SCIENTIFIC ABSTRACT ZILBER, L.A. - ZILBER, L.A.

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SCIENTIFIC ABSTRACT
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ZILIBER L. A* Baydakova, Ze 1. and Zillber, L, A* "Vari4billty of gr.ppe viruzn VoproW med. virusologii, IssUe- 2. ly4ys p. 2il-08s Tlib-.-og: 91tems, 80t U-3042, 3.1 March 53,,(Letopis 1zhurnal IrWkti Statey, No. lo., 3.949). PA 47/491'93 9. mr r7~ I I 1 1! 1.: q 1 LA LA ol; T, I =,(,I Fir ,~31 RIJ -, ~ fig, 1.1 T I , i s I ,i . 1! 1 F ! M, : I I 'I P q, 1; 11: T :, i : i I I i i li Iiiii :1 .111111 ~ .11111. ~ -11 , F1 - . 1-~ ZILIEM, L. -A. USSIZ/Vadicina Viru--olcgy YA7' "A Scientific Session Devoted to the Yiemory of D. 1. IvanovijRiy,"~ Yu., 1. Milenushkin "Priroda" No 5. pp 64-86 At a special session of the Dept of Biol Sci,.All-Uninn Acad of Aj;r Sci imenit Lenin, the memory of D. I. Ivanovskiy (1864-1920), discoverer of the tobacco -mosaic virus, was honored. Yany papers in the field of virasolog-j- were.pres*ented: on that occasion. L ndcro~'- A. Zillber discussed tho s~nnlAosia of ~viruues and IZr t) ----dapLallon c). ~ani cultivation of smallpox on yeas , the ri-,ut4id a of the 2 rartnera in this process, and the modificaticns (:UumMolcL?~cal, etc.) which both partners and specifically tl~.e virus undergo as a result of syrbioois. He further said that many viruses (e. g., herpes, breat, canc6r of mice) rem-ain in the host during the latter's whole life, but they never cclnfer'a so-called~ nonsterile kn-unity in such cases. R. P. Chumakov in his paper shzu-ply criticized G. 141. Foshlyan theories. Other participants praised Boshlyaxi and his contributions to science and referred to Ivanovskiy as a procur3or of bosh,Ynn.. PA 21IT76 70, 01 1 MI, I FBI ~iili rw Noteorologicia.Abst. 4.7-64 551-510-42. VOL A, NO; 7- Sbvartsq 1A. I and Allbergi L. A."v Zonallnoe:, 4uly 1953. issladovanie zagiaznennosti atmoefern~go V*ozdukha, Itructure aM Physics vokrug tolevogo zavoda.' (zonal InvestigWons of :ok the Atmosphere atmospheric pollution around a glue fdoto4q] Gigisn'a i:. Sanitarlietv 7353-51+t July 1952. DLO"Air sapplea warp., - :J -taken at ievel of 1.5 to 2.5 m RboveAhe gr'o .und at ver*9 distances from the factory. The diniancesivaried ~i accordingto the natum of the conti6inanto: .tested. - I*tA on the conc on IP'802 "d:d a a trati of hydrocarbot ust at tb respective f ur zones axe preoented.; 604ect Headingst, 1. Atxoepheri~'poll'A$on 2s A' r ei~p)iilng, SO Analyst# cancer- -Tj~n#eb:52 .::.__"ztjol6gy and-Pathogenesir. orr Cancer_ Demons-trated--by I_ 1. A. Zilber, Act Member, Acad Medical: "Vop Neyrokbi ug" Vol XVI, 17o 1, p 12 __R1Rcq,!nt research and expts advanced the theory that- ~,Lmcaneerous -growths are produced- by vir-user. --penctrat- _`1J4-_-'t4be organism- from vithout-. I- Carriers -of --these .viruses have been identified in 2 cases only: papil- it rabbits transmitted by. t:Lcks, and malignancy_~,-!:. mi PeTiztration the virus may remain inactive over a -24ag period, of time It, develops on1V under,_. 222T18 vr6pition"i conditions -in focal centers-of:prolifer-. sting cel.1s. A virus penetrating a group of thcae 4~iils Initekferes with metabolism -and -disrupts the protein synthesis, producing abnormal cells. This is the essential process of malignancy. Factorsreg- ulating the development ot cells vithInormal protein tontent are unable to cope with the contaminated ells, the protein content of which has become can- -cerous. A rapid increase in the number of contami- nated ce2la forms a malignant growth (tumor). ifter the interruption of the protein synthesis, the virus is usually blocked by the newly formed proteins and camnot be detected by ordinary methods.' This theory considers the origin of a malignant growth as a chain reaction Some of the links in thid chain~are 221T38 claimed to be now available for anal is and treat- ys .~ment. Furtber research calls for an immunological s~stuay,of,the_malignancy process, immunization of:the., ~tellx in,the cancerous-grovth. 221T36'.] vl~ ZILIBIR L.A.; R=IKHOVSrAYA, R.K. Experimental studies on Im-nity to neoplasms. Part 1: Artificial, immunization against Brown-Pearce carcinoma. M=.nii:iobiol. epid. i Immun. no.9:64-70 5 154. (MLFA 7:12 1. Is otdela virusologil (say. prof, 1.A.Zillbe'r) InatAtuta epidsmilo- logil I mikrobiologii imeni pochatnogo akademiim N.Y.Ganal4i AMU. SSSR (dir. prof. G.T.Vygodchikov). (MWPLISMS, experimental, Brown-Pearce carcinoma, prey. vacc.) (VACOnM ARD VACCINLTION, Brown-Pearce carcinoma) TI-T _'T i F ]TITI i TI -I II IPill IT i A -.' i, - 1~ 1 11 . - 1, , I 'I ~ it: hn L 1: i i ~'! 2 ; I - ~ If; I - 1, 1. .. Il~'A ' [1L1, -i I m, i I 1 1, 111, 11 HII 11 ~' I mu, 1 p j!.1111 I I lllf~ 2! vM11 I I IT IfIrlil "Itill ir, IV 11fillirripwri-mi . . I : 1 1 1 . . . 