SCIENTIFIC ABSTRACT VENULET, J. - VENUS-DANILOVA, E.D.

• Document Type: CREST
• Collection: Scientific Abstracts
• Document Number (FOIA) /ESDN (CREST): CIA-RDP86-00513R001859420001-1
• Release Decision: RIF
• Original Classification: S
• Document Page Count: 100
• Document Creation Date: November 2, 2016
• Document Release Date: September 1, 2001
• Sequence Number: 1
• Publication Date: December 31, 1967
• Content Type: SCIENTIFIC ABSTRACT

71
POLAND / Pharmacology, Toxicology. General Problems U-1
Abs Jour i Ref. Zh.-Biol, No 2, 1958, No 7875
Author s Skovronskaya - Serafimova B., Venulet, J.
Inst
Title Chemical Structure and Biological Action.
Orig Pub t Wiadom. Chem., 1955, 9, No 12, 597-615
Abstract s The similarity of spatial configurations of stilbesteral
and estrone probably explains the biological similarity of
their actionD. The che nioal struot,.re of a substance
accounts for its physico-ohomical characteristics which, to
a o:'reat extent, influence its biological activity. The
bi-logical activity in a homologous series frequently changes
with an inorease in chain length and with an associated al-
teration in the physical peGularities of the homologues. By
Card : 1/2

U~~SR/_Pharmacology. Toxicoloj~y- Chemotherapeutical V
J."reparations
Abs jour i~ef Zhur-Biol., No 8, 1958, 37706
Author -4amul-Qt I., Yakimovskaya K. 9 UrbRnskaya A.
Inst : Not given
Title : Conduct of Hydroxamic Acids in Animnl. Orga-
nisms (Povedeniye gidroksqmovych kislot v zhi-
votnykh organizmakh)
Orig Pub : Byul. Poll.-.koy AN, 1066, Otd. 29 49 No 5, 195-201
Abstract : The blood conte-nt of salicyl hydroxamic acid
(1) 5-brom-salicyl hydroxamic acids (11.) was de-
termined colomet.rically. 1 and 11 were found in
the blood in the amount of 16 mF/ml In the first
'~ minutes after their adninistration in a dose
of 0.05 g/km the color reaction disappeared
minutes later. In lar;~e quantities both prepara-
/0 nd in 3(f,')
tions (50"') combine with erythrocytes, rV
Card 1/2

V
,reparation-.
Abs Jour o, f "hitr-Bicl. No
AbFtract nuantities with the proteinz. 1 and 11, how-
ever, rapidly disappear framblood circulation.
Their disappearance is apparently connected with
the metabolism of the hydroxamic acids in the
organism. In addition the authors established
that the liver and to a lesser degree the re-
nal oraans actively decompose 1 and 11.
Card 212

ulivua. J.
Wsp6Xczesne problemy farmxoterepit (Contemporary problems of pharma-
cotherapy), by J. Venulet. Reported In New boggo (love AsizaXi), No. 0,
March 15, 1956,

GAYSCrA, I.; SZMAL, Z.; VENULIU, J.
Iffmct of Ph7soatignine on action of pendiomiae. Act&
physiol. polon. 7 no-3:351-358 1956.
1. Z Zakladu Farmakologii Inotytutu Lekow w Waresawie Kimrownik:
dr. J. Venulet.
(PHYSOSTIGMIN'S. effects,
on reactivity to pendlomide (Pol))
AUTONOMIC DRUGS, effects,
pendiomidm, eff. of physostigmine an reactivity (Pol))

TEMIr, Jan
ft- waftum"W.
Recent concepts on action of bacterial pyrogens. Folski
tygod, lek. 11 no.40:1719-1722 I Oct 56.
1. Adres: Warszawa, ul Sandomierska.
(PTROGMM, effects,
concepts of mechanism of action of bact. pyrogens (Pol))

VLEAJULE-7- ~J-,
POLAND/General-iroblems of Pathology - Pathophysiology T-4
of the Infectious Process.
Abs, Jour : Ref Zhur - Biol.) No 1, 1958, 3037
Author : Venulet, J.
Inst
Title A New Outlook on Bacterial Pyrogens.
Orig Pub Farmac. Polska, 1956, 12, No 6, 144-146
Abstract Administration of somatic antigen from a number of gramne-
Sative bacteria caused an elevation in animals' temperatu-
te. Lipid A (phospholipid), and not the protein component
of an antigen, had this pyrogenic effect. The phospholo-
pid had a high biological activity. For example, coliform,
bacilli preparations in a dosage of 0.0012-0-003 gamma/kg
caused a temperature elevation of 0.60 C. The rise in tem-
perature began after 1-2 hours and persisted for 8-12 hours.
It was caused by an insignificant rise In metabolic rate
and, chiefly, by a decrease in heat loss due to cutaneous
Card 1/3

