SCIENTIFIC ABSTRACT YARMONENKO, S.P. - YARMONENKO, S.P.

• Document Type: CREST
• Collection: Scientific Abstracts
• Document Number (FOIA) /ESDN (CREST): CIA-RDP86-00513R001962130003-6
• Release Decision: RIF
• Original Classification: S
• Document Page Count: 73
• Document Creation Date: November 2, 2016
• Document Release Date: September 1, 2001
• Sequence Number: 3
• Publication Date: December 31, 1967
• Content Type: SCIENTIFIC ABSTRACT

P.Pipo; AVRUNINA-,,- G.A.; SRASHKOV9 V.S.; GOVORUN,, R.D.
Action of radiation protectors in vbole-body irradiation by
bigb-energy protons. Probl:kosm.blol. 2088-392 162
16 W
(RADIATION--SAFETY WASURES)
(PROTONS-MSIOInGICAL EFFECT)
mp

ZHMBCfffi74KO, P.G.; KRASI,~YM, I.G.; KUZITEtS, Ye.I.; SUVOROV, N.N.;
SILASHKOV, V.S.; YMIOIW.7..O, S.P.
Radioprotective effect of the combined uuo of amines. Med.rad.
no.3t67.-72 162. (IIIRA 15:3)
(RADIATION PROTECTION) (AMIM)

g
0
hO478
S/205/62/002/002/011/015
1020/1215
AUTHORS; Lebkova, N. P. and Yarmonenko, S. P,
TITLE: The time factor in the radiation-protective effect of lecal asphyxia of bone morrow
PERIODICAL: Radiobiologiya, v. 2, no. 2, 1962, 304-307
TEXT: This is the writinuation of a previous study. Adult mice weighing 18-22 g were irradiated in a special
apparatus which allows automatic application of a tourniquet. A single dose of 700 r for 40 sec at a rate of
1050 r/min was applied with a PYM-3 (RUM-3) unit. The tourniquet was applied 2 and I min before
irradiation and 10 sec after irradiation. The smallest injuries to bone marrow were observed when the tourni-
quet was applied 2 min before irradiation. In another experiment the mice were irradiated with a single dose
of 700r (35 r/min). The tourniquet was applied on two legs 5-10 min before irradiation. From one leg it was
removed immediately after irradiation and from the second 20 in later. Some differences in the mitotic index,
chromosomal aberrations and telephases with chromosomal bridges were observed in bone marrow following
postradiation asphyxia, but these arc not conclusive. A tourniquet applied for 2 hours caused degenerative
changes in the bone marrow in both irradiated and non-irradiated animals. There is I figure 4 and tables.
SUBMITTED: July 28, 1961
Card 1/1

-%IOU
8/205/62/002/001/003/01C
D268/D302
'2
Avrunina, G.A., Shashkov, V.S., and
AUTHORS: Yarn, gprlm- S.P.
Crovorunf R-Do
TITLE: The oxyr-en effect in whole-body irradiation with
0
high energy protons
mrdIODICAL: inladiobiologiyaq v. 2, no* 1, 1962, 125 - 127
TEKT: Biological protection and its dependence on the oxy-:~en ef-
feet were studied in Tqale white mice (weight 21 - 23 9) chendically
Drot-,ected by peritoneal injection of the following 10 - 15 min. be-
iore irradiation.- MEA (bet-a-mercaptoethylamine chlorohydrait-le), cy-
szamine dichlorohydra-te, and A'LET (S, beta-aminoethyli-sothiouroniu,-.,
bromide hydrobromide) -at 3 mg/mouse, 5-methoxytryptar-ine chlorohy-
drate at 1.5 mg/mouse, and Serotonin (5-hydroxytryptarine creatin-
ine sulfate) at 1 mg/mouse. Serotonin and 5-methoxytryptamine were
synthesized by N.N. Suvorov, and the remainder by F.Yu. Rachinskiy.
irradiation was by proton ira-pulse beam (660 viev) at a dose rate Of
300 - 400 rad/min. from. the synchrocyclotron at the Oblyedinennyy
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S/205/62/002^011/003/1j! 0
The oxygen effect in whole-body D268/D302
17UCle
institut yadernykh issiedovaniy (Combined instIt-te for a-
Research). All compounds tested increased survival, the avera.-a di,,-
ration of life in Protected animals ocing ts.1 - 16 days with doses
in the range 1,070 11472 rad as aGainst 5.9 - 8.7 ctays "or uno Io-
tected with 1,070 1,360 rad. Reduction in the biolocical effect.
can be attributed to reduction in ionizing density in relation to
the acceleration of high energy Drotons. There was an increase in
H 0 yield in water irradiated with accelerated protons partici-ila-r-
2 2
I I/
ly at 1.8 - 7 Mev, which can be interpreted as an indirect inlicn_
tion of the oxygen effect appearing in p'Mportion to particle acce-
ieration. Since the oxygen effect increases under the action o--:'
nigh energy protons, it Vlas thought that radiation sickness could
be alleviated by preparations in which the oxygen effect plays a
major role in the mechanism of radioprotection, and thi2 was con-
fir.med ex-oe riment ally by local bone Marrow aspPyxia in Mice irrad-4-
ated with protons (660 rev) at 1,300 rad. There are 2 fi~fures and
10 refoerences: 6 Sovieb-bloc and 4 non-Soviet-bloc. The references
to the English-language publications read as follows: If.K. Patt.,
card 2/3

