk-h caused tlycelytic oxi- 0 dation-"duction and the Mcilfwation of inors. pbos- phates, indicating that for this pgoorm the 0 unnecessary. The factor is inhibited by 0 .=1 M~C:. je S. A. K3r4l& I L A 1191FALLUSSICAL LITZRAIL49 CLAJUFKAIIOW be* -'7 7' 143000 .0 1 $43043 .19 O.V Q41 ----A '10 P, pit" fill NO qx Ittlit HOMWA 1 2114 MA I I a W 0 :* 0 0 0 0 0 0 0 0 0.0 0 0 0 , " 0 : : : : 1 4 0 0 6 0 0 0 0 io :1411 0 0 : 0 0 0 0 0 : * & * 0 BELITZER., V. A. "The Application of the Radio-Active Elements in Biochemistry" (P. 157)by Belitzer,V.Ab SO: Advances in Contemporary Bioj2jZ, (U.spekhi-Sovremennoi Biologii)., Vol. 1, No. l., 1939 - - ~7, - " . .--~ - 1-1 -, -,: -; ~ --,~- . .- lzzn, - . - - ~~J~ "'.. - ... - ~ -- -11 ;~` -, - -'. 1. Ii, ': - 1, - - OEMucidation -of thetermentation, ProcessO .(P. .372) by Belizer, V. A. SO- a;~s in Moderm Biology (Uspekhi Sovromennoi.Biologie) Vol-CII, No. 2, 1940 !Go** o a 0 W *lot v a .0 .0 LL; .09 oo~ P-Wad- *I a CA rue" o.1 M. 1. "'ind. :: 0 M I Agfa Witt uuth%c (C.A. 31," -00~ bem CWAM'i 41,41111 cl"Veic a. ki 1T1L'IIKmIv,. Ttw In imkinit -Id"I, so A,ut,. lot p1%.phates. d"ide. and Acti, mvi to) 1110 lort Ind 10 the Clot- IdISA1110 IsT wwww'I y"ot-tioluctle 110111.. -0. tkedcolkily. ortutivias %be YCAIAS thquagh ".11ifusatit I lit ell. %vato suot hestird - It. 111k,11cor 0 90, V LAB' OF ORGUIC & BIOWGIrAAL CMKMTRY OF THE ACADOff OF ? USSR,, MScoW zoo jt use .00 lit CLASSWIC'Mclo, WA~WrKAL L'Ifet,14; &%o S L A Ape -Lt Otto or of a a 3 1 -opt t It PC cc It It x 111-4 is It P, 1, 1, 69 It IS I 1 0 0 0 0 0 0 o 0 :Is 0 so', da The a' A. Dditacr and 1. V.. Samiko "Kvcv f iflifavot sm l ~ o . )" YAf l(Wam cfil~ IWater te; sa Vol. of 30 cc. awl twOM twilk)"- The Ill- I treated with 20% Na.,90~ solit, to remove Da fous, filter and mutritlized with 2N Snol-I agullist btolmot ymol blue, The resulting of add cc.) Is nifiled with 6 m 1.3% ~Nti CON 011). und'13 cf. I ter. hxuhatvil foc 6 miu, With -A%~l wit WITaW 111:11thilvil wit ,%-)I I aphist pheth1h)II ~ttut Kk mvisde, md, 'file adds" of 'M cv. MIN AS- X()~ it, Wl* 11101.4, ticid tilt the'Ag-RA wlt~ '17milluvra With 1 0 JlVm it of the Usk ml! A& it Im tilsid. Ill Ylvid hum 'I r %'Jit, [IV I Ilt. 4111114. ig R(Oll. Wvriler 311001"'If 4 BELITSER,. V. A d f h h M rate o t erniqdynan " e In blocitenil lave ti T Iklf d + M W A . (w t. onu. _ ocix-so Acod; M. _U i _~ Wokkin. Zkur; 18, 273-MON) (lit Ritulan).-InsWe the cell reactions occur which am op- purcittly Incompatible with each other, t hus eg. glueogo "lay 66'split by clixyllws Into lactic steld but abo fuld- 2 ide. atid COs. Tito rUttloil, I hCXW f, 1) tosphs -8 . 1111 cimspholyloto - KWO Cal 1 leV X i mile Mls, ittill lit the oppo ' -. . 1. on in I to Smethnes SH grotlps an used in Prot ving an S-S lhikage. and s=ewhcm the an I - ~ r Chemical Ab3t- of foratation :tbt" y'drolyzed. Ures an the enera 4 f 13 d h h l 2 diff h VOL 48 NO- t e ol er elements o AM c4. an y am cds for Its syntheshi: 2 NHs +HM'.14 M ent met U I " t t - 2% 19 Apr. W 2H0 +. 7100 cA.; 2 NR,* + 2 MCOs- - CO 11 290 All h O t N ff s i d6 . - Biological hemistry - , - . ca suc rmt ~2 Hj + 111 , app crepanda am casly understood If the laws of thermodynam- ks,xro ACOFbIlIlly applied 0 the cell Vx*8 t' ll= '12, l ith But inci The r v m e. - w o a e s pr ppme p y Irroveritible procemits Is undentood, If one Vistwim that the final readlon protlucV huMe the call might become ac tivi in a way not posobte'is Or& Thus e.r. glycom I' l If h 1l i A d D i l ow an can t react aga ls. e on am- o ng add6b, (A) I/a MH,A). + HO - 2 1;, (B) 3 HIM a creadne (U) - 0 phosphoffestine (M),-r 3 H:O' to 1/h (CjHw" + 3 lfsPOj + 3 U 214-3 M + Of Meet V. A. bftm (Aced. W it;~I-kZLA Baru Gutal B] 9 (J) ol The -mechanism of protein. denaturation. IL ~'Thi edenaturs. 9~;eLof the protein molecule. V. A- 1ff1 ' _ 14'&r an mffMr an -666i 1 S I = R u k 62 W Chemical Abstracts . . r. !lx ' in. Z r_20, 322-9 (in Russian, 330--l (1948); cf. C.A. 46, 8173h, lfwlb~-7 -14ay 25j, '1954 The action of urea (1) an egg albumin (ID is investigated In conms.*which are not enough to cause a complete denatura- iological Chemistry tion of the IT I*Ifp FM OM of I per- ml. After 5-10 Mr. min. at room temp. there is no obvious denaturation, Rs.11 does not ppt& at the isoelec. point and the amt. of HS groups titratable with Fe (CN)gl- does not change. But the oc- t t currence of a reaction is shown by the fact that the optical: rotation of the H increases about M'Vo and the III i Spec c vis- cosity increases 3-4-fold. For this reaction thee ression ptedenaturation (JIM Is coined. No definite exp 100 i h ven at t can be g It Is suspected that this e present time, state Is caused by a breakdown of the H boncting in the native protein mol. Denaturation Is not an 11911 or noth- Ing" step'&i was believed until now;. - this intermediate step definitely does exist, and perhaps there *111*be othirs.~; Certainly no activation energy Is needed for the M as It i t I h W -------- 7-1 -"_'-'~ n r se s t away at room temp. emer g _~ ----------------- MLITSER. V.A. Denaturation and the accompanying changes In proteins, Uspekhi Blol. Khim. it 33-69 150. 1 (MLRA 5:8) (CA 47 no.14:7007 '53) --