SCIENTIFIC ABSTRACT SEVERIN, V.A. - SEVERNAYA, O.A.

• Document Type: CREST
• Collection: Scientific Abstracts
• Document Number (FOIA) /ESDN (CREST): CIA-RDP86-00513R001548220004-5
• Release Decision: RIF
• Original Classification: S
• Document Page Count: 100
• Document Creation Date: November 2, 2016
• Document Release Date: August 23, 2000
• Sequence Number: 4
• Publication Date: December 31, 1967
• Content Type: SCIENTIFIC ABSTRACT

-SEYERIN,,V.A.; VERKHCVTSEVA) T.P.
I' Ai
Studies on a I*ijsibility of the synthesis of synn tin by P.
chrysogen,40 Antibiotiki 5 no.3:U-15 ltr6-wTi '60. 1... . 14:6)
1. Voesoyuznyy nauc~mo-lssledovatellskiy imtitut antibiotikov.
(SM04ATINE) (PMCILLI%I)

SEWRIN, V.A.; GORSKAYAq S.V.
Synthesis of streptomycin in enriched synthetic meedia. Antibiotiki
5 no. 5:21-25 S-0 160. (MIRA 13:10)
1. Vsesoyuznyy nauchno-issledovatellskiy institut antibiotikov.
(STREPTOIAYCIN)

SEVERIN V. A., GORSKAYA, S. V., and GRACHEVA, 1. V. (USSR)
"Amides in the Biosynthesis of Streptomycin and Glucosamines."
Report presented at the 5th International Biochemistry Congress,
Moscow, 10-16 Aug 1961

GORSKAYA, S.V.; SEVERIN, V.A.
Effect of carbon sources on the biosynthesis of streptomycin.
Antibiotiki 6 no.3:210-215 Mr 161. (MI&k 14:5)
1. Vsesoyuznyy nauchno-issledavateltskiy institut antibiotikav.
(STREPTOMYCIN) (ACTIN014YCES)
(CARBOHYDRATE METABOLISM)

ox
-10
-gen in
c -h- and
(mTRA, stQ
a-n. t i-b-' .--, t
k

---
SEVERIN, V. N.
ItPrevention of Operation Shock," Voyenno-Med. Zhur., No. 11, P. 73, 1955.

sxmilj, V.11.
Multiple bullet wounds of the abdominal region. Xhirurgiia,
no.11:85 N 155. (HLRA 9:6)
1. Iz khirurgicheskogo otdeloniya 14-skogo gospitalya.
(ABDOMIN-WOUNDS AND INJURIES)

SEIMIN, V.N., gvardii DodDOlkovnik med. sluzhby; PRILEPSKIY, G.P., polkovnik
--- -mod. sluzhby
Treatment of perforated ulcers of the sto.7ach and duodenum in remote
areas. Voen.-med. zhur no.5:31-34 W 157 (MM 12:7)
(PKPTIC UICIR, perforation,
ther. in field cond. (!his))

7'1~-,a -, , - - - e:I I I .
1,
SwERIN, V. 11. - ,,
Postoperative fistula of the pancreas. KhiruLrgiia 33 no-11:113-114
If 157. (KIRA 11:2)
(FANCRUB. fistula
postop., ther. (RuB))

SEURIN, V.11.
Large open wound of the abdorinal organs
plications. Xhirurgila 35 no-3:123 Mr
(ABDOIM, wds. & inj.
large open wd. of abdom.
with multiple com-
'59. (MIRA 12:8)
organs, Burg. (Rue))

SEVERINY V.N.
- - -- - -----------------
Thrombophlebitio after hemiotomy. IDdrurgii 36 no.4-'105-107 Ap
160. (HERIIA) (VEINS-DISEASES) (MJU 13tl2)

KOCHETKOV, N.K.; DDMBROVSKIT, Tanush; BAZHENOVA, A.V.;!~S~VERIN, Ye.S.; NESMNYANDY,
A.N.
P-amisevizal ket9ses. Part 4. Synthesis of ketones of the p7ridize
series. Izv.AN SSSR Otd.khim.nauk no.2:172-176 F 156. (NTQA 9:7)
l.Mookovski.v gosudarstvennyy univeraitat imeni M.V.LomoneseviL.
(Ketones) (Pyridine)

ATITHOR S: 11. K., Ambrush, Ivan, SOV/79-28-11-27/55
Kochetkov
,
Ambrush, T. I., Severin, Ye. S.
TITLE: Synthesis of Aliphatic P-Chloro-Vinyl Ketones From Oxy-
Methyl Ketones (Sintez alifaticheskikh P-khlorvinil-
ketonov.-Iz oksimetilenketonov)
PERIODICAL: Zhuri-Ld obshchey khimiJ., 1958, Vol 28, Nr 11,
PP 3o24 - 3o27 (USSR)
ABSTRACT: The most convenient synthesis of the accessible
and reactive P-chloro-vinyl ketones is offered by the
direct condensation of the chloric anhydrides with
acetylene or vinyl chloride (Refs 1-5). Another
one is given by the treatment of the correspondinj
oxy-ethylene ketones with phosporohalogen ketones
or thionyl chloride (Refs 6,7). The latter was
employed for the synthesis of aryl-p-chloro-vinyl
ketones (Ref 8) but not for the most simple alkyl-p-chloro-
vinyl ketones, as these can be obtained more easily
by the first mentioned method. In the case of a
Card 1 failure of the first method the second may be of

Synthesis of Aliphatic P-Chloro-Vinyl Kutones From SOV/79-28-11-27/55
Oxy-Methy). Ketones
importance. Two examples of the synthesis of the
aliphatic P-chlorc~vinyl ketones from oxy-methylene
ketones were Givcni, which can in all cases be used
for the aliphatic series as viell.'The reaction of the
oxy-methylene pinacoline with thionyl chloride
in benzene solution was investiGatod in detail. It
was found that the substitution of the enol hydroxyl
of the oxy-methylene ketone by chlorine takes place
sufficiently easily. In this case the yield of alkyl-
P-chloro-vinyl ketones amounted to 70-80%, which must
also hold for other al"".yl-P-chloro-vinyl ketones. The
earlier inaccessible a-alkyl-P-chlo'ro-vinyl ketones can also
be obtained accordin- to this method. There are 15
references, 9 Soviet references.
ASSOCIATION: Moskovskiy gosudarstvennyy universitet (Moscow State
University)
Card 2~-

AUTHORS: Khomutov, R. M., Karpeyskiy, M. Va., SOV/79-29-2-60/71
Severin, Ye. S_ udovskiy, E. I., Kochetkov, N. K.
_L_B .'
TITLE: Cycloserine and Related Compounds (Tsikloserin i rodstvennyye
soyedineniya). VI. Synthesis of Cycloserine Analogues With a
Substituted Amino Group (VI'. Sintez analogov tsikloserina s
zameshchennoy aminogruppoy)
PERIODICAL: Zhurnal obshchey khimii, 1959, Vol 29, Ur 2, pp-642-650 (USSR)
ABSTRACT: To investigate the relation between structure and chemothera-
peutical activity in the lately discovered 4-aminoisoxazolidone-
-3-derivativesp the authors applied their earlier worked out
method (Refs 1,2) to the synthesis of cycloserine analogues
with a substituted amino group. In the course of this work,
F. corm and collaborators (Ref 3) published a different
synthesis of two representatives of this series. The synthesis
of the above-mentioned analogues of cycloserine took place
according to scheme 1. Other vrays to form compounds (II) meet
with difficulties. a-chloro-p-isopropylidene aminoxy propionic
acid (I), one of the intermediate products in the synthesis of
cycloserine (Ref 2) served as initial product. On the reaction
Card 1.13 of compound (I) with various amines in aqueous and alcohol

