SCIENTIFIC ABSTRACT BLAHA, K. - BLAHA, K.

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BLARA, K. I i~ IICI Mechanization of cleaning cattle. p. 23. S-DIT-IM. IRADA r I'X"," ! S , A C L A ELEDT..MIMP.CE ZEM FWTAVI A MSTIRTZ. Praha. Vol. 211, No. 1, Apr. 1955. SOURCE: East European Accessions List (ETMAI) LibraxT of ConLress Vol. 5, No. 7, july 1956. 0 OU NTRI czechaslova'kiri CAT"I"GORY 1. AB3. JOUR. RZKhim., No. 20 1959, 110. 7JL,5~ .AUTHOR Blaba) K.; Sule, J. INST. T IT LE" Statistical Control Method in Paper Manufacture ORW. ?UB. :Papir a cel,0,, 1959, 14, Vo 21 30-31+ ABSTRACT ;k statisticial ,-Egulation method ha.5 made It T,osasibii~ -'L*.c, maintain within predetermined litaits the langti: of shects of paper out bY an automatic cutter, ana el~jj.51'4te pl'-c,~uctj.on of sheets that are off-size In length. It was fo,,uid that one of the knives wa-s functioning with a lowQr degreF of precision and caused grvaber deviations from the standard length, than the other knife. As a, result of the use of statist 'ical control method, savings in paper and cost have been attained. WD: NAM, K. Statistical acceptance In paper making. p. 255. PAPIR A CEWL05A.(Kinisterstio lesu a drevarskeho pawq lu) Frahajo Czechoslovakia,, Vol* 14, no* n. vov. 1959o Monthly List of But NAropew Accessims (IMAI) Up Vol. 9,, no. lp Jan. 1960 Uncl* BLAIIA, KARU Lzeen LA: 47:lU33 Ath RWkLF LUK6S Tech. Univ., Prague) Czech I'llie action of arignard reagents on tne ajidde 6roup. XVil. ii nt:w mutitocl fcr tiie preparation of tLi6ner dicaruoxylic acids." ~nem- Listy 46, 726-31 U952); cf. GA h5, 10245f BIAIIA, K.;LLIMS, R. "Preparation of Grignard Reagents from Vlll'-Ctibro-,i-n-alkanes."P- 450 (COLI X-TION OF CZECHOSLOVAK CIVICAL Ca-11-IMICATIONS. SBOMIK 0IIEKIIOSLO-iA-I!SKMH KTIMICHESKI-KH RALOT. Vol 18, no. 4, Aug. 1953; Praha, Czech. ) So: Monthly List of East European Accession3, (PEAT), LG, Vol. 4, no. 4, April 1955, Uncle* &CUM of Grin Anew gn 0d for On the Im C.A. ORNX:. - I I -a ~ I ~ -- . - v 61. MU-7-lVid , 5 - %,~ ---- e pa-awa.ii. , - - , - I- ~- , - ", 11 ~ y . . , - , r- - 7. i . BLAM4. K. ; FERMS, M. "Alkaloids with the '111yrrolizidine Ring System", P. 284, (CH&MICU, LISTY, Vol. 4B, No. 2, Feb. 1954, Praha, Czechoslovakia) SO: Monthly List of East European Acces3long, (EEAL), LC, Vol. 3, No. 12, Dec. 1954, Uncl. 7 !ALMWILIA e-Imd out. 1-y dt~-ocodiug' p fill r A, if 1 11, u CA I ,:t t d. ~V; Of 1 .3 N 11 .0 11 if I I v::t II N . 144-5`~, Th'. thm: )k:9 v-lt:ii it cis- (V) 11 vl~-Ilw'd olit,U ttwi. tcf27~11':t~ and a4ld 14-7-"' ro,7, R, I! V t-) IOC'I 1,CQ!) I kill" 11'. V.:V" TV. C). 1 va ~-f:' 0 -',;t, with :0�A) (A I t" 'kil. lv~!' "S~d VI. CZECHOWMAKIA/Ch-Ical Technology. Chemical Products and X-3 Their Applications. CautchukNatural and Synthetic. Rubber Abe Jour: Ref. Zbur-Khimlya, No 1,, 1958,, 3201. Author M. Felix, K. MWz. last Title On the Use of Statistical Methods in Rubber Ccmpo=dir.-. Orig Pub: Chem. prunwel, 1956, 6, vYP. T, 291-292 Abstract: Meisener and Schaetz's article (see preceding abstract) does not pay sufficient attention to experimental errors. Card : 1/1 CHECHO.MVAKIA/Orpnic Chemist4b Spt6tic Organic Chemistry. E-2 Abs Jour: Ref Zhur-Khlmiyaolo 6, 1957, 19193. By the Gringurd reaction, from C H MBr (0.656 mole C6- H5Br, o/695 mole mg) and ethyl eate? of cyanoacetic said (0-266 mole) In 650 cc absolute other (10 hours,-200) is obtalned eth I ester of 3- aminocinnamic acid ~V), yield 63~., b.p. A4-A50/lo m., 2oO o.16 m. From V 5g.) by boili it with alcohol 70cc), saturated HM (Sao), and Vater12.5 cc) in the course of 60 min. ethyl enter IV, Yield 57~, is obtained b.p. 1560/14 mm, the hydrolysis of which according to Kloze (see FzWihimp 1955, 9522) produced IV, yield 77op m.p. 990. Solution 1 (1 mole) Lnd IV (1,25-2.0 mole) In a buffer mixtu2v with a PH 3.3- 6.6 in left standing at 20-250 for 3-502 hours, acidified, extracted with ether III, evaporated and CHC13 III, which in isolated in the form of a picrate, m.p. 154-1550 (from water) is extracted. The optimal conditions of the con- Card 2/3 cifr,,.,ti,)-~-,LOVAICTA/Organic Chemistry. Synthetic Organic Chemistry. E-2 Aba Jour: Ref Zhur-Khimlya# No 6.. 195T, 19193- densation; proportion LIV a 1 mole: 1.6 mole, pH 4-T-4.9 (buffer solution cytrate-HU-NaOH), time 190 hours, yield in 46,,.. Card : 3/3 inn, oulv, ~ K. The meanine cf confornation in organic chemistry. p. 223. (Chemie, Vol. 9, no. 2,, Apr. 1957, Freha, Czechoslovakia) Bonthly Index of East European Accessions (EEIJ) LC. Vol. 7, no. 2, February 1~'58 J7,11, jjO3LOVAKTA / organic Cheimistry. Natural Subs'as- v and Their Synethetic Analogues. Abs Jour :Ref. Zhur, - Khimlya,, No. 15, 1958p No. 50499 Author :Lukes, R; BlaWL, K.; Kovar, J. Inst ,-T.