S/205/62/002/UO1/00.)/Olrv
The oxygen effect in whole-body ... D2()B/D302
J.1,7. Clarckt H.H. Vogelp Proc. Soo. -.T-"xpti. Biol. and Vred., 84, 159,
1953; H-1)". Patt, R.L. Straube, Radiation Res., 1, 226, 1954; A.
Forsberg, Acta radiol.t 41, 56, 1954; P. Bonet-I,'aury, Disc. FaradL-;
Soo., 12, 71, 1952.
ASQOCIATIOX: Institut gigiyeny truda i profzabolevaniy AlMi SSSR,
Moscow (Institute for Yfork Hygiene and Occu-pational
Diseases, MiIIIS USSR, Moscow)
SUBMITTED: July 18, 1961

s/o2o/62/142/005/026/027
B144/'DIUi
AUTHORS: Kurlyandskaya# E. B., Avrunina, Ponomnre-ja, V, L.,
"I orova*__V_1xj Yariovnkaya, 11. 1., tinrl Yarmanenko. S. P.
TITLE: Relative biological efficiency (PBE) of 660 Yov proton3
-705
PERIODICAL- Akademiya nnuk SSSR. Doklady, v, 142, no. 5. 1962, 702
ical efficiency of 660 Mev protons produced in the 6 z
TEXT; The biolor
Oynchrocyclotron of the.0b"yedinnnnyy institut yadernykh i.9sledovamy
(Joint Institute of Ifuclear Research) in Dubna wna invoutigated nr0
compared with the effect of x-rays. White mice and ratn were ohole-body
irradiated with doceu of 260 - 440800 rad -ind 300
160b red, reap9ctiveV
The interdependence of perishing time and radiation dose and the influence"K
on the hematopoletic system were similar to those of x-rayal but the
rolevnnt HbE was much lover. Irradiations with proton doves of 565 red
nnd.x-rity donea of 400 rad which are about equal as to their Itthal offect
produced, however, significantly different aftereffects. The ponads
proved to be the moot conaltive organs 1). The caneeropenic effect
of 660 Mev protons was equal,or someshat stronger khrm that of x-rays.
Card 1/3

Relative b1ologic-I -fficiericj...
The pau~tblllty of increnninr the i-ndloreiintaoup In anim'1151 Ill
blockera wlia attvlied- P-mercapto ethyl nmirto hydrcchlorid-, hydro-
bromide ofJ',O-amIno ethyl ioothi,)uronikim bromiAn, ani rierotanin rre-atinine
silltnte y1olded p0jiltive renisl L)i .Thin Ii probably -iu-? to tilt, led,ired
ionization detlaity or 660 Mov proton3. Their low HIM nuy reatilt fr')M ib,
puloe churneter of the proton boum, Oic hij~-.h does) Ititonotty, nn,l perImp-.1
aloo-fron the riZdiiction of the 11nenr-c-nerry expPOIture with Increnning
particle energy. Thio problem han utill to be uolytvl. 'rho POE of
different radlatiorin should be detailed ito to Individual body oyatemi;
anti different perlodu ofter irradiation. V. P. DzhOIOPO7 fill"
Kt)mochkov ure thanked for aaalutance and advic(i. Vj'~ro are I fIj-,?jrei, I
table, anti 9 rerorenovn~ 5 S-Iot and 4 non-Onvit)t, - Tho rr)i)r rf4forer.con
to English-langunge ptiblientlorin read tin folloRn; J. D. Itorrtr, P. 3,
Harris et al., Radiation, Rea 6, r'O. 2, ion (1957); It. Ghyll, Intern.
J. Rad. Biol., 2, 11o. 4, 399 619TO)l )J. M. patt, J. W. Claz-ck. H. 11,
Vogel, Proc. Sac. Exp. Diol. and Med. log (1953)1 11. m. Pntt,
R. L. Struube,. "diation Ron., 1, 2, ;~!~1'09'5'4)-
Card 215