Cycloserine and Related Compounds. VI. Synthesis of SOV/79-29-2-60/71
Cycloserine Analogues "Nith a Substituted Amino Group
solutions no alanine derivatives (II) were found in the re-
action mixture, contrarily to the case in which inert solvents
are used and also in case the reaction takes place without
solvent with an excess of amine, The amination of (I) was
carried out with methyl amine, 1.1-phenyl ethyl amine, benzyl
amine, piperidine and morpholine, which were all taken in ex-
cess to the initial chloric acid. The result in the crystalline
state was a-methyl amino, a-benzyl amino, a--phenyl ethyl amino,
a-piperidyl-p-isopropyliden2 amino oxy-proplonic acid, with the
specified radical values, iii yields of 25-70 %- No pure
crystalline product was obtained with morpholine. The next
stage was the transition of (11) to the dichloro hydrates of
esters (III), which was carried out with a mixture of hydro-
chloric acid and alcohol, with subsequent esterification. They
were partly obtainea in the.crystalline and partly in the non-
crystalline state. For the synthesis of other analogues of
cycloserine (IV) the oily dichloro hydrates were used, which
were not obtained in crystalline state. It was shown that the
substitution in the amino group of cycloserine completely stops
Card 2/3 its chemotherapeutical activity. The above-described

Cycloserine and Related.Compounds. VI. Synthesi3 of SOV/79-29-2-60/71
Cycloserine Analogues With a Substituted Amino ",roup
cyclization of the N-substituted substances of P-chloro alanine
hydroxamic acids into the deriva--,ives of 4-aminoisooxazoli-
done-3 is preferable to the othe::7 schemes suggested by the other
authors. There are 3 references, 2 of which are Soviet.
ASSOCIATION: Institut farmakologii i khimiote..7apii Akademii meditsinskikh
nauk SSSR (Institute of Pharmaco:'Logy and Chemotherapy of the
Academy of Medical Sciences, USSR)
SUBMITTED: December 17, 1957
Card 3/3

5 (3)
AUTHORS: Khomutov, R. M., Karpeyskiy, M. Ya., SOV/79-25-4-62/77
Budovskiy, E. I., Severin, Ye. S.,
Kochetkov, N. K.
TITLE: Cycloserine and Related Compounds (Tsikloserin i rodstvermyye
soyedineniya).VII Synthesis of 5-Methyl-,'~-Aminoisoxazol'Ldonal-3
7
Cyclotreonine) [VII.Sihtez 5-metil--4-aml--ioizoksazolidolia-
~tsiklotreonina)]
PERIODICAL: Zhurnal obshchey khimii, 1959, Vol 2q, Nr 4, PP 1328 - 1333
(USSR)
ABSTRACT: In the present paper the 8 thesis of the 5-methyl-4-am-4noisoz--
azolidone-3 (cYclotreonineris described. The reason for this
choice was the authors' desire to -aae the method earlier worked
out by them (Refs 1,2) for the synthesis of the 5-subst-ituted
homologues of cycloserine, and since the latter is genetically
related to the vital amino acid-trecaine. This fact permits the
assumption that cyclotreonine is as well biologically active.
When this investigation was finished a report was published
(Refs 4,5) on the synthesis of cyclotreonine from treonine over
Card 1/3 the corresponding hydroxamic acid. The synthesis of cyclotreund-ne
(VI) carried out by the authors is illustrated by scheme 1.. The

Cycloserine and Related Compounds. SOV/79-29-4-62/77
VII Synthesis of 5-Methyl-4-Aminoisoxazolidone-3 (Cyclotreonine)
initial product (I) was obtained by the chlorination of methyl
crotonate in methanol at 10-150 (70-CCFP' yield), contrary to the
complicated prescriptions in the publications. The condensation
of (I) with the sodium derivative of acetoxime (Ref 2) led to
the ester (II) which was saponified into the)acid (III). Com-
pound (III) yielded the amino acid (IV) O(Yfa with excess liquild
ammonia at 45-500 within B-10 hotirs. Phe hydrogenation reaction
CH 3>
,vas used for the determination of their s'x 1.ctu:-_e2
CH3
since it proceeds without contact with the asymmetrical P-carbon
atom (Scheme 2). This way is a new method for the determination
of the structure of the a-amino-P-isopropylidanaminocxy Pacids.
The result of the reaction was the s3-,aration (871/4o) and the
identification of the d0-allotTeonine which points out that(IV)
belongs to the erythro series. The ne:-t stage was the transition
of the amino acid (IV) to the compourni (V) (50-6M,) * The last
stage consisted in the cyclization of the dichloro -hydrate M
Card 2/3 into the cyclotreonine (VI) by a caustic potash solution in

CycloBerine and Related Compounds. BOV/79-29-4-62/77
VII Synthesis of 5-Methyl-4-Aminoisoxazolidor-c.-3 ("yolotreonine)
methanol solution (80-8%~.). Since thal structui~e is not, chan~--ed
by the cyclization the formula cis`f, 1-5-methyl-'-amin-aisex-a--c-
lidone-3 can be ascribed to the crcloit--reonina. The i,9
also confirmed by the data of the infrared s]?P-ctrum. Its
arity was determined by means of the paner chromatography.
Cyclotreonine has a distinctly mar,'-,e:l ant�tuberoular activity.
There are I figure and 5 references, 3 of which are Soviet.
SUBMITTED: February 10, 1958
Card 3/3

170) SOT/20-126-5-62/69
MITHORS,
BudovmklZ,j~j.. S ... ri.. To. S.

TITLE. The Unhook" of the AAtiblatt Lff I of Cyclos.ria. (0
.., UAL". "t, his tich.,kc. &:I.t,iy& tatki-rine)

rlUODICALt Boklady kkadeali cook 353R, 1959, Vol 126, Nr 5v Vp 1132-11)4
(0331)
ASSTRACT, Th. cycloserino us. paid att4stion to since Its discovery 71)
ons
,! -the now head se, high effective antitubarcal
(I'll
tt
.
a...%other b&a4 a. as interesting ant suitable object
:
to . dy the 4.p-d..o f the biological effect " the truc-
,
the Im.utt.
t
wAU- 4 :a he Association for ....
7.aro t.41 of the (4-4-- ,.0-
leanzasolidone-3) and r.2.%.4 acmpo"4. he. been carried out
R
.
tltod. W
O.Uan veral coupounds of this ..rise
f
.
cv .:
1. ri. lt-~If Is Is act
steed.
,
=
In
osl,y of Interest be- ISa; .Z. t.;I. structure but
I- at Its -aw-l couples Of properties by hl.h it

