SCIENTIFIC ABSTRACT OPARIN, A.I. - OPARIN, A.I.

• Document Type: CREST
• Collection: Scientific Abstracts
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• Document Creation Date: January 3, 2017
• Document Release Date: August 1, 2000
• Sequence Number: 17
• Publication Date: December 31, 1967
• Content Type: SCIENTIFIC ABSTRACT

UPARIN. A. 1. (Moskva)
.............
Present status of the n.-c-.Ipm ~, -,.~ - -1 ~'! r. -f I i fe . U13P .!30vr. ~ I , . .
44 no.2:158-172 S-0 1~7. (MIRA 10:1 )
(LLFE--ML;IN)

20-2-30/50
AU'THORS: Cparin, I., Academician, Deboriiij G6. A., abd Baranova, V. Z.
TI:LE: The Influence ofDesoxyribonucleic Acid on the Breaking Dcwr~ ~f
Protein.9 by 'Iryp3in (Vliyaniye dezoksiribonukleinovoy V.4sluty
rasshchepleniye belkov tripsinom)
PERIODICALt Doklady A-N SSSR, 1957, Vol. 116, Nr 2, pp. 270 - 2112 (USSR)
ABSTRAM The influence excerted by substances from the above-mentioned aroup
on the enzymatic activity In in-vitro-tests Irew the ;ittention of
scientists upon itself during recent years. After a survey z~f P,,1-
lications the authors state that the interaction mechanism of nuc-
leic acids with the enzymatic proteinsvas hitherto not sufficient-
ly solved. The formation of complexes is assumed whose components
are connected with each other by means of electrQ3tatiC inter-
action, hydrogen binding, Van der Waals'eforces or a co-vilent
chemical bond. The authors studied the influence of a hij~hly-pjly-
meric deoxyribonucleic ncid (called DNS in the f6llowinE) ,r, 1.,1. e
proteolytic process under conditions above the it3oelectric ;,oint,
i.e. wher the interaction of DNS with the enzyme does nct lead tc
Card 1/3 precipit~Ition. DNS was produced from the thyroid rland of calves.

20.-2-30/ 50
Inf 11.;ence of Ibsoxyribonucleic Ac! ' or. tne Breaking Down of Prcteins by Try-.-
sin
6.
Its molecular wei,,1A aas 0,8 1 , 4 - 10
Crystalline try
I . ~sin
was produced accordint, to Kunitts & Nortrop. The test
described. Fig-ure I shows the curve of proteolysi3 by try~sin ~~f t
serum albumin, eg, albumen and casein, to.-ether with control
ves. In the case of individual sub3trLta this process is markedly
inhibited. In order to determine the nature of the pr~)cess ~f ir-
hibition in the presence of DNS, the influence of a previ-1:9 in-
cubation with DNS with ar, enzyme or with a substratum on the c,_urse
of proteolysis was investigated. Fii.-ure _2 shows the data obtained
from a test of this series. The curves show that a rar.id inhi~'._
tion only takes place in the case of a previous incubation --f the
substratum with DNS, and not of the enzyme with DNS. On tl~e basis
of thetest results the conclusion may be drawn that DNS influences
only the substratum and not the enzyme. In the crise of a lwge
excess of DNS, e.g. in the relation DNS t serum albumin = 1 : 0,6
and 1 t 0,5 no firther inhibition is caused, although the inzreaSe
in this relation up to this value increased the inhibi~4on. in the
case a very large excess of serum albumin over DNS, inhibiti-,ns of
proteolysis wereobserved. As ~igh-polymeric rucleic acids z 're
highly capable of interaction with proteins, an investigation IMS
Card 2/3 made of the influence excertedby the polymerism of DNS or the

20-2-30/50
The Influence of Deeoxyribonucle,~c Acid ~n t:..-j Breae_ini: Do-ar, ,f Prrteins ty
,sin
course of the pr-~te 3 -j'-' -_ a 6 u , r. ~.' trypsin. Fi,_,L~re ' sh.cws
'hat the strcngest in-.i~'Ltior of the prcteolygis tcok 11aci-- w-en
DNS with the higl~oot, weight was used. -.~e smalle-st -n-
hibition was obtained when a DNS was used that ha3 been treated
with deoxyribonuclease. It Was already earlier proved that enzymat-
ic processes outside the organism may depend on the Fresence of
small amounts of lipoids which form complexes with proteins. The
totality of these and the above-mentioned factors indicates a Ereat
variety of the manners of regulation in a system sc comllicated
and rich in components as the cell, There are 3 figures and 12 re-
ferences, 3 of which are Slavic.
ASSOCIATIONt Institute for Biochemistry Jmeui A. M. Akkh, AS SSSR
(Institut biokhimii im. A. N. Bakha Akademii nauk SSSR'
SUBMITTEDt June 26, 1957
AVAILABLEv Library of Congress
Card 3/3

sdu(3 o;t>Ajo3t>o:) u! popnpul sOwAzu3 JO uO!PV s4i
~Xl
~T -:47~Gju MG-~V T-~ wDH:av
IMmik, Im m macmmw
7
e2~
a

~ i Al A. I. (,-'~Us -~ %, ~
::,
1, 1 i. " . '-- !~
-f", . , , , ~: e: . , . I. , .,. . ~ , . .-
peper psoented at tho 4th Intl. Congress of Blocb9mistry, Viorms, 1-6 3--~p ~58.

OPARIN, Aleksandr Ivanovich, akademik; DIBMIR, Gavrill &ramovich, kand.
Blgtid~Oi. O.K., red.; SAVCHIM, Te.T., tekhn. red.
[Preeent-day scienoo on the orW, n of life on oarth; results of
the International 69yWosium on the Origin of Life in Nosoow,
Autugrt.lg-?4, 19571 Sovremnnaia nauka o voznikuovenii zhizni na
Zemle; k i2ogam Mozhdunarodnogo aimpoziumn po proiakhozhdeniiu
zhizni, sostoiavehagosia v Moskve 19-24 avgusta 1957 goda. Hook7a,
Izd-vo "Znante," 1958- 34 p. (Vaeeoiuznoe obahohostvo po raspro-
stranenitu politichookikh I nauchnykh znanil. Ser. 8. vyT).l. no.5).
(Id f @--Origin) (MIRA 11:9)

akuden
DZEFTUKRAM, Konstantin Melitoanvich~-~ , 1k. rod. ;
SHTERIMERG, M.B., r,d. lzi-Ta; PCIANDVA, T.P.. tekhn.red.
[Principles of biochemical control in tea production] 09novy
blokhimicheskogo kontrnlis chaiRogo proizvodetva. Moskva,
led-vm Aked. nauk SSSR, 19SR. 167 p. (MIRA 11:12)
(Tea)

KRITOVICH, Vatelav, Leonovich; OPARIN, A.I., akademik,, otv.red.; ANTONTUK,
L.D., red.izd-va; SffUCMMO, G.N., tekhn.red.
[Biochemistry of grain and bread] Biokhimiis zerna i khleba.
Moskva. lzd-vo Akad.nwak SSSRO 1958- 172 Po (MIRA 12:2)
(Grain) (Tiour)

BOUCHAVA. Mikhail Aleksoyevich,prof., doktor biologicheskikh nauk.;
I-OPARIN. A.I., eked., otv. red.; BUNDELI. A.A.. red. izd-v,3.;
z -
PRWAYNX,--T.A., tekhn. red.
[Biochemistry of tea and tea nroduct ion] Biolrhimiia chata i rhainogo
proizvodstva. Moskva. Izd-vo Akad. nauk SSSR, 195R. 536 n.
(AIR-A 1~ :12)
(Tea)

