SCIENTIFIC ABSTRACT FR:NESTERENKO, L.N. TO:NESTERENKO, L.N.

• Document Type: CREST
• Collection: Scientific Abstracts
• Document Number (FOIA) /ESDN (CREST): CIA-RDP86-00513R001136700043-6
• Release Decision: RIF
• Original Classification: U
• Document Page Count: 12
• Document Creation Date: November 2, 2016
• Sequence Number: 43
• Publication Date: December 31, 1967
• Content Type: SCIENTIFIC ABSTR

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a~. inta~~t brain. Acety~.cho~.~.neaterase ~~+~t~.ai~t~r oP the cortex, thal~~rtturs
4~;~pothe~amue,P aatidbrain, and medulla oblongata wEta determd.ned bar a
phot�e~.e-ctro~aolorim~tri~c method developed b~ ~~. k. Panoayan. Eke
a~~tivity~ of the seneomotor and. opt i� ares,s wa.~ r~scorded by an eight
eh.annel Kag~er glectroenaephalogrEpha ]'ind9.n~;s show that gal.antham~.nt~
i~~lbibita th� aa~tyl.chol:ineatcrase activity of the brain to the same
degree f'tz axri.a with a ,preen�aextcephal:ic section as in e~nimais witk~ ~~n
intact brain� Meta fo:r eaerine ~,n a corresponding do~~e of 0.9 m~~~~6
WElre a3milarr Ito ~ activation reaati+~n wag found for i~nimals with
th~~ premesencephalio eect:ton despite alanoat complete inh:ibitiori of
ac~E~tyleho~.inesterase activity above the section. HoweveaAf a dist~.nc:t
vh;~urag~ inn biae~~~trio aat:Cv~,t~r way found for anima~,s witka an intact
br~Eih~ w;~.th E~ aetivati.on directl.g d�p;~ndent an the degx�a� of nc�t~pl-
CYac~l3nea~~erase activity izxhib~.tion ~.n tlae mere;r~cenha].~.a Mart of the
brain, ~l'he autbArs conclude that EF,~ a~~tivation depends not on1~r on
acet~rlcht~lixaeeterase activ~.t;~ inh~.bition oi` th~~ brain, bust also ~n t;he
presence of a aonneation bettireen the coy^t�x and mss�nce~~,alic reticular
l~artaatiox-. Omig, art. has: 2 tables aald 2 ~iE~rea.
~~ cotes ~sr ~r~aM nA~: G~A.pr61~/ oi~Ia~ ~; 003/ o~~ ~: oolF
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Atl~HO~~: I~~uchenol~, R.T"~'u.,~ l~testerext~,~ ~r~ ~
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oRG: Pharmacology Labaratury of the DApartraent of Exp~er~.mental ~33.o:~.ogy
and Ps-thology of th� ~t�1.o and Gerxatics :fin ~~.~,afriA~._,.
'BrancYi AN ~ Navoaibirs~k aborator:[ya ~~rmakologi3. Otdela
'e~~~x- ens r~oy o o ~ atologii znet:Gtuta taito~logii i genet~iki
Sib~.r~~kogo �tdele~~iya A~ ~SSR~
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'TI7!LE~ ~f~ecte of sestina and galanthami.i!~� on ~_c~~t~lcholinesterase and
r ~a a+~tivit o~ the brain in an-imals~ wit s a pr~er~eserice~ic
bietel~kct i Y
S~d~t~,~111 ''
501]RC~C s ~3;yul~.etens ekgperimental'no~yr b:l~o~.c-g;li i m�dit~ iny, v. ~o, no.
~TnPY~ ~'Aa~ t ~~c~riment ax~ima~~ r~ervausi e;~'si;em dry cn~yme,
a1~at~c~CB~c+~,~.ogrephy, brain ~ieen~~~ rnidlnr~tin, oerebr~al cortex,
`bioel~e-atri~s ph�nomenan, caa.orimetrics as~,].~~re:te
.~~~~T~1-CT. E~~eate o~ ant3,eho~ineatera~~~ prtipara~Mions on ac�ty7.chol:ines�
te;r~ae~- act:tvity and bioele~etric act~.vii~y of tt~e gar in ware studi�d .in a
eories~ of ~~xr~.mente on c~,at$. ~alantl~~umine~ { q mg~kg) and �~erine
(4.9 ~~k~;l were ac~min3,ste~red lntraven~~usly to groups of animals with

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~ ~1 ~~~
;ACC iNiRs ~#t'502~1Bi
1 .,,
'mine lYad ao affront on cholines~terage activity ~,n tl~e meeaencep~ialot~-df,er~a~phaic-u
i
~r8g~~t~ and ~medul].a oblot~gatia cari Sri the b~,oe],scfi;ric~~1 activity c-f the cart$x, px~s-
;bably because th� drug dyes nc~t re:sdi,ly pene:tra~ts !khe blond-br~~in barrier. Hawr-
~ovar~ dir~at i~~eat~.a~st int� ~tta~ ven�p~~ia~~e ~~ha~ply la--ered ~ho~,inesterase actir~~ity
la~1d ;[reduced ohangen in biaelactric~tl activity s.imi;lar to those obaPrverl after the
~admi~~~lat~t.ic:n of tertiaryi anl:ichalin~esterasu c~aunds (galarttamine and eserin,e).