f
diff
ron other known sstlbt y paper.
,
P

Card 1/4
ltL (26.-
:%::
set :
ost, :
af
%he th ... zi .4 In the till
any be &uPPQw4d that the essential part of the sati.-
o4tivity of Us oyelog.rice, to It. zh Icrobi.
" rog"
ft-tabolLsm of the alarg.or,nal".. the paper is d.L:. ad 10
the dl"-Gt- of the prob&Mo nature of this influence
GOna-OtlOw -ith "0 hypothesis at the bi,,h,.L,al ff.,t,4.f
OYOIOSOrtS- proposed by the "there. Cy.loo.rine reacts easily
with LramUa aldbydoo (datas, of %his ... *ties are psullaboa
ara,!~) MAS fares LAStabl- samothlo. 44ri,ativ..
:." '.4:r&);tTbay U%RmfQm Quickly into Isomeric. stable
Dompoundo an& It *QA t"Us: Tb:l th A. d.rl,ati,..
harn & sack "Unlare ma%ff..% Cy with
~QboUtated motime group and each without mine group are a"-
Pl %*17 LR&GU"
teethe natural :,Th* ""noto Or tA- antibiotic I- not Saforlor
womer in ralstion to -ttli%7 but it .,.. a_-
P4ss4& tkv latter samotlues Is We "Card. This cannot be vj-
Plain" till --- (The said &OUrIty of the single
V-8,10wastid-Ut "der Sho d1racU., of pre. ,.,N. ChwTnUkba by
1K. . 1kragr. 1. 1. S&Iyn- . T. p. 0. A. con,., X. A.
ulint". a. To. KlwaL1M, T- S- JUIrnfAu-1, S. 0. Rktd.*,
Card 2/4 T. E. Solow-Y." B. 2. 3001'.1ko", "d J. V. ChanaU..k, 1,
Pposs %bar- the-
Is now of "he ..at I.Partmet
amallotatione of the antibtotto aouvity of cycle
(R.f It this Is right bon the cycl ... rIAo an., 1. In,.
the tramassLin' ties ro"U" mvv- ;aincly. Actually xp.rta..t
Ma 'a by To. 11. Tyh4paA and 1. 1soon - no the request of the
authors have she- that cycl-ria. Osivl.t.ly Inhibit. the
p
onsymotl tics, In tiss system py"vic sold - gl-trla
said in :.ftU2:%xu#Ao&. carres"A41mg to the beettrt-tatto on&
(5-10 y/al). The original eattom of the LabibittoA meah"Ism Is
the formation of the amemothl" dortrati- by me"s of easy..
wof.ruests cat.4.1ag the U-sonim.tion with the pIrldox.1
,be. photo. Th. re"Itine be** ..at b;c:::.1.o:mpb11-d
Mah cannot 4-poss agalm, Possible ways a 111s..
U" are 1.
'A. suporr routed. By-Uo "I& original &.Stan %be ynth..J. of
,he d". !I and glaUxto "it "d of the gly.ine I. uppr' $.ad.
., -00 - - -- blev"%ho.to of the specific must.*-
. ro ..... ... mod thereby Is* fw example lethal for Xiorobaot*rim
I tob.ravlo.l. at kich they &" *be mala part of its proteins
(Is f -)). Th. "Us giewn here ore I. 1t%. with the ox1,s%Smg
Card 314 data. concerning the GtlVttr of the analogues of this "it-
wi.ti. (It.fs 7.10). Tba-60tlautlwn does a' t-sectio. .12 tho-
being forced
,,oloa.rL- GtI-ft but Goly W% of Lt- with been
city by 67-1--orts. -a it$ 4o
r fith-
I:r:" be %axle for the a,%" rgmlsaa or th8Y.Gonew
::to a ,h
(,.. Co. La. 1Lg) out or 11, the
C-1 .14, T o are to reference-, 4 Of
ASSOCIATM. j..%jtut fr"kol.gii j kki"OW-Pit
;.61.14.1 . ,Anatitat. or rbsraeGolua and Ch a*tb4r-PY of the
'door of 44414-1 Q332,
womm.f.a. Kern h a. 1959, by j. S. p.,swayeaev. Academician

BUDOVSKIY, E.I.; KHOMUTOV, R.M.; KARPEYSKIY, M.T.a. ;__SEMI N. Ye.S.;
KOCHETKOV, IT.K.
I
Some substituted 2-aryl-5-aryliden -A" ~.-imidazolin-.4-ones. Zhur.
ob.khim. 30 no.8:2~69-2573 Ag l6o. (MIRA 13:8)
1. Institut farmakologii i khimioterapil Akademii meditsinakikh
nauk SSSR.
(Imidazolinone)

KOGHETEDV, V.K.; BUDOVSKIY, E.I.; KHOMUTOV, R.M.; KLULYSKir, M.Ta.;
SLVMIN, Ye.s.
Stereochemistry of azlactones. Zhur.ob.ichim. 30 no.8:2573-2578
Ag 160. (MIRA 13-8)
1. Inatitut farmakologii i khimioterapii Akademii meditsinskikh
nauk SSSR.
(Aslactones)

SEVERIN. Y. N. S., YjU"MSKIY, 14. YA., KH%IYTOV, R. H., BOGDASHOVA.
L. S. (USa)
'Synthesis of,9-(N-Pyrazoly1)-Alanine."
Report presented at the 5th International Biochemical Congress,
Moscow, 10-16 August 1961

SEV~--,Pl n. 7 , TO~CHr?'SKIY, Y7. M., K`CMUTOV, R. M., Ga-T-1HPI, N. V..
-_ ~,-- -- 'YA . , and 707-Y,~-':10VSFlY, 0'. L. (USSR)
"The Mechanism of the Inhibition -f Flyridoyal 7nzymes by Cyloserine
~nd 7el7ted Hydorcylamine Derivatives."
Report presented at the qth internationRl Biochemistry Congress,
Yoscow, 10-16 Aur 1961

13. TREUSOV, YU. NI., KAIPE"MHY,
if
ynthesis )f Certain Biologically Active lyiroxylamine
Derivatives.
Report .presented at the 5t,,' Int,-.rnational HophemLstry Congress,
Mo~,cowy 10-16 August 1961

KHOMUTOV, R.N.; KARPEYSKIY, M.Ya*- SEVERIN Ye S
Relationship batween biological action and chemical properties.
Biokhimiia 26 no.5:772-781 S-0 161. (MIRA 14:12)
1. Institute of Rhdiation and Physico-G6mical Biology, Academy
of Sciences of the U*SoS*Rep Moscow*
(CYCLOSERINE) (BIOLOGICAL PRODUCTS)

SEVERIN, S.Ye.; DIKANOVAI A.A.
Amino ac-id composition of protein-free filtrates of smooth muscles
in vertebrate and invertebrate animals. Biokhimiia 25-ho.6:103.2-
1017 N-D 160. (MIRA 14:5)
1. Chair of Animal Biochemistry the State University, Moscow.
(MUSCLE) (A~UNO ACIDS)

XHOMUTOV, R.N.; KARPEYSKIY, N-Ya.; SEVERIN, Ye.S.,., GNUCHEV, N-V.
Mechanism of the interaction of cycloseriine with pyridoxal and
pyridoxal enzymes. Dokl. AN SSSR 140 no.;?:492-495 S '61.
(MIRA 14: 9)
1. Institut radiatsionnoy i fiziko-khimic'ieskoy biologii AN SSSR.
Predstavleno akademikom V.A.Engel'gardtom.
(Isoxazolidinone) (Pyrldoxal)

KARPEYSKIY., M.Ya.; KHOMUTOV, R.M.,*_~EV71
ERIN, Ye.S.._
New synthesis of canaline. Zhur.ob.khim. 32 no.4:1357-1358 Ap
,62. (MIRA 15:4)
(Canaline)

SEVERIN, E.S= KHOMUTOV, R.M. KARPEISKIY, M.YA. AND IRISUS1707.1 YU.N. --
."The mode of interaction of some cyclic derivatioves of hydroxylamine with
pyridoxal and palp-enzymes.
1-~5
Paper presented at the SYMPOSiUM on Biological ahd Chemical aspects of
pyridoxal catalysis . Rome, Italy 2U 21-31 Oct 1962

ITOLMUTOV , R.M.; YAPTEYSMY, M.Ya.; Blll'(;ER, ~I.A.,- SSVER'"Ili, Yc.s.
On some apalo~~aes of cycloserine with antitubercular effect.
Vop. ined. khim. 8 no-4:389-391 JI-Au 16-2.
0
(MIRA 17:11)
1. Laboratoriya khimicheakikh oanov biologicheskogo kataliza
Instituta radiats-ionnoy i fiziko-khimichaskoy biologii AN SSSR
i otdela khimioterapii Instituta famakologii i khimioterapii
Allf SSSR, 14osk,.ra.