1) If . i . . . ic Joe A and unINDOWal experiments (Russian OV) Klin Mod., 1954, 32/3 (9-16) The most discussed theories on the origin of cancer are the chemical and the virological ones. There. is a considerable number of cancerogenic substances, which certainly produce carcer in animals, but it has not yet been possible to produce cancer in tissue cultures br adding these substances to normal cells (Bonevolenskain, 1951) without addition o oncogenic viruses. This supposition was expressed by Meftikov, but could not be verified on account of lack of appropriate examination! methods. Now, some. authors have succeeded in demonstrating virus bodies in animal band human tumours by means of the electron microscope (Timofelevsky and Derjughi, 1952; Cross, Cessl6r, McCarty and others). Special attention should be paid to experiments carried out' by Timofejevsky and Benevolenskaja with the nucleoprotein fraction of 11ous sarcoma on embryonic chick mesenchyma cultures. After 15-17 days the. tissue culture showed malignancy; electron-microscopical examination revealedF globular bodies of the type of the Rous sarcoma virus. Methyleholandirene alone does not give rise to malignancy of fibroblast cultures; this is effected after addition of mammary carcinoma virus of mice or of extract of rat sarcoma. Virus from Shope-papilloma also brings about malig- nancy in dultures of rabbit epidermis. Thus the carcinogenic substances prepare the tissue for the action of the oficogenic viruses. These experiments rule out the mutation theory for the origin of cancer. However, it should be bome it) mind that it has not yet proved possible to cultivate viruses from a considerable number: of tumours.~ In these tumours it is present in a 'masked' form (e.g. breast cancer virus can only, be demonstrated with the help of mice not older: than 2 to 3 weeks). A feasible method for the demonstration of 'masked! viruses seems the immunolojEcal dem'onstration of a cancer protein' (cf. Zilber, Fortschr. Biol., 1950, 30) which has been effected mi sqme tumours, e.g. Hous sarcoma (Radzichovskaja, 1950) and mammary carcinoma (Nttd- vedev, 1951). This cancer protein seems to contain not only virus protein, but also another protein, which is not present in normal cells. Bardakov' a and- Hadzichovskaja (1950 and 195111 demonstrated that animals immune against a 6rcinogPnic virus fell ill after inoculation with tumour tissue. It is, therefore, probable that tum6ui cells contain, besides the virus nrotefn. another 'heterolog-ous' Drotein and that thuo the content of 11 -[Iv ill V I 11"1'A3 1! 1:11119111 U Min- tissue antigens changes as the tissue grows malignant (this was demonstrated by Zilber vei and Artamonova in rabbit papillorna and carcinoma). Recent in tigatidns by Zilber,: Artamonova and Postnikova led to the conclusion that tissue which has been made malignant blocks the pathogenic properties of the virus-, after 15 min., active papilloma virus mixed with washed tissue which has been made malignant, loses the capacity to produce papilloma and its immunizing properties as well. However, nqrmal rabbit epidermis, mixed with virus does not bring about blocking of thb virus, but even slight activation. In the development of carcinoma 4 stages are distinguished: (1) Symptomless stage after invasion of the virus. The means of entry of only a few, carcinoina viruses. are known as yet: mammary carcinoma with mill, sperma or lice; rabbit papilloma virus through ticks; chicken lymphomatosis in the egg. The canccrogenic viruses may remain apathogenic in the body throughout life and require additional factors for their manifestation. (2) Formation of foci of cell proliferation, regarded as pre-cancerous because they promote the virus development. ~At this stage propbylactic measures' should be taken. (3) Development of malignancy in the proliferating cells which statt... to produce 'cancer protein'. Further biochemical investigations. on this matter are. '(4) Crowth of the cancer cells: The 'foreign' protein. components produced' necessary. in the tumour cells possess antigenic properties, which disturb the growth regulating mechanism of the body with as a result the development of a turnatir. a Brandt - Be 'r I I 1 11 1 11 i I I i V .; 4 Al I Fi* 71"1 11 : 11 111: 1 IIFI! 411 IQ 11111 .1 i 1 1: -HPA 1 1, F..R; I I - - I RIMIll, USSR/Biology 1,',1crobio1oFj Card 1/1 Authors I Zillbert L. A. Active Vemb. of Acad. of Med. 13c. and kr~rmnoilova, Title I About the so-calltd blocking of virunen cnimAnf Oloalling, to 57i-. 54- I Dol(l. M _SSSR,: F~1~ '1060j: Juno 1'i~9j,.- :Abstract The so-called blocki .ng of t%urb~-eausing virmse 1 9, noma- 7 tous viruses lose their disease causing effewtivel, after -c qling in con'Lact with &Ibumina of cancero-us In aLl eq:ierirrejn1;s ~&inre tht lur~.~- cstuslnp virut~ m-aq mlxi~j -vrlt~ 1.,Lru,1 fram a r.-An- and dur-ing ccr,mj~; 11,i-,e ir, -al-in of I : 5 P wag inoeulati3n of such mixture papillo-~,a apneavmj in none of trie. test canis. The experiments were ninde on live rabblt3 arld moin letailed results are given in tablms. Onn reference. Taljlmij. M]IC"IKdV, I.I.; KROTKOV, F.G., radAktor; ANICHKOV, S.N., redaktor; TOW24ISHZV, V.N., rodaktor-. YYGCDMIKM. G.V., redaktor-, ZPAKOT,, V.M., rodaktor- ZILTERR LU., rodaktar: 131AUTSKITO N.A., riedektart, FAVLOVSKIT Ta.JIt.