NINCRENKC, V.S.; BOCHAROV, M.D.; KRISTOSMITAN, N.G.; CHERKASOV, V.I.;
ANMYANOV, V.V.; KAUFMAN, V.M.; PAKHKANOV, V.r.; ZVORYKIN, A.A.,
otv.red.; ANICHKOV, U.N., red.; BARDIII. 1.P., red.; BIAUWIAVOY,
A.A.. red.; VVXMNSKIY. B.A., red.; &RIGOROYEV, A.A.. red.;
LAPUSTINSKIY. A.F., red.: KOLMOGOROV, A.B., red.: HIKHAYLOV, A.A.,
red.-. OPARIN. A.1., red.; P9TROV. P.N., red.; STOLSTOT, V.N.' red.;
STRAKHOV, NX. red.; FIGUROVSKIT, N.A., red.; KOSTI, S.D., tekhn.red.
[Biographical dictionary of leaders in the natural sciences and
technology] Biografichaskii slovarl deiatelei asteatvosnaniia
i tekhaiki. Vol.l. A - L. Otvetstvannyi red. A.A.Zvorykin. Red.
kollegiibt B.N.Anichkov i dr. Mos1cva..Gos.nauchn.izd-vo "Bollshata
Sovetekaia ltntsiklopediia." 1958. 548 p. (MIRA 12:4)
1. Hadaktaiya istorii eatestvomnaniya I tekhniki Bol'shoy Sevetakoy
AntaMopedli (for Hemchenk-o, Bocharov, Kristosturlyan. Cherkasovi
Andreyanov, Kaufman, PHkhmanov).
(Scientists)

AUTHORt 0 p a r i A - a -1
-----------
TITLE: The Present St%te (7' tale Pr-,LleT of the Cri6~r, of 'a',I.,~S~v-
i e i- o m y ; r s k z
PERIODICAL: P r I rd a. r 1, 1 - 16 ( 11 S S R )
ABSTRACT: Th i n ii r t i i-r; t :i t h (', r'y , t i t I I Pr 1 f I F(i A. -
cordirit~ t'. ! :f(l Jvvvlilped it! the l'-1 i ~ V. I rlc~
t h r (, e s t. 11, the emert-ence of hydrocarb..-,ns a r d ', h e : r
closest derive, ti vts , ( : . I . Mendeleyev haEi shcwr. ti.,it ",Y~`ro-
carbons !eve I ~-T rrcc. tf.e 4 n t(-rgct 4 on of carbi dies 'e, ~ ti. w~, -,(- -)' 1
2) t~ie emergence (,, n~imclxis complictited and high-molle-u1tir
organic crm;-ounds, amcr.C them, the allbumincid substances; 3)
the emert,,~nce of :,-'bum4n system endowed with mft.-~bc-1,sm.
Further ieve'lrpn~ont '~', t'IE .:,trLcsj.here and th-
eart~, r~su-.-J an,: aiso v-ry cemi licatrd
founri ir. A-f,~Iri.;M.S. The Inistitut b~okl.irp- i AN -.3SH
(Instituto cf (if tne -'~S U133R) ex t-
tained aminr, ~.c ;ds, by rra~iiatini7 ~,ydroc-irbo.-.s -~..tn utra -
Card 112

I _L -,- - ~
.a
I The Present 3tate of tnc !-r,,t.om of trr, O.,;gin of Life
vi c) It., t i i(Lh t .
Title: Orgin of Life
i Biology--Theory
Card 212

OPARIV, A.L. akAdemlk
Itsporta nt the conference dedicnted to the 25th nnniver,3rtry of tro4
foundation of the ITIStitUte Of Microbiology of the Acndemy of Srierices
of the U.S.S.R. Introductory address at the anniversary session
of June 20. 1955. Trudy Inst. mikrobiol. no.5:3-5 158 (MIRA 11:6)
(WHOBIOLOGICAL RRSEARCH)

AUTHOR: Oparin, A. T_ , Merr,!,cr, Acade7,~y rf 3(.-.e~.ces 29- 5&5_ic/2~
TITLE: From Matter to Existence (Ot veshchestva k aushchestvu)
FERIODICAL: Tekhnika M,,lodezhi, 11)58, Nr 5,
pp 12 - 1) (USSR)
ABSTRACT: It Is quita understandable, says the author, that everybodyshould
put himseLf the question where living beings originate,
Bas,d on trodern conceptions three stages can be formed throughwhicb
developmert from matter to the creation of life passed. The
first Bta,-e is the for-tion of such organic substances from
which the structureE fu.' a.-Il plants, animals and microbes are
formed wi-,hout exception. The second stage reSUltS in
those most complex organic compounds ior:.ied o.L IV-vocarbons
which now form the composition of living matter: albumen,
nucleic acids, porphyrine and other high-molecular compounds
which relresent the basic substance for the formation of the
living c-ill. Finally the third stage: ~t ~a a prQce-sain which
the complex organic compounds form such systems which can be
Just.1y designed as the most primitive beings. When, in 1924,
Card 1/4 the author picked up the subject of the creation of life V.ere

From Matter to Existence
29-58-5-lo/26
existed the opinion that the original formation of the motit
simple organic substances under natural conditions was riot
pos,ible. This was justified insofar as the research was
:-escricted to the conditions existing on the earth. By exte--._~-
i.ig the investigations also to other celestial bodies th
result was somehow different. At present it is gei.erall,,'
known that in the formation of the earth an interplan(:t-ry
gas-dust-matter served as a basiB.It also seems to be proved
that during the formation of the earth a completely dliferent
atmosphere was surrounding it than is now the case. The in-
vestigation of radioactive isotopes shows that the alge of the
earth sinse its formation to a planet can be estimated to be
about 4-5 biLlion years. At the same time the investigations
of sulfur ivotopee showed that the earth entered into an
oxidation state from a reduction state about 7oo-8oo billion
years aE;o. Of special interest is the problem how and under
which conditions of the original earth atmosphere the albumins
could for:.,i. They are the basic subotancea of any living
organism and are at the came time the main participants, direc-
Card 2/4 tors and ret;ulatore of t~iose processes representing life.

From Matter to Exi-stt-!;ce
Che77,,istr.y ias, ~ta~e - r, ~t -ress in tie inve~:tiz of al-
bu~i i:. s T.-;e possil~jlities of t7~e ~;ri--i:iry f of am i n 0
acids on t e tions exibtiii, ;urint, t:-. for at:on of t-.e
earth n, -I t`ie sta-es of existe::ce -,.-er- ex..erimen-
-~-nese sce-.tist Sh. recently
1- 1 ea, -,ely t-at t-e alb~.mirs rne J
I ro,n
i t..e ;redece,,~sorr of t%e amino acids. This o;,iz,ion V,',s
proved by exp~-rimeiltzs. Today it can be assumed witi, certainty
t.-~at t,,,e abioJeno,--s for--ation of t~ie most complex su'..st&:.Ces
took pl-,ce in t!,e waters of t,,e original ocean- or in ct:-er
waters. T:.erefore also tie second sta.-e seemb to I e
solved. The most i-.-,portant si6n of life is one of t',e for: s
of mot-~on of' matter, the motabolium of albuminous su~st~-.-.ces
interactior, of t.-.e ork-anipm with its surroundin,; world. It is
important to find out how this characteristic fu%ture of
living-matter organic metabolism could form. The mechanis::: of
separating albuminous, lipoid an otner sul-utances in forn of
coacervate drops is at present inventi.' -ated in de-ail and can
be traced experi.---entallly. T-ie coacervate iilbumir -1roi, cI,,.n rt act
Card with t.,.,e surroun~i:.6 medium- Tl~erefore a esis of nev;