Relative biolorical erficiency ... B144/11101
ASSOCIATIOII:. Inatitut piglyeny tru4a i prnfznbulovnniy AknIcnit
meditainnkikh nnuk (Inntitute of 7whintrial 11p,lene
and Occupationnl Dinerinca of the Aondpiny of 11kdIon!
111n)
111190MITED: July 24, 196), by 1, 1, 34mallipitizon, Aindenic kn
SUBMITTED July 21, i901
Card 3/3

;ACCESSION NrR: AT4042722 S/0000/63/000/or,,0/0510/0514
AUTHOR: Kurlyandakaya, Z. B.; Avruaina, G. A.; Gaydova, Ye.S..
...;.'Govorun, R. D.; Orlyanskaya, R. L.; Paly*ga, G. F;; Ponomareva, V. L.; Fedorove.,
V. 1.i Shmakova, N. L.
-TIVEW,,~~'Rcactions.4to radiation an' chemical protection of animals oubjected to
theeffects of high-energy proton.;
SOURCE: Konforentsiya po aviatsionnoy i kosmicheskoy meditsine, 1963-
Aviatsionnaya i kocmiihookaya meditsina (Aviation and space medicine); materialy*
-konferentsil. Moscow, 1963, 510-514
TOPIC TAGS:, corpuscular radiation, high energy proton, synchrocyclotron, gamma
ray, radiation effect, radloprotective agent, RBE
ABSTRACT: Experiments wore performed to determine the immediate and the delayed
effects of high-energy protons and their RBE on animal organisms. High-energy
protons of 660 Mov were generated on a oynarocyclotron, Comparative tooto using
gamma rays from a Co6O s6urce were used in establishing the RBE. Nonpure strain
mice and rats were used, in addition to mice of the BALB and C-57B1 strains.
ml_

ACCESSION NR; AT4042722
All materials were subjected to statistical analysis. In comparative experiments.
perfo.rmod on, rats subjected to a dose of 500 rad, the dogree'of injury to hemo-
..poietic organs by protons was considerably less than injury caused by gamma
radiation. The depression of hemopoiesis in the bone marrow and the spleens of
animals irradiated by protons was less profound and less prolonged, and regancra-
tive processes began earlier than in injuries produced by produced by gamma rays.,
This difference of effect was particularly clear in the dynamics of the periphol-al
blood. After exposure to gamma Irradiation, a profound and prolonged anamia
developed, accompanied by a loss of 440,19' of the erythrocytes and 51% of the hemo-
globin. An equivalent dose of protons caused only insignificant lowering of these
ifidices. Similar effects wore observed in the white blood *corpuscles, particularly
in respect to neutrophiles. The results obtained confirm that the condition of
'peripheral blood does not reflect the true depth of radiation damage to hemopoiesic.
In experiments with white mice, a study was made of early destructive changes
_n the brain marrow, the dynamics of mitotic activity, and the kinetics of calls'
-with chromosomal injuries. Exposure to protons induced typical radiation de-
generation of cells of the bone marrow, a slowing down of mitotic activity, and
Waa~
injuriesto the chromosomes. A*strong lin:ear relationship of injury-to-dose
IC~~ r~d
2/5