- Title :Structure of Nitrogen-oontaining Substancea. III. Structure of Sedamine. OrI15 Pub :Chem. Usty, 1957, 51, #5, 927-936 (Czech); Collect ozechool. ohem. commun., 1958, 23, #2# 306-316 (Ger). Abstract :Stereolsomers of 2-(p-pheny1-p-oxyethy1)- piperldidine-nor-sedamine (I) and nor-allo- sedamine (II) form stereoisomeric 3,4-tetra- aothylone-6-phonyl-tetrdVdro-1,3-oxazlno (III) and allo-3,4-tetramethylene-6-phenyl-tetrahydro- Card l/ 7 CZECHOSLOVAKIA / Organic Chemistry. Natural Substances G and Their Synethetic Analogues. Abe Jour Ref. Zhur. - MalmlYal No. 15, 1958, No. 50499 1,3-oxazine (IV)-, upon reaction with HCOH. In a similar manner I and n-NO C HJ19 CHO M gave -806% 2-n-nitrophenyl-.5,4-?;trl'im6tbylenc-6- phonyltetrahydro-1,3-Oxazine (VI). At the same conditions 11 and V gave only - 20% of stereo- isomeric allo-2-n-nitrophenyl-,3-4-tetramethylene- 6-phenyltetrahydro-1,3-oxazine (VII). YIxture of I and 11 (1:1) with a mole of V yielded only VI. Compound VII may be hydrolized 60 times faster than V1. Only I led to the correspond- ing tetrabydrooxazine derivative, wit'.1i piperonal (VIII)o while II didn't react with VIII at all. Compounds derived from I were therefore most stable. Based on structure anslyete, I had an erithro, and 11 threo structure. Tharefore, oard 2/7 CZECHOSLOVAKIA / Organic Chemistry. Natural Substances G and Their Synethotio Analogues. Abs Jour Ref. Zhur. - Xhimiyaj No, 15, 1958, No. 50499 IX and X. Reduction of XI (after Methylation of I and Il with a general yield of 42%) with LWH4 yielded a mixture of IX and X (1:5.5) 1 m.p. 98-990 (from bon-one petr. ether); (I) hydrochloride m.p. 158-159. (from acetone CH30H) M.P.of: 11-112-1130 (fr. benzene-betr.- ether), II chloride 153-1540 (fr. acetone). From 1, 37% aq, HCOH and 95% HCOOH (12 hvirs 1100) IX could be prepared, 75% yield, m.p., 69- 900 (from pet.-ether). By analogy 71 yielded X, 82% yield, m.p. 67-680. 0.3 9 Ii in 4 ml glacial CH3COOH 85 mg CrO In 3 ml GH GOOH and 0.5 ml H20 t50-600, -90 min) gave il, 34% yield. Melting points of X1 and derlvaUves Card 4/ 7 CZECHOSLOVAKIA / Organic Chemistry. Natural Substane. G and Their Synothetio Analogues. Abe Jour Ref. Zhur. - KhImlya, No. 15, 1958, No. 50499 were; X1, B.P. 1650/8mm; plorate, 161-1620, bromide 182-182.50 (from aootone-ch 0H). From 0.5 g I and 0.375 S V In C6H6 (3 hoars of azootropic digtillation of water) VI was pre- pared (85% yield). M.P. of V1 and derivatives; VI 118-1190 (fr. ether-pet. ether), VI-Picrate 208-2090, Vi-ohlorobydrate 212-213 (from acetone- OH30H). From a mixture of 250 mg I and 250 mg II with 190 mg V were obtained 250 mg VI and 180 M of regenerated 11* 200 mg VI in -0,5 n HCl N8 hours, 200) yielded 165 mg VI. At 1000 VI was bydrolyzed to I and V In I hour, As do- oribed earlier 11 and V (upon chromatography) gave VII, 12.1% yield, m.p. of derivatives: VII - Card 5/ 7 CZECHOSLOVAKIA / Organic Ohemistry. Natural Substances and Their Synethetic Analogues. Abe Jour Ref. Zhur. -*Khimiya~ No. 15, 1958, No. 50499 125-1260 (fr. benzene pet. ether); picrate - 177.5-178-50. Boiling II and V in chlorobenzene for 6 hours, led to the formation of 42.b% VIIs which can be hydrolyzed in 3 hours to 11 and V (90%) by 0*5 n HC1, at I'l-200 . From 0.25 g I and 0.15 9 VIII., In boiling ohlorobenzene, 2- (3,4-methylene-dioxyphenyl)-3,4-tetramethylene- 6-phenyltetrah ydro-1,3-Oxazino, 0.205 g yield, M.P. 117-1180 (fr. pet. ether); picrate M.P. 2090 (fr. acetone - CH36H) was prepared. In bunzene this reaction could not be achieved. 11 didn't react with VIII, even In chlorobenze-e. upon reaction of I with an aq. solution ~f FICOH in presence of E2MS (10 hours, - 200) 111 was formed, 90% yield, B.P. 1750/12 mm or 1650/8mm, C,-rd 6/7 CZECHOSLOVAKIA / Organic Chemistrye Natural Substanc-, G and Their Synothetic Analogues. Abs Jour Ref. Zhur. - Khtmiya,, No. 15, 1958p No. 50499 m.p. 39-400v chlorobydratele m.p. 184-1860 (fr. acatonel, gigrate's m.p. 1400, chlorohydrate's m.p. 18 1 60 (fr. acetone) picrate's m.p. 1400 (from a1c). III could not te hydrolyzed appre- ciably upon t4iling with an aqueous-alcoholio sol. of H01.. -Upon reduction of III by LiAlH4 in ether (1.5 hour boiling) IX was fo d~ 81, rm:n %0 yield. A similar reaction of 005 11 mg iorates yielded 46 of IV, b.p. 160-1608 mm, 1) m.P. 1550 (from water). Upon slow distYllation of 130 wg IV with 10 ml alcohol and 1 ml ln HOL, 95 mg II were prepared. CH20 was also formed. Upon reduction of IV by LIAM4 In other X was ob- tained with a 156.0o yield. Article II, see R. Z. KhIm, 1957, 51108. 1. Card 7/7 CZECHOSLOVAKIA / Organic Chemistry. General and Theoretical Topics of Organic Chemistry. Abs Jour: Ref Zhur-Khimiya, No 189 19569 6o614- Abstract: The lengthening of the raeemate chain or of the optiually active a(-aminophenylacetic acid according to Arndt-Eistert reaction did not succeed, because chlorides of corresponding N-formyl- or N-tosylsubstituted acids did not produce diazoketoneso 392 g of 0(-phthalimi- dophenylacetic acid (I) chloridej melting oint 143 to "0 (from benzene) is obtained of & 9 of I and 10 ml of 30012 (1 hour boiling)$ that acid chloride# interacting with ether solution of CH2N produces c7, 4.7 x 10'~- The IR spectra of all WO are furnished. Card 5/5 CZ%CH/8-52-11-9/" AUTHORS: Kloubok, J. , loAf, J. and Bl&A. I- TITIM Z A Not-9 on the Hess Synthesis of Hygrins R synthese bysrinu) FMOPICA.Li Chemicki ListP 1958, Vol 52, Xr 11, y94 2081 - 2069 (Czechoslovskis ABSTRACTs The authors state that they are able to show that the Ness (Rof 1) synthesis of bjgrirA (1) actual does not yield a product Identical to the natural alk!Sid ut to Us isomer totrahydrooxatine (XII). The CneraLl Ross reaction of formaldehyde with &Ica la in the presence of hydrochloric &41.d at raised temperatures and pressure has been re-examinod with the use of a number of --- leg and negative results have been obtainecL In fact, Ease hics*191cibroed the editors of Sellatein's Handbook that the pr-3d=te of the majority of the alkaline oxidation reactions gave parbpas oxat,olidinas or totrabydro-axazines (Ref 10 - First Supplement, Vol 21, 4tb edition p 262. Springer, Berlin, 1935). The authors give extenalve practical details not only of the reaction of formaldehyde with a and 0 Cardl/2 isomers of 2-(P phenyl-P hydroxetbjl) piperIALne but of the reactions 0f Hess's "Hygrins". They conclude that there is no evidence for the 'Seen reaction- and that the first actual synthesis Of hygrine in tbAt Of F. Aorn (Chen. Obzor, 1945, 20, 136; Collections of the Czecho- slovak Chemical Society, 1941, 12, 245). There are 26 references, 5 Of which are Czech, I Soviet, 13 German and 7 English. ASSOCIATIONt Laborator' ~eterocyklick lo=rtnin, &skonlovensk; Skadomiq v vompouncal 1090cfMc-Ure5st-cyclic SUHjaTTXD: w-rch 24, 248 Card 2/2 4 "IT We 0) Am 1: The co:raftu- cl WtroM-conWaft compunds. V 13yath of batituted 44aknoc damummi, K. ov. Cum eAmer- -24, IM-tKigMim R"jlish).--Sft C-4. 32, 12SUft M. liud)kkl COUNTRY C=, CHOSLO VAKIk G CATEGORY Organic Chemistry. General and Theoretical . Problems of Organic Chemistry ASS. JOUR. RZIdii-M., ~-O. 23 19591 ;0- 62170 AUTHOR 'Kovar, J. ; Blaha, It. T IT U?, The Confl.guration of Con-po-ands. V1. '1he Coaigviration ot' Sl~bsti- tuted 2-aminocyclohexanols 0214. PUB. Collect. Czonhosl. Chem. CwDnuns, 1959, 2)1,, 111o 3, 797-803 ABSTRACT No abstract. See RZ-hK-hin., 1958, No 24, 11o 81:560 CAM: 06607 AUTHOR: Bl&ha,_Kax*j-. CZECH/8-53-1-3/20 TITLZ: On the Definition of the Term Alkaloid PMODICAL: Chemickif listy, 1959, Vol 53, Nr 1, PP 10 - 13 ABSTRACT: A review of t1io historical definitions and the group division of criteria (chemical structure, country of origin and physiological activity). There are 31 references, of which 3 are Czech, 9 German, 6 English,.2.Dutch, I Swiss, 1 Swatsh, 3 Spanish, 1'French, 2 Soviet and 3 international. ASSOCIATION: LaboratoF heterovyklickfch sloueenin, CSAV, Praha (Hetero-cyclic Compounds Laboratory, Czechoslovak Academy of Sciences, Prague) Card 1/1 PITHAp Jo; HORAKq Mo;.KOVAR# Jai-ALAHAs KO Configuration of nitrogens containing compounds* XI. The effect of configuration on the infrared spectra of some aminohydro.Vtotralinas Co3-l Oz Chen 23 no.lls2?33-2?45 N l6o. (Ew lo,6) 1. Laboratory of Heterocyclic compounds and Institute of Chemistryp Czechoslovak Academy of Science, Prague. (Nitrogen) (Spectrum, Infrared) (Amino froup) (Hydroxy compounds) (Tetrahydronaphthalene) w ZO/008A 1/000/001/001/005 0 E112/E253 AUTHORS: BlLa, K, and Forles, 1-1. TIME: Academician Rudolf Lukes. (Obituary) PERIODICAL: Chemicke' listy, 1961, No. 1, PP. 1-15 + 2 plates TEXT: Academician Rudolf Lukevs, D.Sc. who died on October 17, 1960 was Professor of Organic Chemistry at the University of Chemical Technology, Prague, President of the Czechoslovak Chemical Society at the Czechoslovak Academy of Sciences and Director of the Laboratory for Heterocyclic Compounds at the same institution. The present paper is an appraisal of his scientific and pedagogic achievements. Starting his career as a theoretical sugar chemist with E. Voto~ek, he concentrated later on the chemistry of heterocyclic compounds, this work being initiated by his discovery of the reaction of N-succinimide and N-methylglutarimide with the Grignard reagent. This method permits the lengthening of aliphatic acid chains by 4 or 5 carbons and makes readily avialable a nupAer of new heterocycles, e.g. pyrrolones. It was shown by Lukel that the two carbonyl groups in the cyclic imides display different functionalityg and that only Card 1/3 Z/008/61/000/001/001/005 E112/E253 Academician Rudolf Lukeg. (Obituary) one of them was capable of reacting with the Grignard reagent. During the German occupation of the country and the closure of the Czech universities, Lukeg worked for the Society for Chemical and Metallurgical Production, Prague, where he was concerned with the chemistry of furane and discovered an electrolytic method for the reduction of keto-di-carboxylic acids (reduction of chelidonic- to pimelic acid). A new reaction was also discovered during the electrolytic reduction of dilevulinic acid: In addition to the expected sebacic acid, valeric acid also formed by fission of -C-0-chain between both carbonyl groups. In the field of furane chemistry, the 2.5-dicarboxylic acid was reacted with ethylene glycol to produce fibre forming,monomers, similar to the poly- ethylene terephthalates. Work in the field of heterocycles, carried out at the above firm produced interesting results by the reduction of quaternary pyr dinium compounds with formic acids, leading to piperidine and A -piperidines. The latter products, which, so