The .[nrpez~eabi3ity of the ,blo~rd-brain barrier t~~ uE~ostigmine is relative. Intr~a-
rre~x,uar ie~eotidn of a large dc~e (1 mg/kg) inhilfit~td antfchalinesterase activity
.and ~nt-aelu~a~ted #~~ oort#.ej~l ~i+~potentiala. Or'lg. art. has s ~ figur+~e, i table.
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AU'CHOR: lkEl~1C# Nemt~r~:nko_~ L. N.
' `pflci+:'d4A.nE SVlNmty +.v.'Gx�e,: _...t%.a.~.':}!;j'r.V,:
~)10RC:s ~xpE!rirn~~nt~ll Bfolo~y Sc~tion, Institute af~,~rtol,o~,~'V.~nd Genetics S3.bertan
ilDe ~ax'tment AN ~Sft.. Novnaibirsk {Qtd+~l ~!keperi~ental~nay bial~ogii ~Instituta t,si~tola~
~"~gen~i~~~ S~i`r~kogci..~~deieniya ~t ssS~} t%,
;~
iT'I't,'L~: Bioelectric sand ~nt~4~cl,~ia~estera~~ atctivit3r of the br.ai~n after the ew~inis-
~trpttion oi~ neostigmir~ (~-rozerin j
l
'Sa~IRC~; thN S~SR. ~,~birskpye otdeleniye, Ixveetiya. Serig~e bi~~lo~a-meditsfnek;tkh
~neutk, no. 2, 1.965, 171~�~,7!4 j
TQPI~G ~'~t~ t electrophyeiolo~y, brain, nervous system drub, c~~i~ebral cortex,
electric potential
':ABST;R,AC~'s ~~peri~nents ~aex~e perf~-rmed em cn~ts to ~detexwnl.�e wh~!ther tl~ere as a rele~
tia~ti~hip bet~leee the de~r~ee of inhibitifln a:~ ah+a~.;tnestez~~!e~e ax:t~,vity end change in -
bic;e~eet~ic.~~, act~v~t~ oi' the brain indua~d by th+~ in~ectian c,f neostigmine d~:reet-
ly ia~to the lateral aentr~fclen. xntriavenoue in~elction of t).Q~~-O.l m~lkg of n~cosQtig~---
hard 1~2 ~ Ul?C : 615.7 X17
_. - _.
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~oth~~r hand, no such t~l~~tianship was noted betwe~er3 the close of nlvala.n and t;he de-
'gl'ee of :tnh~.bitian of bi^ain cholinesterase aciti.v~ity; 2.5, 5, and In mg/kg dares
~re~'�,tced this activity 1.,4, l.T, and ?. times, ~res~pectively, below the os.'~ginai lev-
',el. While the ~.5 mElkis dose shy YlY red~~ced blood chalinesteras+e activity Cc- ap-
.praxfma~taly vneW~aurth ithe orig$t~al laver la~~gsr closes had :no significant e?`fect.
The author concludes thtct nivalin has both ~an an.ticholinesterase effect on tlhe adrer
nal cortex end, to some extent, g choainomia~eitic. effect. Orig. art. hail ~, 1 table,
~ ~lg,ue
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ACC Nis Ap50241BO SOURCI~ CODS: UR/029~D/65/p00joo2jOlf;!9j0171
AUTHOR s Nausnenko, Ye , V. ~ ~teuterenko , L. ;N . ~~
t.
OiRG: Experimental Biolog~~ Section, Institute of Colo a~~d GereticB, ~+er
De~ arta~nt AH 555, Novos;ibirak {Otdel ek~;pe~r mental nayb +alog~nstuta tsita
gi ganef rs ogo c~Ieniya AZ1 S6~SR;i
;~, ..
T~'~'t~t Adrano~artiaal ~un~t~on and blood end bin nho~t~ act~vit~r ait;er
the adrninietretion of niv~~lin
SOURCE: AN SSSR. Sibi~bkoya otdeleniye. Y;avestiya. Seriya ~~iolago-meditsinf:kikh
na~uk, na. 2, I9frS, 169-17:L
TO:~IC TA~35~ physiology, b~-in, blood, enx;;rme~, acetylcholin~r, nervous systens drug,
pi~tuitarq, corticosteraid
AB~S~'RACT s Experisn~nts on guinea pigs ; n j~erte:d with the ant~tcholinesterase ~igent
niwalin revealed a direct ~iroportional re.l~rt~.onship betr~een the dose in~ectE~d and
the blood cortiaosteroid level t a tN0- sand fourfold increase in nivalin caused a
tx~n- a~-d~ fourfold increase in 17-oxycorticosterc~id c~+tent x~f the blood. Ors the
UD~CN~ 615.7 ~ 615.7~~ + 615.45
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ce~rebra"L cortex. or~.g. aY't� hae: 2 tidb;1~~~.
otde~ el~~por~.menbt~.~noy` bi~~ol,c~gii, In~ti~~;~t b~rimen ~.
