SCIENTIFIC ABSTRACT KHNYCHEV, S. S. - KHOCHOLAVA, G. M.

• Document Type: CREST
• Collection: Scientific Abstracts
• Document Number (FOIA) /ESDN (CREST): CIA-RDP86-00513R000722110020-6
• Release Decision: RIF
• Original Classification: S
• Document Page Count: 100
• Document Creation Date: November 2, 2016
• Document Release Date: September 17, 2001
• Sequence Number: 20
• Publication Date: December 31, 1967
• Content Type: SCIENTIFIC ABSTRACT

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N A-4-3 P.Mdiallon Trestments In Mommels

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In the
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Coolvel 014priltissides 14 Animal VrIne Fallovina Radlatine Dnese&#
P. D. GorlAttav. T. A. Fidoma. K F. Winest, Va. A. M,%" And V
l(Wisav,
Ch3nni In the level or DNA rnetabolhei of body fluids am a specific Index of radiation Oarnare. Ind the
estimation of their content In therning maysense as a good blochemicad lettibr this tbm;jc.Thq: test may be used
to nAloate therarcuticase"ll aprlicd for the treatment afradiation sickness, as vo at tor the evaluation ordrug,
protectims animals Against Irthal radiation doses.
Using paper cluomtovaphy and " exchansa column methodi, tievkv-
th)-midine, 4coxy3denosint and deoxytu3notine were Wnti&d in On uristil of normal and inajtatcd snimalt.
Qusntllall~e chartri In Their Conitnt In the 24 hr sporlmem of mi. mouse iuW dos urim %vrt established during
l
f
the covm otradistion diseases
nduvd by kthal dom O
X- And y-rays.
The dcoxyribosides %tre estimated In the erim of normal And Irradiated Itl following the transplantation to
them of the bone marrow cells.. This %r.- done In order to elucidate some asotco Of the mcchanism of bivcherniml
thantm and to evaloate therapeutic them It w-Is establhhed that The tramplantation of bone mffvw cells to
normal rats lowers the level of doosyributil4re tdcox"Idine Incheded) by 10 to 601A. Intravenous iftiection of
be" marrver celb to rats irradiated 961h lethal dries Alto lowrs the content or nuctrosides in the urine. 11 poinli
to the IntertsifK2 lion of DNA syntheiis. which has been inhibited by i radiation.
1~ft~ s/PaUkrnd-d~-Y W&k-,% Af-, tMA

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AccEmom as AT4o42653 510000161(000100010*610060
AUTHOR: Baranov, V. 1.1 0yurdthian, A." A. I 16mova, M. A. I 11adkevich, L. A.1
Tutochkina, L. T.1 Fedorova, T. A.1 Furayeval L. P.1 Kh0chov, S. 9.1 Artes0yeva.',
TITM Th&~sffect of gravit-t an the development of orpniv;n
SOURCEt KonftroAteiya po aviatelonnoy IkosmicMako.Y'seditioine. 196
AviatoiQnnPq& I Xcomicheakaya neditaina (Aviation and space'sedicine3j materialloi
konferentaiis Moscow, 1963, 56-60
TOPIC TAM gravitye. gentrifuge, orguiss development, phydologital function,
rat, chronic centrifugation, blood composition, urine componitions- Coriolis
acceleration j
AMRAOTS In this investigation, Baran Ioy ead his co-workerv designed a centrifuge
for small anisials with'aA era radius of,13f cm which could ka regulated to produce
artificial gravitational fields of frioji 4 to 5 S. The centrifuge was arranged
in such a way that the - arms and cages st; the end of the -arswi would simultaneously
rotate around their axes producing Coriolis a4etloratioDs. A single control panel
Card
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ACCESSIOM M AT4042653
regulated the photography and illumination of cage Interilors, Automatic feeding
of the animals. and the revolving rate of the centrifuge., It was possible to
record five separate physiological functions from some olmotally prepared animals**
Experiments were conducted on whtte.ratoq commencing on the firot day after birth
and continuing for 25 do... rUtLera consisting of 200 animals were divided into
experimental And control groups. All animals were born at approximately the
same time. Experimental animals were subjected to accelerations ranCing from 1.5
to 3 g for periodo of from 4'to 6 hours, 6 daya per week. The waighing of all
animals took place every three days no did biochemical asimys of the blood and
urine. tests of vestibular activity, and the determination of the time of sexual
maturity in female Animals. At the termination of the ox1mriment. a comparative
test of tfie rouponae'of be *t1i experimental and control saleals to brief accelera-
tiona,of 5, 10 and 20 g was conducted. After 20-25 days, the body veight of
chron~ically centrifuged Animals van 60--80% that of the controls. The compost-
tion of erythrocytes (89.6%). leukooltes (93.4%), and hemoglobin (99,1%) in the
blood of experimental Animals with respect to control animale reflected &
slightly anemic coadition.~ 17hile blood albumin in experimontal Animals was some-
what lower khan in the controls, serum mucoid composition iras highero indicating
a change of dystrophic ch6raoter. Urine assays of experimental animals showed
that the levels of Diche-positive substance Altrosev (62%), creation (31%),
Card.2/3'.

