SCIENTIFIC ABSTRACT KOZAR, Z. - KOZARENKO, T.D.

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• Collection: Scientific Abstracts
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• Original Classification: S
• Document Page Count: 100
• Document Creation Date: January 3, 2017
• Document Release Date: July 31, 2000
• Sequence Number: 15
• Publication Date: December 31, 1967
• Content Type: SCIENTIFIC ABSTRACT

HIRSCHLWWA, Zofia;.,,.KOZAR.,__gbl ow
Sabin-Yeldman test as a method of Investigation of the
resistance mechanism. Bull. Inst. Marine Trop. M. Gdansk
7:P-145-150; Russian tranel. p. 150-152; ftlish tranal.
P. 153-155 1956.
1. Z Panst. Inst. Mod. More. Trop. w Gdansku.
(TOZOPLASHOSIS, diagnosis,
dye test (Pol; Rue; Znglish))

EXCERPTA YEDICA See. 17 Vol- 3/3 Public Health Mar. 57
774. KOZARZ. Padstw. Inst. Med. Morsk. iTrop., Gdadsk. *Further in-
-vTe-sf'1gations upon occurrence of toxoplasmosis in Po-
land (Polish, Russian and English text) BIUL.PA~ISTW.INST.
MED. MORSK. TROP. GDAIiSK 1956, 7 (156-164)
Clinical diagnosis of about 400 cases of toxoplasmosis in human beings in Poland
was confirmed by Sabin-Feldman te8ts and In some cases by complement fixation
tests, although toxoplasma strains were not isolated. Tha authors consider that
toxoplasmosis exists among human beings in Poland. Zuckerman - Jerusalem

KOZAR, Zblgniew; SOSZKA, Stefan
Hormonal factors in the development of toxoplasmosts. Bull.
Inst. Marine Trop. M. Gdansk 7:165-168 1956.
I. Z Panst. Inst. Ned. More. Trnp. w Gdansku I Akad. Ned. w
Bialymetoku.
(GONADOTROPIRS, PITUITARY, effects.
(To on exper. tozoplasmosis (POW
XOPLASMOSIS, experimental,
off. of pituitary gonadotropins (Pol))

MZAR, Zbigniew: SZYKMKA, Helena
~-
Epidemiological investigations on intestinal parasites at a
psycbiatric bospital. Bull. Inst. Marine Trop. M. Gdansk 7:
169-180 1956.
1. Z Panst. Inst. Ked. Mors. I Trop. w Gdansku.
(HELMINTH INFXTIONS, epidemiology,
survey In psychist. bosp. (Fol))

EXCERPTA ITEDICA Scm 7 Vol. 11/7 Podiatrics Jn1Y 57
1873. KOZAR Z. and SZYMAf4SKA H. Padst. Inst. Med. Mor-sk. I Trop., GdaA~'_-.
VA cont-ribution to the frequency of Incidence of intestin-
al parasites among the rural children of the Gdadsk
districts (Polish, Russian and English te-,.t) MUL.PAt3TW.
INSTNED. MORSK. TRORGDAPS11, 1956, 7 (179-18G) Tables 2
The diversity of the rate of Infection with various parasites in children from
localities situated close to* each other suggests that it Is determin--d by local
factors. Some rural communities showed lower infection rates than the city of-
Gdadsk. Bals - The Hague (N-VII, 7)

KOZAR, Zbigniew
-------
Immunologic phenomena in trichinosis. Postep7 hig. mad. doew.
10 no.4:329-358 1956,
1. Instytut Medycyny Morskiej'Gdansk-Wrzoescz, ul. Hibnera 1 o.
(MICHINOSIS, immunology,
review (Pol))

KOZAR,,,,Z_,,...
Polish Parasitological Society. Zool.zhur. 35 no.6:947-948
Je '56. (MLRk 9:10)
1. General'W sekratarl Glavnogo upravlonlya Pol'skogo
parazitologichaskogo obahchestva.
(Poland--Parasitological societies)

KOZAR, Zbigniew
-
Ten years of Otivity of the Parasitological Laboratory of the
Institute of Marine Medicine In Gdansk. Viadomosci parasyt.,
Warsz. 3 no.1:19-25 1957.
(PARASITOWGY
Parasitol. Laboratory of Institute of Marine Had., Gdansk,
Poland. activities (Pal))

KOZA-11. Zbigniew
Critical survey of research on nroblems of medical parasitology carried
aut since the lant meeting (11)54-1956) 'diadomosci parasyt., Warss.
3 no.2-3:10?-148 1957.
1. 1 Instytutu Medycyny Morskiej w Gdansku.
(PAWITOIDGY
research in Folnn(l (Pol))

KOZAR, Zbigniew
Institute of tropical medicine in Hamburg. Wiadomosci parazyl.,
Warsz- 3 no.5-.505-514 1957.
(MIDICIN3, TROPICAL
BernhArd-Nocht Inatitut fur Schiffs. & Tropenkrankheiten
In Hamburg (Pol))

EXCERPTA YEDI^IA Sec 17 Vol 512 Public Health Feb 59
713. SEARCH FOR A RESERVOIR OF TRICHINELLOSIS IN SMALL MAMMALS
OF rllE BIALOWIEtA FOREST - PoszukIW2nie reterwuaru w1odnicy wAr6d
drobnych ssak6w Puszczy Bialowieskiej - Ko z ax Z. and W a r d a L. Zakl.
Parazy1ol. Inst Med. Morsklej, Gdailsk - AT-T-A-P-A-WASIT, POL. 1957.
5/ 13-21 (481-485) Tables 1
1,759 small forest mammals (6 species of Insectivora and 11 species of Rodentia)
caught in the Dialowieia National Park during a few years were examined by the
compression method. TrLchinella were never found, Contrary findings by other
workers are discussed. it is suggested that the Trichinella larvae were confused
with the larvae of other nematodes (e.g. of the genus Porrocaecum), which were
found by the present authors as well.

WZAR, Zbigniew
Proper position of medical parasitology. Polski tygod. lek.
12 no-7:257-260 11 Feb 57.
1. Adres: Gdansk-Wrzeszcz u. Hibnera 1c. Instytut Medycyny
Morskiaj.
(PARASITOLDGY
in Poland, review (Pol))

"AM , Z.
...
Yifth Congress of the Polish Parasitological Society in Warsaw,
Hadeparas. i paras.bol. 26 no.2:248-250 Mr-Ap 157. (KW 10:7)
(POLAM-PARASITOLOGY)

PowiD/zooparasitology - Parasitic Protozoa. Flagellates. G.
Abs jour : Ref Zhur - Biol., tic) 21, 191518, 95285
Author : Komi-, Zbigni,-w
Inst :
Title : Problom of Toxoplasmosij thc Coigress oi, Parasitology
in Prague.
Orig PLfb : 'Riadom. parazyt,--jI., 1958, 4, NO 1, 39-49
Abstract No abstract.
Card 1/1
4

Control of TrIchinella and tapevorms. Viadomosci parazyt., Warss. 4 no.
3t2ll-218 1958
Z Instvtutu Kedycyny Morsklej v Gdanska.
(TRIGHINOSIS# prevention and control,
in Poland (?o1))
(TAPEWORM INFECTIONS, prev. & control.
same (POI))

7EX6FRP A nDICA ISee 4 Vol 12/9 Med. Micro. Sep
59
2909. ACTION OF HYALURONIDASE 014 INFECTION WITH TOXOPLASMA
GONDII IN NUCE - Wpfyw hiaruonidazy na zakaienle Toxoplasma gondii u
myszy - K q z a r Z. Zak?. Parazytol. PAN, Warszawa - WIAD. PARAZYT.
1958, 4/5-6 (427-430) Tables I
Hyaluronidase was prepared according to the method of Freeman et 21., and stan-
dardized according to Kass and Seastone. Despite a certain toxicity of this prepar.
ation with respect to Toxoplasma, accelerated death of infected mice after hyalur-
onidase treatment was demonstrated. Application of hyaluronidase may be useful
In Isolation experiments. Adamski - Poxnafi