far, were not easily accessible, opened the way for an easy synthesis of a number of pyrrole derivatives. New methods Card Z/008/61/000/001/001/005 E112/E253 Academ Rudolf Lukes_, (Obituary) were to isolate and characterize the new bases and Lukes found that P-alkyl-substituted derivatives could be isolated as quaternary salts with dinitro-chlorobenzene. The last period of Luket' activities were occupied with the study of alkaloids and particularly with problems of their stereochemical relationship and biological syntheses. Preparatory work consisted in establishing the relative configuration of some aminoalcohol followed by determining the absolute configuration of a number of alkaloids (sedamine, hygrine, anabasine, etc.) The stereochemical course of many reactions, which could be taken as model substancesd for the understanding of biological alkaloid syntheses, was investigated. The work has not been completed. Lukeg and collaborators were the authors of text-books on Organic Chemistry 12 volumes) and Fundamentals of Preparative Organic Chemistry R volume). A list of original papers (189), patents (2). preliminary communications (35 , lectures in print (7), books and manuscripts (12) and others (7~ is appended. Card 3/3 LUKES, R.[deceaBedj; DIHNSTBIEROVA~ V,; KOVAR, J,; BLARA, K.. Configuration of nitrogen-containing compounds. XII.Configuration of W-balostachine. Coll Cz chem 26 no.2:466-470 F 161. (EFAI 10:9) 1. Laboratorium fur haterocyclisehe Verbindungen, Tachechoslowakisobe Akademie der Wissensobaften, Prag. (Motbylaminomtbylbonsyl aloobol) (Nitrogen) PITRkp J.; JONAS, Z.; KOVAR, J.; BLAHAp K. Configuration of nitrogen-containing eompounds. XIII. Proparstio". and tautomertm of aninooxaxoline. Coll Cs Chem 26 no.32834-846- Mr 161. (Ew 10:9) 1. Jetzige Adresm: Institut fur organisebe Chemie und Bioebsmi* Toebecloslowelisebe Akademie der Viasensobaften, Prag (for Pitbal. 2. Laboratorium,fur beterocyclische Verbindungen und Institut fur organiache Chemie und Bioebemis, Tacheehoslovakische Akadembs.Aer Wiamenschaften (for Jonas, Kovar and B14m) (Amincomsoline) (Nitrogen) BIAGA, K. [Blaha, K.]j FMSp M. In memory of Academioian Makes. Zhur.ob.khim. 31 no*10;3487- 3489 0 61. (MA 14t.10) (Iiukee, Rudolf, 1897-1960) WEST R. (deceased]; PITHA, J.i KOVARI J.; BIAMI K. Configuration of nitrogen compounds. Part 14: On the Unetics of solvolysis of condensation produots of vicinal aminohydroxytetralins with p-nitrobenzaldshydes. Coll Cz Chem 27 no.2-.328-336 F 162. 1. Laboratorium fur heterocyclische Verbindungen, Tschechoslowaldsche Akademie der Wissenschafteng Prag. 2. Jetzige Adresse ~ Institut fur cvrganische Chemie und Biochemle., Tachechosloaakische Akademie der Wissehachaften'. Prag (for Pitha and Blaha). BIARA j X, "General organic chemistry" by 0. Wichterle. Reviewed by .1~-Blahao Coll Cz Cbem 27 no.7%17W1748 Tl 162. St~ r In -,:t LA, n)ti~i~.j J..ic i c: j ~rv 7: 4. f-t-, Z.-.-l f M.-Ii-I t7 021.xta.,J. t.: er.f, 7- 0-1 A'~17---" ~h Of tn~ '..i 5. -.;~t 'r. ut, cr~,T-: of 'L1 Ar U Eli CZECHOSL3VAUk LURES, R; KOBLICOVAI, Z; BLAHA, K. I Laboratory of Heterocyclic Compounds of the Czechoslovak Academy of Sciences, Prague (for all) Prague, Collection of Czechoslovak Chemical Communicationsp Vol 8, 19639 pp 2162-2197 110g the Reaction of Angelicalaotone with Amines." CZECHOSLOVAKIA KOVAR, Jp JARY J; Blaha, K. Laboratory of Monosaccharides of the Technical Higher School of Chemistry (for h11) Prague, Collection of Czechoslovak Chemical Communicationst Vol 8, 1963, pp, 2199-2205 "On the Configuration of Nitrogenous Compounds XVI. On the Oxydation of Aminoalkohols with Periodic Acids." .BLLUI 1. "n".- .4 Im- ~-, no The 5th European 4yapooium on Peptide Chemistry in Oeorda, Chem Bity 57 no.31287-290 & 063, -&a&** 1 SOBOTKOVAI H.; KOVAR, J.1 BLAU)'K, , I i Data on the configuration of nitrogen containing compounds. Pt. 171 Coll Cz chem 29 no.8sl898-1903 Ag 161+ ( :11 le Inatitut, fur organische Chemie and Biochamie, Tachechoslo- wakische Akademie der Wiasensahaftenp Prague (for Blaha). 2. Spolana., Neratovioe (for Sobotkova), 3* Laboratorium fur Mono- sacharide, Technische Hochschule fur Chemie, Prague (for Kovar). TROJANF.KV J.; STROUP, 0.;-BIAHA, X.; DOLEX, L.; HANUS, V. - On alkaloids. Pt. 12. Coll Cz ahem 29 no.8:1904-1912 Ag 164. 1. Research Institute for Natural Drugs, Prague, Institute of Organic Chemistry and Biochemistry., and Institute of Physical Chemistryp Czechoslovak Academy of Sciences,, Prague. BUHA, Karal So.' I u S wt,-Ion c-1' v, transportati . h~lpm u-iine thq frea npthod. Stro4, n- zprac inf 10:241-250 164. 1. Technical and Economic Research lnsti!~uta of Cheuical Im..ustry, -rague. BLAffik, Karel; Pj1--IF-ANOVA, Bozeria Utrant from tile detailed flow chart for the oolution of the trans- portation problem. Stroj na zprac inf 10:26D-266 164, 1. Technical and Economic Research Institute of Chomical Industry, Prague. IMBEK0 J. (Jr); KOVAII, J,j, PIJEWSKA, L,,; SANTAVY, F. Rata, on the configuration of nitrogen containing compounds. Ft. 18. Coll Cz Chem 29 no.10&232&2340 0 164, 1. Laboratorium fur haterocyclisobe Verbindungen, Tachechoslowakische Ak-ademie der Wiseensahaften, Prague und Institut fur Chemie,, Vadizinische Fakultatt Palacky-Universitat, Olomouc. BLAHA, K,; MROUT, V. ............ Report of the 3d International Symposium on thr ^hemistr7 of Natural Substances hold in Kyoto. Chem lisiy 38 no.11t 1363-1366 N 164. - BLAHA, K.; FRIC, 1. Amino acids. Pt.46. Coll Cz Chem 30 no.1:304-315 Ja 165. 1. Institute of Organic Chemistry and Biochemistry of the Czechoslovak Academy of Sciences, PraMie. Submitted July 2, 1964. __.~_kAHA,_~,; RUDINGER, J. Amino acids and peptides. Pts.47,48. Coll Cz Chem 30 no.2: 585-604 F 165. 1. Institute of Organic Chemistry and Biochemistry of the Czechosl-,K Academy of Sciences, Prague. Submitted July 23, 1964. 2. Chief Fditor, "Collection of Czechoslovak Chemical Communications" (for Blaha). SANTAVY, F.; KAUL, J.L.; HRUBAN, L.; DOLEJS, L.; HANUS, V.; BLAHA, K. Constitution of rhoeadine and isorhoeadine. Coll uz unem 30 no-1:335-338 Ja 165. 1. Chemical Institute of the Medical Faculty of Palacky University, Olmouc (for Santavy, Kaul and Hruban). 2. Institute of Organic Chemistry and Biochemistry of the Czechoslovak Academy of Sciences, Prague (for Dolejs and Blaha). 3. Institute of Physical Chemistry of the Czechoslovak Academy of Sciences, Prague (for Hanus). Submitted July 22, 1964. BU111A, jK4 RUDINGER9 J. Institute of Organic ",hemistry and Biociiemi-stury of the Czecuoslovak AcadeLiy of Sciences, Pra--ue (for both) ci Prague, Collection of Czechoslovak Chemical Uoiviuni cations, No 10-1-1965t yp 3325-3331 &*** -.f "Ahaino Acids and Peptides. LVIII. Cyclization of Pel-tides with 2-EtIlYl-5-Phenylisoxazoliur-1-31-Sull-,Iionate.11 0 Z Ev'" WVA'.: I A v! !..WLv J, L; HIMBIU9 L; DOL:Z30 L; ILVIUS", V; BLMIA MOSSt A.D. 1.Chei:Udal Institute of tho FaCUlty of Palaclzy University, Olomouc (for Bantavy, icaulg Hruban); 2.. Institute of Organio Cheinistry -and Biochemistry, Prague (for Dolejsl Blaha); 3. Institute of Physical ~;hcmi3try. of the ~'Izec'ioslovak Acddomy of Sciences, Trague (for Uanus); 4 Syntax 'llesearch Center, Palo Alto, California, U.S.Ao (f;r Cross) Fra.-ae, Collection of Czechoslovak 'hemical -,ommuni cations, ito i0. 19659 pi~ 3479-3499 "Constitution of lUloeadine and Isorhoeadine.11 CZECHOSLOVAKIA FLAHA Y.- FRIC, I; JAKUBKE, D.H 1,Institute of Qrgnnio Chemistry and Biochemistry, Czechoslovak Academy of Sciences, PrEgue - (for Maha and Frio)& 2. Institute of Organic Chemistry, Martin Luther 'University, Halle (Saale)o German Democratic Republic - (for Jakubko) PrAgue, Collecti2p -of Czechoslovak 0hemical ko_m_m_un_l- eatloiLao No 2. February 1967,, PP 558-569 "AnLino acids and peptides, Part 67S Optical rotatory dispersion ofo~amino &old selonoaryl esters and some isologous phenyl esters." BTAHA, Karel, Dr. Styloid process as a cause of neuralgia of the glossapharyngeal nerve. Cas.lek.cesk. 91 no-7:216-218 15 Feb 52. 1. Z otolaryvgologicke kliniky university Irarlovy. Prednosta: prof. dr. Ant. PreceoMel. (MOMAL Bag" styloid process causing neuralgia of glossopharMeal nerve, surg.) (NMIM, GLOSSOPHAMMU, diseases, neuralgia caused by styloid process. surg.) MU IA K. BLAIIA K. Otolaryng. Klin.p Karlovy Univ. Praha. *,Diagnosticke problemy oto3m7ngologicke pri kilistove meningoencephalitide. Otolarynogological diagnostic problems in tick-borns meningoencephalitis Co"L.OTCLAR. (Praha) 1953) 2/2 (116-122) Description of a case of purulent sinusitis of the left antrum of Highmore and the frontal sinus. Cerebral and moningeal symptoms which did not disappear sinultaneously with the successful treatment of the purulent focal infection with penicillin suggested a viral superinfection. Uds was proved by the neutralizing test in the CSF for the virus of the Western type of epidemic seasonal tick-borne encephalitis occurring in wooded parts of Czechoslavakia since World War II. The epidemiological nature was explored and demon- strated, The action of this virus is stimulated by bacterial infections elsewhere in the body; otherwise it may be latent. Zia patient recovered. Bloch - Amsterdam (XXpllj8) SO: EXCERPM MICA, Section 8. Vol. 7., 140- 5 May 1954 Bua, K. a1--, ologic diagnostic problems in tick meningoencephalitle. 09sk. otolar. 2 no.2:116-122 June 1953. (CLML 25:4) 1. Of the Zarg Nose and Throat Clinic (Read--Prof. A. Prscechtelg X.D. ) of Gharles University, P!rW*,, EYCERPTA )MDICA See 11 Vol 9/7 O.R.L.- July 56 1110. BLAIIA K. and UNGAR U. Oto!3ryniz. Klin. SF,*%': Onkolog. f1st P.N. Praha. h Ktin-IMrriii-Wri a v(,sledky 166by Ca laryngu tnetodu Hzenelin d6vkovAni. The clinical cout-He and therapeutir rehult a (if the - Arealnicill of larvngval varrinonia t),v the melliod of re. CUlatpd do-4,ige W. UK. ftS. 1955, 94147-48(1283-1289) tt the, basis of the courses and results of the authors' treatment the following conclij- lions may be made: (I ) Ir ra if is *. ion ca r r ied u tit by the me thod uf re g u Is t e d do s a ge e n - ,bled the authors to cure small defined tumours of the vocal cords as well as ex- jensive pharingo- laryngeal tumours, and even those where cartilage was being destroyed. 