-r-*HWcr; SOBOL-11- SPL#, rodakto r; BMIN, ReIi,l rodaktor; ;O;iiI, V.A., redaktar; GAHMMW,:H.I..,tekhnicheskiy redaktor; POPRYADMIN, K,A., takhnicheakiy radaktor. [Collected 'works (Acm~smy eiditl~n)] Akadenichaskee .asbraj~ie Be ,chinenii. Red.kallegila: F.G.Iretkoy i,dr. Moskva, Goo. isd-yo med.lit-4. Vol. 1. 1955. 390 P. (BIOLOGT) (M.LRA 9:5) --7 HEGBHIKOV,I.I. (1870) NXSIIASOY,A.D., redaktor; KROTKOY,Y.G., redaktor; BXKMISMff,V.11., redaktor; VYGOOHIKOV,G.V., redaktor; ZHDA;iOYj Y.M., redaktor- ZILIM L.A. redaktor; KRAYNVSKIY,11.A., redaktor; PAVLOVSKIY.Ye.Ii-.-~,.-r-d7' 51~060L',S.L.. -,edakt6r; BALKIII,R.I.,~ redakto1r; GABL?JAND,H..I., tokbnicheakiv "daktor [Academy edition of his collected. vorks] Akademicheskos sobranie sochinenii. Hoskva, Gos.izd-vo med. lit-ry. Vol. 3.. 1955. 504 p. (BIOLOGY-COLLXCTMD WCRKS) (MLRA 9:3). IIIIII !AIN I111.1111, 11 M 1111 11 1~ R, ~111 1', ZILIBXR, L.A.; BAYDAKOV. %.L. Immunization against mouse mammary carcinomas sonks..l noo5: 14-20 %55- (MLRA 1911) 1. Is otaela virusologii (2av. - L.A.Zillber) Instituteepideitdologil; i mikrobiologii imeni pochatnogo akademika N.F.Gimalirs (Cur. - G.T.- Tygodehikov) AcIres avtorovi Moskva, D-182. Shebukinskaya u1., d.33, Institut apidamiologii i mikrobiologit im. H.T.Gamalaya. (11OPIASMS, experimental, mouse mamma ry carcinoma, vaco.) (VACCINES ANDIVACCINATIONt mouse mammary carcinoma) WdUST neoplasms, mouse mammary carcinoma, vacc.) E ~L USSR/ Medicifie Diseasas card 1/1 Pub. 86 6/37 Authorm I M 'I-er . L, A*Ji Act. Kam. Acad. Nk. So. Title On the aWdy of the nature of, eancer Periodical t Pi-ircda 44/4, 51 -- 60, Apr 1955 Abstract t The nature of tumrs f-m explained. TwD thearies a-ra presented cf thosi, --mlitgnant tu-i-rv. knovr. U17. ins t-'tu'~10-1 Subri6tted Fjr,1114" Ell I !!I'M ~USSI Medicine Virusolo'Tv Pub-22 35/52 Anthors Zillbr-r I A Hebb: Ot 'Adad.i of M ed. SO V'! -Title Y-, r tocalization-of-spe~ific ti s~ In s a won6i , n gpn l l Periodical Doki AN SSSR 100 2~ hn' 11; -1 955~ ~'!Abetrskct i Eiper-Iments were: 'condui-ted cn ~1 I '!'r~at~Ao (IOLO-m"Lhu U~eii s~r.Ao ity of f r%Ac on sl a Igen e ti nt s) ~tr atea rrom dwollorl 1,jaskirs , L ina from mitochondria and microsoibe and the first j,rla1fij.k.'.n fracl,ion 4 jnon- strated maximum serologic-al aqtivity. A unich lesser ity,was shown by. -the, s oond,gjdbulin f6ctldjiiand i0v 1 albp;mW h' electro horeti st d wu b L f 1l cti d 4., : In, - 1 on"; u e c~ a c were ;im . ~ra jec y o p Se r- ological test 5h alred that the iactive fractiolm were amlogouO iin their . composition. Three references: 22 U&'jR and I U3A (1945-1950). Td bio. Institution Acad. of Hed. So. USSR The N F. Gamaleya 1ndtitvk'te of 1,p1dqAio1dgy-- and Microbiology, Viru&~~ Faculty. Submitted July 23, 1954 4 "On the Question of the Epidemiology of C.~ neer." "On Some New Studies in the Field of Immunology." [paper read at an unidentified scientific conference held by~the'10titute 6:1955-1 Proceedings of Inst. Epidem.and Microbiol im. Wwleyu 1954-56. Division of Virology, Zillber, L. A., professor, Active Member,11cademy of Medical Sciences, USSR, head, Inst. Epidem and Microbiol. im. Gamaleya AM USSR. SO: Sum 1186, 3-1 Jon 57. "Report on the Scientific Research of the~Division of Virology." (paper read at an unidentified scientific conference held by the instituti duriA the first half of 1954-1 Proceedirgs of Inst. Epidem and Microbiol imt Gamoleyn 1954-56. Division of Virology, Zillber, L. A., professor, Active Ylember,:Academy of bbdicel ScAncee USSR, head, last, Epidem and.Microbiol im. Camaleya ANS USSR. so: Sum 1186, 11 Jan 57- 1 4 . . . . . . . ....I"' - mm - - -- -- -, -- . . . . . . . .I ---- 1~- ZILTER. L..A., WXIZIKHOVSKAYA~ R. M. USSR/Virology - Human and Animal Viruses. E-3 Abs Jour Author Inst Title Orig Pub Abstract Card 1/-l Ref Zhur Viol-i No 31 1958, 9661 Mechanisms of Purifying orpaisms.of Viruseso Voyr. virusologii) 1956., No 11 49-54 A critical review. The author comes to the conclusion that in the process of natural purification the organism eliminates viruses through undamaged kidney epithelia. The point of view of ". ftorodintsev is criticized, ac- .cording to vhich in unsuseeptible organismsviruses pe- rish under the influence of -temperature. Bibliography, 29 references, Pill ZTVRRR---"r-,-AARTSISSOV, N.Y.; BIRYULIXA T.I. (Moskva Z-162. Shchukinskaya, D. 33, Institut splmlologli linikrobiologii im. X.7. Gamaleya. Passive hemagglutination caused by the chicken sarcoma virus [with summary In Bngliab) Vop. onk6o 2 no.6:&6-649 .1~6 (HLU lo:4) 1. Ix otdola Immologii zlokacbeetvannykh op oley (zav.-daystv. chl. ANN SSSR prof. L.A. Zillber) lastituta epi imlologil I mikrobiologii im. pochetn. skid. R.F. Gamalsia, (dir.-daystv. cbl. AMR SSSR prof. G.V. Vygodchikov) (AGGLUM&TION passive, of rabbit erythrocytes, by Rous sarcoma virus) (VIRUSES Rous sarcoma virus causing passive agglute.of rabbit drythrocytes) ? ~ USSR/Virology Iux and Animl Viruses. 