KHOMUTOV, R.M.; KARPEYSKIY, M.Ya.; SEVERIN, Ye.S.
...... ;--
Synthesis of tetrahydro-1,2-oxazin-3-one. Izv.AN SSSR.Otd.khim.-
nauk no.6:1074-1076 162. (MM 15:8)
1. Institut radiatsionnoy i fizik-o--kblmi,.-heskqy biologii
AN SSSR.
(Oxazinone)

KHOMUTOVS R. M.; KARPEYSKlY. K, Ya.; SEVERIN, Ye. S.
Derivatives of hydroxylamine. Report No. Al': Synthesis of
evclocanaline (homocycloserins) and relatod compounds. IzV.
AN SSSR Otd. khim. nauk no.12.-2161-2166 1) 162o
(MIRA 16:1)
1. Institut radiatsionnoy i fiziko-khimic)leskoy biologii
AN SSSR.
(Isoxazolidinone)

KHOKMV, R. M.; KARPEYSKIY, M. Ya.; SEVERIM, Ye. S.
- - I- -.... .. .
"Rational design of amino acid antimetabolites for specific inhibition of
enzymes."
report submitted for 6th Intl Biochemistry Cong,, New York City, 26 Jul-l Aug 1964.

K110,14UTOV, R. ~1.; YJUTEYSEY, It. Ya.; SEVERIN, Ye. S.
~ I
Derivatives of hydroxylaraine. ReDort no, 6: S5mthesis and some
reactions of B-aminohydroxyalanine. Izv AN SSER Ser Khim no. 4:
680-685 Ap 164. (MIRA 1?:5)
1. Institut radlatsionnoy i fiziko-khimicheskcy biologii AN
SSSR.

K 110 t1l T l';V it, 14. 3,
A-1;Uted J- I 3cxpzn'" a Or. t
3
bio"-

uomu,rov, R.14, SE111FRIN, Ye.S.; KOVAIEVA, G.K.
---. - . ~ - -- ~ I :- - -- -~ ---
Controlled synthesis of inhibitors of enzyiw.tic glutamic acid
transformations. Dokl. AN SSSR 161 no.rl:122"-123,0 Ap 165. 18-rl)
1. institut radiatsionnoy i fiziko-khimiche!koy biologit AN SSSR.
Subm.l.tted June 17, 1964.

K11i",%! IJIPOV, R.M.
K(IVI- LFVA
J.n -.rnsenc-~ of -,c 'Ose rJ nP- and i t~'
a -1;~ rj -110,G S-0 5,
(MIRA 18: 10)
f 1 --ii-c--kh-imic~Ieskoy bic)-lot-ii AN S SR,

UwV'rhy : Ubbit V
CATEGORY Pharmacology and Toxicology. Narcc!tics and
Hypnoties'
~
~5
4
A BS. JM . i RZhBiol..,
3
0- 1 1?59., No.
AUTHOR Dunayeva, V. F.; Ivanenko, Ye. P.-, Severina, A.1
DIST. t Kharkov Pharmaceutical Institute
TITLE Effect of Narcosis on the Shift o.-.' Sulfhydryl
Groups in the Cerebral Tissue of white Mice
-ORIG. PUB. ; Tr. Kharlkovsk. farmatsevt. In-ta, 1957, vYp. 1,
3o4-306
: During sleep Induced in-mice by ether, barbamyl
fa-mytal sodium7, medinal and urethane, the quan-
tity of SH-groups in the cerebrum somewhat in-
creases in different degrees under the influence
of various prepara~jons. This inc;rease occurs
proportionally to the duration of sleep and the
concentration of narcotic drugs. The content of
SH-,groups changes unevenly during various periods
of narcosis: during the period of excitation it
rises only insignificantly, during sleep it In-
CA RD: 1/2
A

rY.
44,
rix.
24, Awl 4~.,IWUO
ma
m
o
..... IV
kave-
b L

GEGESI KISSP Pal, dr.. akademikus; HJ40'Yl, Bela, d2-.; BtIRTRA,, Iajos, dr.;
HCRVATH, Laszlo,Gabor, dr.; P.LIEIE-IUIAIi);Lu(;y; PMGZII., Jozsbf., dr,;
LENAPD, Feren-- dr.; G6-IR6ZIU, Janos, dr.; UYLRI1~9,Erzsebet dr.0
KARDOS, Lajos., dr.
The 1962 work of the Comittee on Psychol3Ey., Hungarian Academy of
Sciences. I-Iagy pszichol szemle 20 no.3.337-386 163.
1. Magyar Tudomanyos Akademia Pszichologiai Bizottsaga elnoke
"Magyar Pozichologiai Szemle" foszerkesztoje (for Gegesi Kissi.
2. "Magyar Pszichologiai Szemle" szerkeszto bizottsagi tagja
(for Horanyi, Bartha, Horvath, P.Liebermann, Lenard and Kardos).

GORICINP V.Z.; SEVERINA, I.S_.; POLETAYEV, A.I.
Effect of dimethylhydrazine and tetramethyltetrazene on the activity
of mitochondrial monoamine oxidase. Zhur.VKHO 9 no.l.-115-1.16
1649 (MIPA 170)
1. Institut biologicheskoy i meditsinskoy khUdi ANT SSSR.

fz&zen,-* of O-uviL~z~ Lizz of blood. =4 Partial
K.~TILIISUY Of GIF-Mul &BUS110 f0la 01311 in UVO :hkk IME dfCdg.
7 i lii5i 1 :67 'W4 . Urle,as /i
7
-0 A,
Aftcf 24 !,r 74,
48 ;,r Addition In the S-Pc-n~~'I--
;I; ln~- wl,ls - tugethet witil
glucose fl"00-46S 'u;~ L a, of p.,dactwn of 1 24 hr aitcr
tile start A SZar-1-3) Ih,, ;-(h~l approx the level Ul iynthe~iis In
nor nial chick, m tttc full---g d-tys of starvation a lesi miirk~i
effect was observc-d. Lrs~; ol hNgAl (3- -5 lilt. once or twice), krnuunt-
ing on the wverage to 4-- 9 g. per 100 g. of b'x.1y ivt.. showed no
noticeable effect. After partial removal fit the liver (ap rox. 400%,
of its totm wt.), tile sUces of tile remaining regenerAting river USSUO
showed after 24 lir. a considerable deprossion of the ~Yntheiis of 1.
and even a disappekrance of pre-existing I ; after 2--5 days the
production of I ii%~reazcd sharply, and much -xci--ded the level in
the same.chi~-ks before operation. Tile amount of I in the plasma
was soynewhat lowered by partial bepa~tectomy. (Ruuian)

S-EVEREIA, i. S.
Severina, I. S. - "Investigation of the Formation of Serum Album-in in the
Surviving Liver Tissue of Chicks under Normal Conditions and under Certain
Influences Changing the Conditions of Protein Metabolism." Acad Med Sci USSIR.
Inst of Biological and Medical Chemistry. Moscow, 1956 (Dissertation for the
Degree of Candidate in Biological Sciences).
So: Knizhnaya Letopis', No. 10, 1956, pp 116-127