From Matter to Existence
29-58 11-loj2~
sutstances can take place in it. Besides thio .-roceBs _3so
a reversely directed process - the decomposition )f t~'e : '~I;-
sta.ices of the coacervate drip - can be observed. I., t,.e
process of trio exi~ann,.on of orFanize(l. matter a new rule rLs
fori-,ed %-.,hi.-h canrot be found in physics, but represents a
characteri.-;tic for biolo,-,.ical objects. The proce.,;s investi at(,J
showed t:..%t the roacervate drops became more anal --;,re per~'(-.-ct
and adjusted to outer conditions. As fir-al results of th.--
procecs t!.ey trans-cr--ed into such syste.--.s in which t-,e ~!oir-
cidence between tl~e deco-ipoEition a:,,d the syntbesis, bet-.-.-een
assi-iilation and disDi:iilation, became perfect. This is
charar.teri--tic for tl~at f,~rm of motion of matter called li`e.
There are 7 fi~-.ures,
heory
Card 4/4

ATIJTI!OR: None 31ven
TITLE Lect-.;res .De.:vpred) by "oviet 3,-.ertists at t,.e Z! 77~ 5 s e5
."Le?.ts,,i sovetskikh ucheny'r-n na Rrvus7e:
vystavkp.~
PERIODICA:.- i-rtr-da, ':r 13,
ABSTRACT: 'r Ai.,ougt the preatest Soviet scientists wi:', de'.iver
lertures )n the ar~,ievemerte of scietco in the at the
Brusse's Fa,,r. In t~.e field of natural 9clences the follow
ing wi:-' lecture: the academlciar.s Semerov, N.N. on --nair:
~ien7ti-)rs ir, 7',,.err.,lgtry, V '.'. ~:ordrat,Yev on S~-,~v,~et X-rws ~r.
Yass-"')pectroscopy, A.P. Vinotgradov or, the 4i(,chprr,.qtr:;
isotcpes, A.V, 31-~ubnikov on the 3rowth of "rystals, 1; S
Shatskiy on the Tectonic Map of the I '; , A C, 2 a r i non
the Present State of the 1'roblem on the r
.rigir. of '.ife,
-sitsin, N.V. on Y-roblems of Distant 'Iybridiz~~tion, : V
Tyurin on 3cils of the Scviet Union and their TItilizaticr,
The followirp lectures will be delivered by corresponient-
members AS P.M. Emanuel' Dr "'eW !vestit7,atiors :r. trp
d Df Cha~r .4eactiors, Andrianov, A r. 'i ~ : . r --) c, r 7 a r: . 2
e I -
lo-Tounds, Ye.K. Zavoyskiy on Phenomena of Elect= i'aramaF-
neti - I-esonance , 1 V . Frank on the ApTli2ation of -.tcmic
Card 112 Energy f or Peaceful Purrnses , V. ; . Popkov on a ':ni~i-,e

'3' 7-1 .'~ _'
Lectures (Delivered, t , .",,v4et Scent:sts at the Br-_ls!:eIs ilx~-.-.b: t~ 'n
,qetiC System in the -he d-'Ivered lectures w--: te
available In Enp,',sh, French, Flem,~s~. a_nd -,erman as ,n-
dividual brooh-t-ires.
i scientifi,, Reports--USIiR 2. Scientific persowne i- Per Comman -I-
5. 3-ierIA.'ic person.:-iei--USSR
Card 212

~CWARIM, A. I.
IntarnAtionn1 Symnoalum on the Problem of the QrlFin of Life.
Izv.AH SSSR Ser.biol. 21 no.2:240-?44 Mr-AD 158. (MMA 11:4)
(LI"--ORIG IN-CONGRESSES)

OFARIN, A.I., GEWHAN, V.S.. ZHUKOV.A. 1.G., LU11YANOVA, X.A.
Interrelation of the enzyme activity of the di- and tricarbo2:ylic
acid cycle and the proteplast structure of Kicrococcuslysodeikticus
[with summary in English]* Bickhimiia 23 no.6:909-916 1-11 '58
(MIRA 11:12)
1, Institut biolchimil Imeni A.B. Bakh& AIR SSSR, Moskva.
(OXIDATION. PHYSIOLOGICAL)

OPARIN, A.I., akademik
From matter to living substance. Tekh.mol. 26 no.5:12-15 '5P.
(MIRA 11:5)
(Lif e-Drigin)

OPARIN, A.I.. akademik.
Prosent status of the problem of the origin of life. Priroda 47
no.3:11-16 Mr 158. (KIRA llj3)
(Mfe--Origin)

AUTHoRs. OPP. Acade,~y of
Sciences, USSJ9, Se:ebrovskaya, K. B., Bardinskaya, M, 3
TITLE: A Study of Ribonuclease Activity in the Preseixe of 3um Ar;~~.~:
(Izucheniye aktivnosti ribonukleazy v prisutstvii
?E111ODICAL: Doklad-- Akademii nauk SSSR, 1'.'59, Vol 12o, Nr 6,
pP 1311 - 1313 (USSR)
ABSTRACT: The problem of the ferment mentioned in the title was sti,.'ied
by meaT:s of rdbonucleic acid (RNA) in continuation of the in-.-rf
tiLqations (Ref 1.) or. the interaction between proteins and
saccharins started by the author and in connection with tne
formation of coacervates the ferment preparation y-elding =a-
cervates under certain conditionr. In this conz:Pction it w-.s
of interest to determine the activity of the ribonuclease
to investii,-ate L*-,c reaction in coacerv"te q
,yst 8 JIB is ft'~)W-
lysine (the ter.--,,inal amino acid ribonuclease molecule, Ref 2)
shows a sli~-tit interaction with carbon hydrates (Refs 3 - 5) it
was necess.,~ri to finJ out whether a lzse of activdt-,. of t~.e
ferment tat~es place, Thc- res,-,.lts of the i~reli7.inary ex-peri en's
Card 1/3 are given on table 1 . It c -n 1~e seer. from it t~iut under t~.e

A Study of Ribonuclease Activiij in the Presence of 2o-12o-6-41
Gum Arabic
presence of jE7um ar'~4bic not only tne capability of t:!e fer, e.,-,t
to i.-reci;,itate by protein preoipitL~tors chai-.,-es (in ac-,-r.JLL:.ct~
with Ref 1~' 'cut also itz; fictivit t
y remtins more const, -.
heating to 400. Fi,rt:~er experd-ients at low teimperat,-ir-s ',20i
shavied th,~t t-,e fer-ent c,-..n.,,.ot be preci~itatel of
preci;)it-itorn (trienlironcetin 4cric acid, tqrinin) 'I'll, S
could riot be &chievel even after from. 6 - 8 hours at f rom
18 - 2o0 The dlita on the leter-.iir-tion of activit.; of t- e
ment a:::-' o f t:.e coi!,i;i ex af te r a 2 It hours incul at i o:-~ -.t
cir titij'r. ' it r - he seen frcn it t~,nt t.le prese:.ce 'f
ji ven
I
~ne pol~-oaco".,Lrci,1e u t~ie activity of tlic, 1'er-ei.t T'. i~ ~r
also t~,e case viiti yezist invertaL3e (Refs I
fiL~-ure, 2 tL",lC'4J, and 16 reference.9, f. of ri~ic)-, .,,re SOV'OL
ASS~~CIATIO'!-. Institut biokIii-iii im. A N.Bf~kha Ak%~emii n:--u'r. SS'-"(
of Bioc"r,e:-istr I
y i-erJ A
51;~~MIT-ED March 14,
C-- rd 2,'3