EXCERPT.A FEDICA See 17 Vol 5/9 Public Health Sept 59
2607. INVESTIGATIONS ON THE EPI[JFMIOLJDGY OF 'roXOPLASM0516- BY
MFANS OF TUE INTRADERNIAL 'rEST - Batianin nad epidemiologil tokso-
phtzmuzy przy pomocy prdby Arddskdrnej - K n z a r Z. Dept. of I'arasilol.,
Polish Acad. of Scia, Warsaw - ACTA 6!8-21 (225-
249) Tables 4 Illus. I
In the Bialystok palatinate, 1.410 persons were tested int rade rni ally with an anti-
gen prepared by the author: 39% reacted positively. Among the various localities,
the proportion of positives varied from 19-7G',"o. Of the women 441a were positive,
of the men 309,'*. This difference may be traceable to it closer contact of women
with animals and their products. The incidence of positive reaction-4 increased with
age. the maximum for women occurring from 30-60 yr., that for men from 5U-
60 yr. Of tile various professional groups, sanitary personnel such as 11lidwives,
nurses, etc. were most frequently positive (71%). The author states that in tile
provincial hospitals sanitary conditions are often poor. Remarkably, tile second
most affected group was the Intel lige nt sia, with 560i. positives; in this group. tile
.men had far more positive reactions Min the women. The agricultural and house-
keeping groups showed 4516 positive reactions, the school youth 35%, anti physical
labourers 24%. Intradermal tests with both toxoplasmin and trichinella antigen
atthe same time were givento 1,326persons. In 65% of these there was agreement
of results; ir 50% both tests were negative; in 1476 both tests were positive. Of the
35% where there was no agreement, the toxoplasmin test was positive and the test
for trichinosis negative in 23%, while in 1216 the former test was negative and
the latter positive. De Roever-Bonnet - Amsterdam (XVII, 50)

F,'"TA -.D'L^,A 7 Vol 13P PPdi atrics Ailv. 59
2131. INVESTIGATIONS ON TRICHINOSIS WITH THE HELP OF THE INTRA-
DERMAL TEST.I. THE SIGNIFICANCE OF THE INTRADERMAL TEST
IN FRESH AND OLD INFECTIONS - Untersuchungen (lber die Trichinelloss
mittels des Intradermaltestes. 1. Bewertung des Intraderinaltestes bei
frischen und alteren Infektionen - Kozar Z , Kolloto B. and
Ward& L. Inst. Air Meeres- uti7fr'o~ejmed , GdaAsk- Sanit. Epiderniol.
Station, Bialystok - Z8L.BAKT.I.ABT.ORIG. 658. 172/1-2 (164-174)
Tables 4
it preparation of Iyophilized antigen from Trichinells, spiralis larvae, obtained
from an artificially infected pig, was made by Witebsky, Wels and Heide's
method (N. Y. State J. Med. 1942, 42, 431), 0.1 ml. of the antigen In 1: 10,000 dilu-
tion was Injected into the skin of the forearm, and the result read after 30 min.
I hr. and 24 hr. Two groups of patients were tested. The first group consisted of
180 subjects who. had contracted the infection 7 to 28 days previously. The 2nd
group was composed of 99 po.-rxons who had been Infected with Trichina not less
than 6 months, and In some cases as much as 20 yr. previously. In spite of con-
siderable variations In its Intensity, the test was found specific and rather sensitive,
It first became positive about 20 days after Infection, and remained positive for as
long as 20 yr. The Intensity of the infection was found to somewhat influence the
time of appearance of the reaction. and also its duration. In the first weeks of the
disease. appearance of the reaction was accelerated; in the late stages. delaye4.
V
ighelyi - Budapest (L. 6. 7. 17)
d
7

fiCERPTA. MEDICA. -See 17 Vol 5/6 Public Health Ju'ne 59
1691. MESTIGATIONS ON TRICHIXOSI.,; WITH TIM IIELP OF THE 1%.rRA-
DFRMAL TKST. U. EPIDEMIOLOGICAL DIVESTICATIONS IN THE AREA
OF BIALYSTOK - Untersuchungen tiber die Trichinellose mittels des Intca-
dermaltestes. 11. Epiderniologische Unicrsuchungen im Gebiete von Bialystok -
K o z a r Z, K o I I o t o B. a~d W a r d a L. Inst. f(ir Meeres- und
'T75-1,enmed. , Gdafiak; Sanit. Epiderniol. Station. Bialystok . ZBL. BACT.,
1. ABT. ORIG. 1058, 172/1-2 (175-183) Tables 3
For years, the highest incidence of trichinellosis in Poland has been reported from
the northwestern region of the country, the area around Bialystok. This area in-
cludes part of a virgin forest. in the Russian part of which up to 51'. of the animals
were found to be infected. To establish the human Incidence of trichinellosis in the
area In question. some 2,500 persons were subjected to the Lntradermal test. A
positive response was obtained in 38116. Postmortem studies in Bialystok revealed
an over-all infection rate of 15%, with 4616 In the 31-40 yr. age group.
Wghtlyi - Budapest (L. 17)

KOZAR,,;~~gniew ,
Problems of pathogenesis and therapy of trichinellosis. Postepy
hig.med.doew. 13 no-5:587-628 '59-
(TRIGHINOSIS)

KOUR. ZbIgniev
Hundredth anniversary of the discovery of trichinosis. Wiadomosci
parasyt., Wwrsz4 6 no-10-10 160.
(TRICHINOSIS hist.)

KOZAR,Zbigniew
Reflections after a visit with Bulgarian medical parasitologists.
Wladomosol parazyt., Varsz. 6 no.1:41-52 160. -
(PARALSITOIOGY) "- ,

KURYLO-BOROVSKA, Zofia; KOZAR, Zbiguiew
The general chemical composition of muscle trichinella spiralie
larvae, Wiadomosci parazyt. 6 no.4:357-359 160.
1. The Institute of Marirm Medicine in Gdansk and the Department
of Parasitolog7 of the Polish Academy of Sciences in Warsaw.
(TRICHINELLA ahem)

KOZO, Zbigni6w; KOZIR, Naris.
Influence of muscular work and other factors on the course of
the invasion of trichinella opiralis. Windomosci parasyt. 6 no.4:
363-366 160.,
1. Department of Pares itolo Polish Academy of Sciences, Warsaw.
.(TRICEIMOSIS

- KOZAR, Zbigniew
Studies on the problen of the role of toxoplasmosis in obstetrics.
Wiadomosci parazyt., Varsz. 6 n0-5:399-414 160.
1. Zaklad Parazy-tologii PAN, Warszawa.
(TOXOPLASMOSIS In pregn)
(PREGNANCY coMl)
(ABNORMALITIES etiol)

NOZAR Zbianiew
Certain pathological and di W ontle:probless In toxoplasmosis
and.trichinosis. Pat. 'Isks 11 no.4:4W-416 160.
PO
Z Zeklada Parssytol4il lust. Kedycyny Norskiej v GdAnsku,
Kierowniks docdr Z. Nazar*
(TOMPLASKOSIS)
(TRICHINOSIS)

I I
KOUR,-Zbi ew
- ~b~
Mechanisms 6f invauionand migration of parasites in host's organism.
Wiad. parazy-t. 7 no.3t#41-559 161.
1. Katedra, Parazytologii i Chorob Inwazyjnych WSR, Wroclaw.
(PARASITIC DISEASES transm) 1FROTEASES metab)