2--Vol 10
A Vf Y
4298. BRAUNSTEIN A. E., SEVERINA 1. S. and BABSKAYA Yu. E. Lab. of Nitro-
gen Metab. , Inst. of Biol. and Med. Chem. , Acad. of Med. Scis of USSR,
Moscow. *Inhibition of the ornithine cycle of urea forma-
tion by a-methyl-DL-aspartic acid (Russian text)
BIOKHIMIJA 1956, 21/6 (738-745) Tables 7
Me-AS a-methyl-DL aspartic acid (0.03 M) causes 6-100% inhibition of the over-
a 11 synthes Is of u rea I roni N11 3 in live r slices and of it rea f ormation I rorn citrul-
line (CTR) and AS in liver homogenate; a-methyl-DL-glutamate and ct-methylala-
nine are not inhibitory. Me-AS fails to inhibit the following intermediate steps
of the ornithine cycle: formation of CTR from NH3, C02 and ornithine (with wash-
ed residue of liver homogenate), cleavage 6f argininosuccinate, and hydrolysis of
arginine by liver arginase. Moreover, me-AS does not interfere with transamina-
tion reactions, respiration of liver cells or respiratory phosphorylation. The
experimental data show, in accordance with the earlier suggestion, that me-
AS interferes with the synthesis of argininosuccinate by Ratner's 'condensing en-
zyme', acting as a structural analogue of L-AS. The inhibition of the second
phase of urea synthesis by me-AS is non-competitive with respect to the concen-
tration of AS, CTR or respiratory substrate (a-ketoglutarate). Preincubation of
the homogenate with me-AS enhances the degree of inhibition.

I SEVERINA,
Role of glutamine in the formation of urea. Biokhimiia 25 no.5:
847-854 S-0 160- (MIFA 14:1)
1. Laboratory of Nitrogenous Metaboliemp Institute of Biological
and Medical Ghemist--yp Academy of Medical Sciences of the U.S.S.R.,
Moscow.
(URFA) (GLUTAMINE)

SEVEILINA I.S.
Synthesis of urea from omega-amino acids and citrulline in mat liver
homogenate. Biokhimiia 26 no.5:943-951 S-0 161. (141RA 14:12)
1. Laboratory of Nitrogenoys Metabolis, Institute of Biological
and Medical. Chemistry, Academy of Medical Sciences of the U.S.S.R.,
Moscow.
(CITRULLINE) (Upah) (AMINO ACIDS)

GOTKIN, V.' ; G'rZIDNTVA, L.I.; ROMANOVA, L.A.; SVERINA, 1.S.
~-eter:--ilnation of the ac-tvli-~,y of witochondrial mo?ioa=no oxidase
by spec "rcphotc-me try. Eiokhiniia 27 no.6 - 10C4-102-/,'- 11-D '62.
(PERA 1725)
1. LaIr-oratorlya biokhLTAi aminov i drugikh azotistykh osnovaniy
Instituta biologicheskoy i meditsinskoy khimii AW SSSR, Moskva.

BRUSOVA, L.V.; GORKIN, V.Z.; ZHLLYAZFOV, D.K.; KITROSSKIY, N.A.;
'EVA, G.A.; SE17ERINA I.S.
LEONT
New 3pectrophotometric method for determining moncardne oxidaae
activity in 2iver homogenates. Vop. med. kh1m. 10 no.1:83-89
Ja--F '64. (KTRA 17:12)
Institute of Biological and Medical Chemistry, Academy of
Medical Sciences of the U.S.S.R,~ Moscow.

-if tije rat 14% r oy 1,ari~:u~- ~7,-77.Lir-O'
Di.ol-1.1mila 29 -nc.6-1093-13-02 11-10 164.
(!-1.1FA 18212)
%lokhImli wnlnov 1. drugi-.+ niz- t--' I Ly kh
u '13 IlLr- ulc--y !Jd:fai IJIIN
no- i i t.--ta- bio:iogichemkoy C.S
Moskva. 6ulmilittp,l April II 19 (1

KORABEVICH, Vatslav (Korabiewicz, Waclaw]; BEVERINA, N.Ya.
[translator]; KHODOSH, I.A., otv. red.; MAKSBIOVA,
T.G., red.
[With the peoples of Fast Africa; safari mingi.
Abridged translation from the Polish] IJ narodov
Vostochnoi Afriki; safari mingi. Moskva, Nauka, 1965.
152 p. (MIRA 18:11)

50) SOV/79-29-6-42/72
AUTHORS: Korobitsyna, I. K., Severina, T. A., Yurlyev, Yu. K.
TITLE: Synthesis of the 4-Oxymethylene-2,2,5,5-tetr.--alky1 Furanidones-3
(Si-n&(~i 4-oksimetilen-2,2,5,5-tetraalkl;lfuranidonov-3)
PERIODICAL. Zhurnal obshchey khimii, 1959, Vol 2S), Nr 6,
pp 196o - 1964 (USSR)
ABSTRACT: in continuation of a previous paper (Ref 1) the authors describe
the synthesis of the fl-ketoaldehyde of the 4-formYl-2,2,5,5-
tatraalkyl furanidones-3. They found that the 2,2,5,5-tatra-
alkyl furanidones-3 enter the condensation with ethyl formate
according to the Claisen reaction. In carrying out the reaction
in absolute ether with finely ground sodium 4-oxymethylone-
2,2,5,5-tatraalkyl furanidones-3 are formed (yield 56-66%).
Card 1/3

Synthesis of the 4-Oxymethylene-2,2,5,5-tetraalkyl
Furanidones-3 HCOH
HCOOC H
R
==_
R Na. Re
Re
R~ ~O
SOV/79-29-6-42/72
(I) R.R'=CH 3'
(II)R=CH 31 R'-C2H5
(III)R
R~>
(IV) R
R
These furanidones are crystalline pro(-.ucts very unstable in air.
They must be stored in dark glasses if possible in unpurified
state. They take a cherry-red color w:.th FeCl and form green
copper salts with copper acetate. The absorption spectra of
these copper salts in methanol show In the ultraviolet range
the maxi..ia characteristic of the copp-ar salts of thel3dicarbonyl
compounds. The percent content of the enol form was determined
according to K. Meyer (Ref 2) (Table ). The data in the table
show that the ketoaldehydes of the 2,2,5,5-tetraalkyl fura-
nidine se PS-well as of the alicy3lic series (ilefs 3,4) are
Card 2/3 a mixture of the formyl and oxymethylene form which is in equi-

Synthesis of the 4-oxyinethylene-2,2,5,5-tetraalkyl SOV/79-29-6-42/72
Furanidones-3
librium. In this case the latter considerably predominates.
Tile data on the table also show that with the increase of the
radicals in the positims 2 and 5 of the furanidine cycle the
enolization of tile formyl group increases in position 4. In the
action of the benzoyl chloride on the pyridine solutions of
the compounds I), (III), (IV) the corresponding 0-benzoates
(VII),(V) and RX) were obtained. In the case of the action of
the sodium compounds of the same OXYMEthylene ketones the com-
pounds (VI), (VIII) and (X) were obtained (Scheme 2). There are
1 table and 4 references, 1 of which is Soviet.
ASSOCIATION: Moskovskiy gosudarstvennyy universitet (Moscow State University)
SUBMITTED; May 9, 1958
Card 3/3

KUCHEROV, V.F.; IVANOVA, L.N.; SEVERINA T A.
Synthesis of some monoketones of the cis-bydr-indan series.,
Izv. All SSSR. Otd.khim.nauk no-7:1348-1350 J:l 161. (MIRA 14:7)
1. Institut organicheskoy khimii im. N.D. Zelinskogo AN SSSR.
(Indanone) -

KUCHEROV, V.F.; SEVERINA, T.A.; IVANOVA, L.N.; KOGAN, G.A.; RUDENKO, B.A.
Synthesis and the character of enolization of some /1-diketones of
the perhydroindan series. Izv.AN SSSR.Ser.khim. no.8-.1428-1438 Ag
163. (MIRA 160)
1. Institut organicheskoy khimii im. N.D.Zelinskogo AN SSSR.
(Ketones) (Indan) (Enols)

I VANUV A, -1 ~ !' ~ ', I NA , ir -k- ; Klj,-l.EdUV , V . ~,.
yl ether of cis-1 -nor-
---,n~cal transforiration5 of met,~~ 8
Z) q (,,) pstra-15,17-dione. 17v, AN 33SH. Ser. khim. no.53
843-84o 165. (MIRA l8s5)
1. ln3ti'-.~it orgzmiclneskoy 1%hi.,irll im. N.D.?Allnskogo AN SSSR.