ACCUS
wo HR: AT4026~3
and creatinine were lower thanIthe toAtrol saimalil. Finally, the astral
cycle of experimental females was sign ficantly altered, though one female gave
normal birth to young. In the second investigation, controll animals exposed to
brief accelerations of 5 9 showed noticeable Increases in Ithe level of non-actaritiod
fatty acids, decreaseia in **no muccid,composition, and inareases in the Albumin-
globulin ration* However, at 20 S there was an Increase in serum w4caid composition
and a decrease in the albumin-glabulin rationa Bioehexia&3'variations in exparimento
al &nimals~eubjoctod to the "At accelerations were inaigniX Least. The authors
conclude that gravity plays a Complox.role In the physloloj;ical processes of the
developing organims but that the true ikohanism of this role is far from being
understooA.
ASSWIATION1 mans,
suamr=i 27"P63 zww~ 00 Ma GOD91 L6
no
W SOVI 000 02 1 000
Cara 313

NR3 APG001322
At,
0
600'rad each, Fou~ ases-,srer. ~A~,~Ing the course-j'
e d scern e iOf the
--a- -tion ( 1--r2 de follow
-disease -Phase-- I- -primary re c ing irradi~~tion),
ye
II--hidden (3-6. days), III -peik-_(7-45,days), lv-recoverj~-(201~130 days)
Detailed-descriptions phy'Olcal- appeavance and be-
-bavio - -of the'ani, _G: the four'pbases- 66 weii as of tbel'~changes
r - mal -during
found ~ in the cellular composition of the..bloodl", -bone marrow aw~ spleen-
changewin the 'clqtting~~..System ot the -blood- were"[ observe'
following irridiation: initial decrease. (Pbasii - 1) -followed -by"an in-
in the -coagulation time reduced .toleratice of plasma to'~beparin,
iminished prothrombini-acti ity, increased thr4~mbin time and filbrinogen
d v
concentration,- first -an increase- Jphase -1)-, then- a -decrease (Pbiise 111)
in thrombin -concentration,. reduced thermal ~stahility,_ the emerg:ence of
fibrinogen B, reduced fibrinase,and-increased JFibrinolytic activity,
.diminished - - p!-atelet - count and ---delayeA-retractit~n-of-tbe~-dlbt. 'The elee
~trom_ m-icroscope showed disturbances in the f iblq4n fibers -such ais rup-
ture and vacuolization., It is evid ent that th4i hemorrhagic sytdrome
appears in, the f irst -phase only- 2.4 hours. af ter'~ irradiation -as i.,ndicated
by tba-presence,of-blood.-in The - fe c'es at tb at i Ijo e. It can the [ refore i
c 0 __Aamage.. -to Ahe- blood, -ves-
be concluded that in acute radiation,ei kn so
eel walls -f irst---occurb ju the- and -0 -later
,gas rointestinal,~Aract nly
F-77
tb of--tbe--sk

BILUDA,, V.P.1 LYSOGOROVj,KV, C #."S,S.t ISHMUKHAMETOVA, D.N.p
FMWBNXOVA, Zh.N.; G1OANff06VrA_p_'f.'1 ALMAKOV, I.A.; SUSANYAlt, T A.,
Blood coagulation and its fibrinolytic acitivity in acute
radiation sickness, -Vent, AOI.SSSR 20 no,~9tVO_74 165.
(MIRA 18: 11)
Is Institut maditainskoy radiologii AMN SSSR, Obninsk.

RUDAKOVA, S.F.; ZHUKOVA, N.A.; KMCW S.~.; SUSAMAN, T.A.; KqZLOVA, r,.I,
Some now aspects of the effect of ?_.-aminocaprole acid
on the Organim.,Vest,, ANN.SSSR-20 no,9874-77 165*
()URA 18:1il
I* Institut meditsinskoy radiologii AMN SSSR, Obninsk.

ALEKSANDFOV, Nikolay Nikoloyevich; KOCHERGINAp Arms, Vasiltyevna;
POKHOVSKIY, Leonid Alekseyevich. Prinimal uchastiye
jW=N,,-Y-F-;.LOGUNTSOV, B.M., otv. red.; GEYW, L.M.,
red. izd-va; MAKSIMOVA, V.V., tekhn, red.
(Contemporary meahanization for working placer deposits] Sov.,
remennaia makhanizataiia. dlia rasrabotki rossypei; Bpravochnoe
posobis, Moskva, Gosgortakhizdat, 1963. 462 po- (MIRA 16:7).
(Hydraulic mining-Equipment and si%pplies)
(Automatic control)

KHNYKIN kand. tekhn. nauk
Compactness of hydraulic giant Jets and selection of the
optimum diameter of nozzles, Ugoll 39 noji.26-29 Vq'64.
(MIRA 17:5)
1. Inatitut gornogo dela im. A.A. Skochinskogo.

MARTMOV, A.A.1 KHNrKIN, V.I.
Distribution boundaries of lower Permianaalt-bearing sedimrits
in the Daiaper-Donsts Lowland, Trudy- UkrXIGRI no,500-33 16T.
Ninciples of the struatural regionalizatton and identification
of the promising uplifta of the Dnieper-Wnets Lowland. Ibid,934
(MIRA;1813)

KHNYKIAp.L*Ao
Phamacognootlo study of crude skullcap ~�autollaria lAicalers'is
Georgi. Apt. dolo n no.li27-30 Ja-F (NIRA, 1514)
1, Tomskiy meditainakiy institut.
(SKULLCAP (BOTANY)) (MMACOGNOSY)

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