ACCESSION NR. AT4042722
observed in all three indices within the 250--1000.rad range. Exposure to
oequivalent doses;-of gamma rays produced more pronounced changes, indicating that
:the RBE of protons'is, equivalent to 0.5--0,7. Preliminary administration of radio-:
protective agents _~- AET (S,A -aminoothylisothioronium), MEA (mercaptoethylamine),
.:and 5-MOT(5-methoxytryotamina) __ diminished the numbor of degenerating and aber-
rant cells in-the'bone marrow in 7.-oportion to the effect of the indicated drugs
on survival. The most effective appeared to be a combination of F-EA and 5-MOT,
..whose use assured the survival of 50% of the mice when irradiated by dosea of 1900~
rad.; If irradiation is fractionated, the protective effect of the drugs is re-
duced~sharply, or it di'sappoaks altogether. In experiments on male mice of the
BALB strain subjected to doses of 5W and 700 rad, reversible changes were observ_"--
ed in the weight of testicles. The change of weight and its subsequent recovery
i,was due to the death and the subsequent regeneration of germ cells. Protons have
a typical:aterilizing effect on the genitalia, but their RBE, in comparison
with gamoki rays, lies between 0.6 and 0.7. The use of antiradiation drugs
did.not prevent the sterilizing action of protons, but it caused a somewhat smaller.,
loss of weight of the testicles and produced a shorter period of sterility. White,
imalle mice.which had been protected by ALT,'HEA, 5-HOT, and cystamine from the
effects. .of proton doses of 1300--1600 rad recovered their generative functions
rd 3/5
;CO

71
ACCESSION NR: AT4o42722
m a nt of
l olt complet,~ly four to seven months after irradiation. The developme
a
the first generation of 290 mice obtained by crossing the protected and irradiated'
males with intact females took place without visible somatic injuries. The
relative effectiveness of protons and gamma rays in causing somatic mutations
was.studied on livers of white rats who were subjected to doses of 150 rad. Re-
generation of the liver was induced by removing the large left and the front
right lobes of the liver. The operation was performed 24 hours after irradiation.
The animals were killed 30 hours after the operation, i. a., during the first wave.
of the increase of mitotic activity. Control animals hid 6.9% of aberrant cells, 1
while after irradiation by protons and*gamma rays, the number of aberrant cells
was 20% and 29%, respectively. This indicates that the RBE of protons in respect
to.somatic mutations is around 0-7. New data were obtained on the blastomogenic
effect of protons. Out, of 85 irradiated rats, tumors were found in 39. Twenty-
A-'ive of them had multiple tumors in various locations. In experiments on non-
6
pure strain white mice, it was poesible to show that antiradiation drugs, while
increasing the ratio resistance of the animals, do not prevent subsequent develop-;
nent of new growth. Out of 65 irradiated mice who diod at varioua periods i . !
after expoouro,to protons in doses from 1300 to 1500 rad (after having previoualy~
received antiradiation protection), fourteen had leucosis and four had ourcoma.
Card 4/5
-- ----- - --------------

L 17054-63 EWr(m)/BDS/ES(J) AMCIASD/AiWL 3/205/WO03/002/(YWO24
AR/K
-T--AUTHORS dF-'-
ei'action,,a hi energy pro ns& opo
mitotic
Cdii - degerLeTation. an& activity -.t bone marrow cells of mice
-e
e al-:~# OWIM
bj4dt .d- to7th tot aution Wital 1660 ve.1779r
PEUODICALs Radiobiologiya.4 ve 3) no* 2. 19631 291--293
ah-d subaequent regenerative prooes~es in the bone marrow of mice,, subjected to the
total i=-adiation with 660 V.9v protonz in 800-1000 rad doses. The irradiation With
protons caused in micq typical radiation induced degeneration of bone marrow cells
and suppression of mitotic activity, The degree of these effe-ts depended on the ab-
sorbel dose. The tot4 biological effect of 660 Mev protons with respeet to the at.-
4. on of ~f -,ays of.0000 in equal absorbed doses (800 rad)., judg~ing from the number
of degeneratkre cel2a in the bone mwrevw in the period of the first 24 hoir--s com-
pviss3 or- the average 0.3. The authors exl=esB their gratitude to I. M. Shapir for
consul1Wion and aid in methods in tho. course of experimentatior, There axe 3
-LXMVM*Y- Inatitutt-of-libi~i~Eiiie~~7--dn -Dccup&tionaI-Diseases,-:-.
Moscow.
------------------- -----~
7 j-
q