IVANOVAY L.N.; SEVERINA, T.A.; KOGAN, G.A.; KUCHEROV, V.F.
Some reaction of /6-diketones of the perhydroindan series. Izv.AN
SSSR.Ser.khim. no.8-.1438-1445 Ag 163. (MIRA .16:9)
1. Institut organicheskoy khimii im. N.D.Zelinskogo AN SSSR.
(Ketones) (Indan)

SEMINA, V.A., GRACUVA, I.V., GORSKAYA, S.V.
Amino nitrogen balance and metabolism in Actinomyces str~Dtozvcini
during growth and development [with summary in Finglish]a -Topmed.
khim.4 no.6:455-463 N-D 158 (MMA 12:1)
1. All-Union Research Institute of Antibiotics, Moscow.
(ACTINOWORS, metab.
amino nitrogen in Actinomyces streptomycini (Rus))
(NITROGEN,metab'
same (RUB);

17(2,3) SOV/2o-126-5-54/69
AUTHORS: Severina, V. A., Gorskaya, S. V., Grachevap I. V.
TITLE: Effect of Amides on the Biosynthesis of Streptomycin (Vliyaniyr:
amidov na biosintez streptomitsina)
PERIODICAL: E-oklady Akademii nauk SSSR, 1959, Vol 126, lir 5,
pp 11o3 - 11o6 (USSR)
ABSTRACT: It was previously proved that various amino acids such as gly-
cine, a-alanine, valine, arginine, histidine, lysine, isoleucine
and phenyl-alanine, stimulate the streptomycin formation both
in the usual fermentation of the actinanycetes, on a simple
synthetic medium, and in severe experiments with cultivated
mycelium. Various other amino acids do not show this effect,
while others (eystine and tryptophane) suppress the formation
of streptomycin. Moat of the stimulating amino acids disappear
from the nutrient medium after 40-48 hours. Ammonia is formed
due to a desamination of the a-amino group; besides, arginine
serves as an ammonia source on account of the arginase- and
urease-activity of the actinomycetes. As is known, the strepto-
mycin molecule, namely its streptobiosamine part, contains
U
Card 1/3 methyl-glucosamine. There are publication references on a role

Effect of Amides on the Biosynthesis of Streptomycin SOV/2o-126-5-54/69
of the gluta:aine in the glucosamine synthesis by transamination
(Refs 1-3), in which glutamine acts as a distributor of the
amino group. Under these points of view, the streptomycin pro-
ducer was struck with the idea investigating this process- .
Asparagine and the genus LS-1 were first used for this purpose.
For the method of cultivation, see reference 4. A culture with-
out amide served as control. Table 1 shows that the activity
of the culture-liquid increased by 25-4o% as compared with the.
control. Further 13 severe, even more accurate, experiments
have shown (Table 2) that the said increase may even attain 6o%.
Thus, asparagine takes part in the streptomycin synthesis. Further
experiments, with ardwithout glucose, have shown (Table 3) that
glucose raises considerably the yield of streptomycin; thus,
according to an opinion uttered, asparagine has something to do
with the formation of glacosamine. The control of the glucose
consuimption showed (Pigs 1 a,b) that, in the presence of aspara-
ginev the decrease of the glucose is higher than in the conirol.
No spot of any amino acid could be ascertained chromatographi-
cally (Fig 2: 1-5). The disappearance of the amide strip 3Deaks
for a utilization of the nutrient by the fungus. A further task
Card 2/3 would be the testing of the effect of glutamine on the processes

Effect of Amides on the Biosynthesis of Streptomycin SOV/2o-126-5-54/69
in question. This could further clarify the mechanism of
participation of the said amides in the building-up of the
antibiotic molecule. There are 4 figures, 4 tables, and 4
references, 1 of which is Soviet.
ASSOCIATION: Vsesoyuznyy nauchno-issledovatellskiy inatitut antibiotikov
(All-Union Scientific Research Institute for Antiobiotics)
PRESENTED: March 19, 1959, by V. N. Shaposhnikov, Academician
SUBMITTED: March 10, 1959
Card 3/3

SEVERINA, V.A.; GORSKAYA, S.V.; GRACHETA, I.V.
Studies on the role of amino acids in streptomycin synthesis. Top.
med.khim. 5 no.6.-448-457 N-D 159. (MM 13:3)
1. Voesoyuznyy nauchno-ionledovatellskiy inatitut antibiottkov, Moskva.
(STRMOMYCIN chem.)
(AMINO ACIDS chem.)

SEVERIN~ V.A GORSKAYA, -V--
. .1 A,
Role of amides in streptOMycin biosynthesis. Dokl. AN SSSR 139
no.3:736-730, J:L 161. 14:7)
1. Vsesoyuznyy nauchno-issledovatell ;skiy institut antibiotikov.
Frerlst.~orlpnn akaripmikom A.I. Cparinwi.
(STREPT(EYCIN) (ASPARAGINE) (GLUTAMINE)

SETIMINA,_.I.A.; GOliSKAYAO S.V.; GRACHEVA, I.V.
Role of amides in the biosyntheoU of streptomycin. Vop.
med. khim. 7 no-4:425-433 JI-Ag 161. 15:3)
1. The All-Union Research Institute of Antibiotics, Moscow.
(STREPTOMIN) (AKIDES)

SEVERIh'As,.V.A.; GORSKMA, S.V.j- GRACHEVA, I.V.
Effeet of cycloserine on the bio"mthevis of glucoaamine
and streptomycin. Dokl. AN SSSR 154 no.4:960 F 164.
WRA 17:3)
1. Vaesoyuznyy nauchno-issiedovateltakiy institut antibioti-
kov. Predstavleno akademikom A.N. Belozerokim.

FONIN 9 V.,~~' . ; S"I".7FRITTA , V.A.
Som6 physiological properties of organisms producing novobiocin.
Antibiotiki 0. no.4:375-379 Ap 164. 0-11M. 19: 1)
1. Vsesryuznyy natichno-iseledovateliskiy institut antibiotikov,
Moskva.

FONIN, V.S.; SEVERINA, V.A.
Studies on the process of biosynthesis of novobiocin in synthetic
media. Antibiotiki 9 no.9:801-806 S 164.
(MM 19:1)
1. Vsesoyuznyy nauchno-issledovatellskiy institut antibiotikov,
Moskva.

EIINAP YE. F.
23235. Kratkiy rezuIltat lopyteniy shakhtnogo elektrooborudovaniya za 1948
God ?O~ rudoyanije, dopushchennoye d1&. Frimenenlya v kamennougollnykh
sha~htaU Sbornik statey (gos. makeyevsk. nauch. - Issled. in-t Po
bezopasnosti rabot T gornoy prom-sti), 1949, May. c. 1-9
SO: LETOPIS' 31, 1949

9 i , ;1. -, '-ElvL:~Liff, , yfj.y-.
SO t I i N IA
I A I .
Principles for conatructing, blastproof battery azvL&a4a*xgL...Trud* .
Mak-Ull 'Ll.Vop.gor.elaktr~o~me~~l~.no.ja-86-103 160.
011ne rallroade-Batterion) (MIRA 16951)

KOLMAKOV, S.; SEVERINMO
Constraction organizations need ultrashort wave radio stations. Radio
no.12:25 D 154. (MLRA 8:1)
1. Starshiy Inzhener otdela avyazi upravleniya stroitellstva
"Ukrvodstroy" (for Kolmakov). 2. Starshiy makhanik otdola avyazi
upravleni.va stroitellstva "Ukrvodstroyl (for-Severinenko)
(Radio, Short -wava --Stations)

BELENIKIYY B.G.;-SMRINETS, L.Ya.
Microdetermination of calcium in organic substances by photometric
titration with complexon-III solution. Zhur.anal.khim. 18 no.$,$
950-955- Ag 163. (MIRA 16:12)
1. Leningradskly nauchno-issledovatellskiy institut, antibiotikov.