TT'- E onu

ro
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T , E " :'- - ', , " :t: ~,,: : .. E, - -i in : ~' -.- ' I D:' - j . ,
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I
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- Ili - I

t

OPARIN, Aleksandr Ivanovich, akademik: MORIN, G.A., kBnd.khim.nauk,
Ta.w., red.izd-va: ANIXUA. R.P., tekhn.red.
(Origin of life] Proinkhozhdanie shizni. Moskva, Voen.izd-vo
H-va oborony SM, 1959. 125 P. (MIRA 12:10)
(Life--Origin)

SARTCREV, Boris (kior,viyevich; OPARIII, A.I., nkFidemik, rettenzent;
nONIN. S.I., nuetared.; BAZARSOVA, V.H., spetered.;
WIRASUNA. 0.1., red.: SOKCLCVA, I.A., tektin.rgd.
[Production and biochemistry of rye brand] Tekhnologiia
i biokhimiin rzhanogo khleba. Moskva, PishcheT)romizdat,
1959. 197 P. (MIM 13:1)
(Rye) (Broad)

PHASK I KOK UPWIT&TION SOV/ 3493
v4soorusnoya soveshahway, po fllosofskim Toprosax yestv~tvozh&hIy'
P'llooofsklys
roblemy sovrosohn,oge y*atestvoxnanlya; trudy fovleh-
Chanlya.. Philosophic Problems of Modem Natural Scle-,
.T
21-OnsactIons, of the All-Unlon Conference an Ph1losoprit: Pnobl-
of Natural Science) Moscow. Izd-vo AN SSSH, 1959. 6to p
ItrMt a *lip Inserted. 6,000 cople. printed-
SpQ"oring ftsncy~ Lbcadoal" nauk SSSR.
f Publishing House; A.I. Kompaneyets; Tech . Ed. I.N frokhL.4;
23.
Itorial Ccoo4tt- P.M. Pwdo-ey-, C-rmspo-41-1,g Me.~b.r & -, -_
1;
of Sciences mzz (Chalruan). a.m. VuZ, Cor-.sponal,g x-r~r.
A 44-7
or .1 ..... . F-54r. i-y
or a- ioncs USSR, V.N. 3to2oto Prore ... r, #-,J Y..N Cb'---'
CaAdIlato of Phl1O&QphIC4LI SCI:A... (S~i..tlfl: S.cr-t-y'
PUR"39: This book is Intended for natural scientists ani pr I los.
,p h~ r
who are Into me to :11n co~ordl net Ing C ~anlst philosophy with -ie c
:

9 blicatLah of the transaction. of th~ Al
COVEUGE: "'hlato a
Conforshoo on Phd1od,ph-1c rroblema of N&tUrl, S:j*n7q ~hj:h t
place In "cow, October 21-25, 1958. The Conf-n- -ss
attended by 20 ac&Jemlcla~,s end 30 correspondl -4 -7.1~ r. ~ r t he
heads US-AM. 15 and 34 memo- of -
y of Sciences
J:
-l" 186 univer.l,y -4 "J-g~ - rk~rw.
bl
I
!

240 Toclontifle research Inatitutts, ~J 75 p%r'.y
sp c
&c&4 -
T
Officials. The purpose of the ca ~femnce, as -pressei ty t he
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to unIte the ff~rt. or so,iot phii...pherv &h1 -1-ntl-t- t,,
the dial ctic:1-asterislistic interpretation of the --nie-m-t2
of Modem science, and to provide the phIlosophl:41 b-gr-,d
required for the study of sodern scientific proble-,
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Card 3/'3

UPARIN A I akudemik, red.; DRAUNSHTEYN. A.Ye., red.; PAS11JSXIY, A.G.,
pro?-.,red.; PAVWVSKATA, T.Y,., kBnd.biolog.nauk. red.; ZHAMEN-
SKAYA. M.P., red.izd-va; BUIMMI. A.A., red.izd-va; POIMOVA,
T.P., takhn.red.
[Origin of life on the earth; trnnsactions of the international
aymposium of August 19-24, 1957, in Konoow) Vozniknovenia zhizni
rLa zemle; trudy mezhdunarodnogo simpo2iumn 19-24 avcuuta 1957 goda,
Moskva. Moskva, Izd-vo Akad.nauk SSSR, 1959. 671 P. (MIRA 12:12)
1. Daystvitelinyy chlen AMR SSSR (for Braunshteyn).
(LIPE-ORIGIN-CONGRESSES)

OPARID, A. I.
*The Problem of the Spontaneous Generation and the Origin cof Life on the Earth. "
report to be submitted for the Intl. Symposium of En*rimental Biology,
Reggio Emilie, Italy, 2-7 MaY 1959.
Biochemical Inst, Aced. Scl. USM

BU07ZR XIY. Andrey Nikolayevich; OPARIN, A.L. aimdenik. otv.red.;
POTWIRA, N.A., red.izd-va; KARKOTICH. B.G.. takhn.red.
[Nucleoproteids and nuclain acids in planta and their
biological significance) Nukleoprotaidy i nuklainovye
k1eloty restenli 1 1kh biologicheekoe snachenie. Koskva.
Isd-vo Akad.nauk SSSR. 1959. 45 p. (MIRA 12-6)
(Nucleic acids) (Nuclain) (Botanical chemistry)

AUTHOR: Opaxin, A.T., Academi;3ian SOV/26-59-1-1?/54
-1ITLE: Technical Biochemistry in the Food Industry 'Tek~ini_
cheakows biokhimiya v pishchevoy promyshlennosti)
PERIODICA,L: Priroda, 1959, Nr 1, pp 40 - 43 (USSR)
ABSTRACT: The author outlines past and present theories of'
human nutrition. He points out that recent concepts
of the metabolic processes in the human body are
bound to reflect strongly on the selection of food
to be recommended and its processing to obtain max-
imum values. Vitamins are of paramount importance
and will be incorporated also into such basic vic-
tuals which by their very nature contain little t~~
no vitamins. Vitamins are also thought to be of
value in removing undesired side effects of antibi-
otics. Vegetable fats are to be preferred to ani-
ma-1 fats. This is to be considered in the culti-
vation plans for agriculture. These concepts are
similarly applicable to feeding and fattening pro-
blems in animal husbandry. Vitaminized food gives
Card 1/3 a far greater yield than conventional food. Rele-

Technical Biochemistry in the Food Industry SOV/26-59-1-17/-1,4
vant research and experiments were conducted over
the past _- years by the Institut biologii AN Lat-
viyikoy SSR (Institute of Biology of the AS of the
Latvian the Latviyskiy institut zhivotnovod-
stva i veLcrinarii (Latvian Institute of Livestock,
Breecling and Veterinar~~ Problems) and the Institut
bioknimii AN SSSR (Institute of Biochemistry of the
AS USSR) in cooperation with the industry for com-
bined feeds. Thus, the Rizhskiy zavod (Riga Plant'/
enriched cattle feed with vitamins and micronutrient
substances and determined the resulting nutritious
effectiveness. Similar investigations are being con-
ducted on the effect of ferments on foodstuffs and
their possible use in food processing, in order to
establish a special ferment industry. Thus, the
addition of 20 grams of a preparation of fungous
amylase to 1 ton of white flour improved greatly
Card 213 the sugar content, volume, porosity, taste, flavor