L 13812-63 FUT r3dT(M.)/MS/FZ (b WTCIASD AR/F.
L., CIZBTCV TiRt AP3QM_5___ - 5/020~/631003/0a/0576/0581
AUMCRt xvanoy,_ V4121, 7
:=_~L7~~:~=~~T3!1~T,41.~-Reprodt-mtive-abiUty _of mice irraUated vith high-energy prcrvoas and
7 tre ata-viflaa ~em i-al-- -prote ct
::$MMCBi Radicbiologiya* vo 3,, no. 4o 1963f 576-581
TAGS; proton irraiiation, cysteamine hydrochlax~d*,-ey6tamine hydroclaorlde,
AET,, 5-methatytryptemine, hydror4l=ine, radioprotector, reproductive ability
tMTRAM, The reproductive ability of irradia7Lcd male mice wma stu&'A--ed by s%~b-
jecting them to total-body irradiation with a collimted -,rotmi beez of 660 Mev
from a sync2irocyclotron at the Cb"yedineaay+`y institut yadernyflth issledorvaniy
(Joint Institute of Nuclear Research)o The animals Vero given intraperitcneal
injections of the fol.lowing protect,).-s: 150 mg/ke cysteamiiie hydrochloride 5
-to-10-min-be-Z-ore -expwurre7_1 150 zg/kg- cystamine hydrochloride 20 min before ex-
posu-MA 150 mglkg AET 5 to 10 min before exposure, 75_Vfz/k"4 5-tMSthoxYtrY-Ft=ine,
hydrochloride, 20 min before e-.pwua*", and 60 mg11w, biVroxyle4ine 5 to 10 min
'before exposure. After 6 month3, 26 male mica "re rated vith 78 intact femles
~.2 to 3 months old (three females for each male). The reproductive ability of
Card 1/2-,

L 13812-63
ACCZ53IO11 HRT AP", 3935
the mice was determined by the number of pregnant females, and the number and
development of the offfspring. Of 78 females, 4abecame pregnant (62%) and gave
birth to 237 young. The reproductivo ability of male mice treated with radio-
protectors before exposure to protons of 660 Mev in dosea of 1300 to 1900 rad
was fully recovered in 4 to 7 months after irradiation. The moot effective pro-
tectorwas 5-methoxytryptsmine, alone, or in combination Vith cyateamine; less
effective were AET and hydroy.71amine, or a combination of both compoimd3. gow-
ever, it is possible that the apparent advantage of some preparationG over others
is due to natural variations. Since the regeneration of spermatogenesis occurred
four months after Irradiation with 1900 rad, the sterilizing effect of protons
does not dIffer markedly from that of x-rays or Y-rays. It is quite significant
that the development of the first-generation progeny from irradiated male mice
R
protectedagainst the action of protons vas normal. Orig. art. ha.. 3 tables.
ASSOIIATION-. Institut gigiyeny* truds, I proftabolevaniy, Ala SSSR.. Mosecror
e- of Indust- al Rygiene and Occupational Diseases, I SS
(Tnstitut ri P141 S R1_
3UBMITTED: .32JU163 DATE ACQ Wu~63 ETTCL: 00
REF SOV: 007 OTHEP.: 008
StM CODE: AM NO
Card. 2/2
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G 10271- 63
NR:. AP300.2859 S/0241/63/008/006/F~/0042
~AUTHUR-'_Yarmon46ko, S, P,
TITLE,; tlie-effect-of radloprotective-- agents --from _ifi-e_sta]x~p-o1-nt --of
their practical. use
MaditsInskaya radiologya,,,V, 84 no, 6,..i963, 32-42-
-TOPIC TAGS: radioprotective agents, cystamine -~.,&:li3ricirochloride--AETbrondde---,-
bydrobromide.,-5-.meth 0
omrtryptemine hydrochloridep mercamine hydrochloride,
redioprotector/radiation dose ratios, frectional irradiation
ABSTRACT: A--study.waB made of the relation between the dose:of antirediation
drugs (cystemine 'dihydrochloride, AET bromide-hydrobromide, 5-methoxytryptamine
hydrochloride, and mercamine hydrochloride, the last two given both singly and
together), radiation dosage, and protective effects. White mice were Irradi'ated
with Ge= rays from a Co sup 60 radiation source at a dose rate of 57 r/min.
-Since ionizing radiation effects are cumulative, the study was conducted with
repeated- sublethiLl doses until a cumulative lethal dose was reached. Survival
Card, 1/3