1-3 Abs Jour Ref Zhur Biol.., No 3Y 1958, 9663 Author Zillber) L*A. Inst Title Answer to A.A. Smorodintsev. Orig Pub Vopr. virusologi-i, 195T, No 1, 61-62 Abstract The author mentions that secretory processess concern the inmmity mechanism, and quotes some factual correc- ' tions to the statement of A.A. Smorodintse4 . (See previous abstract.) Card 1/1 HEM CZECHOSLOVAKLI/Gneral Pr.)blct3s Df PatholoMr - Tumrs. Immity. U. Abs Jour : Ref Zhur - Biol., No 2, 1959, a&)9 Auth:)r : Zillber, L.A., Biryulina, T.I., nartsissiv, N.V. Inst Title Passive Hemeglutination Re3ction and the Inhibition of It in Chicken Sarcom Orics rub Zh. C~i(;iyeny, epideniol., nikrobiol. iiimaunol., 1957, 1, No 1, 68-74 Abstract ND abstract. Card 1/1 37 1 1 11L1; 1111H~Xj IJ 1111 fill-t U : ZILM;R, L,A,; KRYUIWVA, I*N, Haemorrhagic disease of rate due to the virus of chick earoomm. Acta, virol. Ingl. Ed. Fraba I no..1-4a56-16o ruly-IDIc 57. I* H. P. Gamaleya Institute of spidemiology and Microbiology, Academy of Medical Sciences, Moscow, U,S,S,R* (VIRUS DISBASIM, exper. chick earcoma virus inducing hemorrh. dis. In rate) (KINOPEMG3, exper. same) I f IT ;i i rr ZILIBER, L.A.; KRYLMOVA, I.N. Hemorrhagic disease in rate caued by chicken sarcoma virus [with Ummary in 4glishlo Topavirus. 2 no.41239-243 Jl-A '57- fMIRA 10:12)'~ Inatitut epideniologii i mikrobiologii imeni K-F.'Gamaleya ANN M. Moskva. (HWAMAGIC DIATHISIS, experimental$ hemorrho die* in rate ceased by infect. with Roua sarcoma Time during embryonic stage (Run)) (SARCCKA. experimental, Rous sarcoma virus infect. of rat ei,mbryo'caueing postnatal hemorrh, die, (Rua)) (HROPIASKS. experimental, same) 1116111! HIM HIT'N 151,111,1111 -11MOU I : :1 .1i; I'll 11 11!AIN , 1111"1111 IT 4111161111 itili! 1V1 I Mi tlll!Y ., I ~ lijullimp Uf:ERFTA I M-ICA See 16 __VO3-- 5/9-- -Cancor 3275. F. Gamaleya Inst. of Epidcmiol. and Microbiol., Moscow Studies on tuntor antigens nat. Cancer I nst. 1957, 10/3 (3,11-35E.) Tables 6 The anaphylactic reaction to tumour fractions evoked in animals descimitized by normal homologous extracts makes possible the detection of antigens in tumours of animals and of human beings. These anti ens are missing in corr4ponding normal tissues. The antigens in question can also K detected in tumoun.induced in inbred mice by carcinogenic substances (hcpitoma induced in WHA i b 4-o-talylazo. m1c 0-toluidine). In Shope papilloma, as ivell as in carcinoma that devefops from this papilloma, there is present, in addition to the viral antigen, tissue antigen missing in normal rabbit skin. In the experiments' with Shope papilloma and Rous sarcoma the observed differences in the immunizing Mechanisms against. turnour cells and viruses indicate that both turnours possess s dd' 'on to viral anti- pccific tissue antigens, in a kti gcns. In contrast to tissue antigens, the viral antigen -from Shope papilloma can be adsorbed on crythroc tes of rabbits and other animals. The data presented reveal the complex nature Ylturnour antigens and emphasize the need for further investig-* ___Ation of the problem. USSR/Gencral Problems of Patholomr Tw-.iors Filtrablit Factors. U Cabs Jjur Ref Zhur.Biol.) Ho 1).1959, 4169 Author Zil'ber, L.A., Kryukava, A,N* Inst Title A HemorrhaGic, Disease'af. Rats. Produced by the Virus of , the dhickew Sarcorn Orip, Pub Vopr. viiusoloigii, 1957,: No 4,- 23�74.43 Abstract Pregnant rats (comon breed and Wister) were sLibmitted to laparotomy and 16-18-day-old embi~os were injected~ with 0.025-0-05 n1 otsupeniatant Mid of an extract: of chicken sarcom. The newborn rat6-were a[pin injeo- ted with Rous's virus.(0#2 ml) at tb 16 ace7of 7 days, in some experiments repeatedly. In cohtrol experiments.en- bryas and -neonates were injected with an extract of nor- mal chicken muscle. within 2-3 weeks following the last injection of Rous ' s virus nimerous: cysts 4ith hemrrhagic transudate appeared in a part of the tolerating small:rats. Card.1/2 25 i ~M I RjkLm. 11111 JLajjLaLLLj jum' I gIgj, M RIMINI '"N' F11111 =1111 11=111111 MR111 =11111. ... . . . I - - .! 11:1 . :.. ... I I I ZILIM, I.A., prof. Viral theory of the etiology of tumors according t* modern experimental data, Pat.fisiolo I skap.terap, 2 n6333-9 yq-je I$ DerstvitelInyr chlen ANN SSSR, (HBOPLASMS. experimental, viral theory$ review. (YrRUSIS, viral theor7 of exper, cancer, raview:(Rux)) WSR/General Problems of'Pathoiogy Ttmore, Filtr'Ale Ficlttors. bioi.,j No 6, Abs Jour Ref Zhur i9$% 0350 Author Zillber, L*A*., Kryukova) I.N. Inst Title Fibr M~tosi'q 'Rabbits Ind:uc6A':by: :669'''Vir'ud" 06 R Orig Pub Vojrv-viiudold6iii~1958; N-O~~3):-166476T~ Abstract To one-day-old rabbita,.4 time every other day, I ml each of a susponsioa of Rous sarcom (n) was introdu- cod. After 3 weeks, multiple solid nodes appeared under: the skin which coneisted of fibrous tissue with a great of cells. A number of animals Wished; all rabbits were behind in growth. In thode which suznrivedj~ the nodes gradually sclerosed and soms'.resoppUd- In I rabbit, fibrous nodes (FN) were discovered in the liver.;. Introduction of FN suspension into the .muscle of chickens did not induce sarcoma but lymphoid proliferations, Aqueo-saliue extracts of FN reacted in CM with the serum Card 1/2 12 ZILIBER, L.A. KRYUBTA, I-IN-t NARTSISSOV, N.V., BIRYMNI, I. I. Serological differentiation of Rona sarcoma and normal tiOBUO OXtrnC-t$ [with summary in ftlish,10 Vop.onk.4 no-3:268~270 1,58 (MIRA l1t8) 1e Is InRtituta spidejolologil i mikrobiologii