POLAND/General Problems of Pathology - Pathophysiology T-4
of the Infectious Proceus.
Abs Jour Ref Zhur - Biol., No 1, 1958, 3037
vasoconstriction. At first there was a leucopenia, which
was followed by a leucocytosis. Intravenous administra-
tion of a blood-pyrogen mixture that had been previously
incubated shortened the latent period and caused a rapid
elevation of temperature. The phospholipid had probably
combined with an euglobulin of the blood. Pyrogens have
a low level of toxicity; their lethal dose for the rab-
bits was a million times that causing a pyrogenic effect.
Under the pyrogen's influence the body's resistance in-
creased and there was an improvement in various diseases.
Their effects resembled those of cortisone and ACTH, but
differed in many respects; e.g. unlike the hormones, the
pyrogens -favored healing. Pyrogeas were successfully used
to treat gastric ulcer, to promote regenerative processes
in the central and peripheral nervous systems, and in cuta-
neous inflammations of a trophic or allergic character.
Card 2/3

POLAND/General Problems of Pathology - Pathophysiology T-4
I of the Infectious Process.
Abs Jour : Ref Zhur - Biol., No 1, 1958, 3037
In addition, although they are not proteins, pyrogens
can be used in protein replacement therapy and should
be used in lieu of panodin, Delbet vaccine and milk
injections.
Card 3/3

F 11"el
XINMYNSKI, Z.; VINUIAT, J.
New net1wd 9f measurement of heat loss. Acta ph7siol. poloa. 8 no.3:
377-378 1957-
1. Z Zakladu Parmakologii Instytutu Iokow w Waroxa-die. Kierownik:
dr J. Venulet.
(BODY TIKPZUTUEM
heat loss, measurement (Pol))

VINULIT, Jan; MISPIRAK, Anna
Certain pharmacological properties of pyrogen of 1. coli. Med. doew.
m1krobs 9 no.3:253-258 1957.
1. Z Zakladu Farmakologii Instytutu Lekow w Warssawie. Xierownik:
dr mad. J. Venulet.
(ESCHIRICHIA COLI,
pyrogens, pharmacol. (Pol))
(PYROG M , preparation of.
from E. coli, pharmaool. (Pol))

1471. THE METABOLIC EFFECT OF A LIPOPOLYSACCIIARIDE EXTRACTED
FROM ESCIL COLI Ober die Stoffwechselwirkung eines Lipopolysaccmirida
aus Escherichia coli Venulat J. and Desperak A. Anst. fur Phar-
makol., Arzneimittelfo-r-ird-b.---Insr:T War5chad - EXPERIENTIA (Basel) 1957,
13/9 (364-365) Tables 2
Rabbits were injected intravenously ikith 0.01 jig. per kg. of a lipopolysacclia ride
extracted from E. colt by the Westphal method. It has a strong pyrogenic activity.
Injection caused hyperglycaemia and decrease of the concentration of lactic acid
in the blood. The oxygen consumption of the livers of the treated animals increased
considerably. This was also observed in vitro when the pyrogenic substance was
brought into contact with renal and hepatic tissues. Cavallo - Naples

- A - 7 11-
,v- fv tI F- IJ /T I'V
A KI MOVS styna; V-,,MMT,
~Iffeot of antituberculous agents & other nreTArations on egg-white edema.
Gruzlina 25 no.12:959-967 Dec 57.
1. Z Inetytutu Gruzlicy D:~rektor; prof. dr J. Hisiewicz i z Zakladu
Farmakologii Instytutu Iekow w Warazawie Kierownik Zakladu-. dr med.
J. Venulet. Adres: Warszawa, ul. Chelmska 34.
(RMU, exper.
induced by egg white, eff. qf antituberc. agents & other
drugs in rats (Pol)) it
(BGG WHITJ, off.
induction of edema, off. of antituberc. agents & other drugs
in rate (Pol))
(TUBEHGUWSIS
ant!tubaij3 agents, eff. on edema induced by egg uhite in
ra M

POI:ITD / Pharmacology and Toxicology. 0 hamthorapoutic Agonta V-10
Abe Jour :Rof. Zhur - Biologiya.. No 17, 1958, No- W709
Author :Urbanska, ILlicja; Vonulot, Jan
Inst :Not given
Title :Influence of Pharmacological Drugs on tho Content of
Isoniacid in the Blood arxi Tiasuos
Orig Pub :Gruzlica, 1957, 25, No 12, 969-976
Abstract The influonce wau studied of hietamino (I) antiatin (II),
largactyl (III), doril (IV) and pyrogon (V~ on the content
of isoniacid (IS) in tho blood and tissues of the lungs.,
liver and kidneys. The greatest decrease of the contont of
IS In the blood sot in under tho Influence of I; the
weakest effect was from V) III and IV. Incroaso of tho
content of IS in the tleaues occurred under the inMonco
off U and 11V; In lesser degree, from III and I. The influence
of II did not chango, the content of IS in the blood and
orgails
Card 1/1
43