L10275-63
i--.-ACCESSIM IM:~ 'M002659
th
~--rtiUs-of.~the-Eir~imals~~receivi-ng-,~rar,i-ous - amunts-of -~raliookotect4-ve.,agealts-,-vere en
riddii -under--the-
-compared iv rz;bE4-of--controls-Irr ated saw-conditims--"
_;-~~lisving:~recei-~ed'radioproteetco~i~.--"Tbree te -a es vere-ra-de ukri
yere
ed- in -fal:and half dose
adrainister s pre=Ung eight irradiations tote2ing r
In the second series,'the drugs were-administered. in-h elf doses only-and,the
number of irradiations and administrations of the drugs wrs out from eight to two
tsted of four
total radiatIon dose., of i selfo.re4uces the effectiveness of ra&aprotectors.
Simultaneous reduction of ediation (to one-fourth lethal dose) and drug (to one-
third optimal d6sil) dosage caused the protective effect to dioappear, The
author reviews - Scriet and non-Soviet literature on chemical radioprotectors mid
+ cation. 7-OrIS. art..has: 3 tables.
Aheir -practical appli
Card 2/3
a-14 ~2
ILI
ZiM.

L IM75-mO
ACCESSIOU-NR: AP3002859
ArSOCIATION, Radiotoksikologieheskeya laboratoriya Institute. gigiyezW truda. i
AHT SSSR (Radiotoxicology Laboratory of the Institute of
Industrial Hygiene and Occupational Diseeses of the Acadeny of Medical Sciences
-MY.

OVAKIMOV, V.C,.; YARMOIT11KO) S.P.; MAIM, V.N.
State of the centna-I M-clnoline reactive systems in Cc-60
irradiated m4~ae. Radlobiologiia 4 ro.11:414-418 164.
(MI RA 17., 11
1. Institut gigiyony truda i pi-ofessioriallnykh zabolovaniy AMI
SSSR, Moskva.
20,

ad" E"I
ABSTRACT: T, r e

UZZ ~71
ER

,043313

ACCESSION NR: AP402512i' S/0241/64/009/003/0066/0070
AUTHOR: Yarmonenko, S. P.; Paly*ga, G. F.
TITLE: Analysis of the action mechanism of antiradiation arents
during their application (Protective action of rectally administered
preparations)
SOURCE: Meditsinskaya radiologiya, v. 9, no. 3, 1964, 66-70
TOPIC TAGS: antiradiation agent, Arcamine, 5-methoxytrypta=Lne,
AET
ABSTRACT: The toxicity and protective effect of mercamine, 5-
ricthoxytryptamine, G-.,d AF.T were studied in experiments with
white male raice exposed to total-body y-irradiation from a
GUBE- ,800,apparatus with 900 rad at 241 rad/min. The antiradiation
agents were introduced intraperitoneally, orally, or rectally
30 min before irradiation. The rox--'c affect produced by rect-
adminiitratioR of all*three preparations was lower thar. zl-.ar- uL
Cord 1/2

ACCESSION NR: AP4025123
the intraperitoneal adninistration. Nercamine (150 mg/kg) produced
.no rz
adioprotective effect when introduced orally, intraperitoneal
administration produced a marked protective effect, rectal adninis-
tration produced a similar effect only when larger doses
(450-600 mg/kg) were used. Rectal administration of 5-riethoxy-
tryptamine exerted a mark-ed radioproteccive effect on the test
animals. A dose of 150 mg/kg resulted in 66.7Z survivall a dose
of 300 ng/kg, in 83,3%. Rectal administration of nercamine '
(150 mg/kg) produced 10% survival; with 300 mg/kg mercamine, all
test mice died. AET had hardly any radioprotective effect when in-
troduced rectally. The protective effect of combined intraperi-
toneal administration of mereamine and 5-methoxytryptamine
(150 + 75 m.-/kg) resulted in 95% survival. The same dose intro-
duced rectally resulted in 50% survival. Orig. art. has: 3 tables.
ASSOCIATION: none
SUBMITTED: 18Mar63
SUB CODE: LS
Card 2/2
DATE ACQi 17Apr64
NO REF SOV: 000
EN CLt 00
OTHER: 000