im. Gamaleva AJOI OSR. Adres nvtorat Moskraj 182, Shchukinaknya ul...d. 83. Inatitut apideniolo ii i mikrobiologii im. Ganalaya. ~SARCOM. exper. Rous sarcoma extract,serol. diff,ereutiation with normal tissue extract (Rua)) 26-58-5-10/57 AUTHOR: Bekol I ts, V.M, Candidate of Medical Sciences TITLE: On the Problem ofEtiology of the Neoplasms (K voprosu ob etiologii opukholey) At the Second All-Union Congress of Oncologists (Na 2-m vsesoyuznom sllye.zde o,nkologov) PERIODICAL: Priroda, 1958, Nr 5, PP 57-59 (USSR) ABSTRACT: The Second All-Union Conference of Oncologists in January 1958 dealt with problems of the etiology of tumors,~pre- tumor diseases, chemotherapy of tumors, tumors of the bones, and the organizatioh of the anti-canoer fi ,ght in the,USSR. At the first oncologistal conference 11 years ago, only one paper by Professor L.A. Zillber dealt with the virus theory of canner. This the-ory be one of the principallthemes at the new conference. It was opened.by N.H. Petrov, the oldest oncologist of the USSR and Hero,of SocialistiqLabor. The first paper was delivered by Professor:L.A. Zillber. It was intitled "On the Virus Nature of the-FTm-orsof Man" and described over 20 tumors and similar processes in ani- mals, the virus origin of which he thinks has been proved. Among them were the sarkoma and leucoais of chickens, the Card 1/4 papilloma and fibroma of rabbits, mammary gland cancer and 26-58-5-10/57 On the Problem of Etiology of the Neoplasms. At the Second All-Union Congress of Oncologists leucosis of mice. Under the electron microscope, virus- like etiologic agents were found in:matter isolated from the tissues of men suffering from leuposis, but the virus origin of most malignant tumors of man have not as yet been demonstrated. A.D..Timofeyevskiy found virus-like globular bodies measuring from 40 to 80 millimicrons in the extracts of diverse tumors of man (cancer of the stomach, the mamary gland, the lung, sarkoma, etc). Immunological reactions showed the specific nature of these bodies. Professor L F. Larionov criticized the virus theory. He based his d;ubte on data from medical.literatuie but.thought itwas possible that some animal tumors were,of virus origin, al- though there is no evidence yet withzespect to man. Pro- fessor M.A. Morozov, in:his paper "Virusoscopic Observations in Malignant Tumors of Man", holds that virus penetration from without is the etiologic factor. I.N. Mayakiy and M. M. Kapichnikov delivered a paper on the immunology of malignant neoplasms. In sarkoma of chickens and several tumors of man, special antigens were found. This agrees Card 2/4 with A.D. Timofeyevskiyls discovery of virus-like bodies 26-58-5-10/57 On the Problem of Etiology of the Neoplasms. At the Second All-Union. Congress of Oncologists Card 3/4 found in the blood and:tissues of people sufferingXrom~ malignant neoplasms. These bodies could be cultivated in chicken embryoes and possess specific antigen properties.. It was demonstrated in the State Oncological Institute imeni P.A. Gertsen that in the organism of leucosis, patientsa non-aellular etiologic agent can be f oun& that has many characteristics of a virus. Most ancologists, hovever did not hold true that viruses are the only etiologic fa to in malignant tumors. They think that chemical substances and penetrating radiation must be.oonsidered of similar etiologic importance. The papers delivered-by L.M.'Shabad, M.F. Glazunov, A.M. Neyman and othits' were concerned"with the morphological and experimental data characterizing the pre-cancer stage in various tissues and organs.of the ani- mal organism. According to L.M. Shabad, every cancer has its special "pre-oancer". The importance.of early diagn osis and therapeutic measures was stressed once more. Professor L.P. Larionov pointed out that more than 30,chemical, drugs have been successfully administered igainat malignant tumors in recent years in the USSR. The drugs include the follow- 26-58-5-10/57. On the Problem of Etiology of the Heoplams. At the Second All-Union Congress of Oncologists ing groupst hormones (estro ens, androgens,: cortisone); antifolic, drugs (aminopterial; derivativeslof purine ands pirimidine (mercaptopurine); chlorethylamines and their ~ derivatives (embichine, nitromine, derganol. dopan sarko-. lysine); ethylenimines (TET, TEF9 E 391 etc.-, eaters' Of mathaneaulfooxylic acids (mileran); aatibiotice (al~tino- mycin, sarkomycin f etc. In some oas ,esj such as lymobo- granulomatosis, metastases of cancer 6f the mammal glindo seminoma, etc; long-term healing waslachieved by aid,of these drugs. While they mv vsefal in cases of lympbogranu- lomatosis and leucoses p there is almoit no YW they can be 4plied in the more important and frequent cases of malignant. tumors of the stomach, alimentary tract# lungs, etc. Al-~ though 23 papers dealt with the results of new experidental research, new methods of a combined chemotherapy, radis.- tion treatment and surgical measures were raoommended.~.. ASSOCIATIONs Goaudars tvennyy onkologicheakiy institut imani. P.A. Gertsena-, Moskva (State Oncological Institute imeni P.A. Gertsen~j ko,.scow) AVAILABLE: Library of Congress Card 4/4 1. Cancer research USSR 2. Tuinors Therapy. 