13) It was eonfirmed thm the success of irradiation treatment was not dependent so much on the extent of the neoplastic proliferation, or on the duration o0ke disease, on other factors of which infection of the Lumour ranks first. (3) The sinus morgagni. rossa piriformis and tumours of the anterior with spread into the base of the epiglottis proved to be unfavourable sites to tumours that particularly resisted irradiation treatment. (4) As a post-irradiation complication perichundritis of. variable aetiology was observed. Its course was protracted but could he cured without surgical measures with antibiotics aided by vagosympathetic cervical blockade. (5) In cases resistant to treatment by irradia- tion which were later operated on, e5peciDIly in the ones where the laryngeal cartilages were involved, the pnst-operative healing was uneventful. (6) The treatment of laryngeal carcinoma is becoming complex and an integral part of the work of the radiologist and laryngologist. Authors' summary (XI. 5. 161 EXCERPTA MICA See 17 Vol 5/7 Public Health July 59 20G8. TIIE IIAZARD OF NOISE IN MINES - Itisiko hluku V hornivtvi -HlAha V. Krajjjkd hyg. Elad. Stanice, Udbor II)g. PrAve. knitrava 1012 (203-209) Graphs 14 i No t se cautted by instrunietilti rind machines in the minitig industry uttually surlsass- es.the limit considered by regulations as acceptable and safe. The great'est noise 'from machines and instruments in mines is caused by air engines running blank. When working, these engines are less noisy and the work changes their sound- spectrum. Ilower-driven machines are acoustically more suitable for mines than are air-driven ones. The harder the rock. the less favourable the noise from min- ing instruments. In coal mines. coal absorbs the noise. In the fight against noise, at the noisiest sources simple absorbers can be used with excellent sosults (tlar- bines), The spectrum of the noise of mining machines in in sonte instances very simple (almost pure sounds); in some instances it is a 'combined' spectrum. In practice. we must almost always assume complex sound spectra with a complicat- ed effect on the sense of hearing. 13MU, Ure 1; RMUMVA, I*& Diseases of the tipper respiratory traot In Iron workerB. Cook. otolAr 8 no.2168-77 Apr 59. 1. aRL )mtedra, vedoucl akadmik A. Precochtel ORL oddeleni FakcLltni polikliniky v Praze. produosta doe. dr. K. Blahs. (OGCUPATIONAL DISIONO romp,' tract'dis.-An iron workers (Cz)) (Mt-PIRATORY TBACT. die. 'In Iron workers (CS)) BLARA, I.; SIRMY, A. Vertigo caused by lesions of the cervical sympathetic eyetem. Cesk.otolar. 8 no.6:334-339 D 159- 1. OtorinolaryngologickR kRtedra KU. vadouci akademik A. Pro- cechtel. CEL oddeloul fakultul polikliniky, prednosta doc.dr. K. BLaha. (SPDM dim.) (VMIGO stiol.) BLAIIA,.K,,--HOUSTKOVA, E.; HLAVAC, J. Qualitative changes in the bacteria flora of the npper resDiratory tract In workers exposed to industrial poisons. Acta univ.& carol. [med.) Suppl. 14:229-236 161. 1. Katedra otorinolaryngologie fakulty vaeobeeneho lakarstvi University Karlovy v Praze, prednosts. akademik A. Preceolitel Otorinolaryngologicke oddeleni fakultni polikliniky., prednosta doe. dr. K. Blahad (RESPIRATORY SYSTEM microbiol) (AIR POLLUTION) (POISONS) (OCCUPATIONAL DISK&SES) BLARA, HOUSTKOVI, I.; MWAG, Jo On the effect of fluorine compounds on the upper respirator7 tract* Cesk.otolsrao no.i.--38-4z 7 161. 1. latedra ORL. vedouci &kRdemik A. Precechtel. (7WORIINS toxicol) (PIESPIRATMY SYSTEM dis) BI-ARAX, K.; HOUSTKOVA, E.; H~4VAC, J. Clinical patheloU of the upper respirat?r7 tract and lu7nx in velders. Cook. otelar-yng.-.12 ne.3:1614167 Jo 163. 1 1, latedra 01M fak. voeeb. lek. KU v Praze, vedouci prof. dr. K. Sedlacek. - ~JIARTNGITIS) (RHINITIS) OCCUPATIONAL DISFASM) (WMIKG) ;7 dr.; VYI-101,A, F.; Z.; Y , .1. Expo-rierxos with phagothorapy J.n otorhinolsryngolo~gy. C-isk. c.tolaryng. 14 no.2:66-69 Ap'65. 1. I;cit,edra cAorinolaryngologie TJDL v Praze (vedou,,~,' : doe. dr. K. Blaha); Ustav epidemiologie a mikrobiologie v F:-aze; a Katedra mikrobiologic UDI, v Fraze (vedouci: IfUD-.. L. S.Tmu-ekc, c,8,,. ). JEUICKOVA, Z.; TflJOLA, F.,- RYS,E.-, BLAILA K. doc. dr. The problem of Ireatarient of pyocyaneus infections. Gesk. otolaxymg. 14 no.2.-61-65 AP*65. 1. Katedra mikrobiologie UDL v Praze (vedouci : HdDr. L. Syrucak, CS-): Ustav e;Ademiologle a m1krobiolugle v Praza a Katedra otorinolarylgologie UDL v Praze dock. ir. K. Malla). CZECHOSLOVAKIA UDC 616.28-008-1:616.21-007-009.8-036.21 KREMENOVAp Je; ~IAQ. KS;_1HLAVAC,, J.; REISENAUER, R.; Research Institute or Endocri-nolo y (Vyzkumny Ustav EndokrinoloQieky), Prague, Chief (Prednostal Docent Dr K. SILINK; Otolaryngological Department, Plolyclinic of the Faculty Hospital (Otolaryngologie- -ke Oddeleni Polikliniki Fakultni Nemocnice), Prague, Head (Vedouci), Docent Dr K9 ZEMAN "Contribution to the Investigation of Endemic Degeneration. IV." Prague, Casopis Lekaru Ces1cych, Vol 106, No 7. 