ORIG. RUSSIAN: COMPARATIVE CHARAC. OF FATE OF 3 PHENOTHIAZINE COMPOUNDS ON THE ORGANISM

Document Type: 
Collection: 
Document Number (FOIA) /ESDN (CREST): 
CIA-RDP88-00904R000100130001-6
Release Decision: 
RIPPUB
Original Classification: 
U
Document Page Count: 
28
Document Creation Date: 
December 22, 2016
Document Release Date: 
August 27, 2009
Sequence Number: 
1
Case Number: 
Content Type: 
STUDY
File: 
AttachmentSize
PDF icon CIA-RDP88-00904R000100130001-6.pdf1.84 MB
Body: 
Approved For Release 2009/08/31 : CIA-RDP88-00904R000100130001-6 -7- xJieTtlaTxK noxa3aJII4, tITO OI-II?I B MII) llO,il ItOJ.[;1LreCTBe 061-1c'Ipy}IMBaIOTC,H '3!t S'35 Ha MecTe BBe,I1aeHIIIH, ripwwwIOP? -- [Tom' 3I4II 1'.I xJIoprerla 3NH Bcachi BaIOTCH 3aMeTHO Me1JIOEiHeO,uuc,',i ..~ 35.-a7 1i'Ha3NH (Ta6JI. 1). Ta6.nnia5 Colep aHHe S 8'S-aMMHa3NHa, S'5_.ripoMa3N- Ha 14 s 3-xropMerIasMHa Ha MecTe BBegeHNx B noAKOMJOi KJleTtraTxe B Y/o K BBO 3HH0I A03e S kI -xuopMer1asMHa m npx rIOAKO>I IOM BBe4eH1rx. . B h 35 P HV pH J JUIrIHHOM, - a AJIH -apoMasmia p y oJlbl{o 143MeH$IB T h Ka THHV paenpeAe neTNR n N T 6 C35 B orlitTax Ha co6axax, xoTOpN11 S 35-aNIKHa3MH BBOANJI14 BHy'Tp1 muuie'uio (pic. 4). xapTKHa pacapeAe.ueii no opraHai Pi TxaHmd 6btna B OCHOBHOM TaIa$I me, KaK xIp BHyTpMBeHHOM .M fO,IUx03KHOM BBe,geHNN Kp0JINHaM ICI KpEW8M, HO B KOpe 6ojmuil{1 rIOCTe BJIefiH orll imt Ha xpoJIMI{ax, KOTO- . pHIvl arvIMHaEMH r1 npoMaSNH BBO,UMJII~i B a. ca"--ot~s m J /)OZ (pic. 5). I3bMpaTeJlbHOCTb HaICOnJIeHUH M2, B ,I6xiix npi4 3~PoM 6inia ewe 6ouuee BHpaxexa : y AeJlbxaA pa,L(Noa5CTI4BHOCTb JiE ri rx. 6iYJIa B 10-20 pas 60JIb[1e, ueM up y r Nx opraHOB .. Bbi,;3CHMB xapTMuy MaxpocKonv~Iecxoro pacnpe,~eJIeHMg, Ham xaaajlocb HepacTBopI4I&ie B BO 8 OCHOB HUR - Bce OTO 3aT1CyAHSIeT Bcac~IBaHNe, 8 uacoB IS35-aMNHa S 35-npo-. Ma 3NH 35-XJIOp- Meria3MH KaB BOCriaJIeHMe Ha MecTe BBegeHVIR, Tax N TIpenpageHNe NX B }Caic MH rlpe,loJlapaeM, Bce 3TN C aKTOpbi IIOOTOM Hecx Approved For Release 2009/08/31: CIA-RDP88-00904R000100130001-6 I Tab u to 2. rlpodueHT pagKoaKTMBHOCT1 , H,3BtexaeMI3K ISIS 1 r CHPO9 TKaH3~I (100%) xpHc tiepe3 2 traca nocne no Komioro BBegeHHH s 35 aMVHa BMHa opraf-ui JierEze notrKK neqeiib BO Haft 75-80 40-55 30-40 CnrapTOBa$ 75-&5 50-60 40-45 i-pxaa 30-40 25-35 20-30 eJlox rrociie OT- Mr3BaHKSI 1-3 2-4 8-16 Approved For Release 2009/08/31: CIA-RDP88-00904R000100130001-6 Approved For