1 2178. IMMUNOLOGICAL TOLERANCE IN TUMOUR RESEARCH - Imunologickd sbl,'2enf v oftkologickdm vJzkumu - I I b e r L. A. Inst. Epidemiol. I i Mikrobiol. AMN SSSR, htoskva - 714 (270-380) Tables 2 Illus. 3 Using the method of acquired immunological t lerance. specific sera against the 0 Rous' sarcoma virus were obtained by Injecting rat embryos with an extract of normal chick muscle tissue. Later, sera from the rats which grew from these embryos and which were Immunized with Hous' sarcoma e xtract. 'reacted in 4 complement-fixation reactions out of 7 with the sarcoma extract only, and not with normal fowl tissue. Similar results were obtained In rabbits injected post- natally with an extract from the wall of a normal human stomach and Immunized in adult life with gastric carcinoma extract. The sera of some of these rabbits reacted in a complement-fixation with the tumour extract only, and not with normal tissue extracts. Adaptation of the Rous' sarcoma virus to the young rats was obtained by contact of the rat embryos with the virus and by again Inoculating the newborn animals with the same virus. Infection was thanifested mainly In the formation of cysts, which were first filled with serous contents and later with blood. It was found that a test turnour graft grow In resistant rate treated with a homogenate of the tumour. The results are discussed from the aspect of the XYZ factor. (V, 4. Is) 307/26-5P-1 2-111/4d AUTHOR. Zillber 1, A. Active Member of the Academy of.Yedical Sciences oP_;F'e-USSR TITLE; At the V11th International Cancer Congress (Na VII mezhdu- narodnom rakovom kongresse) PERTODICALt Priroda, 19581,?Nr 12, pp 67-70 (USFRNI ABSTRACT: The Seventh International Cancer Congress that took place from 6 to 12 July 1958 in London was attended1by about 2,500 dele- gates from over 60 countries. A total of 60C papers were read. In one of the plenary sessions limited to themes in the fight against cancer, L.F~ Larionov (USSR) reported~ on cancer chemotherapy. The following papers were read,by Soviet researchers: N.N. Petrov and L.M. Shabad, in detail on the origin of tumors in monkeys under the in fluence of radioactive substances and on the development~of cancer caused by endo- and exogenous factors including~those in the surround- ing medium. One of the strongest cancer-4producing substances (3-4-benzopyrene) has been discovered in,the air of several cities. This may be one of the causes of cancer of the lungs. Card 1/3 A.D. Timofeyevskiy and his assistants found in 40 to 50 % of~ 1911jinill Dili 14-1114, -' ill I Pli idl 11.1;lli i I At the VIIth International Cancer Congress SOV/26--,8-12-11/44 various tumors in man, virus-like globular corpuscles:Pf 40 to 80 millimicron dimensions which prop.ngAted In cultures of tissues and in the choricallantoic membrane of the chick embryo. R.Ye. Kavetskiy gave data on the dependence of, ~the~ effect of the virus of cancer of the mEL.Mm.Rry glands on pthe~ condition of the hormonal balance controlled! by the central nervous system. L.A. Zuillber stated that the method of Ipro- cipitation into jelly permits the development of new specific antigens, absent in normal tissues, in a tumor that ori- ginated and was passed on in inbred mice; with this a simpli- fication of the antigen structure is given,.which is connected with the disappearance of certain antigt_,ns of the normal . tissue from the tumor, NN, Blokhin .-ea~ a.paper on chemo. therapeutic preparations obtained by LIF, Larionovand.co-, researchers, and said that such preparations as embikhin, dopan etc, are on a level with similar'~foreign producte, Ye.Ye. Fogosyants and his,assistants reported on the hamster as an animal for the study of cancer; M. Savitskiy and SI.A. Kholdin on clinical data concerning the treatment of cancer of the lungs and the breast in Soviet clinins; Ye,G, Prasdni- kova on the organization of the anticancer service in the Card 2/3 USSR. Of the 50-man Soviet delegation.1 individual members H 111111T;1111~ IFFIFIFIF 1111,11-111111 HIN 11HAT131 11"IMP11 11'V!N At the VIIth International Cancer Congress 507126-r,8.-12-11144 were active in presentations and discussions fit almost.all, sections of the congress, Professor N#N. Blokhin was elected vice-president (1 of 5) of the international lociety for the Fight Against Cancer for the next 4-year period,- Data~on the study of the metabolism of the hepatoma in mice caused by chrysoidin were presented by Allbert and other researchers from Poland. Graffi from the ~_KXA gave data on the virus of myeloblastic leukemia in mice$ the virus was separated~out from tumors which had always been treated as.non-transferable by filtrates and not cantaining any viruses (e.g. Ehrlich's cancer). The next Cancer Congress willbe in 1962 in,Moscow:~ ASSOCIATION: Institut epidemiologii i mikrobiologii1m~ N',,F. Gamalei, .Moskva (The Institute of Epidemiology and ~ftcrobiology N.F. Gamalel, Moscow) Card 3/3 DAVYDOVSKIT, I.V., prof. (Moskva), otv.red.; 2ZO)UHN, N.1f,, profo (Moskva), red.; VASILOYEV, Yu.H.,.kand.mod.nauk, red.; ZBA=IT, I.B.. prof. (Moskva), redi; ZIL!BIIRL 4,' f, pro (Moskva), red.; KOSWOV, Polls. pro ra . f-TAAMOV, L*l?o s prof. (Hookva),,red.; SAVIT.SKIY, A.I., prot.'