AggoC IATIDN ;'
i ane~3.k~. ~ibira~oga ~bde~.~ni a A~ 884~,~ ~~~ o~it~t3~.iu~~ot ~ha
8 ~ f?e a~tm~ ~~ ~~ ~ o~a~ and t~~~t ,.,.~..~.., .-~.
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!par-ts of tho brain, mostly in the cerebral cortex. and me~dul.la
~ablongata and to a much Lessor dElgree in the rrtidbrain. ,Ag far
b~.oel$ctric activity, nc statistically rHliabl,e changes were found
lwith galanthamine doses up to ~ mg/kg� ~�argex~ closes (~ to q mg/kg)
~s~.gnificantly depressed acet~~lcholines~~it~aae E~ctivit~r ~.n. all parts
,of the t~ra~.;n except the midbrain~ The ~-~.~oalec:tric act:vity chan~ea
!fo:l.lo~r3.rtg lets�r dose administration acct~:x�ate~.y reflected the
!ac+stylc~lo~.3,nesterae~e changes. 3~.milar ~~�~sultsx ~�re four,-d with eserin
~administ~ration (in doses 10 to ~.2 tunes s~mallE~r1. These data
~auggest~-d that the act~.vntiz~g effect o:t' a:n.t~.ctzolinesterase substances
is baaecf speoifiaal~.~r on depressed ace~~;~:~chc-~.:~.ne~~terage act~.vit~ of
the midttra~.n. To test this hypothesis., a~~~.dit;'.ons�~. experiments were
carried out an oats with. a ~-remes�ncheph;~lic ,~eetion. 1rJith
~ga.l,anth~.n4e aril eserine admSn~.stration;, the degree of acetylcho:~in-~
esterase acsti~~,t~ deprer3sion in all par-'~s of the brain, including the
:pasts atxove the secti.on~ etas f sand the ,gsane a,~ ~'or animals w~.th an
'intact 1~rai.n~ Ho~rever the anticho~.~.n~~~~t+~rs,e~s substances did not
~prvduce and ~4 aotivi~y* ~'hus, b~.oel~~+~t~wio s,ativetion apparentiY~r
~require~~ b].oeking of the gn~~ ~ the ~aidb~~in~ 3n ~dd~.tiari to
;dep~ees;~e~ e~' ~cd'~~�~ht9:L~.~i61~~-~~- ~~dt;l.~~~,~~~ ~~ ~h~ dia~~aeph~.en sued
Coed ~t/3; ~ .~ , ,_._..... _ _. __ _ _ . _,.__ . _ _._...
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. Me sterenko~ L ~ N ~~ ,~~ , .,~~'
T1'~LE: correlation betwsen bioelec~ri.i, a~1d. aced; lcholines~~eraae ~
activ~.ty changes of the bra3~.n t~.nder th4~ a~~t~.on o. ge an ani nee an`d
eserin~
~34UftCE: 1ilN' S~~R. ~ib~.rskaye otda~.en~.~~3 ~ :xzvsstiya. ~eriys,
b io~.Gga-~rne~c~it:i~.nsk~.kh nau~c, no ~ ~., 19C~;a ~ '~~.'~w~.~~9
TOPT.C. TA4~: e~per~.ment ar~.mal, ner~~ou;~ s;y~~.tcm, drug, drug ~~~'fcct,,
b3.ooYectric p~~.enomenon, enzyme;, ^ersbr~,~.i I~c-rtcx, cerebellum, midl~ral.n,
AaS~N.~iC`P: In t;!xperimenta on lib cats s,ae�~ylcr~o].:~nesterase activ:Lty
was deter tined ~ 'the cerebra. cortex, th,al,atm:~s,, hypothals.tm~s,
midbxain,, ~d :nedul~.a obla-ngata b~ a phat;t~~;o~.c-ra-,~tr~.e method
following intr~.~enoue administration of g~s:l.eniPhE~mine or e~;erine in
~rsry~.ng dc~seg, ~airi e~.�ctrio aat~.v~.t�,q~ ~r,ss recorded b art 8�chs~^anei.
eleatroeh~tep~a,'Lagraph x:itb �~.eotrodes impl,an~~~d int� df~-r4nt~ parts
of the s'~i~ax,~ I~inding~ shc+~ ~~t etten ~ X1;1,` dose of ga~~antha~a.Lne
C 0.1 mg/?~~) dept�seee acet~rl~s1av13.~estera~~a etv'~i~rity in i~"feTent
Cord ~~
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