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vhen cello vere removed for examination., The mitotic index was determined In
controls and the animals of the first lot* tollowing stimulation of liver cell
division by removing part of the liver the animal were sacrificed* The mitotic
index., number.of damaged chromosomes and extent of damage vere determined, Results,
are figurede 'The mitotic index of the second lot did not differ much from con-
lower the done., the lower was the percen
trols. The tage of cells with chromosome
aberrations* 'This effect increased with time; after b months hardly anj difference:
from controls was observed,, Thin wan apparently due to repair of chromosome
injuries in the resting cells (60% with one injured chramosome,.'40% with 2 or
On the basis of observations it vae calculated that with tide the nuaber
more
Is tends to reach 100%. This finding is supported bY the absence
of repaired ceL
of cells with 2 or more acentric fragments wA bridges upon longer exposure. The
concepts on the cumulative effects of exposure may thus have to be re-examineds
Such simmuLry effects may weaken or fail to appear with very low doseea It appears
that the determinant faotor in these tests van the low done rather tbaa prolonged
exposure, It may thus be possible to regulate chronoo Irradiation vithout recourse
to observations from a single irrsdiation* Origs arts has: , 2 tables and 2 figurest
i ABSOCIMTCK s Xastitut gigLeuy* trads, L proftabolmay Akedeall seditsinsidkh
A -2/3

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1, k 4 IF p I t 4 L",
Ti T-f- -Af.t"r- f-T-r- t'h.
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lradiaDrotective azents viCh differentiation between Ene 9LGe erEccLs anu LnOsu
ny) P C Orm
blned uae of varjn~ig caimpou-nds 11007 for
conalcluns OL ruuLAMLL~l
At) P1 I T1 1 DR.
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L 59546-.65
[ACCESSMAV NR: APS015733 3
F-28.58 577.391
!AUTHOR: iamm P.__,; ryvak_im~v, v. p a iyz a, F. rednqpye
larasen~r
-and-1hi- -ef f6ct - f --)chiei~
T onal-4-irrad -at 0 ad motf~i
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SOURCE
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Ibrain, reaching a maximum 30 minutes after injection. When doses of *fT knourr, to be
,fatal are iriected, the ahsolute an-maunt of tne compound in the brain when ~he animal
died is une-half to one-fourtn that when tolerable dosea are used. Consequently,
CentT'al action plays a secondarv nalp in the T-.4.--hanism -f acutte toxicit-~ kE-.
1toxicity. Orig. art. has: 7 tables.
A

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LAI 11
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FIT=

ALMH -iarmonenko, S. P.; Y-a~,~~anri~kov. A~. G.; Suvorov, H. N.; re-dn"ue-,
Ai~:~T;A-

mas -s-
-t4 hich
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1.L., akedemik
'10ric aci d)
Cystaphoa (moncsodi= Balt of jk -azinoo IhylthiOjjhQ3j,. &
as a mewas for increasing the affectiv~enoss of the.chomotherapy
of tumors. VokI. AN SS."3h 162 no.2s47&479 MY '65. 180)
~A. Institut gigiyeny Lru,Jpl I I
t Lit. Y,',h' Ga r t o;, r; a
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L 14251-66. 'E'1,jT(l)/D4T(n S(v)-3- TB/D-TAAP DD/RD
CC M: AT6003849 SOURCE CODE: m/2865/65/oo4/000/0139/016.4
AUMOR: YarmonenkoLS. P.; KbELoLjVMikov, A.G.
ORG; none
oblem of the RBE of
TITIZ: Antiradiation n connection with the
ErotectioA i pr
radiationli-dith ToWgpecllid 3.6nizarions
SOURCE: -AN SSSR-0 Otdeleniye -biologicheskikh nauk. Problemy kosmicheskoy
i biologiij v- 4, 1965, 139-164
TOPIC TAGS: ionizing radiation., REE linear energy transfer, radiation protectiong
j
x ray irradiation, gamma irradiation, experiment animalt-rato mouse, ceu
physiologyp funguso radiation dosimetry, antiradiation drug
ABSrTRACT: r-"ev article, the authors present the results of 14 Soviet.
n this iew
and 50 Western studies in tabular and graphic form., Some of the Soviet
results are presented in the following figures and tables:
Card 1/15
-2v;
i 27=3~
aliffm M
M!
.4~

--L -14251 66
ACC NR: AT6003849
'
'
Table
l. The' RBE of radiations of
'. .low specific Ioniza tion (linear
energy transfer -(LET),-in kev-per-I micron -of -passage)