(Hosk"), red.; SAMEBROV, A.I., prof., red.; CHMM, A.V., kand.med.nauk (Leningrad), red.; SIAM, L.M., prof. (Leningrad)..red.; AVXRRAKH. N.M., red.; ROMANOVA, Z.A., tekhn.red. [Malignant neoplasms; transactions of the.Tdnth Session of the, General Aosembl;~ 'of the Academy of Madical;Sciences:of the U.S.S.R.] '"21okachostvannyis novoobrazoveniin; trudy X nanaii obahchago s6bra~ niin Akademii maditBinakikh nnuk SSBR. Otvet.red, I.V.Davydovskii. Red.kollegiia: H.H.Blokhin i dr. Moskva, Gos.izd-~vo med.lit-ry, 1959. 262 p. (MIRA 14:1);* 1. Akademiya meditsinskikh nauk SSSR, Moscow. 10. neseiia, Moscow, 1956. 2. Deystvitelinyye chleny AXII SSSR (for Davydovskiy, Zillber, Serebrov). 3. Chlany.-korrespondentx AM SIIiSR (for Blokhin, Larionov, Savitskly, Shabad). (CANCER) I I !I III - I I I!" !I ~l PIP] IT -111f I H, III I I viri iiniiiii ii imivi I v,-nivii I it illit I II HECHNIKOV, Illya Illich (deceased]; ZROTKOV, Y.G., glavVy red.; X�~Klbf, R.I., red.toma; STRASMM, I.D.. '* red.tona; AITICHKOV. N.V., red.; BIMMISM, V.N.. red.; VTGODCHIKOV, G.T..,red.; ZHDANOV, V.H., red.; ZILIBER, L.A., red.; KRAYEVSKIT, N.A., red.; PAVLOVSKIT, U.N.. i6dq;':T1'W0T* V.D.9 red.; SINCHILO. K.K., takhn.red. (Academy edition of I.I.Machnikov's collected vorks] AkRdemi6heskoe sobranie sochi"nii. Red.kollegiia: F.G.Krotkov i dr. -Hoo'kva. G Ioe. izd-vo med.lit-ry. Tol.14. Red.R.I.13alkin i I.D.Strashum.' 1959. voi.14. Red.R.I.Balkin I I.D.Strashun. 1959. 426 P. (BIOLOGY) (KIRA 13:6) iUUI~ ,q I b -1 -0 1 ZILIBER, L.A.; ARTAMONOVA, V.A, Mature of changes in the antigeuic structure of proteizw due to the effects of ionizing radiations. Mod, rad, 4 no*'5t3..6 My '50. (NUA; 1247) 1. Is otdela immunologil i z1okacheaktvennykh opukholey Inatituta epidemilogii I mikrobiologii imeni. N.? Gamalei AMN:SSn. (LIVJU. metab. proteins, antigenio structure changwin x-irrad4ted.rabbite (Rua)) (KIUAM,-metab. same) (ROMMEW PAYS. eff. on antigenio structure of renal Ss Hepatic proteins in: rabbits (Rua)) (PROTAIRS, metab, kidneys &,liver, off. of x-irradiation on antigento structure in.rabbits (Ruo)) E411 HIM UTUI OnI I In, 11. "R I I I H33THROV, (Moskva); TUSlfINSKIY, H.D. (Leningrad); GOMIV, 11.11. (Kiyov); DOLGO-SABUROV, B.A. (Leningrad); ZAKUSOV. V.V. (Hoak-va); HUROWISEV, S.N. (Moskva); CHW4AKOV. M.P. (Moskva); ZHWJlOV, V.M., prof. (Moskva); NEGOVSKIT, V.A., prof. (Moskva); BIRWROV, D.A. (I-enlngTad); ' LITVIHOV, N.N., prof. (Moskva); SOKOIA)VA-PONONUIEVA., O.D. (Moskva)-, UFALOV, P.S. (Leningrad); BATKIS, G.A. (Hoskvu); KOSYAKOV, P.H., of. '04oskva); SHHMV, N.A. (Moskva). BUSILOV, A.A., prof@ ' 0:kva); HOLCWOVA, O.P. (Moskva); SUASHMr, I.Do; BLOKHIH, X.R., (Ho k7a)-, PRECEIAZHIMSKIY, B.S. (Moskva); VISIDEVSKIY, A.A. (Moskva) KIY, V-N. (Moskva); PAYLOVSKIY. Te ak%demik (Leningrad); HYASHIKOV, A.L. (Moskva); VINOGRADOV, V.N. KLYEVSKIYO V.I.: I)AVYDOVSKIY. I.V. (Hoskva); UWE, V.I. (Moskva); IURASHOV, S.V.: ANOMUN, F.K. (Moskva); BOGDANOV, I.D. (Kiyev); ZIL'BLM JL (Hosk7a); BRONOVITSKIY. A.Yu.; CHEBOLUM. D.F.0 prof. Debate on the address by Professor V.V.Parit, academician secretax7 of the Academy of MedicAl Sciences of the U.4..S.R.; abridged comments by members of the Academy of Medicine and the directors of institutes. VsslV.Al(N SSSR 14 no.8:19-31 '59. 12-11) 1. Deystvitel'nyye chleny AWl SSSR (for,Nest6rov, Tushinskiy, Gorev. Zaktisa7, Kupalav, Strashun, Preobrazhenakiy, Vishnevskly, Chernigovskiy, Hyasnikov, Vinogradov, Anokhln~, Zillber). (Continuad on*next card) NESMOV, J L.I.---(continued) Card 2. 2. Chlony-korrespondenty AM SSSH (for Dolgo-~burov, Chumakov, Zhdanov, 'giryukov, Sol,-olova-Ponomareva, BatkiB, Shmelev, Rolchanova, Blokhin, Ioffe, Bogdanov). 3. Direktor,Inatituta gerontologit: AHN SSM (for Gorev). 4. Direktor InRtltuta farmakologii i khinioterapii ANN SSSR (for Zalcusov). 5. Deystvitellny7 chlen Veasoyuznoy alm&emii sellskokhozyaystvenn3rkh iiauk imeni V.I.Lahina (VASMiUIL); direktor Instituta apiaemiologii i mikTablologii Imeni % m-lei AM SSM (for l(womtsev). 6. Direktor InBtituta po izueheniZni poliamiyalita AHN SSM (for ChumakOT). 7. Direktor Instituta eksperimentallnov mediteiny AHN SSWL (for Biryukov)'R. 8. Direktor Instituta obshchey i komrmnallnoy~gigiyeny AM SSSR (for Litvinov). 9. Direktor Inatituta pediatrii ANN SSSR (for Sokolova-Ponomareva). 10. Direktor Instituta virueologii AHN SSR (for Koeyakov). 11. Direktor Instituta tuberlailess A)m SsbR (Shmelev). 12. Direktor Inatituta grudnoy khirurgii AM, SSSR (for Busalov). 13. Direktor Instituta pitaniya ANN sssa (for Molchanova). 14; Direk-tor Instituta ek6parimeniallnoy i klinicheskoy onkologii AMI SSSR (for Blokhin)o 15. Pirektor Instituta khtrurgii AHN SSSR (for Vishnevskir). (continued) Card 16. Direk-tor Instituta fiziologli AMU SSSR (for Chernigovskly)0' 17o Direktor Institute. terapii AJOI SSSR (for Hyasulkov). 18. Direktor Gosudarotvennogo lzdatel'atva meditainakoy litemtuz7 (for 14Lvevokiy), 19. Vitse-prozident A14N SSM (for Davydovskiy). 20. Hinistr zdravookhraneniya SSSR (for Kurashov). 