0
Jechnical Biochemistry in the Food 'ndustry SOV/26-5,)-'-17/54
and color Df the crusu of the bread prepartd from
the enriched flour. There is I photograph.
ASSOCIATION: Institut biokhimii im. A.N. Bakha AN "-)'SSR /Moskv~a
(The Inst3tute of Biochemistry imeni A.':. Bakh of
the AS USSR /Moscow)
Card 3/3

OPARIN, A. I.. skademik
Biochemistry serves the people. Zdorove 5
3 '59.
(BIOCHBMSTRY) (FOOD-PMERVATION)
no.11:6-8
(MIRA 13:3)
IP

GELIMS, U.S.; ZHlJXOVk, I.G.; LITKOYANOVA, H.A.; OPARIN, A.I.
Succinic oxidase and malic oxidaseB in stnactural elenents ol.
Hicrococcuo lysodetktiells. Biokhimiia 24 no-3:481-488
lt7~Je '59. (MIRL 12: Q)
1. Institute of Biochemistry, Academy of Sciences of the
U.S.S.R., Moscow.
041CROCOCCUS, metab.
lysodeikticuo, succinic & malic oxidases (Rils))
(bUCCINIC OXIDkSg,
in Micrococciia lysodeikticus (Hus))
(OXIDAbICS,
"uccinic oxiduse in Hicrococcilo lysodeikticlia
Ohis))

OPARIN, A.19
Problems of technical biochemistry in the field of the food indastr7.
Biokhiaiia 24 no.5:769-776 S-0 159. (MIRA 13:2)
(310M PROCESSING INWSTRT)

GILIMAN, N.S.; ZOKOVA. 1.G.; OPAR117, A.I.,
llffect of a surface active substance on the enzymatic system
oxidizing malic acid In cytoplaamle membranes of Mcrococcum
lysodeikticus. Biokhimiia 24 no.6:1074-1078 N-D 159.
(MIRA 13:5)
1. Institute of Biochemistry, AcadeaW of Sciences of the U.S.S.R.,
Moscow.
(MICROCOCCUS metab.
(MOATES metab.)
(SURFACE ACTIVE AGENTS pharmacol.)

17(2,3) SOV/2~)- 126- 1- 54/62
AUTHORS: Gellman, N. S., Zhukova, 1. G., Qk~, Academician
TITLEt The Effect of Desoxyribonuclease on the Oxidation of Malonic
Acid by the Lysates of Micrococcus Lyodeikticus (Vliyaniye
dezoksiribonukleazy na okisleniye -:ablochnoy kisloty lizatami
bakteriy Micrococcus lyodeikticus)
PERIODICAL: Doklady Akademii nauk SSSR, 1959, Vol 126, Nr 1, Fp 1)8-199
(USSR)
ABSTRACT: Malic oxidase - a fermentative system which oxidizes malonic
acid, is of considerable resistance as far as the disturbance
of the protoplasmic structure is concerned. This system is
localized in the oytoplasmic membranes - the "shadows". Such
shadows can be obtained by treating the protoplasts, the bac-
teria mentioned in the title, with water, as well as by a
direct lysis of the same bacteria in an osmotically unstabi-
lized medium (Refs 1,2). The effect of the malonic oxidase is
completely stopped due to the splitting of the highly molecu-
lar desoxyribonucleic acid (DNA) present in the lysate - by
means of desoxyribonuclease (DNA-ase) - into cytoplasinic mem-
Card 1/3 branes which the lysate did not separate. This is expresoed by

50V/20-126-1-541/~Z
The Effect of Desoxyribonuclease on the Oxidation of Malonic Acid by tho
Lysates of Micrococcus Lyodeikticus
the fact that the oxjgen absorption is stopped by the iis,~te
at the expense of' the malonic acid (Ref 1). The present e~ork
tries to explain a relation between the development of thp DNA
in the lysate containing cytoplasmic membranes, and the a~-
tivity of the system of oxidative-reductive ferments. For tho
purpose of explaining the cause for the suppression of the
activity of malic oxidase in lysates treated with DNA-ase and
RNA-ase, the authors quantitatively defined this activity from
the oxypen absorption, The preparations were observed
simultaneously under the electron microscope (Fig 1). The
lysis of the bacteria with lysozym DNA-ase and RNA-ase was
made with both Mg-ions being either present or absent (Fig
As the results show, lysozym in an osmotically unstabilized
medium causes the development of lyBates containing cyto-
plasmic membranes. The active malic oxidase is maintained in
these membranes. Their effect can be found by 0 2- aboor~tion
Lysis caused by lysozym together with DNA-ase completely sup-
Card 2/3 presses the fermentative system mentioned. Magnesium ions

SOV//20-126-1-54/62
The Effect of Desoxyribonuclease on the Oxidation of Malonic Acid by the
Lysates of Micracoccus Lyodeikticus
stabilize not only the structure of the cytoplasmic membranes,
but also the malic oxidase. The experiments proved that the
DNA splitting of the bacterial lysate neutralizes the effect
of the malic oxidase. Since this effect is maintained even in
the presence of Mg-ions, although the Mg-ions do not prevent
the fermentative splitting of DNA, it is most probable that
DNA creates a spatial organization of the fermentative system
of the malic oxidase on a supra-molecular level. An analogy to
reference 8 may be seen. There are 1 figure, 1 table, and
8 references, 3 of which are Soviet.
SUBMITTED: February 16, 1959
Card 3/3

OPARIN. Aleksandr Ivanay1rh_ MSON, A.H., red.
[Origin of life on earth; album] Tozn1knovenif, ~~ii-ni na Zemle;
allbom. Moskva, Izd-vo "Sovetsksia Roseiin." ig6o. 47 plates
(MIRA 14:5)
(Life-Origin)

._gWjj,_AjRksandr ~yanqyichL skedemik; SMOVATOTA, I.B., red.izd-ve;
TOLKOVA, T.T., tekhn.red.
[Life. its nature. origin. and evolution] Zhizn*, as prirods, .
proiekhozhdanis I reavitie. Moskva. Izd-vo Aked.nauk SSSR.
1960. 191 p. (KMA 14: 3 )
(Life)

RUBIN, Boris Anisimovich; ARTSIKHOYSLATA. Telena Vladimirovna;
CWAAXN.,,~, skedemik, oty.red.; EH"OVATOVA, I.B., red.
izd-va; YMMOVA, N.Y.. tekhn.red.
[Biochemistry and physiology of irmminity in plants] Biokhi-
miia i fiziologlia immunitets reatenii. Moskva, Izd-vo Akad.
nauk &IuSR. 1960. 350 P. (MIRA 14:2)
(Plants--Disease and post resistance)

MIMIB, Wvid Mikhoylovich; UPARIN, A.I., akademik, otv.red.: MAKAROVA.
0.Y., red.1zd-va; GUSIKOVAO O.R., tekhn.red.
LBiochemiatry of call restiration] Biokhimile kletochnogo
dykiianiia. Moskva. Izd-v AkBd.nouk =R, 1960. 414 p.
(miRA 14:1)
(USPIRATION) (CM KRTABOLISM)