Release 2009/08/31: CIA-RDP88-00904R000100130001-6 -8- HHTepecH1 4 npociieAxTb c KaKirnn' KOMnOHOHTaMM xneT-OT-IH1rx CTpyKTyp opra- HOB CPFi3HBaPTCH aMKHa314H. B COBMeCTHOH pa6oTee c rV T. IIepKytoBHM H I.A. IIo6epKft (21) HaMM 6LIJ1O npoBe,exo Murtpopko.RHoaBTOrpac1ecxoe KsyueH1e pacnpeAeJleHKfi S -aMNHa3MHa B TKaHfX KpUC. IIpoBe,eHHUie oruTbl noxa sat1, tTO B TICaHM JIe,rKoro, o6pa6oTaHHo i f{aK McTOROM BaMopaKMBaHHH, TaK 14 McTOAoM (JYIIccau4M B IGi,,KOCTM Kap- Hya, S 35-aMHHa3MH Hs(5zpaTe,rrbHO HaxanJlxsaeTCfr B S pax orII TejrHajTb- i x x.ueTOK aJibneoJt (pi,-.-c. 16). B notgxax- S -a yHHa31H xoHqeIiTpK- pyeTCe npeMIMyupeCTBeHHO B a nnITeJI-IatbHHX o6pa3oBaHKHx xa.HaJ1brAe,B H 6oy1eHOBO9 Kancy,lr, (pMc. 7). CpaBHHTenbHO 6onbulaH xoi1LXeHTpau,1. S "5-aMNHa 3HHa 6HJIa o 6iiapy Zexa B C oJIJJY i y Jiax u MTOBI'IAHOcI. meJie su (plc. 8). PaAmoaiTKr3HOCTb ceporo Bew,ecTBa 6OJ1buwx ;OJIyl.uap1il tiwiia saMeTHO 6onbuie,ties 6eJrioro Beli.ecTBa. B ceiie 3exxe KoxgeT7TpaU,Ma. S 35-aMHHaaMHa B o>I> tiynax 3Hati1T.eJXbxo B e,treM B NpaCHOR nyuhne. B TicaHHx HaAnoxieIHKKOB ii netaeHK pacnpegeiiemie HOCXXo 6o i e Rw - JsHHk xapaKTep. KpoMe TOM Mbr IIpOBOAMJIM OnbrTFZ 1.70 (pa1LUbi0HHPOBaHMlOTxaxeH uer- ic x, Iiotiei{ H neLTeHH icpHC noCJle no,~KOXHOPO BBegeHza s -aM1Ha3MHa (Taft. 2 H 3). Approved For Release 2009/08/31: CIA-RDP88-00904R000100130001-6 c O 1c) O O O O LO rn0C\2 d'm C\2 LO lco w Approved For Release 2009/08/31: CIA-RDP88-00904R000100130001-6 Approved For Release 2009/08/31: CIA-RDP88-00904R000100130001-6 -15- E L I Fa 11 Yl o r F AIM 1. Chinn H. 1. , - "Effect of chlorpromazln on emesia Scheldon G.L. 2. Stender H. St. , Hornykiewytsch Th. after radiation".Proc.Soc.Exper. biol.a.Med.,86,(2),293-295,(x954) "Uber die Beeinflussung der Strahlen- empfindichkeit bei Ganzk6rperbeetrah- Iung durch Megaphen". Strahlentherapie, 96,(N 3)q 453-457,(1955) 3. HOn2.THV1HOBa 0".0. - EPOi;)YIJI3I,TZI{1 H TepafHH JI/4eBO141 GOJTe3HH 4. Z(OpOB P .A. vt 1IHOJrL C.J. Ilpia JIe s Lo s 0, C J CD CV) ca Ca xms C%2 H H ca X00 x cu t:4 x co ca` I s -3i sCI F3 ci N 0 CC cu?, I c) Approved For Release 2009/08/31: CIA-RDP88-00904R000100130001-6 0 CO tI4 C'? U sx ca U H /N t-q O U -:4 ca CI) U I O s U w o " P4 oas co C) O r., C ~ x 1 P-4 Cu to r-, H M 0 H `O O O n 1 1 U C ,s o .= ca ct3: x xi cz rci -~[ it s 1 '. cD x cts 1 Approved For Release 2009/08/31: CIA-RDP88-00904R000100130001-6