21. Direktor Inatituta inf ektsionnykh bolazuey AMU SSSR (for Bogdanov). 22. Chlea-korrespondent AN BSSR: predeedatel' Uchenogo meditsin- skogo sovata Ministerstva zdra,7ookhrananiya BSSR (for Bronovit- skly). 23. Predsedatell Uchenogo meditainakogo soveta Ministeratva zdravookhraneniya USSR (for Chabotarev). (MEDICIM') ME 4 fiffil. fill 11 M :1-FIRIP1,11,111 W1,11, Milla-M I M11,111, Will"m --" - !. . : a : 4 t 1 -1 1 1 1 "!"11:11 HM PTFIT Fil 111til r? d5di 1-4111 lidlt~ i I i I I I 17(3) AUTHORS: Zillber, L. A., Member of the Academy of Medical Soi4nces,usn, Abelev, U. I., Avenirova, Z. A., Engellgardt, 11. T., Baydakov.a,Z.,L. TITLE: On the Differences,in the Antigen Structure of the:Cytoplasm Granulae of the Liver and of the Hepatom~ in Mice (0 razlichiyakh antigennoy struktuxry tsitoplazmaticheak:U&,gMtlnLroechani i gepatomy myshey) PERIODICAL; Doklady Akademii nauk SSSR, 1959, Vol 124, NrA, PP 937939 CUSSR) ABSTRACT: Malignant tumors contain specific tumor antigens (Refs 192), the isolation and study of which is at present among the most topical roblems. The evaluation of the precipitation~reaction in the gel ' tion~of tissue~antig'ens Ref 3) combined with the chemicalsepara t proves appropriate for tble purpose. By this method, the number of the individual antigens in the system can be determined, and:these individual antigens can becompared with each:other. Said,rea,ction has several advantages over other reactions. The author6'ctudied its applicability in the gel, in order to clarify the antigen dif- ferences of tumor and normal tissues. Contrary to previous papers, an investigation was made, not of the protein.fractionsi but of the cell granulae, as they undergo antigen changei on malignisation Card 1/3 (Refs 7-9). For the purpose of a comparative evaluation:~of the On the Differencealn the Antigen Structure: of the Cytoplasm Granulae~of the Liver and of the Hepatoma in Mice Card 2/3 result obtained by,different methods, the anaphylaxie reaction with a desensitization was employed. The work.was carried out with the en-- twisted heparomata of strain C HA mice (Ref 10) and with the-,livers 3 of these mice. The granulae mentioned irfthe title wereilsolited from the perfused liver by means of a separator, from a,1.0 %.rhomo- genate in an isotonic saocharose solution. Electron microscope analysis showed the granulae fraction to consist of a mixture of mitochondria and miorosomeb. Rabbits were immunized (a):with:'a lanolin depot, and (b) without a depot.'For the purpose of a;better clarification of the qualitative and quantitative differences be- tween the preparations to be compared, the reaction was carried out 'in the following way: homologous sera and the:antigen were placed at opposite angles of a square (Figure 1). The antigens common to the systems to be compared yield a uniform spectrum ab, which is situated between the alveoles with heterologous antige~:ind serum. Antigens that are characteristic of one system only show bands running along the diagonal.of the square, their ends touchling the containers of the heterologous systems (.Ed, of). Figure 2'gives the results of the comparison between the protein fractions MmP and 11mG. BOV/20-124-4-60/67 On the Differences in the Antigen Struotuxe.4 of the Cytoplasm Granulae of the Liver and of the Hepatoma in Mice The results attained in the agar medium by the:mothod of,pre.cipita- tion were compared with those obtained by~the method of anarWlaxis (with desensitization). Table 1 shows that the;tvo methods yielded identical results (cf. Refs 6#9). Thus the two~above mentioned methods lead to the detection of a specific antigen in the heparoma granulae in mice which is but absent in.the liver. At the same time antigens were found in the liver granulae' 'which disappear on cancer- ization, The method described facilitates the evaluation of the be- havior.;otindividual antigene.in complex eystems, and opors new ways:o-f-their chemical isolation.-There are 3 figures, 1 t .able, and 11 references, 7 of which are Sovi9t. ASSOCIATION: Institut epidemiologii i mikrobiologii Im. N. F. Gamaleya Akademii meditsinskikh nauk SSSR (Institute.of Epi.demiology and Microbiology. imeni No P. Gamaley.of the Acade Imy of Medical Sciences, USSR) SUBMITTED: September 4, 1958 Card -3/3 MIT M-M IV", MI, ff 1111MIRPM31 ~11 M, It I I i I I I , ~ I I W ,.I - 11 .I I, FIf I I - 11, ! I lifl, lip!"Ill r 1111 !"1l IT q11,11 1 -11 [:.!~! I I I ZWBER, L.A., red.; KRIVISKIY2~A.S.j kand.biol.nauk; :VENCHKOVSKAYAs H,,V,p t I I I. I : ! :! ~ 1. 1 111 IT Tillilit: 111:111111111, '111111 fIll I 11111; 11111, 111 IM 011 11111TI , . - 1 :1-1 11 "; ! 111, 11 .. 1 1 , I I.1 IT 3 11 11 11 1 : i rif `1 Ifliq 11 f!lll -, I I- ~111 , ~ , F~ 11- 1 . I I ~ : .1 1 1!1 1 U V, Ili T, ~ 1 11 `- 11 1 - I I I'll - --l- 11 ~ ZILIBER LA.,.-OMOGOVSKAYA, L.A. Adsorption of specific tumor antigens by ex7throcytes. Pokl. AU SSSR 134 no.2:489-492 3 160. (KUU 13:9) 1. Institut epidemiologli~i mikrobiologil im. S.F. G~Lmaleya Akademii meditstaskikh aauk MR. 2. Deyetvitel'qy" chlea AMU SSUR (for Zillber). (ERYTHROCYTAS) (ANTIGENS AO ANTOODIND) (CANCIR)