KWj Zbigaiew
Considerations on the epidemic of trichinosis in Mosin. Wiad,
parazyt. 7 no.3:587-594 161.
1. Katedra Parazy-tologii i Chorob Inwazyjnych WSR, Wroclaw.
(TRICHINOSIS epidemiol)

KOZAR, Zbigniew (Wroclaw, Norvida 29)
-- ------
Some scientific and practical problems concerning toxoplasweis,
Viad parazyt 7 no-4/6:867-M4 16.
1. Katedra Parazytoloaii i Chorob Inwazyjnych, Wyzsza Szkola
Rolnicza, Wroclw4.
X

KOZAR. Zbi ev, prof.
gni
Activities of the- Polish Parasitological Society in the years
1948-1960. Nauka Pol 9 no.4:179-169 O-D 161.
1. Przewodniczacy Polskiego-Towarzystwa Parazytologicznego,
Wroclaw, u1. C. Norwida 29.

rn
SUXIANZ, Given Names
4
Country: Poland
Academic Deerees: Prof Dr.
lty of Parasitology and Invasive Diseases (Kate6ra
Director Facu
Affiliations Parazytologii i Chorob Inwazyjnych), Wydzia
Waterynarii), College of Agriculture (W8R--Wyz;za Szkola Rolnicza,
Wroclaw
Source iWarsaw, yALIyonrt 1-jotgrynaryin Vol XV119 No 6# june 1961, pp 332-
DOAA4- -336.
Data: "'Trichinella Free,1111
ON 961643

I
M. !
KOZAR, Zbigniew, professor
4 -- . I '. -
The Polish Parasitological Sociity. Review Pol Academy 7 rio.1:63-65 Ja-YIr 162'
1. Chairman of the Polish Parasitological Society, Wroclaw, u1.
Norwida 29. - -

KOZAR, Zbi iew, oserstary of the..co=iasion
The met outstanding actual tanks of the International Co=isoion on
Trichinellosis. Wiadomosci~para~yt. 9 no.l: 11-16 162.
1. Department of Paraoitologyp.Norwida-29, Wroclavp Poland.
(TRICHINOSIS)

KOZAR, Zbigniew
Summint~ up of the conferenceD on the problems of toxop1wmosivin
men and animals. Wiad parazyt 7 no.4/6963-965 161.

KOZAR Z -
',,,I
Tfie review of current literature on trichinellosis. Wiad. parazyt. 8
no.6-.651-701 162.
(TRICHINOSIS) (BIBLIOGRAPHY)

KOZAR, Zbigniew
Progrese in the therapy of helminthiases of domestic animals.
Wiad. parazyt. 9 no.33211-228 263,
1. Katedra Parazy-tologii i Chorob Inwazyjnych WSR, Wroclaw.
(HOPOR DISEASES) (CATTLE DISEASES)
(STRONGYLOIDIASIS) (OXYURIASIS)
(TRICHOSTRONGnOSIS) (REU4INTHIASIS)
(FASCIOLIASIS) (ANTHEMINTICS)
(PARASITIC DISEASES)

KOZAR, Zbigniew; KOURp Maria.
The course of experimental trichinellosis in micee Methods
of infectian and the influence of carious invasive doses on
the mortality and weight of the animals. Wiad. parazyt. 9.
no.5:403-418 1163.
1. laboratory of AnthropoiDonozes of the Department of Par-a-
sitology of the Polish Academy of SciBnees and Department of
Parasitology, Veterinary Faculty, College of Agriculture,
Wroclaw.

KOZAR, Zbigniev;SLADKI, Edward; KOM, Maria
Studies on the possibility to make use of pharmacological pro-
perties of azulenes for the reatment of acute and chronic
trichinellosis. Viad. parazyt. 9 no.5*.419-434 161.
1. Iaboratory of Antropozoonoses of the Department of Para-
sitology of the Polish Academy of Sciences and Department of
Parasitology Veterinary Faculty, College of Agriculture in
Wroclaw, and the I Clinic of Internal Diseases, Medical Aca-
demy In Lodz.
)L

KARPIAK, Stanislaw,E.; KOZAR URYOKI, Marian
Ghanges in the metabolism of the skeletal muscles of guinea
pigs caused by the invasion of Trichinella spiralis. I. In-
fluence of the invasion on the carbohydrate metabolism of
muscles. Viad. parazyt. 9 no.5t435-446 t63.
1. Laboratory of Anthrophozoonozes, Department of Parasito-
logy Polish Academy of Sciences, Wroclaw.
4-

ZARZYCKI,, Jan; KOZAR Zbignievr; CZAJKOWSKA, Jadwiga.
Supravital staining of the intestine and muscle tissue during
infection with Trichinellae. Viad. parazyt. 9 no.59447-451 163.
1. Department of Histology and Embryology, Veterinary FRoulty,
College of Agriculture, Wroclaw, and Laboratory of Anthropo-
zoonozes of the Department of Parasitology,Polish Academy of'
Sciences, Wroclaw.

KOZAR, Zblt~iiev; KARFIAK., SA-Lanislaw; ',R2Y?,ANl(jJ33KT, Mirjwi, F'(CAR,,l-'arlrA
Metabolism of Trichint!lla spIra,"tzi lanrae. nv,rr~?yl- 10
no.4.,2F.O-281 t64
The effect of tTrichiw~Ua spix~a Cn- fat`i,6 i
.
and enzm-e activ y of the Krebs 'In :02etal munnies ~f
guinea pigs. lbid.:282-~~83
_1~)g; 7~01g - L d m-,
., I -- L k e 1 Lim e * i
1. Fracownla Antropczomcz Zukladti
Nauk, Katedra Parazytolog". i Chorob I Kafedra Chemli
Flzjologiczne~ `Ilyzsma-2 Szkolly Rolnlcze4, '~,rc-law.

KOZAR i Al'j.. ZV.GKTj Jan; 33111UTA, Fzza; IRARTYNIOWTU, Trideusl;
KASSNER, krzv
"-!istochemical studies on the Jntestlnal phase of -Itrichl-nosis in
mice. Wlad. parazyt. 10 no.4t293-291* 164
1. Pracownia Ant-ropozoonoz Zakladu Parazytologit Po'-,klej Akad-!~mii
NaiA, Wroclaw; oraz Katedra Parazyt.ol-agiL I Chorob In-wawjnr-h i
Zaklad Histologli Vyzszej Szkoly Rolnionej, 'groclav.

KOZAR, Zbigniew; OGI=KI, Leslaw
Trichinosis in pJgs in Poland. Wiad. parazyt. 10 no.4:352-353
164.
1. Pracowria Antropozoonoz Zakladu Parazytologii Polsklej
A'kademii Nauk i Katedra Pa, azytologii i Chorob '-,iwazyjnych
Wyzszej Szkoly Rolniczej oraz Katedra Higieny SrocU--.ow Spo-
zywczych Zwierzpcego Pochodzenia, Wyzsza Szkola Rol-nicza,
Wroclaw.

Chronle trich-Incs-is la, dl3eV.!;e3 f)f t~'U and a -:;I
S-,(stems. Wlad. paraz~it. 10 16
f'a-r%,
,U,ademl I Ilauk, Vrvc-I.%,rp Ix'I "l, or ~-,b z" I L?.I!
Medycmej, lodz.