KHCLLICHER, Val'ter [11ollitschor, Walter); AKCHURIN, I.A. [trnrB1atorj;
ARMUGEL' SKIT, U.S. [translator]; MOCHALO, D.N. [translator];
OWA'YANOVSKIY. M.N.. akademik, red.; b)mde--dk. red.;
HASKVICH. A.G.. doktor fiziko-matem.nauk, red.; ~&_CMIIIIYOV, N.Y.,
kand.filosof.nouk. red.; TYURYUKANOV. A.11., kand.biolog.nauk. red.:
GALIPHRIN, P.Ta., dotsent, red.; URYSON, H.I., kvnd.b1oloi,.nauk,
red.; KAKAROV. A.A.. red.izd-va; ZCTOVA, N.V., tekdm.red.
(Nature in the scientific picture of the world] Pr1rods v nBuchnoi
kartine mire. Obahchais red. I vatupitellnoia statlia M.E.
Oml.lianovBkogo. Moskva, Izd-vo inostr.lit-ry. !960. 469 p.
(MIRA 14:3)
1. AN USSR (for Omallyanovskiy).
(Science--Philosophy)

DIBORIN,G.A.; IVAIICVA.V-P-: OPARIN,A.I.; NLODI,P.
Iffect of ergosterol on the enzymatic activity of phosphoglyceraldehyde
dehydrogenase. Acta phystol.hung 17 no.2:133-140 16o.
1. Institut btokhimit A.N. SSSR, Is Bakha, Moskva, I Institut
blokhimit A.B.' Vengrit, Budapesht.
(DIMROMASIS metab.)
(VITAMIN D Oharmacol)

GELIMANj N.S.; LUXOYANOVA, M.A.; OFARIN, A.I.
CyUchrcme system in the cytoplasmic membria s of Micrococcus
lyrodelkticus. Biokhimiia 25 no. 3:482-486 My-is 160.
(KERA 14:4)
1. Institute of Biochemistryp Academy of Sciences of the U.S.S.R.,
Moscow.
(MICROCOCCUS) (GYTOCHROME;S)

GEL'KiN, N.S.; ZMMOVj,, I.G.; OP.,,Rlbl, -.I.. akademik
Oxidation of L-malic acid and reduced diphosphoT7ridinemicleotide
in the cytopla8mic membrane of MicTococcus lysodeikticus. -Dokl.
j,N SSSR 1-13 no.5:1209-1?12 Ag 6o. (MIR't 13:8)
1. Institut biokhimij im. A.N.Bakha Kkademij nauk SSSR.
(K-Alic acid)
(Nucleotides)
(Micrococcus)
(Oxidation, PbVeiological)

G31L'HkN, N.S.; ZWKOVk, I.G.; CIPARIN, A.I.,&kademik
Iffect of desorycholAte on the oxidation of reduced diphosphop7r i dine
nucleotide, L-malic and L-lactic acids in the c7top"smic membrane
of Hiarococade lyeodeikticus. Dokl. AN SSSR. 135 no.1:200-203 N 160.
(MIRA 13:11)
(MIGROGOOGUS) (OXIDATION, PHYSIOLOGIGAL) (BACTWOLYSIS)

S/0 20/ 60/ 1 ootq'o
B 0 1 b/B Ot, 0
Lj
M'THOR S Se ret. -,o%-:,kay.-, , K . B- ii,; I Oparin, AA ctidemi c i an
TTTLB~ A C~acervate Syc--t.--m C n1,air,,.nt- RNA and Chlorophyl I
PERI~~DICAL Dok'A'ady Akademii nauk SSSR. '-~60. V~!, No. t,
Pp. 1~15"-I-~5
TEM The autnors repor" on their at*empts of working out quitabie
meth:~~s :! introdu- inr :hlnr--)phy11 in cDacervate drops, In this way they
wanted t-- t~inC about plintochemical reactions in these drops. An artif -,ci,~
complex was prDduced by way ,f pilverizing equal parts by weight cf
crystalline 2hj,)r-)Phylj ( Sklr~pl ,ed by V~ B. Yevstigneyev and V. A, Gavr'' 1,
arid ribonucleic, acid RNA Thig mixture w,-is dissolved in water or (with
m-~re advantai ' k
i n a berat e but fer ' PH '0 . The potass ium tetraborate used
f th i ~; pu rprse was -,Yr, ! hr~s ized f r I I - w i n6 inst ructi one o f t he Inst i tu t
-.1,istyk)-j rt-akt,)vov lr'-,ilitute cf' Pure Reagents) Fig. Curve ~ shows
the spectra of this mixture beside the spectra of a real chicrophyll
solution in ethanzil (Curve 1) and cillorophyll in the live. leaf (Curve 2).
It is observed from a c3myarison cf these curves that the chl~)rophyll! PFA
Card

87417
A Coacervate System Containing RNA and s/o2o/6o/135/006/OA,5/037
Chlorophyll B016/BO60
compound rapidly loses tne shaTj. r T'Lc 420 - 4 30 m.-- and 6'0 ~2-
ranges, as are -ypica-1 of real A coacervate was prepared fT,.)M
the mentioned in the preser,ce of serum albumin and potas-3ium
oleate. The chlorcphyil partly acquires a red fluorescence in the coaceiNW~e.
This possibly occurs due to its bond with both the protein and the lipold,
Summing up-. 1) As a consequence of chlorophyll mixing with R19A in the dry
state ohlorophyll becomes soluble in water and salt solutions, 2) Thp
spectrum of the chlorophyll-RWA complex prepared in this way differs From
the spectra of real ethanolic chlorophyll solutions and colloidal
solutions (Fig. 2)? the absorption maximum is shifted toward the longwave
range and thus comes near the chlorophyll spectrum in chloroplaste
(Pig.li2). 5) A prior t-reatment with ascorbic acid is necessary to paB2
chlorophyll from the compound with RNA into an organic solvent (Fig. ~)-
4) The chlo.rophyll-RNA compleT entirely lacks the fluorescence which is
typical of the initial chlorophyll (Fig. 1 : 3)~ 5) The said complex
forms, with serum albumin and with potassium oleate. a coacervate differing
from the initial solution as to its properties. It is weakly fluorescent.
The pigment cannot be extracted from the complex with organic solvents
even after treatment with ascorbic acid. PaperB by H. M. Si8akyan and
Card 2/3

,OFARIN, A~I., akademik (SS.CR)
Life in Fpa.--P. Mir nauki 5 no.4:2-6 '('I. (YlikA :1"'i
(SPACE KOLOGY)

.--- HMNI AA- - SERFBROVSKLYA, K.B.; AUFMAN, T.L.
Synthesizing activity of the polynucleotide phosphorylase of
Micrococccus lysodeikticus in solution and in coacervate systems.
Biokbimiia 26 no-3:49c)-504 My-Je 161. (MMA 14:6)
1. Institute of Biochemistry, Academy of Sciences of the U.S.S.R.,
Moscow.
(~acp'OCOCCUS) (POLYNUCLEOTIDE PHOSPHORYIASE)

OPARIN, A.I.
Organize new industries on the basis of latest achievements in
biocher-istry. Izv. AN SSSR- Ser. biol. 26 no.15:664-66F S-0 '6,1.
baRA 14:9)
1. Institute of Biochomietryp Acadwq of Sciences of the U.S.S.R.,
Moscow.
(C.EIILT7 'GS)

