SCIENTIFIC ABSTRACT FR:MIFF, N.P. TO:MIESOWICZ, M.
Document Type:
Collection:
Document Number (FOIA) /ESDN (CREST):
CIA-RDP86-00513R001033800008-6
Release Decision:
RIP
Original Classification:
U
Document Page Count:
9
Document Creation Date:
November 2, 2016
Sequence Number:
8
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Publication Date:
December 31, 1967
Content Type:
SCIENTIFIC ABSTR
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CIA-RDP86-00513R001033800008-6.pdf | 2.94 MB |
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EXCER~"I'A 1~!EDICA Sec 2 Vol 12/9 Physiology Sept, 5Q
~~_
4448. DEVEI.OPMF.NT OF PEPTONE bHOC"K IN Hl'PUTHER1~tIC LUGS - Vcr-
Iauf des Peptonschocks bei kllnstlich unterktihlten Hunden - M i~ t k i e w s k i
l;, , Gracki H. and S�r,czepafiski I3. 1'hysiol. InsC:;''~tt~;ficad`;
~cxer_in - ARCH.INT. NE:[JItOI,. 1358, 117j3.4 (328-340) CJraphs 5 Tab?eg 5
� Experiments were performed on hypothermic: dogs (thiopental anaesthesia, budy
tempcruture 25-2G�i, I. v, infection of a `l5% solution of peptone (l,'L ml, /'kg.) Pro-
duced in control animals and also in hypothermic dogs a shock state which was not
much influenced by simultaneous administration of chlorpromazine (4-5 mg, jkg. ),
Chlorpromazine sometimes even protracted the duration of shock. I. v. adminis-
tration of antazoline (5-10 mg, /kg,) did not completely abolish the manife,statians
of peptone shock; only the blood pressure and the frequency of respiration return-
ed more quickly to the normal state. It is suggested therefore, that the mechanisrr.
of this form of shock depends on a direct toxic action of the injected peptone and
not only on the release of endogenous histamine. Guxek -Cracow (II, 5~) ;
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U-1
� Poland/General Problems of Pathology ~ Shock
� - Abs Jour Ref Zhur ~ Biole, Noy 18, 1958, 8~~11
Author , Mid kiewski:;, E---~ ~ Grack3., H,, Szczepanski, Po
Inst s No institute is given
Title Peptone Shock in Dogs during l,rtificial Cool~.ng
Qxig Pub I~cta Physiol. Polono9 157, Vole 8, Noo ~t~ 637653
Abstract Under pentothal narcosis 25 dogs were caused to undergo
shock by the infection ilutionsofloeptone,~Inft o2e
ml/kg of a 20 percent so p
cooled to 2526 degrees C, shock came on more slowly
and was mi~.der than inetdh~op e ~hanuintthemnormaltcorn-
tions of shock persist g
trols. The preliminary infection of four to five mg/ kg
of largactyl to the cooled animals deepened the peptone
shock. The intravenous infection of four to ten mg/kg
of antistine did not protebutt theamanifestataonsgof rem
the development of shock,
shock wer� oiiminat�d morfl quickly. In non ;cooled can-
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