URBANSK, Tadeuuz; BELUCKI, CzeBlaw; CIMCB314M, Bozenal, CHYLDISKA, Barbara;
MBROWSXA, Halina; FAMCKI, Xerz;r; GURIM, Daniela; HAISKI, Ieszek;
MALINOWSKI, Stanisl9tw; SMUMMA, Barbara; ZYIDWSKI. Jerz7; SMOM
Stefan; XAMINISU, Irena; MMLET, Jan; JANOWIZC, Kieczyalaw; JAKIKOWSEL,
Krystyna; U10WISKA, Alicja-, _K6211mrux , Anatol
Searching for new anti-tuberculosin dx-age. Gruzlica 26 no.11:889-917
Nov 58.
1, Z Zakladu Syntezy IAkow Inntvtutu Gruzlicy Kierownik Hakladu: prof.
dr T. Urbanski Dyrektor Inntytutu: prof. dr J. Misiewicz Fracownia Synt.
Lekoi., Przeoiwgruzlicyoh, Warszawa, ul. Koozykowa 75.
(TUBBRCUWSMS, therapyl
investigation of 300 cpds. for anti-tuberc. eff. (Pol))

JANOWISC. Miecui;law; VMMLET, Jan
ftnerimental ocular tuberculosin in rabbits. Gzuzlira 27 no-3:213-216
Mar 59.
1. Z Zakladu Parmakologil Int3tytut lokow w Warezawie Kierownik: d- mad.
J. Venulet. Adren: WarRzava, ul. Chelmaka 30/34.
(TITMOUIMIS, OGUIAR, experimental,
In rabbitn (Pol))

JAKDIOWSKA, Kryatyna; WITKT!7,llC'Z, lla-ria; VPjPJL!:T, Jan
Pharmacrilogy of (T-72).
Pol. 15 no.5MI-712 S-0 16~1.
1. Z Zakladu Famakologii inotytutu !-,-kc)-w w Warnzaw-le (Ki~-
rownikt doe. dr. J. Venule'.).

JANOWIEG, Mieczyslawi VFNULET, Jan
Experlmantal tube.-clilosis in hooded rats. Yed. doT4. mikrobiol.
16 no.1?13--20 164.
1. Z Zakladu Farmkologil Instytutu Lekaw w Warazawle (Yierownik,
doc. dr. J. Venulet).

JANUWIEG, Mieczyslaw; WOJCIK, Ryszard.A.; VETULET, Jan
Associated effect of inonicotinic acid hydrazide (MR) nnd
of some drugs influoncing the macro-organism in experimen-
tal tuberculosis, I-Ted. dow. mikrobiol. 15 no.4011-315 163.
1. Z Zakladn Farmakolo.gii Instybitu Lekow w Varszawie
(kiemmik:doc.dr,med. Je Tenulet) i z Katedry Statystyki
Matematycznej SGGV w Varszawie (kicrowniks prof.dr, Z. Nawrocki).

JANOWIM,, Mieczyalaw; VENULET, Jan
Ahtitubercular effects of ethyl acetoacetate isonicotinoyl-
hydrazone (T-428) administered jointly with ultracortenol
and somatot-rorin. 111'ed. doqw. mJkrobiol. 15 no.41317-319 163.
1. Z Zakladu Farmakologii Instytutu Lekow v Varszawie;kie-
rowniki doc,dr. J&Veriulet.
4-

JAN01,41EC, Mieczyslav; VENI=, Jan
Experimental tuberculosis in rats. Gruzlica 31 no.6t712-716
Je 163.
1. Zaklad Farmakologii, Inetytutu Lekow,, Warszawe.

IMIGE, Jerzy; URBANSFI, Tadrwjz; VE1,11JUT, JaT4
Preparation and biological activity of the derivatives of
phonylauceinic acid. 11ts.2-3. Ror,%.chemii 36 no.11:1625-1638 16"',
1. Department of Organic Tochnolry 119 Institute of Technologry~
Warsaw.

1ANIGE, Jerzy; URE~111SKI, TP-deusz; V1-,:1'1'UUT) Jan
preparation and biological activitY Of the derivati'ves Of
phenylauccinic acid. Ill. Rocz chemii. 36 no.11:1631-1638 162i
1. Departme,.t of Organic Technology Ili Institute of Technology,
kjttrsew.