OPARIN _AI.,_a~4qem:Lk
11 - - -
Origin of life. Nauka i zhiznl 28 no.1.1.-4&49 11 161.
(YJRA 14:12
(I,ife--Origin)

OPARIW-,-, A. I., akademik
The universe and life. Priroda 50 no.7.5-12 J2 161.
(Y,UA 14:6)
(Biology) (Space biology)

OPARIN, A.I., akademik
Biochemistry and life. Priroda 50 no.12:8-15 D '62.
(YIFLA 1-:12,
(Biochemistry-Congresses)

OPARDIP k 1 _J)Irector,
"Organic reoche-Acal iqpecti of the origin of 'ife on earth"
To be presented at the Geochemical Society International
Meeting on Organic Processes, 10-12 Sep 1062.
Institute of Beoche- istry ireni A N. Rakh, Mo~-cow

OREKIIOVICH, Vasiliy Nikolayevich; SHPIKITER, Vadim Olegovich;
OPARIN,A..-I., akademik, otv. red.; FATVEYENKO, T.A., red.
1-7-A--va; GUSQOVA, O.M., tekhn. red.
[Biological role, characteristics and structure of soluble
collagenlike proteins (procollagens); read at the 18th annual
Bakh Lecture on March 17, 1962]Biologicheskoe znachenie, svoi-
stva i stroenie rastvorirykh kollagenopodobxWkh belkov (prokol-
lagenov); dolozheno na vosemnadtsatom ezhegodnom Bakhovskom
chtenii 17 mafta 1962 g. Moskva, Izd-vo Akad. nauk SSSR, 1962.
29 p. (Bakhovskie chteniia, no.18) (MIRA 15.12)
(Gollagen)

OPARIN, A.I., &kadeair~.; BOKUCIIAVA, M.A.
Probiems of bi,chemisLry in Lc:a iroouctioL. Biokhim. chain* proizv.
no.9:3-5 162. (14IRA 16-4)
1. Chlen-karrespundent AN Gruzi.:)h (for bokuchava).
rese&ruh)

_PPARIN.- A.I., akademik
Organic substances of meteoritea. Starsh.-serzb. no.9:30-31 S
,62. (MIRA lrl:ll)
(Meteorites) (Life-Origgin)

SEREBROVSKAYA, K.B.; YEVSTIGNE)IV, V.1b.; GAVHILOVA, V.A.; _.O],AiilV,- A.l.
TIrtosens5tizing activity of cidorophyll in coacervates. BicfizLc,~ 7
no.1:34-4.1 162. (Ml?,A 15;5~
1. -istitut biokhimii imeni AJI.Bakha AN A;'SR, Moskva.
(cilLORDPHYU) (COACEHVA",'~S)

OPARIN AI,-
Fifth International Biochemieal Congresu. Izv. AN SSSR. Ser.
biol. 27 no.1:141-152 Ja-F 162. (MIlbI 15:3)
(BIOCHENISTRY-CONGRESSES)

OFARIN, A.I.,, akademik
------------------
~btabolism iB the main thing. Nauka i zhiznl 29 no-4s8 Ap
(1-aRA 15: 7 )
(NETA.BULISM)

. - OFARXNP A. I., akademik
International Conference of Representatives of Science and
Institutes of Higher Mucation. Vest. AN SWR 32 no.l2t68-
70 D 162. (MIRA 15:12)
1. Vitse-prezident Teemirnoy federataii naucbo*h rabotnikov.
(Research-Congresses) (Bducation--Congreases)

OPARIN A. igirsidemik
Universe and life. Av.i kosm. 45 no.10:12-15 162. (MM 25:10)
(Life on other planets)
I
4*

OPPRIN, Jk-l-, akadendk
Life in rjuter space.. Priroda .1 no.9:21 S '62. (14 I:-,A --~ : - (-,I
(Space biology)

OPARIN, A.I., akademik; YEFREINOVA, T.N.; LARIONOVA, T.I.; DAVYDOVA, I.M.
Synthesis and decomposition of starch In coacervate drops.
Dokl. All SSSR 143 no.4:980-983 Ap 162. (AURA 15:3)
(Starch) (Coacervates)

OPARIN, Aleksandr lWovich.._akademik; ISAYEV, V.A., red. izd-va;
SIMKINA, G.S., tekhn. red.
[Life as a form of the movement of matter] Zhiznl kak forma
dvizheniia materii. Moskva, lzd-vo Akad. nauk SSSR, 1963. 47 p.
(MIRA 16:6)
(LIFE (BIOLOGY))

I'k- Ill, A.I.: Piz;K
'1'Y, A.N., prof.; NAUMOV, N.F.,
prof.; KOVAL'SKIY, -,.V.; YLI;IOVA, I.L., dots.; PLATONGV,G.V.,
prof.;KAGANO%, V.v.; ~URJWI, A.Ye., dots.; ~ELATEMV,
1;.V., prof,; ;.,,,V, V.F., kanu. biol. nauk;
ZJU.'.C!*-VE-LZ!-'.IK(--. , N.N.; BONDARENKO, F.P., prof.;
MAYAR, 1.1*:., pru'.; TRIBULEV, G.P., dots.;
I'SAFLEGOROIY13h-V, G.I., dots.; DOEROKHVALOV, V.P., kand.
biol. nauk; YAZDOV3KlY, V.I., prof.; VIKTOROVA, ~., red.;
CHER12-WKE, I., mlad. red.; ULAEGNA, L., tekhn.red.
[Studies on the dialectic of living nature] Ocherk dia-
lekt:Lki zhivoi j?!-i---ody. Moskva, Sotsekgiz, 1963. '127 p.
(MLrU 16- 12)
1. Chlen-kor:- ~,~nt V ra-,ovuzi.oy hh~-Iemli sell--kokho-
zyaystvenWk!. im(~iA '..I.Lcnina (for K,- 'al I skly).
Deystvitel'.-~Yy chlen AMV 3SSR (for Zbukov-!'erezhnikov).
(Bioloa--Philosophy)

~ 1"
-I OPARIN, Q.,.almdemik
Facts, trur-misee, and aammptions. Nauka i zby-ttia 12 no.2:
21-22 F '63. (MIRA 16:4)
(Life on other planet4)

OPARINY A.I*
Life in the universe. Izv. LE SSSR Ser. biol. 28 no.10-8 Ja
F 163. (MIRA 16:8)
1. Institute of Biochemistry., Academy of Sciences of the
U.S.S.R.2 ~bscow. (SPACE BIOLOGY)

GELIMP N.S.; ZHUKOVA, I.G.; QJFARIN, A.I.
Preparation of dehydrogenases of 1-malic acid and the rpduced
form of diphosphopyridine nucleotide from cytoplasmic membranes
of Micrococcus ly"eikticus. Biokhimiia 28 no.lsl22-127 Ja-F
163. (MIRA 16-4)
1. Institute of Biochemiatry, Academy of Sciences of the
U.S.S.R.0 Moscow.
(CODEMROGENASE) (MICROCOCCUS) (MkLIG DWfDROGENASE)

OP-EIII, A. I U'AAYA, PAN FSKI~AVA,
E
Diokhirr.ii--.
T , St r
I . . irv~n~

(IPARIN, A.I., ak-ademik
Life In the universe. Priroda 52 no.2sU-21 163.
(MIRA l6z2)
(Life on other planets) (Life-Origin)