SOLOVIYEV, S.N.; SEVERINETS, L.Ya.
Isolation, properties and separation of individual components of
the antibiotic 1130/12. Antibiotiki 10 no.1:9-13 Ja 165.
(HI RA 18: 4)
1. Leningradskiy nauchno-issledovatelisk-'y institut antibiotikov.

sm.,Pawrs, L.Ya.
Classification vnd characteristies of pentaen antibiotics. Antibiotiki
10 no.6s496-502 je 165. (MIRA 18:7)
1. Laboratorlya khimil fzav. S.N.Solov?y-ev) ~eningradskogo nauchno-is-
sledovatell5kogo Irstituta antiblotikov.

L
22246-66
)LT
ACC NRs AP6014,828
AUTHOR: Solov, V, S. N... Saverinets, L. Ya.
ORG- loonin act Scientific Research Institute of.Antiblztics (Leningradskiy nauchno"
issledovatellskiy institut antibiotikov)
TITIE: Isolation, propetties, and separation into comj*nents of antibiotiAl~/32'1
SOURCE- Antibiotild, v. 10, no. 1, 1965, 9-13
TOPIC TAGS: antibiotic, bacteria, solvant extraction, mouse/3-130-12 antibiotic
ABSTRACT: ThO antiVioiic 1130A2 was Isolated from tha myceliiii~'of_& strainl
of Actinomyces xantholicus by extraction with.ethanol.' It is in the form
~of light-yellow amorphous powder, soluble in dimethylrormamide, low alcoholej,"
acetone) glacial acetic acidj glycol) and pyridine; it is insoluble in chlor-
oform, ether) waters and petroleum ether. A qualitative analysis indicates~.*
the presence of a polyene grouping, and the absence of sugarsp glucosaminesst~
sulfur, and haloids. The steps required for the ii3olation of the antibiotic.'
are as follows: a) oxidation of the cultural liquid dilutedwith JIM to
A PH of 3.5-4.0; b) 'isolation of the mycelium; c) triple treatment or
the mycelium with ethanolj 1:2 (weigh L/volume); d) noutralization of the
.extracts W a PH of..740; e) concentration under a vacuum; f) p'recipita-
ition by water; 'g),'-- separation and washing of the pr cipitate with waters."
Card 1/2 UIX,,: 615.779.2311-0111014

L 229h6-66
ACC NR: AP6014828
,h) 1yophylization.' The substance obtained has-'bee'n- -J:o'und to be ahighly.'
!complex antibioties,with antibacterial and'antifungue propertiesi. Two
iprepar 'ti--- -h-avoi -6bfa-in44'fro-a the substanc . 1)- a preparation isola-
a ons -Veir~ 6
,,Ited from the mycelium which could not be separated into components; 2), a
preparation obtained from the mycelium consisting of inactiveadmixtures and.
4an amorphous antibacterial componenti The antibiotic has been found 'to be*
4active against Staphylococcus aurbus 209, other Staphyloeocci resistant to
iothe~ afitibiotics# and against Streptococci.' It is themostablep' retaining
its activity when heated to temperatures of up to 90 degrees to~pH of 4-0,
~6.0. Its LD 0 when intraperitoneally administered to white -.mice.in-acuts-
experiments'le 250 milligrams per.kilogram -body_:wqigkt,' The authors thank A. No
Ydgore'nkovaya and V. No Shatik for biological control; A* Ao He ~d~?vaya
and Be Vo
Sokolov determIning the wide antibiotic spectrum of active biotics; V. Go
Ovc ov for determining the toxicity; and v s 11 and Lo~ B. Sokolov for-p-aix-rYin-g-
a 0 YMYU
OW-Me-formentation and isolation preparations ---O-R-9, art-.-Na-557-3-lNghres and
1 table. fj-FRJS
suB com. o6 sm DATE: 31JU-163 ORIG REF.- 002
Card

SZAIAI., Sardot,., dr.., akademikusl HORVATHp lAszlo Gabor, dr.; FODOR, Mark,
dr,j*, ILLYES, Gyulanej CSIRSZKA,, Janoo.. dr.; SANDELHAUSEN,
Miklos, dr.1 RETI, Ieszlo, dr.; SEVEMI, Erjq!~~,, dr.j
PERCZEL, J6zsef, dr.
Discussion. Magy pazichol szemle 17 no.3:296-~317 160.
lo Magyar Tudomanyos Akademia Kozlekedestudomanyi Fobizottsaganak
tagja (for Horvath).

MATRAI, laszlo, :lr,. akademlku!5~ GEGY-S-1 K-as Pal. dr.. akademikusj
HOROFYI, Be-,a, dr., az arvostudem-anyok doktora; SAULMNS Jeno,
dr.p a pazicholog-'ai tudomanyok kancdifdat-u3a~ -HORVATIH, leazio
Gabor, dr- a pszichclcg:~&:~ tudcMairlyck doktora; LENARD, Ferenc,
EPINT
dr,- a psz;cholaglai tudcaranyok kand4datusa,; SEV zsebet
r -
The 1963 work of the Cowe-ttee on Psychology of the Hmgarian
Ar;adomy of Sciencee. Magy pszi~ahol Fizemle 21 no.3029-354 164.
I. Editor-in-C-1hief, "Magypr PazicholcgiaL Szemle", Budapest (for
G-egeai KisB). 2. Editorial Boa!~d Member, "M-agyar PBzichologiai
Szemle'~ (for Mat-rai, Homr-yi, Salliumon, Hor7ath and Lenard).

It DA , 1. IL SENUINO
Sea~or.aj changes in the c.nntent of ascorbic acid In potatoes
-1 1 -- no.'-78--79 Ni,P, 160'
of Crimean Provnct6. Wp. pit. 2-~ 0~
MIRA 17~5',
L
(
1. 1z hal'edry gi.glyeny iza,,. - dc!,,ent Kryiaqkcgo
metilt.,flngkogr, ins-.ttutap

KALISADA, T.N.; SEVE-RINOV, I.S.
Chemical structure and content of ascorbic acid in vegetables
from the Crimea. Vop. pit. 23 no.2:84-65 Mr-A-p 164.
(Mj~iU 17: 10)
1. Kafedra gigiyeny (zav. - dotsent V.A. Ovsyannikov) K--ymskogo
meditsinskogo instituta, Simferopol'.