K07 AR, Mar'a; KOZAR, ~bigrclew~ YAITATIT~,, f,-Lryntyria
Z, I .
romwirri!A1.1a 131,raluaLion of tasts in the
Of trichiriosis. 'ellad. pjjxav,,,-L. 10 n,-,.4r34-!-"46 I il' 4
I . , ta FU--a z ~to I c, g I I I ~c Is k i ~,- i
" `ta,~ovm- Antropozo(moi Zaklada
Aka-demli Nawk~, i Katedra I Clti3n~b
wazytayr:ih Vrzszej Fzkoly Rclnic~:e,',

Y(-,'Z,AR, 73bignisw; EURCTO, Vladyslav
....... :.,.- ~. - - - , - .
Epidemikologir ,itudy of tv.-O.-h4no.91a by mpan8 of th~, skiri test
on Inhabitants of Mlechow In Cracov region. Wlad. parazyl~. 10
no-4050-351 164
1. Pracownia Antropozoonoz Zakladu Paravytolo-afl. Folsklej
Akademli Nauk, Wroclaw I. Puwiatowy Vydz-',a1 Zdrowia,

KOZAR, Zbigiiew; KOZAR, Maria
Comparative studies on the infectivity pathogenicity of
Tri,chineLla spiralis straiii.9 from Poli3nd and Africa. Iliad.
parazyt. 10 no.4:358-3559 161,
1. Pracownia Antropozoonoz Zakladu Parazytologii Polsklej
A'kademii Nauk, Wroclaw i Katedra Parazytologit I Chorob
Inwazyjnych Wyzsze.1 Szkoly Rolniezej, 'Wroclwt.

lja__j SLADKI, Edward; ZOINTERKOWA, Danuta
Lq4R,_P iew
Clinical aspects of chronic trIchinellosis in people. 1.
Periodical examinations and therapeutic trials in patients
with chronic trichinellosis in the light of recent patho-
genetic considerations. Wlad. parazyt. 10 no.6t651-663 164
1. Laboratory of Antropozoonoses of the Department of Para-
sitology, Polish Academy of Sciences, and Department of
Parasitology, Veterinary Faculty, Vroclaw, Poland.

KOZAR, Zbigniew; SLADKI, FAvard; ZAK, Edward
Clinical aspects of chronic trichinellosis in people. 11.
Studies in patients with chronic diseases of the motoric
system. Wiade parazyt. 10 no.6t665-671 164
1. Laboratory of Antropozoonoses of the Department of Para-
sitology, Polish Academy of Sciences, and Department of
Parasitology, Veterinary Faculty, Wroclaw, Poland.

KOZAR, ZbIgniev; SLADKI, Eft-ard
Clinical aspects of chronic trichJ-nellosis in people. 111. Ana17iils
of clinical and anatomopathologia diagnoses of -.asev in which
a
Trichinells. infection was detected in pogt-mortem eymminations.
leflad. parazyt. 10 no.6z673-690 16-1
1. Laboratory of Antropozomoses of the Tir-,rart4nent of Parasitolog7,
Polish Acacimy of Scionoes, and nepar'ment of Paraaitology,,
Veterinary Fsaulty,, W~7oclaw, Poland.

KOZAR., Maria; KOZAR, Zbigniew; KARMSKA, Krystyna
The comparative evaluation of some agglutination tests in the
diagnosis of trichinellosis. Wiad. parazyt. 10 no.6t717-737
164
1. Laboratory of Antropozoonoses of the Department of Parasitology,
Polish Academy of Sciences and Department of Parasitology,
Veterinary Faculty, Wroclaw, Poland.

KOZAR, Zbigniew; KURCIO, Wladyslaw
Epidemiologic investigations on trichinelloBis by means of
allergic test in Hiechow districtj, Cracow voivodeship.
Wlad. parazyt. 10 no*6e739-746 164
1. Laboratory of Antropozoonoses of the Department of Parasito-
logy, Polish Academy of Sciences and Department of Parasitologyp
Veterinary ftcultyt Wroclaw, Poland.

1~20~~~
The role of the Polish Parasitologia Society In the develop-
ment of parasitology in post-war Poland. Wiad. parazyt. 11
no.lt9-21 165.
1. Prozes Polskiego Towarzystwa Parazytologinnego.

KQq.M,-Zbjgujv&, KARPIAK, Ltanislaw
Significance of atudics cn the metabolism of paravitim helminths.
Wiad. parazyt. 11 no.l.,;,-97 165.
1. Pracownia Antropozoonoz Poiskiej Akademii Nauk, Katedra
Parazytologii i Katedra Chw-ii FizjologIcznej 'Wyzgzej Szkoly
Rolniczej, Wroclaw.

KOZAR ZbI -MI (-w
Garrent scientific and practUcal. problems of trichinosis. Wiad.
parazyt. 11 no.ltl9l-196 165.
1. Katedra Parazytologii i Chorob Inwazyjnych Wydzialu Weterynar.
Wyzszej Szkoly Rolniczej i Pracownia Antropozocnoz, Polska
Akademia Nauk, Wroclav.

iKOZAR, Z.
The review of current literature on trichinelloisis. Wiad.
parasyt. 11 no-41353-423 165.

KOZAR, Zbigniew; KOZAR, Maria
Incidence of Trichinella spiralis in the P(lish ppulation
on -the basis of post-mortem. examinations. Wiad. parazyt. 11
no.4:233-243 t65.
Experimental trieb4nellosis of mice irduced by parenteral
injection of mu5cular larvae. Ibid.:335-349
1. The laboratory of Anthropozoonoses, Polish Academy of Sciences
and the Department of Parasitology, Veterinary Faculty, Wroclaw,
Poland.

KOZAR,,Zb,igniew; OGIEMSKI, Leslaw
Trichinosis of pigs in Poland in the post-war period with
special reference to 1960-1962. Wiad. parazy't. 11 n,--).4:
245-283 165.
1. Pracownia Amtropozoonoz Pols~.ej Akademii flauk, Katedra
Parazytollogii i Chorob Inwazyjnych oraz Katedra Higieny
Srodkow Spozywczych Wyzszej Szkoly Rolniczej, Wroclaw.

KOZAR Zblante-v; RAMISZ, Alojzy; KOZAR, Maria
~.
Tnuidence of Trichinella spiralis in some domestic and wild
I
living animals in Poland. Wiad. parazyt. 11 no-4;285-298 165.
1. Department of Parasitology of the Veterinary Faculty, and
Laboratory of Anthropozoonosen, Polish Academy of Sciences in
Wroclaw.

KOZAR, Zofija
Pulmonar7 resection In two children with postprimary cavernous
tuberculosis. Mravavest., Ljubljana 24 no.3.-104-105 1955.
1. Otroski ocldalek specialne bolnionice za tuberkulozne v Uovem
Gelju, - ravnatelj Dr. Ivan Kopac.
(TUBERCULOSIS,' PULMOMIRY, in Infant and child,,
cavitation. pulm. resection)

VORONTSOV-VELITAMIflOV, B.A.; DOKUCHATUA, O.D.; YEMMO7, TU.I.;
---KOZARXNKO, B.I.; KARIMOVA, D.K.; KOSTYAKOVA, Ye.B.; LOZINSKIY, A.M.;
-NUMtk, "Mi. ; TSITSIN. P.A.; SHAROT, A.S.
Observations of Arend-Rolandle comet (1956 h). Astron.tair.
no.180:2-4 Wy '57- (MIRA 13:4)
1. Gosudarstvannyy astronomicheskiy institut im. P.E.Shernberga,
Moskva.
(Comets--1956)

BUGOSLAVSKAYA, Ye.Ya. [deceased); KOZARENKO, B.I.
The K114-3 measuring instrument. Trudy GAISH 2n:164-180 '61. `
( tronomical, instrument"s") (KRA 14:8)