DESPERAK-NACIAZEK, Anna; JAKIMOWSKA, Krystynaj JANOWIEC, Mieczyslaw;
KRYSICKA-XCZKAL, Wina; PAWLIKOWSKI, Leszek;_VENULET, Jan
Chemotherapeutic and pharmacological properties of the sodium salts
of m-aidnosalicylic acid. Mod. dosw. mikrobiol. 15 no.l.-85-90 163.
1. Z Zakladu Farmakologii Insty-tutu v WarazAwle Kierownik: doe. dr
J. Venulet. -T-
(AMINOSALICYLIG ACfD) (PURMAGOILOGY)
(MYCOBACTERIUM TUBERCUL09IS) (TUBERCULOSIS)

XR'!5XCKA-)-0CZK&L. Hslin4t, PAVLLKOVSXI
Anj VL~'Urwr, ion, Dop-4rtraort of 2hrrTi#c*laCjr far-
11antytut Lekov) Irs waralAw (rP.-
rector. Oou-nt, Dr. J. V)riA.UT)
"Cho.voth4r.,vioutto and M.rinaoologir Prop6ttles, of Sonioca
Salts Of W-MinOlAUCY110
Varsaw,. H(Avvynsk 1M4wiedcgw1n& i Mikrohloia, _.. Vol 15,
PP 0,5-74.
Abqtrnctv r.)Luthural English sum"&ryj Inva3tigationo in
irl era na jr, viva revealed inorely a weitk etatlua or 4he so-
dium salts nt 3-rminosalicylic aeitl. (VAS) upon tuborcI3 ba-
cilli, ai wall &a an experimental tub^rculasis in laborate-
ry anime.L.-t. ishon tested in vitro. X1q was clullar Jn ac-
tion but w*Lkor wan PLS. Both derivativiis or,) less of-
foctive than tronicocinio ueld hydraz!de or Stro:itc%7cin.
The toxicity of NIS is sliEhtly b1g4or than that of r.LS
preparation&. Alt 6 reforeaoss are by Pulish authora
,(in I Gornan, t Trench, and the rest in Polish pitblinati 'In

SZMAL, Vialaw; VEMUU.T, Jan
Effect of oome quarternary =monium ccrnpounds -with aulfur In t,';rj
aliphatic chain on -ayeoneural transmission. Acta physiol. polon.
13 no.6:717-728 162.
1. Z Zakladu Farmakologii Instytutu Lekow w Warazawie Kiercwnik: doc.
dr J. Venulet.
(P1-U,',OT4IUM COMPOUNDS) (SULFUR) (SYNAM-S)

JANOWIEC, Mteazyslaw; VENULET, Jan
Effect of hydrazides of aspartic and glutaraic acids on experiment.%1
tuberculosis. Med. dosw. mikrob. 14 no.3:247-252 162.
1. Z Zakladu Farmakologii Instytutu Lekow w Warazawie.
(ASPARTIC ACID rel cpds) (GLUTAMAVES pharinacol)
(TUMMULOSIS exper)

,-~VENULET Jan z pomoca techrliczna; KALINOWSKIEJ, Marii
On the correlation between anti-serctonin and depressive effects
of certain phenothiazine derivatives. Acta physiol pol 12 no.2:
281-290 161.
1. Z Zakladu Farma ologii Insty-tutu Lekow w WarS2awie Kierownik:
doe. dr, J. Venulet,
(IMIM CONDITIOIED pharmacol) (SEROTONIN antag)
(CHLORPROMAZINE phanracol) (TUNQUILIZING AGIEIITS phanracol)

VENULEIT, Jan
Psychopharnacology. Acta physiol. polon. 12 no.6:915-927 161.
(nYCr:C)?.:UF.XACGLOGY)

JANOWIEC, Mieczyslaw; VENULET, Jan
Antituberculous properties of ethyl acetoaeetate isonicotinoyll7drazone
(preparation T-428). II.
1. Z Zakladu Parmakologii Insty-tutu Lekow w Warszawis Kierownik: doe.
dr med. J. Venulet.
(ISONIAZID rel cpda)

VENULET, Jan
Poychopharmacology. Acta physiol pol 12 no.6:915-927 161.
1. Adres autora: Zaklad Farmakologii Instytutu Lakow, Warszawa 36,
ull. Chelmka 30.
(PHARKACOLOGY) (PSYCHOLOGY, PATHOLOGICAL)

'ver --j
.,
G
Poland
Dr
Liot given]
':!arsaw, LaK,:._acja Polska, Vol XVII, No 15-16, 25 Aucust
1961, -p '10-312
I p )
"Pharmacololzical Investigations as an Approach to
Clinical Tests."

VEIT!js j B. Go
--- ()f If -y-c- , ana Cenozoic 3GQlxeDt5
Mineralogical corl-eiatifin Y j-82 164.
a b~jDr6jsiono V .9 s t, WU 19 no. 6:7'
in thq Amur-ZOY (MIRA 17:5)

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the "yo6~1kthylplarnyIrthylirne oxide that the doulily juhlifitiard a-tym ethvienc
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