SEW-MEOV. K., Geroy Sotsialisticherkogo Truda, Brigadir rabochikh
The Party gav us the wings. Sov..chakbt. 10 no.10.-7-8 0 161.
(MRA 14.-12)
1. Ochistnyy zaboy shakhty No.5-6 imeni Dimitrava. Stalins-kaya
oblast'.
(Communist Youth League)
(Coal miners)

SEVERINOV, Kuzlma brigadir, Geroy Sotsial-isticheskogo Truda
Support the cause of peace with work. Sov. shakht. 11 n0.9:
30-32 S 162. (WRA 15:9)
1. Donetskaya shakhta No.5-6 imeni Dimitroia.
(Disarmament-Congresses) (Coal miAes apd mining)

K , ~rlgadir~ Gevo7 Sot sJ alist-Ichookogo I'suda
'c- -
Uais is Vne matter of 7our ho-norP workezl Sov. profsoluzy 18
c-4 -.4-5 0 ~62.
"0 (Y1IRA 15:10)
n
(Doriets Basin.-Coal rain6rs)

ACCESSION XR: AF3o14918 S/0207/63/000/005/0035/0040
AUTHORS: Arkhipov, V. N. (Moscow); 4
'Rt,'A!~_(Mos ow)
TITLE: Rotational relaxation in a plane-para.1lel rarefaction wave
SOURCE: Zhurnal prikl. mekhanild i tekhn. fisiki, no. 5. 1963# 35-4o
TOPIC TAGS: rarefaction wave.. rotational relaxation, plane parallel rarefaction
wave, rarefaction wave rotational relaxation, supersonic flow., supersonic flow
deflection
ABSTRACT: The effect of relaxation time in a rarefaction wave on the flow
propertles of an inv1scid, compressible, non-heat conducting fluid has been
analyzed. The relaxation equations are written in polar coordinates rj, and
the corresponding differential equations for the two families of characteristics
are derived, which, for the condition are written as
-V V.,
S 0, p p T 0 al -4
C.rd 1/2

ACCE=N MR: AM14918
where angle of incidence less than zero, In the limit r -s. 0 these
equations are transformed to ordinary differential equations describing a super-
sonic Frandtl-44eyer type flow and are solved iteratively for values in the vicinity'
of r a 0. Numrical solutions are obtained for 513., VO - 2, aM -20 and.
the flow field described in the domain r > 0 s "The author is grateful
to V. A.. Ipatov." OrIg. art. bass 31 equations and 5 figureso
ASSDCIATION.- none
SUBKITT-0-. 17Jan63 DATE ACQs 27Nov63 ENCLs 00
SSUB CODEs PH ND REP SOVs 001 OrRM 004
,Card 2/2

--p
'1A P
ACCESSION NR.- AP5014764 URI&ZO616510051003105
517.9t533.7- -
AUTHOR: Sew (Moscow)
__Brinov, L. 3
- - --------
TITLEt Use of "artificial viscositylt in numerical-a0lixtion of the inverse-g&q
dynamics problem
SOURCEt Zhumal vYchislitallnoy matematiki i matematicheakoy fizikip v. 5# no.:3,
19659 566-571
TOPIC TAGS: differential equationg approximation calcalationg gas dynamics
ABSTRACT: By introducing higher derivatives of the desired funotionp- multiplied
small coefficientst into the differential equations of gas dynamicst the author
attempts to regularize the inverse gas dynamics problen. The computations Justify a
faith in this technique as useful for numerical solution of analogous problems.
This technique permits continuous computation through ahook waves. He studies
suDersonio flow around a blunt body of rotation under zero angle of attack, where
the shock wEve is taken so as to obtain a form close -to spherical. In examples of
computations done in this paper, the author considered a qystem of chemical reacticrAs
coinciding with the system of R. E. Duff and H. Davidson (Calculation of reacting
Card 1/3

m ~
.: _i -

SEV INOVO M., shofer.
-, . 7
i~ m)ggestions. Pozh. delo 4 no.5:19 My 158. (KIRA 11:5)
1. 3'Ya pozharnava chast', Minsk.
(Fire engines)

GRTGORIYEV, VikolV Nikolayevich; SIEVERINOV So,.,SV. teranovich:
BAYEV, Yevg., red.
[Yevpatoriyu, the city of sunj a brief essay on the
history of the town. A device for guests at Yevpatoriya
Health Resort. For whom treatment at Yevratorlya is
recommended] E-vpatoriial gorod solntsa; 'ruatkii rasskaz ob
lotoril goroda. Sovety otdykhaiushchim iyi evpatorilskom
ku;orte. Korra rekomendovano lechenie v Evpatorli. Sirfe-
ropoll, Izd-vo "Krym," 1965. 140 p. (VIRA 181.11)

GRIGORIYEV, Nikolay Nikolayevich; SEVERINOV, t anaAdh.
A WAddQ9Jwmm
IVMVA, Z.N., red.; ISUFUVA, N.A., telum. red.
(The resort of Yevpatoriya; therapy and rest at the resort
of Yevpatoriyal Kurort Evpatoriia; lecheae i adykh na
Evpatoriiskom kurorte. Simferopoll;.Krymiz~aty 1963. 130 p.
(MIRA 16:10)
(YEVPATORIYA-HEALTH RESORTS, WATERING PLACES, ETC.)

SEVERIN,jV, V.A.
The workers of the Chu Railroad Repair Shop are saving diesel fuel.
Elek. i tepl. tiaga 7 no.4:11-12 Ap 163. (MM 16:5)
1. Nachallnik depo Chu Kazakhskoy dorogi.
(Chu-Railroads--F,mployees) (Chu-Diesel fuOls)

KICHIGIN, A.F., kand.tekhn.nauk; MATSUTOTICH, O.T., inzh.; SALTAN07,
A.D., lnzh.; SEVERINOV, V.S., inzh.
Device for determining the parameters of rock breaking by high-
energy Impact. Izv. vys. ucheb. zav.; gor. zhur. no. 11:127-132
l6o. (MMA 13:12)
1. Karagandinskiy politekhnicheekly inBtitut. Rekomendovana
kafedroy gornykh mashin I rudnichnogo transporta Karagandinskogo
politekhnicheskogo instituta.
(Mining machinery) (Dynamometer)

CIIIGIRIO NOI&; SM."MINCIMMO 141,
IkchwAzod %=*Ing of glass parisorm fcr tbermce flasks.
Stak. i kor. 22 noll,3.04-35 N 165. (MnA 18:11)

Q:.V,. el 1.T
T_~;c railroad Iill rtr-aiD fFit~IR_11.
P. 25") (Zelezricar. Vol. 5, ncs. 1-6, 8; Jan.-June, 1~;C5. '10. 10, Oct. 1957.
Pralia, Czechoslovakia)
Eonthly Index of East European Accessions (7-EAI) LC. Vol. 7, no2
February 1958

SFVERNAYA, O.A.
Conference of the observers of artificial earth satellites in
socialist countries. Biul.st~i.opt.nabl.isk.sput.Zem. no.10:28-30
,6o. (FJRA 14:11)
1. Astronomicheskiy sovet AN' SSSR.
(Artificial satellites--Tracking--Congresses)

"Investigation of the Technological Process of Leveling the Foundation
Earth-;j3anks of Fine Drainage Networks With Passive-Action Operating Equipment."
Cand Tech Sci, Department of Physico-methematical and Technical Sci, Aced Sci
Belorussian SSR, 19 Oct 54. (SB, 7 Oct 54)
Survey of Scientific and Technical Dissertations Defended at USSR Hi_p'Ier
"~'ducational Institutions (10)
SO: Sum. No. 481, 5 May 55

GIEDIP., Ye.Z.; LEYKIN,, G.A.; LOZIFSKIYj A.M.; LURIYEt M.A.; W"EVICH..
A.G.; SEVERITAYA, O.A. SEPTTSOVAs Yu.Ye.; SLOVOKHOTOVAp N.P.;
TOLtSWA- TSITOIIICHt V.V.
,, V.A.;
Brief report of the Astronomical Council of the Academy of
Sciences of the U.S.S.R. on visual and photographic observations
of artifical earth satellites in 1957-1959. Biul, eta. opt.
nabl. isk.- sput. Zem. no. 6:1-33 160. (MIRA 14:2)
(Artificial satellites--Tracking)-