KOZARENKO, B.I.
Determining the optical center of the AM-1 plate. Socb.GAISH
no.104:39-41 161. (KRA 15:3)
(Astronomical photography-Equipment and supplies)
1'. ,

KOZARENKO, B.I.
Determining the brightness equatiorefor the 400mm. astrograph
of the Main Astronomical Observatory of the Academy of Sciences
of the Ukrainian S.S.R. Soob,GAISH no.104:42-54 161.
(KRA 15:3)
(Telescope)

KOZARENKO),B.I,
PhotographY Of the moon among the stars with the AFR-l wide-angle
astrograpb~t Soob.Gaish no.121 :25-68 6'62. (MIRA* 16.5)
(Moon- Photographs)

ILI 1A
2. 3 Jj,
j 19 iq
i15I
d
Pj
fli
~1332I
C6 00
du g vV
1v
jai

KOZAIREI MKO, R. D.
Korshak, V. V., k6g-ar-enko, R. D. -"Synthesis of hydrocarbons by the action of
hexachloroethane on organomagesium compounds.n (p. 771)
SO: Journal. of Generol Cheqiq.
~rX,(Zhurnal Obstichei Khimii),
.0

IA
09 A low
,
e
e F T. -13 10*
all 46
00 3207- PRODWTION RE w9gang W or HAMNIta
A;G COWW 1*0
*0 BY ACTION 010- Korsh ove and Ilosaronko, T.D. (Raftlady 1*4
qe

~19
Akad. Mauk �.S.S.R. tRop* Aaad, Sol.. U.S.S.R.)# 11 v*l- 761
685 1hose reactions were oxamUed In the laboratory as 4% poesMs,
-00
6041
00 now method of synthesislaS by4rocarbams. K&VW= compounds wore obtained '00
49~t . bromlde and'
- from bromobensen*
, dAramwphtbalftep bonsyl chloride, ethyl w
:
00 4 . ~
,
. u*thyl Iodides Variations won ad* In tw_Worature# concentration of reagent 6:
0
60%,

a solvent (4icthyl other, dibutyl and
duration of process and nature of
** diisoanyl other# and mixtures of the latter two with the first). "roca
00
bon yields were 33-79% of the theoretical calculated from the quantity of
0
004 haloid derivative taken Into the reaction. We .0

Wt I
11
10; U 11 00 Ali i i i i
i

KOZATTITKO, T. D.
Dissertation: "A Study of the Polycondensation of the Esters of i-1phakminoacids."
Carid Chem Sci, Inst of Organic Chemistry, Acad Sci M'SIFF, IN'oscow, 1953. ',eferativnYY
~i
Zhurnal-10himiya, Iloscow., No 7,, Apr 54.
SO: S9-f 284, 26 Nov 1954

~"41-~,--&-itdaio~-- h6it tkir' -

POROSHIN, K.T.; EDZARMUPD, T.D.; KHMIN, Yu.I.
.
Differential titration of tripeptides and diketopiperazines In the
products of polycondensation of the ethyl aster of glycins. Izv.
AN SSSRiO.td.khim.nauk no.5-:626-628 NY 156. (KWA 9:9)
1.1netitut organicheako7 khimli imeni N.D.Zelinakogo Akademii nauk
SSSR,
(Titration) (Glycine) (Condensation products (chemistry))

7, _01
USSR/Organic Chemistry. Natural Substances and Their E-3
Synthetic Analogues.
Abs Jour: Ref Zhur- Khimiya, No. 8, 1957, 27003.
Author Poroshin, K.T., Kozarenko, T.D.,
Khurgin, YU. I.
Inst Academy of Sciences of USSR.
Title Mutual Conversions of Dipaptides and Their
Anhydrides.
Orig Pub: Dokl, AN SSSR9 1956, 109, No. 2, 329 - 331.
Abstract: The stability of glycylglycine diketopipera-
zine (I) and alanylalinine diketopiperazine
(II) in alkaline medium was studied. The hydro-
lysis constants for I and II, equal to pKO 1o.8
and 12.0 correspondingly, were computed from the
measurements of hydrolysis depths of I and II
at various pH in alkaline medium and 400. The
Card 1/2
US8R/Organic Chemistry. Natural Substances and Their E-3
Synthetic Analogut-s.
Abs Jour: Ref Zhur - Khimiya, No. 81 1957, 26003.
alkaline hydrolysis of I and II is a reaction
of the firpt ordtr with speed constaqta of
9.63 x 10-"~ sec-1 for I and 2.56 x lo- sec-1
for IL Partial cyclization of III with for-
mation u~ to about 25% of I occurs, when glycyl-
glycine III) is heated even under the conditions
of incomplete stability of II. The order of the
cyclization r,eaction is not below the second.
Card 2/2

KMAREITKO, T. D., MMI GIII) Yu L, and PAT-110IIIIII) K. T.
"l,lechanism and kinetics of the polycondonsation of esters of amino
acids," a -paper -presented at the Oth Congress on the Claemistr,,- and Physics
of the Polyners, 2,0, Jan- 2 Feb 57, I-10SCOM Research Inst. Organic Chemistry.
B-3,084,395

TU.I.; POROSHIN, 1. T.D.
%&~= 44waftw"
Kinetics and polycondenealvion mechanism of eaters of CC-amino
acids. Report 16.2. Kinetics of polycondensation of glycine
ethyl eater. Izv,AN SSSR..Otd.khim. nauk no.2:174-178 7 '57*
NLBA lo-.4)
1. Institut organicheskoy khImU im. N.D.Zeliusi~Dgo Akademii
nauk SSSR.
I (Glycine) (Cendenvatiou productp(Ghamistry))

'/ /~-
Z~
U&WPhYsical Chemistry - Kinetics, Gmt",uStion, Explosions, Topo-
chemistry Catalisis. B-9
Abs Jour: Referat. Zhurnal Xhimiya, No 2, 1958, 3858
Author T.D. Kozarenko, K.T. Poroshin, Yu. 1. Xhurgin.
Inst Aftden~ of i0r6ces of USSR, Se--tion of Chemical Sciences.
Title Kinetics and Chenism. of Polycondensation of ok-Aminoacid
Esters. 3. Influence of Carbon Dioxide on C=position of
Po3,ycondensation Products of Glycine Ethyl Eater.
Orig Pub: Izv. AN SSSRI Otd. Khim. n., 1957, No 5, 563-568-
Abstract: The composition of polycondensation produzats of glycine ethyl
ester was studied at v&rzious ratios of the initial molar C02
concentrations and the monomer. The reaction product vas
a=a1$zed after the monomer removal. The re-action product was
treated with diathyl ester and vas a thick mass containing a
mixture of peptide ethyl eaters. The obtained kinetic curves
permit to establiah 2, differing by speed, phases in the poly-
Card 1/3 -9-

USSIR/Physical Chemistry - Kinetics, Combustion, Explosions, Topo-
chemistry Catalisis. B-9
Abs Jour: Referat. Zhurmal XUmlyay No 2., 1958, 3858
corAen,satioxx process~ the Isty retuded, pbme depe-nds on the
initial CO concentration, and the 2ad ptme Is subject 'to 1den-
tical kinetic regularities indepe-adent Of the C02 content. The
qualitative investigaticm of the polycon&omsation products was
carried out by the mthc4 of dilatributing &Mwatography on,
paper uBing the system butanol - acttic a,--id - water, pyridine
butanol, - water and p1jawl, - we-or3 up to 0.1% af trilon B was
added to the mobile phase in order to eliminate Vtz influence
of heavy metals contained in paper. It is sh-zm that in the
firat stages of tb,,% proeass, glucilglycine estar is rapidly
c~.-nzwaed in its conversion into diketopiparazine,. as well as
in -the formation of diglycilglycine ester. Me basic reaction
is the addition of tba monomer to peptide eevers,, but not the
interaction of esters with peptideis. The diketopiperazine con-
Card 2/3
_10-
TJSSR/Physical Chemistry - Kinetics, Combustion, Explosiom, Topo-
chemistry-Catalysis. B-9
Abs Jou-r: Referat' Zhunal WIJYaj No 2j 1958, 3858
tent was determined by the method of differential titration in
various reaction stages, as well as in the Sum total of various
peptides' S_-e report I, in Rzb1UAz, 1957) 60782.
Card 3/3 _11-