Recorded Effect a~dard
St Radiation Comp'a-red w-diation
Ty2e LET Type LET PBE

Death of yeast
x-rays
2.9
x-rays 0.^
0.85
Celle 200 kv particles
22'mev
i Same as above,, x-rays 3.0 gamma rays 0.3 0.76
1 haploid strain 180 kv Co-60
' Same as above, x-rays 3.0 gamma rays 0.3 0.84
diploid strain 1.80 kv Co-60
hromosomal
C aberrations
x-rays
3.0
ga=a rays
0.3
in a human cell culture 180 kv Co-60
A ~ at various cellular
hases
tsj,LD 50/30 x-rays 3. Lys 0.3
180 kv
Card 2A5

t

-L 14251466
ACC AT6003849 Table 1. The REE of radiatioi)s of low apvcific ioniza-
tILO r afer
n %jr ap
-
pa~sa (IZT) in key per 1 rucron of
_
'!.Mbb..it~e LD 100130:- x-rays 3.0 gamma rays 00
-180 kv C6_60 1.7
%gs, LD 100/30 x-rays 3.0. gamma rays 0.3 1.3-
I 180 kv Co-60 1.6
Zogo LD 50/30 x-rays 3.0 gatmon eaye 0.3 1.5

A 180L kv- - lCo-60 I - -- I

hromosomal aberrations x-rays 3.0 Igamma rave 0.3 0.7
Cella L
n rat- liver
T
180 kv
ro-60

Table 2. Dependence of
A RBE on the'h ardness of radiation
and species of animal
A nimal il MD 1 -0/30 RBE of Co-60
x-r ys, I
80 kv
gamma
ra
s.
Co-6
xamma rays
-
- _
M ice 700
850
0.82
I M ats 750 1.13

Card.3/15

_5 -r.

Recorded Effect Standard Radiatio n d Rndlati(vi
Type LET !Ty2e IXT PVC

Death of yeast x-rays 2.9 deutrons 0.9 .1.0
cells 200 kv 190 Mev
Same as above, x-rays protons,
0.3-1
O.W
haploid strain 180 kv 130-660 Ifev 0.7 1
Same as above gamma ray
co-69 s 1 0.3 Protnnr. 130--
'ev
660 M p. 3- 1
0. 7 1.0
Same- as -above,- gz~:mna rays 0.3 protons 0.3-1 1.0
diploid strain- Co-69 660 Mev
Sex determined x-rays protois 0.3 1.0
recessive mutations 180 kv 3.0 660 Mev
in fruit flies
Kice, LD 50/30 x-rays 3.0 protons 0.3
!
O-Mev--
-66
-
-
Samelas above -x-rays 3.0 protons .3 0.67
180 kv 660 Yev
I Card 4/15

0-~A k ~I r e- ~_ A t
P,

L 11425j.-66.
-AT6005849 Table- 3.
ACC TIR:
Same as above
Same as above
Same as above
Same as above
Death of mice
180 kv 660 Mev -4
~ Same as above gamma rays 0.3 protons .3 0.75
Co-60 510 Ifev

Same as above gamma rays 0.3 protons .4 0.73

I Co-60
Nev
240
)
above
Same as
gamma rays
0.3
tons
pro
0.7

.70
I Co-60 1 126 Mev

jDcath of rats
x-rays
3.0
protons 0.3

.8
..due to fractiott- 180 kv 510 kv
ized'radiation

C
d5/15.
ar, .7*1
The R les (cont.)
BE of high-energ3r partic
gamma rays 0.3 arotons D.3.
Co-60 ~60 Ney
gamma rays 0.3 protons ).3 0.80k
Co-60 660 Mev
gamma rays 0.3 protons M 0.8

Co-60 1 130 Hev

_.geomma-rays
0.3 !.protons
).7 0.7
Co-60 126 Nev
x-rays 3.0 t protons ).3 %1.0
180 kv 660 -f!ev

141ce, LD 50/30
x-rays
3.0 protons
).3 0

L 14251-66
I ACC Nr; AT600~849
Table 3. The RBE of high-energy particles (cont.)
Tnrotons 1.14
.5eat~ of do'gs garwa rays .1.3
from a single Co-60 jl0 and 240
Nev
lirradiation
'Same as above x-ray.5 3.0 protons '0. 7 1.0
.180 kv 126 Me~
x rays 3.0 protons 00.3
Death of dogs - 1.0
due to fractionized 180 kv 510 Vev
irradiation
Rats, state of x-rays 3.6 protons )0.5