17 Feb 67, PP 187 - 193 Abstract fluthors' English summary modified 7: Investigation of the incidence of impaired hearing and-morpholo,ical anonalies of the ENT system in endemic degeneration showed the following: In the group of the Policka areamore disorders of the ENT system were found than in the Sedleany area. Outstanding was the incidence of deafmutism accompanying cretinism, and the incidence of cleft palate and lip. 1-jorphological anomalies of the face were more fre- quent in the Sedleany area. Qothic palates in impaired development of facial bones were frequent, In manifest cretinism perceptive hearing disorders were frequent in both groups. 4 Figures, 11 Tables, 12 Western, 7 Czech references. (Ms. roe. BLAHA, r"il, inz. Polycyclic impregnation of slesperis,.Zel dop, tech 12 no.1:8-9 164, 26911 Z/028/60/000/001/001/003 .61960 D244/D301 o, c AUTH016: Bl1ha, Karel and Machek, Josef TITLE: Linear programing PERIODICAL: Pokroky matematiky, fysiky a astronomie, no. 1, 1960, 28-41 TEXT: This is the first of two articles to inform readers on linear programming and methods for solving economic problems. The first article briefly describes the simplex method of linear programing and its appli- cation for solving the transportation problemg while the second article deals with applying linear programing to three concrete problems which were practically solved at the VOTE CHP - V~zkumn~ fistav technicko- ekonomick~ chemickfiho proumyslu (Technical-Economic Research Institute of the Chemical Industry). Czechoslovak industrial research centers are lately also paying increased attention to linear programming, the business application of which (transportation) has resulted already in great savings. In the introduction, the authors define linear programming Card L/4 Linear programting 26911 Z/028/60/000/001/001/003 D244/D301 as the solution of the problem to maximize or minimize a linear function of n variables under secondary conditions, expressed by a system of m linear equations (m4en), and the requirement that the solution be non- -negative; i.e. to select that solution (or those solutions if more are possible) of the infinitely many solutions of a system of m linear .4 equations in n unknowns which has all components non-negative, x i = 09 i = 19 29 ooo, nj and where the linear function of n variables, n f(x lto*09 xn x icis reacbes a maximum or minimum in the multitude of all non-negative solutions. The theoretical ;D!xplanation of the simplex method of linear programming, given in this article, is based on a pqper by A. Charnes-, W.--Cooper and A. Henderson (Ref. 1: An Introduction to Linear Programing, New York 1953), This is followed by an explanation of applying the simplex method for solving the transportation problem: Variables are identified by two indices i = l9oo.9 m; and j = 1,o*o, n* The transportation problem is to minimize the function f(x) = f(xlll*Oo Ox'd Card-2/4 26911 Z/028/60/000/001/001/003 Linear programming D244/D301 m n m E Z: o_Pjjxij in the multitude of non-negative solutions Z x ij = Pio. iF41 J=1 n iml j = 19 2. goon; r_ xij = qij i = 1,29 ooot m, where p, and q iare given J=l n a numbers satisfying the condition r pj Z: q,o The practical sense of j=1 i=1 the transportation problem in that numbers qij i = 1., 2, a represent the capacity m of sources of a certain product, numbers p, 1 3 11 29 ***9 n represent the consumption of this product at n places, x ij is the ex- tent to which the i-th source contributes to cover the demand at the J-th place of consumption (which therefore has to be shipped from i to j)$ and numbers c,j represent the costs for shipping the product units from the source i to the place of consumption j. In this case, the transpor..- tation problem is to minimize the total shipping costs. The development Card 3/4 269n Z/028/60/000/001/001/003 Linear programing D244/b30I of the.transportation problem# given in this article, is based on the English- language material by J. Machek (Ref. 4: A Note on the Solution of the Transportation Problem by the Sir~plex Method, easopis pro p9sto- v&ni matematiky (Journal for the Development of Mathematics). This article will be continued. There are I table and 6 references: 3 Soviet- bloc and 3 non-Soviet-bloc. Tho reference to English-language publica- tions reads,as follows: A. Charnes, W. Cooperl A. Henderson: An Intro- duction to Linear Programing, New York, 1953; A. Charnes: Optimality and Degeneracy in Linear Programming, 1conometrica 20(1952); J. Machek: A Note on the Solution of the Transportation Problem by the Simplex Method, Ltasopis pro pZstovAni matematiky. ASSOCIATION: V~zk. Gstav techn. ekonomic* chemick9ho prumyslu, Praha (Techni'cal.