KDZARBNXO# T*Do; FOROSHIN, K,,To; KHURGIN, Yu.1.
Kinetics and chemism of polycondensation of oe,-amino acid esters.
Report No.5.' InterAction of carbon dioxide vith esters of glyolne
glad its.peptides. Izv. AN SSSR. Otd. khim. nauk no.5:640-642 My 157.
(KIRA 10:8 1
1. Institut orgeqddheakoy khImii im. N.D. Zelinakogo Akademii nauk
SSSR.
(Carbon dioxide) (Glycine) (Peptides)

PMOSHIN. K.T.; KOZARZKO. T.D.; KHMIN, Yu. 1.
Kinetics and chemism of polycondeneation of ~ -amino acid asters.
Report No.6:- On the meabaniam of polycondensation of c( -amino
acid eaters. lay. AN SSSR. Otd. khim. nauk no%5-642-644 W"57.-
(KM 1028)
1. Inatitut organicheakoy khimli im. N.D. Zelinakogo Akademli
tauk SSSL
(Amino acids) (Condensation products (Chemistry))

AUTHORS: Andreyeva, N. S., Iveronova, V. 1.9 62-58-3-27/30
Kozarenko, T9 Poroshin, K. T.,
ShiUi6 r
Shutskever, N. Ye.
TITLE: Investigation of the Structure of Peptides Containing
Glycine and 1-Proline (Issledovaniye struktury peptidov,,
soderzhashohikh glitsin i I-prolin)
PERIODICAL: Izvestiya Akademii Nauk SSSR,Otdeleniye Khimicheskikh
Nauk, 1958t Nr 3, PP- 376-377 (USSR)
ABSTRACT: The investigation of peptides containing amino acids is
of importance for the investigations of the structure of
proteins. The stereocbemioal rOle of pyrrolidine rings
within the configuration of the polypeptide chain has not
yet been sufficiently explained. In general it is assumed
that the bends of the polypeptide chains are formed in such
points,whbre residues of proline and oxyproline are present.
At present structural investigations of the peptides and
polypeptides of numerous amino acids are carried out.
There havet howeverg only few works b"-,i published on the
investigation of compounds containing amino acids. The
Card 1/2 aim of this work is the investigation of the above mentioned

Investigation of the Structure of Peptides Containing 62-5&3-27/30
Glycine and 1-Proline
structure of peptides. Glycyl-l-prolyl, 1-prolylglycine,
carbobenzoxyglyoyl-l-prolyl and the anhydride of glycyl-l-
proline were synthetized. Furthermore the first stage of
the x-ray analysis of the synthetized compounds was
finished.
There ar6 1 table and 10 references, 1 of which is Soviet.
ASSOCIATION: Fizicheskiy fakulltet Moskovskogo gosudar8tvennogo
universiteta i Institut organicheskoy khimii im.
N. D. Zelinskoga Akademii nauk SSSR
Ohysi6s Departneft of Moscow State University and the
Institute for Organic Chemistry imeni N. D. Zelinskiy,-
AS USSR)
SUBMITTED: October 31, 1957
Card 2/2

AUTHORS: Paroshin, K. T. , Kozarenko, T. D. , Shibnev, SOV/62- 58- 9- 2o/26
V.A.
TITLE: The Exchange Re~ac`tions Between 1-Prolylglycine-Diketopipera-
zine and Its Dipeptides (0 vzaimoprevrashchenii diketo-
piperazina I-prolilglitsina i yego dipeptidov)
PERIODICAL: Izvestiya Akademii nauk, SSSR. Otdeleniye khimicheskikh nauk,
1958, Nr 9, pp 1129 - 1132 (USSR)
ABSTRACT: Glycine, 1-proline, and a-amino acids in general are
especially important in relation to the question of the
structure of collagen. The separation of considerable
amounts of glycyl-l-proline and 1-prol,*lglycine from
hydrolysed collagen leads to the assumption that both
dipeptides are structural elements in the protein molecule.
The protein hydrolysis has been carried out under various
conditions in the past (Refs 1-3), and thi~~ makes
difficult a clear explanation of the proponderance of
glycyl-1-proline and 1-prolylglycine-diDeptide in t-e chain.
The authors of this brief communication attempted to
form a cyclic anhydride of glycyl-l-proline and 1-prolyl-
Card 1/2 glycine. They further investigated the possibility of

Thq Exchange Reactions Between I-Prolylglycine- Diketo- SOV/162-118-9-2o/26
piperazine and Its Dipeptidea
hydrolysing the anhydride to the dipeptide. It was
found that even under moderate condition:-, the anhydride
of 1-prolylglycine forms glycyl-l-proline in base arid
1-prolylglycine in acid. The hydrolysis of the I-prolyl-
glycine anhydride does not go to completion, but attains
an equilibrium condition. The formation of cyclic anhydrides
of both dipeptides is simple, especially for glycirio-l-proline.
There are 1 figure and 7 references, 1 of which is Soviet.
ASSOCIATION: Institut organicheskoy khimii irn.N.D.Zelinskogo Akademii nauk
SSSR (Institute of Organic Chemistry imeni IT.D.Zelingkiy,AS US':3R)
SUBMITTED: March 22, 1958
Card 2/2

50)
AUTHORS: Poroshin, K. T., Shibnev, V. A., SOV/62-59-4-28/42
Kozarenko, T. D.

TITLE- Synthesis of Peptides Containing L-Proline and Glycine (Sintoz
paptidovp sodorzhashchikh L-prolin i glitsin)
PERIODICAL: Izvestiya Akademii nauk SSSR. Otdeleniye khimicheskikh nauk,
1959, Nr 4, pp 736-738 (USSR)
ABSTRACT: This is a short report on the investigation of the synthesis
and properties of L-prolylglycyl-L-proline, L-prcly.1glycyl-L-prolyl-
glycine and of polymers which contain these groups in the
molecular chain. The peptides mentioned can be synthesized by
the method of the mixed anhydrides (Ref 9) and the respective
polymers by the ihethod of the polycondensation of methyl
esters of these peptides. The synthesis of L-prolylglycyl-L-
prolylglycine esters was carried out in two ways; 1) by gradu-
al addition of the methyl esters of amino acids (glycine,
L-proline, glycine) to carbobenzoxy-L-proline (Scheme, I);
2) by addition of the methyl ester of L-prolylglycine to
oarbobenzoxy-L-prolylglycine (stage A, Scheme). The
synthesized peptides and their esters were identified by
Card 1/2

Synthesis of Peptides Containing L-Proline and SOV/62-59-4-28/42
Glycine
means of descending chromatography (Table). There are 1 table
and 11 references, 2 of which are SoViet.
ASSOCIATION: Institut organicheskoy khimii im. N. D. Zelinskogo Akademii
nauk SSSR (Institute of Organic Chemistry imeni N. D. Zelinskiy
of the Academy of Sciences, USSR)
SUBMITTED: July 199 1958
Card 2/2