-OPARI-N,-A.I., Wmdemik; SERFJIMSUYA, K.B.
Formation of coacervate drops in the synthesis of polyadw7lic
acid t7 polynuclootide phosphorylase. Dokl.AN SSSR US no.41
943-9" F 163. (KM& 164)
(coacervates) (Adenylio acids)
(Polynucleotide phosphorylase)

0PAAjV..- akadelfflkY STMANOVA, I G ; SEREBROVSKAYA. K B ;
NEKRASOVA, T.A,
Electron m-Icrmr.-cpIC StUdy Of coar-ervates. Doki Ali' SSSR
150 no.3,684-685 NY 163. (MIRA 16W
1. Inst-itut blokb1mil im, A.,N, Bakha A.N SSSF~
( C 0a Z6 r-Va t8 23 )~Ele(-tron ml2ros~~opy

OPARIN, A.I., akademik5 SEUBROVSKAYA, K.B.; PANTSKHAVA, S.A.
I-
Oxidation-reduction processes in coacervate drops; dehydration
of DPN - H(NAD - N). Dokl. AN SSSR 151 no.lt234-236 JTl 'L13.
(MIRA 16:q)
1. Institut biokhimil in. A.N.Bakha KN SSSR.
(Coacervates) (Oxidation-reduction rpaction) (Nucleotides)

;-,.:.A ~. - N ,;, . : . v,(Ft lea K
. , I ~ *'r, ,
- - , ~ ~ -.-I ..
i7.. - , ,;2*.--M~-' H ,
r"7--' g , 'I , - C - . ~ . - , ~- -, - -- . - , , 1: 1 1 , .
4 r. , . ; ~ - - )- - '.!,j
--. t'a "(!s . v I. !i - "~ -,~ ) " m .11~ ~I - .1 11

OPARIN, A.!,, akademik
Origin of metabohm and its evolution. Plriroda 5" no-o,.21;-3-- '64,
I
(MDU I'l, b)

OPARIN, A.I., akademik; SEREBROVSKAYA, K.B.; VASILIYEVA, N.V.;
BALAYEVSKAYA, T.O.
Formation of coacervates from polypeptides and polymeleotides.
Dokl. AN SSSR 154 no.2.-471-472 Ja'64. ~MIRA 17:2)

BIRYUZOVA, V. I.; LUKOYANOVA, M. A.; GELIKA11, N. S.; Q~ARIN, A. I.,
akademi-k
Subiinits in the cytoplasmatic membranes of Micrococcus lysodeikticue.
'MIRA 17-r'
Dokl. AN SSSR 156 no, 1:198-199 My 164. 1.1)
1. Institut biokhimil im. A. N. Bakha AN SSSR i Institut radiat-
sionnoy i fiziko-khimicheskoy biologii AN SSSR.

ACCESSION MR: APk*2802 1;/0020/(A/157/003/0729/0732
AUTHOR: Ellpiner, 1. Yes; Butokskayap I. V.; Oparin,, A, Is# Acadenician
TITLE: On the effect of ultrasonic waves upon the structure wA antibiotic
activity of gramicidin C
SOURCE: AN SSSR. Dokl&W,, Y. 157, no. 3, 1964, 729-732
TOPIC TAGS: Gramicidin C, ultrasonic vave, ultrasound affect, chemical ultrasound
effe6t, antibiotic activity, gnmicidin structure, Bac. mycoides, Escherichia coli,
aromatic aminoacid, aminoacid analyainj glioxalic acid, deamination, peptide,
argon, elebtrophoreois
ABSTRACT: Thin work vas based on earlier studies on the ultrasonic effect upon
structure and function of protein and polypeptide molecules Vith biocat&lYtic
properties. Under the influence of ultrasound the gramicidin C molecu-les undergo
a specific chemical transformation. This is acccapanied by the appearance of
organic matter in the solution, with bactericidal properties against Bac. mycoideB
and Eacberichia colij, the microorganisms used for this study. The gramicidin mole-
cule configuration is described. The product vas ueed in 0.2p 0.3 and 0.5% diluted
Card 1/3

ACCESSION NR: Ap4o42802
ethanol solution. Ultrasonic waveG were applied under air, oxygen or argon at 000
kilocycles and about 18 watt/aM2 for 0-5 - 12 hours, after which the aminoacid
composition was analyzed by chromatography, spectroscopy and electrophoreoia. In
the presence of argon or oxygen a strong smell developed. No significant docompo-
sition of the aromatic aml oacids of the gramicidin molecule was observed by
spectrophotometric or chromatographic methods. The clectrophoretic test gave an
additional spot with bromophenol blue. Glioxalic acid was also detected. it in
assumed that side groups of peptidee (leucina, oruithine) were detached, with de-
samination of the terminal NH2 groups, and that the Increased bactericidal activity
was caused by a newly formed, as yet unidentified compound. This i9creaaed activi-
ty was not observed when ultrasound was applied in the presence of hydrogen. These
findings point to a possible new source of biologically active compounds. Orige
art* has: 3 figures ejad 1 table#
ASSOCIATION: Institut b1ologicbeskoy fis1ki Akademii nauk WSH (Institute of
Biophysics,, AcadwW of Sciewmap SWR)
5URaTM: Opaalf4
INCLI. 00
card 2/3

OPARIN Ij Aemik; GELIMAN, N.S.; ZHUKOVA, I.G.; SHVETS, V.I.;
CHERGADZE, Yu.N.; TSFASMAN, I.M.
Lipide of the dehydrogenase preparation from the cyto,4asmic membranes
of Micrococcus lysodeicticus. Dokl. AN SSSR 152 no.1:228-230
S 163. (MIRA 16:9)
1. Institut biokhimii im. A.N.Bakha AN SSSR; Institut tonkoy
khimicheskoy tRkhnologii im. M.V.Lomonosova i Institut biologi-
chaskoy fiziki AN SSSR.
(LIPIDS) (DEHYDROGENASES) (BACTERIA, PATHOGENIC)

Ci
~r "Onamide for lr.*lravenc,,..,, 'nf-ls~onfl
n *:.c- ',ruz.liai 32 no.F:663-H.4 Ag
.3vu k q -
p- rma r- ir.'ki Ftiz,~-wtczne.~,
-eS7'

OPARD~.. A.I,, akademik; KRARTIYAN, Ye.F.; GELIM, N.S.
Localization of hydrogerases and "heir relAtion to Cx7gfm =
cells of LactobacterAum pentoaceria=. Dok.I. AN SSSR 157 no.1:
211-214 J-1 164 (M-IRA 17t8)
I. Instit-ut biokI,'nI,' Im. A.r. Bakha AN SSSR.

OPARIN, A. 1. 1, akademi k; KPI-7( ~. " ~: II" . I
Sixth internat-'ona' t 7 - z ' 1,,est. 1,
, 1,171 ,
nc--:'3--5 .-a '-5. -- IS:-
1. Chllen-korresi--onder.t ;.': --... '. Ifor ?"reLovich;.

A akad a k.
",as= 8L:-~:
n ar. e n z,~ma re:
.-~S. ",Ok- S

METLITSKIY, Lev Vladimirovich; OPARIN, A.I.p akademik, otv. red.
[Biochemistz-y in )-,arvest protection; biological principles
of storing potatoes, vegetables and fruit] Biokhimiia na
strazhe urozhaiaj biokhimichaskie osnovy khraneniia karto-
felia, ovoshchei i plodov. Moskva, Nauka, 1965. 182 p.
(MIRA 18:7)