-Economical Research Institute of the Chemical Industry, Prakue) (Blftha); Hatekaticko-fyaikfAln'A. fakulta KU (Mathematical-Phvsiral Department of the Charles University) (Machek) Card 4/4 27W7 Z/026J80/000/002/001/005 B253/9304 AU*91_~__ 31"a, Karel'aad Macbokp Josef TIIMZ: Linear programing - Had Part Examplex for solving some problems PZRXODICALs Pskrolky natmetikyp rysthy a astronewis, no. 29 19609 199-14? TUTS This in the second of two articles to infers readers on linear programing and methods of solving certain transportation problems. The theory of the. 41mplex methed of linear programing and its application to transportation were discussed in the first article; this part deals with three practical problems solved at the The CHP - Tiz"i U'*Gtkv tochnieks- okenomicki Chomickooho 1~rfmyslu (Technical-Economical Research Institute of the Chemical Industry). The first in to find an optimum technology, namely the optimum adjustment of a plastio-fiber spinning machinot based an pro- viously achieved test results of a e*rtain toohnological sector character- ized by the variables x1p z 2 and 3~o The quality of the plastic fiber in Card 1/5 MtT Z/028/60/000,002/001/005 Linear progrommingees D253/D304 defined by the strength y and the elasticity a wbicbp in turaq depend on the technological parameters Np x 2. and x3. The problem posed is to find mob parameter valueng at vhiob the stron th y Is maximum and the elasticity u ranges between given limits 9 1 Is a 13 1vhilo production conditions roquire parameters limited to I X, & 39 2 S x2 6 59 and 0 3r3 if 4. The dependence of strength and elasticity on the parameterap as determined by previous Ustap ins y w 3970 + 0*10631i - 0.083X2 - 000121x~; Is - 70956 - 002583~ + 0055xp + 0929lx3p and the resulting problem is to aximise the linear function y(Zip X21 Z~) - 3,70 + !0,1063cl - 00 OSSX2 - : 001213r, under the secondary conditions of up %p x., and z~ listed above. After adjustment 'and introdaction-of mxiliaxy ~variablos (up to N.) for secondary conditions, thi p on is to maxidiihs, the function f(Xlq Zg,---t 3 1 - 00106, 02 0.083, 0 3 T- *,Z,, vbere a Card 2/5 1747 I/02SJ60/000/002/001/005 Linear programminge.e D253/D304 0,02219 a4 a C5 W 010 , 09 411 , a12 M 013 M. The final selu- Uon of the problem r9ades. Z4 M 4.2609 X, W 204019 xl a 3t %,, u 2, 3~ 1.859 x9 M 22 x3 - 2el5q mbich,soaaa that the fiber strength y in 3*8W, and the elasticity .,a is 8.91 whom parameters are adjusted to xl a 39 x9 a 29 and x:3 a 2.15. The second problem, quotoi as an example, is to minimize, losses' originating whom large reels of continuous paper are cut to real sizes as ordered by customers* Supposedly it in required to produce reels of the width rlp k. reels of the width r.9.,., and k reels of tho k i M width r -reeling a are determined according to p coefficients of re 91j"I + a2,r, , ... +, *,,ra + pJ a Rtils - It 29-1 Of 'Where R is the width of the original large reel, p iIs the least and a is the mmb*r of various systems which can be adjusted on the reel cutter. By intr ciag xJ as the number of connections of the J-th systea into the solut=(x J Card 3/5 r-71-1 7 Z/028J60/000/002/001/005 Linear programing... D253/MO4 can be 0 or a positive whole mombor), and by elimination of constants, the problem posed is tht minimize the function f(X) x The problem to find the minimum Iona is therefore idontital with that of findi:!dthe smallest amount of original reels to be cut; however, it is prefer to mininiz* the function f~ since p valu*s.can be *Iiuinattd from the calculation when the aimplex method in applied. The original table which contained 75 systems for the possible solution of the problem could be re- duced to 14 by eliminating those columns whose co&rfici*nta can be expressed by a linear combination of coefficients of other columnse The third example given in the solution of the transportation problem for a fertilizer dis- tributor supplying the prodects of throp-difftrent Froducers to eight dif- ferent consumers. Supposing that the entire production In consumed,- tAo basic solution of the problem in obtained by the ind,,%x method, which 'is based on the consideration that lowest freight rates be taken advantage of as much as possibles Tke algorithm for solving the transportation problem in found by aligning the initial basO solution into a table with exactly Card 4/5 27427 2/028J60/000/002/001/005 Linear programmingooe D 25WD304 a+ a - I - 10 fields fill*& ing and by making changes in the table until all free fields have corresponding sion-negative, differences. In conclusion, the authors state that these articles do not contain complete information. Zoocially important is the preparation of linear programing methods for automatic computers. A simplex-methed program for thq first Czechoslovak computer was prepared by 0. Pokorna" (Rof. 7j Instrue"ni sit' pro simplexavou motedu (Pro~raz for the Simplex Method) Zprava Vyxkumn"o uxtavu m&t4Wati- evch xtro 9 1958). The Adop analog computer developed by the Vyzkum4 If A Ustav matomatick~ch stroji (Computer Research Institute) allows transporta- tion problems to be solved according to a method suggested 1~7 Docent F. Welifts, (Rof * 31 0 jednom minimalnl~ probl. v toorii linearniho programs- vi6i (on One Minimum Problem in the Theory of Linear Programing) Skriptaq Matenaticki UfstaT &UVp Prague), There are 11 tables 'and 7 referencess 4 Soviet-bloc and 3 no&-Soviet filoce The reference to the English-langmage publications read* an followas Be M. Markowitzp A* S. Mann*& On the Solution of Discrete Programming Problems; Econometric& 25, 1957; Dorfman, Samuelsoup Solows Linear Programming and Economic Analysis, Now York 1958; Churchmaza, Ack9ff, Arnoffs Introduction to Operations Research, Now York 1957. Card 5/5