5(3,4) 50',1/62-59-5-31/40
AUTHORS: Noskova,.N. B., Foroshin,.K..T., Kozarenko, T. D.
TITLE-- On the.Accolerating Effect of the Pept-ide Esters on the Poly-
condensation Reaction of Glycine-athyl Ester (Ob uskoryay-u-
shchem deystvii na reaktbiyu polikondensatsii etilovogo efira
glitsina efirov peptidov)
PERIODICAL: Izvestiya Akademii nauk SSSR. Otdeleniye khimicheskikh nauk,
1959-, Nr 5, pp 935-936 (ussR)
ABSTRACT: On the basis of the observed acceleration of the condensation
reaction of glycine-ethyl ester by addition of the esters of
the polymer, the autoodtalytic character of this reaction has
already been pointed out in previous papers (Ref 1). In the
present paper the autocatalytio character of the polyconden-
sation reaction of the esters of amino-acids is investigated,
for which purpose the influence exercised by certain additions
of tripeptide and polycondensate upon the rate of the poly-
condensation reaction of glycine-ethyl.ester is subjected to
a close examination. The polycondensation reaction mentioned
was investigated for the purpose of determining its character,
Card 1/2 i.e. with the.addition of CO 2' C02 + tripeptide ester, and

SOV/62-59-5-31/40
Ori the Accelerating Effect of the Peptide Esters on the Polycondensation
Reaction of Glycine-ethyl Eater
further without the
addition of CO 2' addition of polycondenBate,
and addition of,tripeptide ester in dependence on the time of
reaction (Figs 1,42). It was found that the reaction time of
polycondensation in the absence of C02 passes considerably more
slowly and is divided into two stages. A rather long first
stage, in which hardly any polyoondensation occurs at all,
(58 hours) is followed by a second in which the kinetics of the
development, of polycondensation is of the first order. The
presence of polyc6ndensate shortens the first stage. The re'9-
action kinetics of the second stage remains one of the first
order owing to the additions. There are 2 figures and 8 ref-
erences, 4 of which are Soviet.
ASSOCIATION: Institut organicheskoy khimii im. N. D. Zelinalcogo Akademii
nauk SSSR (Institute of Organic Chemistry imeni N. Do Zelinskiy
of the Academy of Sciences, USSR)
SUBMITTED: October 22, 1958
Card 2/2

5t3) SOV/62-59-5-34/40
AUTHORS: Khurgin, Yu. I., Poroshin, K. T., Kozarenko, T. D.
TITLE, The Kinetics 6f the Polycondensation of Glycine-ethyl Esters
in th6-Presence of Its Carbamate (Kine-,;ika polikondensatsii
etilovogo efira glitsina v prisutstvii yego karbamata)
PERIODICAL: Izvestiya Akademii nauk SSSR. Otdeleniye khimicheskikh nauk,
19.59, Nr 5j,pp 941-943 (USSR)
ABSTRACT: In the course of previous investigations of the kinetics of the
polycondensation of esters of the a-amino acids it has been
shown that the i i-tiating effect of carbon dioxide is connected
with the formati-(5ii of the symmetric carbamate:
~ J
R'OOC.CHR.NH + OOC.NH6CHR.COOR'. Carbamate formation is an
'Mdothermi'd"reactioh, 6nd therefore overheating of the reaction
mass m Iay eEC~ily'occur'if CO- is added at an increased rate. The
.-. 2
carbamate itself causes no thei-mal'impediment to polyconden-
sation. In this connection, the kinetics of the consumption
of monomers and the variation of the composition of the poly-
condensed glycine-ethyl ester obtained in the presence of a
Card 1/3 carbamate was investigated in the present case. The investi-

SOV/62-59-5-34/40
The Kinetics of the Polycondensation of Glycine-ethyl Esters in the Presence
of Its Carbamate
gation methods are the same as those of reference 1. The content
of free-monomers, the reaction'prodtict yield, and their diketo-
piperazine and amin6nitrogen content was d6termined. Figures 1
and 2 show the velocity constant of the consumption of monomers
and, accordingly, the concentration of the diketopiperazines
in the polycondensation products when.carbamate and C02 are
used as initiators. From the difference alone between the con-
sumption of monomers conclusions are ' drawn as to a difference
in the kinetics of"the aggregation of the diketopiperazines.
From figure 2, which shows the concentration of diketopiperazines
in the fina.1 products, a distinct difference in the two initiatdrs
may be.recoghized,*especially at the beginning of the reaction.
The difference is caused by heating the reaction mass by the
endothermal formation of carbamate when using the C02-initiator.
When cArbamate is used as initiator, the-reaction product yield
remains proportional to the time of reaction, and also the
amino nitrogen (NH 2-N) content in the reaction products remains
Card 2/3 constant. The authors thank Ye. V. Leonova for her assistance.

SOV/62-.59-5-34/40
The Kindtics of the Polycondensation,of Olycine-othyl Estero in the Presence
of Its Carbamate
The activation energy of the affiliation of the monomer to the
peptide wa3 determined. There are 2 figures and 5 references,
4 of which are Soviets
ASSOCIATION: Institut organicheskoy khimii im. N. D. Zelinskogo Akademii nauk
SSSR (Institute of Organic Chemistry imeni N. D. Zelinskiy of
the'Academy of Sciences, USSR)
SUBMITTED: October 28, 1958
Card .3/3

5(3 X
AUTHORS: Shibnev, V. A.j. Kozarankot To Do, ,Poroshin, K. T. sovl62-59-6-31136
TITLE: On the Separation of L-Proline and L-Oxyproline by the
Rhoder:MMethod (0 vydelanii lo-prolina i L-oksiprolina
rodanilatnym-sposobom)
PE-IdODICAL% llzvestiye; Akademii nauk SSSR. Otdeleniye khimicheskikh nmik,
1959,, Hr 6, PP 1132 - 1133 033R)
AMSTROTt By the rhodanyl method for the separation of L-proline and
L-oxyproline the imino acids are always obtained with some
impurities beowe of the great similAdty f these acids. The
one always contains an addition of the other. Therefore the method
wa's changed somewhat w jha~by of it it is possible not only
to separate the L-proline requirea but also the I.-oxyproline in a
,ohromatographically pure form from the hydrolisate of the gelatin.
The yield in Lmbxyprolin obtained with this method was 12% of
this imino &aid contained in the gelatin. The separation of the
idino acids f'rom the gelatin was made according to Bergmann.
After.the separation of L-proline (rare) from the mixture of
L-proline and L-oxyproline the latter (60Y. is obtained with an
admixture of 40% L-proline. This mixture is treated with methanol
Card 1/2 and dry ether and the powder of the iaino acids thus obtained

Ch the Separation of L-Froline and L-03;yproline by the SOV162-59-6-31136
Rhodanilic Method
from methanol water is subjected to repeated re-orystallization,
which leads to Ir-oxyproline in purest form. The L-proline contained
in the methanol filtrate is then in a similar way purified from
the L-o?qproline still contained in vestige, and thus finally also
purest L-proline is obtained. There are 6 references, 1 of which
is Soviet.
ISSOCIATION: Institut organicheskoy kbinii im. V. D. Zelinskogo Akademii nauk
SSSA (Institute of Organic Chemistry imeni N. D. Zelinskiy of the
Acaderzy of Sciences, USSR)
SUMITTED: December 9, 1958
Card Z/2

