SCIENTIFIC ABSTRACT YAKOVLEVA, Z. M. - YAKOVLEVSKIY, O. V.

• Document Type: CREST
• Collection: Scientific Abstracts
• Document Number (FOIA) /ESDN (CREST): CIA-RDP86-00513R001962010005-7
• Release Decision: RIF
• Original Classification: S
• Document Page Count: 100
• Document Creation Date: November 2, 2016
• Document Release Date: September 17, 2001
• Sequence Number: 5
• Publication Date: December 31, 1967
• Content Type: SCIENTIFIC ABSTRACT

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AUTHOR: BuIcharb, 0. T._;_.Yakcrvleva,,,ZM.-
7 Ebert/
-ORG:- -,Departmant. q~ Microbiqlogy/~Oatded by-N-0fosa
Medicaj.~'rj"stjt t
n u e
TlTLE: Concerning the protective nonspecific action of lysozyme in infection
SOURCE: Antibiotiki, v. 10p no. 21 1965, 151-156
TOPICIAGS: mouse, rabbito vitamin, bacteria, drug effect
ABSTRACT: -Mice and rabbits were used in experiments which were carried out
to determine the efficacy of lysozyme and its combinations with vitamins It-
Bj) B6, and B12) when used for the prophylaxis of infqctiou3 processes indu-
ced by Salmonella_typhimiriurivand Bacterium pyocyan. I Crystalline and
liquId forms of the vitamins were tested. In the experiments with Salmonella
typhimurium the mice were divided into four groups; group one was adminis-
-tered lysozyme only in dose3 of one milligram per mouse; the mice of the
.second group received a mixture of the vitamins, the third group was
administered simultaneously lysozyme and a mixture of the vitamins; the
fourth group received a physiolo3ical solution only. On the day following
.the administration of the proparationap the animale were ouboutaneously
,infected with LE~90 (4000 microbic colls) of Salinonella typhimurium. In
the experiments with Dacterimn pyocyanewm, all of the animals were divided
into six groupop each or the groups having received respectively lysozymop
Card 1/2 UDC: 615-779.935-092.19: 616-022-7/-9

ACC Kt: AP6014661
lysozyme with vitamin combinations and -matures of vitamins administered at
;'diffcrent periods prior to.their infection with the microorganisms which
-were administered in-LDIOO dosesintraperitoneally. The experiments estab-
that lysozyme ana-its combinations with vitamins k. B and BL2 are
prophylactically effective in relation to infections induced t; Salmonella
ityphimurium and Bacterium pyocyaneum; that although lysozyme itself stimu-
lates phagocytoais) its stimulating effect on phagocytosie is more intense
,.yhon applied in combination.with,'the'group of B vitamins; the administration
.of lysozyme and the vitamins elevated the le-~el of'no-rmal typhoids paratyphoid B,,
,4nins in rabbits. Orig. art. has: 1 figure and
and dysentery Flexner C aggl
;4
3 tables.. PPRSI
SUB CODE: 06 SUBM DATE2-`~27M464 ORIG REF.- 012 OTH REF: 006
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1, o6685-67 r, N-1 ( 1) .7 K
6 0 2 8 9 5 0 SOURCE' CODE: UR/0219/66/062/008/6068VO-O70-
AUTHORt Bukha-rin, 0. V,; Y~ikovLeva,.Z. H. ff
ORG: Department of Microbiology /Director-Prof. L. Ya. Ebert/,
binnk Medicnl Institute (Kafedra mikrobiologii Chelynbinakogo moditsin-;
skogo instituta)
TITLE: Protective affect of prodigiozan an experimental infections and
immunologica reactions of the body
SOURCEt Byulleten' eksperimentallnoy biologii i meditainy, ve 62,.
no. 8, 1966, 68-70
TOPIC TAGS: bacterial polysaccharide, immunologyo protective effect,.
.prodigiozan
ABSTRACT: The effect of prodigiozan4)(series 266 developed in Z. V.
Yermol'yeva'a laboratory) on_Salmonella typhimurium~qwas studied using
120 white mice weighing 18-20 g. Prior to the experiment, the animals
were injected subcutaneously with a 1 pg/kg dose of prodigiozont pro-
digiozan with vitamins B1, B6, and B12, or vitamins alone. They were
then injected subcutaneously with a lethal (LD100) dose of Salmonelza
(4000 microbe,calls). Mean viability was used as the criterion for the
effectiveness of the preparation, Humoral factors of immunity were
Card l/ 3 um 615.779o925-06t6l6*9-09299

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studied using 32 guinea pigs and 150 white mice. Here, normal anti-
bodYtDcontent and the immunolo8ical activity of blood serum in guinea i
pigs and mice administered 1 Ijg/g of prodigiozan were determined. After
an hour mice were then injected intraperitoneally with an LDSO
(50 x 1;6 cells) dose of Bact. pyocyaneum. Paired sera were admin-
istored in 0,2 ml doses (1;2 dilution), Some results of these studies
are L'.ivsu in Table 1. It was concluded that prodigioxan was able to
Table 1. Protective affect of prodigiozan on Sal-
monetla infected mice
No* Preparation No* of
animals Haan viabil-
ity (in days) P
1e Placebo 30 4.5.+.0.4 -
2. Prodigiozan 30 6,70,4