50),
AUTHORS: Kozarenko, T.D.j Noskova, N.Be. SOV/62-59-7-25/38
lfo-r disl-i n-,-X-.T-.-
TITLE: On the Chlorhydrate-Methoa tor tho Determination of the
T.
Monomer in the Reaction of Polycondensation of the Esters
of ct-Amino Acids (0 khlorgidratnom metode opredelleniya
monomers. v reaktsii polikondensatsii efiTov Qtaminokislot)
PERIODICAL: IzveBtiya Akademii nauk SSSR. Otdeleniye khimicheskikh naukq
19 59, Nr 7 P pp 1324 - 1327. (USSR)
ABSTRACT: The synthesis of polyamino acids by polycondensation
develops chiefly in the first stage by successive chain
formation from the monomers (Type A) and in the further stages
by int-crreaction of the polymer woleaules
(Type B). The reaction-type A develops more rapidly than
the Vype B. The'consumption of monomers for chain formation
is determined in the final product from the non-reacting
monomers. Separation of these monomer,sr. is easy, but the
determination in the ether extract is connected with some
difficulties. A new method was elaborated by the authors
precipitating the monomers as their hydrochlorides. Beside
Card 1/2 the possibility of quantitative separation of the salto from

On the Chlorhydrate-Method for the Determination SOT/62-59-7-25/58
of the Monomer in the Reaction of Polycondensation of the Esters if
g* -Amino Acids.
the ether extract, this method offers the advantage that
the salts are also not destroyed by warming to
1000 ; so they may be used for further polycondensation.
The determination of the ethyl esters of glycineldy I-phenylalmine
1-alanine, d,l-valine and 1-proline is described in the
experimental part. The results are listed in tables 1-4.
There are 4 tables and 12 references, 2 of which are Soviet.
ASSOCIATION: Institut ox-3anicheskoy khimii im. H.D. Zelinskogo Akademii
nauk 353R
(Institute of Organic Chemistry imeni N.D. Zelinskiy of the
Academy of Sciences, USSR)
SUBMITTED: November 30, 19r,7
Card 2/2

50)
AUTHORS: Khurgin, Yu.I., Kozarenko, T.D.9 SOV/62-59-T-26/38
Poroshin, K.T.
TITLE: The Kinetics and Chemism of the Polycondensation of the
Eaters of g&-Amino Acids (Kinetika i khimizm polikonden-
satsii efirovgX-aminokislot)
VIII. The Influence of the Initial Content of Carbamate
on the Velocity of the Polycondeneation of the Ethyl-Ester
of G1ycine.(Soob6h:!heniye 3.Vliyaniye nachallnogo
soderzhaniya Karbamaza na skorootlpolikondensataii
etilovogo efira glitaina)
PERIODICAL: Izvestiva Akademii nauk 35SR0 Otdeleniye khimiche3kikh nauki
1959, Nr 7 PP 1328 - 1332 (USSR)
ABSTRACT: Intr6ducing the well-known mechanism of polycondensation
of the esters of ot-amino acids under the influence of
simple initiators- in this case CO 2- and the formation of
initiator substrate is described briefly (Refs 1-4). It had
been shown, that the original initiator for the poly--
condensation is not CO,j but the symmetric carbariate as the
Card 1/5 arising substrate. If this is true, it must be the same for

The Kinetics and the Chemism. of the Polycondensation SOV/62-59-7-26/38
of the Eaters of CZ-Amino Acids. VIII. The Influence of the Initial
Content of Carbamate on the Velocity of the Polycondensation of the
Ethyl-Eater of Glyoine
the velocity of polycondensation, no Liatterv&-ether carbamate
is formed by the addition of CO2 or is added directly. More-
over, for a small amount of i/m - i/m is the relative ,
molar initial concentration of the initiator i, related
to the monomer m - the consumption of the monome:t, must
be proportional to the initial amount of carbamate. in the
investigation of kinetics it had boen shown that this
prop ortionality was maintained for all initial
concentrations.. The consumption of monomer may be represented
by the following equationt
m(t) - (1 - 2 ~_,)e_k~~f)t
In this paper.the above named assumption is investigated.
The dependenae.of the velocity of monomer consumption on
the initial concentration of the initia.-ir was investigated.
Cpxd 2/5 The content of free monomers in the reaction product was

The Kinetics and.Chamism of the Polycondensation SOV/62-59-7-26/38
of the Eaters of obv Amino Acids. VIII. The Influence of the Initial
Content of Carbamate on the Velocity of the Polycondensation of the
Ethyl-Ester of-Glycine
determined by means of the improvement method. Moreover,
the consumption of monomers was investigated with
immediate initiation with symmetric carbamate, The
experimental data for the consumption of monomers with
initial concentrations of initiator CO 0.01, 0.02,
2 fo=
0-04, 0.08 and 0.16 are demonstrated in a semi-logarithmic
scale in figure 1. For all i/m monomerls consumption is first
class. The extrapolation of the straight line cuts the
ordinate in the point lgm - O(m = 1). me . m0 is reduced
with increasing Therefore m 0 is the exact initial
concentration fofbt.he secondary stage of the reaction.
In the equation obtained from the experiment;
m(t) - mo * e-kt
Card 3/ 5 M0 and k were calculated by the method of the least squares.

The Kinetics and Chemism of the Polyoondensation SOV/62-59-7-26/36
of the Eaters of &,:- Amino Acids. VIII. The Influence of the Initial
Content of Carbamate on the Velocity of the Polycondensation of the
Ethyl-Eater Of GlyGine
The -results are listed in Table i. M was calculated
T "
as the stoichioraetrical coefficient of the reciprocal effect.
of the monomer with CO2 in the primary stage of reaotion~
In this case of oarbamate initiation m 0was found to
be 0-995 i.e. it was equal to the initial amount of the
monomer. This result may serve as e-.idence that carbamate
is formed in the first stage of the reaction. The constants
of velocity of monomer consumption in dependence on the
initial concentrations of carbamate i/ra are listed in table 2.
The kinettic curve (Fig 2) is a straight line up to
concentrations.i./a - 0-07- moreover the velocity of monomer
conewlition was proved to. be -independent of the length::
of the formed chain of polymers, There are 2 figures, 2 tables,
and 7 references, 5 of which are Soviet.
Card 4/ 5

The Kinetics and Chemism, of-the Polycondeneation SOV/69--59-7-26/313
of the Esters of 4W- Amino Acids. VIII. The Influence of the Initial
Oantent of Carbamate on the Velocity of the Polycondensation of the
EtIlyl-Ester of.Glycine. .
ASSOCIATION: Institut organicheakoy khimii im. N.D. Zelinsko,-,o Akademii
nauk SSSR
(Institute of Organic Chemistry imeni N.D. Zelinskiy of
the Academy of Sciences, USSR)
SUBMITTED; November 30 , 1957
Card 3/5

50), 5W SOV/62-59-8-18/42
AUTHORS: Poroshin, K. T., Khurginp Yu. I., _&ozaranka,_L__R.
TITLE: Kinetics and Chemism of the Polycondensation of Eaters of
the a-Amino Acids and Peptides. Communication 9. On the Auto-
catalytic Nature of the Folycondensation of the Ethylester
of Glyolne in the Presence of Carbon Dioxide
PERIODICAL: Izvestiya Akademii nauk SSSR. Otdeleniye khimichaskikh nauk,
19599 Nr 8, pp 1453-1457 (USSR)
ABSTRACT: In the present paper the assumption concerning the autocata-
lytic nature of the polycondensation reaction of the esters
of a-amino acids in the presence of CO 2 is investigated. For
this purpose the yield of the polycondensation products of
ethylglycine eater was measured and their composition determin-
ed. The condensation product was fractionated and the products
of the solid phase determined by weighing. It consisted of.
ethyl esters of glycine peptides of various lengths, and di-
ketopiperazine. Several test series with different 00 2 con-
tents in the initial products were carried out. From the
yields obtained it could be seen that the polycondensation
of athylglycine eater is an autocatalytic process with a
Card 1/2 gradual growth of the peptide chain. The growth of the peptide