ORIG. RUSSIAN: CYTOGENETIC EFFECT OF IONIZING RADIATION ON NUCLEI OF GERM CELLS OF MONKEYS

Document Type: 
Collection: 
Document Number (FOIA) /ESDN (CREST): 
CIA-RDP88-00904R000100130047-6
Release Decision: 
RIPPUB
Original Classification: 
U
Document Page Count: 
20
Document Creation Date: 
December 22, 2016
Document Release Date: 
August 31, 2009
Sequence Number: 
47
Case Number: 
Content Type: 
STUDY
File: 
AttachmentSize
PDF icon CIA-RDP88-00904R000100130047-6.pdf1.17 MB
Body: 
Approved For Release 2009/08/31: CIA-RDP88-00904R000100130047-6 \``1 BTOpBA MCM(JI,yN2p0AH8A HON$EpBHRNA vV Opf2HN38gNN 0618ANHBNHbIN HBltNl1 IV, 00 IIpNMBNBNNIO MOOR 3HCpfNN 8 MNpAhll{ u811AX He nofnorHHT ornauleHHH) no o4iHItwanbnoro coobutLHHn Ha fioiiiju,pen4NH I TOrEHBTWI. C1{YI9 014(1'BKT ]3O3 EOCTBI4HI MOIIII3ZPYIO ErO I13IIYLIBIII'ISI. HA JI,I1,PA 3A1'0,I1IAI1IEBIIX IMETOR OBMbI-I r.r.TKHRKOB K M.A.ApceIbeBa A/CONF/15/1' 2476 011IGINAL: 1?1.1; ;;'LAN B B e A e H K e IIoBbtlueime # Ha pa,uKaLKH, RBJIRCJIueecR CJIeACTBKeM HCriOJIb3oBa- HMR aTOMHOR 3Heprvl1, nOCTaBIJIO nepeA COBpeMeHHOt Hayxov~I 3aAauy nepBOCTeneHHOR Ba KHOCTLI: OIIpeAeJII'ITb, ISaKO1 BpeA MOUT 6bITb IIp144w- HeH B CBA30 C 3T14M COBpeMeuuoMy K 6yJ yujim rioxoneHKRM 4en0BegeCTBa, He XeHeBCKOA KOHL. epeHLwM no MKpHOMy KCnOJIb30BaHMIO aTOMH01 3HeprKH B 1955 r. BOnpOCbt pa,jJ,1orexeTMqecxoro 3ctx,eKTa Ha genoBexa pacCMaTpMBaJIKCb B )~oxua,JT,ax Meuepa, KapTepu, Pacce)ina x Yonneca (1 O,II,HYIM 113 Tpe6ylOi4I4x OC06eHli0 npLCTaJIbHOro YI3ygeHMA ABJI$ eTCA BORPOC 0 nOTeHuKaJIbHO i OriaCHOCTH IIOCTORHHOrO 06JIy4eHI1 MaJIbIMM Ao3aM. B HaCTonLgee BpeMR H)deeTCfi y e pfu AaHHbIX 0 TOM, q TO Bb13- BaHHI3e OOJIygeHMeM K3MAHeHMf3 reHeTi1gecKoro MaTeriiana CJIyCaT nIpI4~i:i- Hog pnAa aHOMa1IHV y MneicanNTaifliuMx, KaK TO: CTepMnbHOCTM, IIORBJIe- HHR ypOACTB, rM6eJIYi OM6pK0HOB, nOHKdeHM$! M3HecnOC06HOCTI1 4 T.A. K3MeHeHIU, B03HUKaij1LKe n0A BJiMRHG1eM O0JlyueHY1R B COMaTIdueCKKX KAeTKBX, MOryT Ilp1BeCT14 K TaKMM TR e)IbIM nocJIeACTBVIRM, KaK W1e iKe- MHJi K 3JIOK848CTBeHUL 8 OriyXOJIK. He BaIgHOCTb pa3pa6oTKu Beex 3T OX npo6JIeM yKa3UB3IDT Bc8M1;aHHbie 110 3TOMy BOnpOCy, nony4eI1Hbie Ha ii umax. MaTepMa n z MOTOR B Ka4eCTBe MaTepKana AJIR MccAeAOBaHNR dbuIH B3RTH Ode3bAHu (Macaca mulatta), C@MeHHNKN HopMaJIMnIx x odJ'IygeHHbaX O6e3b$H dbinH nony4eubi ripe BCKpbLTNN IMBOTHHX Ha CyxylcKoM meANKO- 6NonarN4ecxog CTaHIJHN AMH CCCP. Bcero dbino NCCneAOB8HO CeML CEMeHHHKOB OT HOpMBJIbHIIX KOHT- pOJII HUX THBOTHUX B BO3jJQCTe OT 4 Ao 7 JieT H IileCTI CeMBHHHICOB OT OdnygeHHbIX peHTreHOBI1MI4 JIyg8MI1i oC06e31 B BO3paCTe OT 2 AO 9 neT (Ta6n. 1) . Odny4eHHe 06e3bRH npOBOANJM peHTreHOEMMM ny4amK npH CneAylo- 1914X yCJOBNRX: 190 KB, 15M4 ()NJIbTpbt: 0,5r (gCUtimm,Af Ha paCCTOA- HHN, paBHOM ABO1HO9 uJIIRHe TyJIOBHi4a 'I1BOTHoro. A 03a B03,1eRCTBNR 150 - 500 p. CeMeHHHKH nepeHOCHiIN B nepBbie 30-20 MNH. noc ne 3ad0H TKBOTHHX B G, MKCBTopH(KapHya K By3H). 1TpenapaTbi OWIM fl M OTOBllexbt AByMR cnoco6aMH. 1. npN fOMOII(N 06bl4HOR napaccMHOBOR 3aJIMBKx C nocne,Ayiolue2 OKpaCKOg EeJle3HHM reMaTOICCHJIYIHOLI, a TaK'e UpH HCUOJIb3OBaHHM c enb- reHOBCKOYI peaKil14M. 2. TOTa,IbHnww 84eTOK8pMMHOBhmL McToAoM. ,J Mccne) 0 aH>h X OMOCOMHbUX peopraMaIIH9 B 3ap0Abimeabix KIIeTKax 6enbix MbiWO 6bIJIM 14cnonb3OBaHbl camg1 nadopaTopHo1 n0flfJI - LjHH B B03paCTe 30 - 40 AHeR, cpeAHN9 sec FOTOpbHX COCTBBJIRII o1COno25.a. Approved For Release 2009/08/31: CIA-RDP88-00904R000100130047-6 Approved For Release 2009/08/31: CIA-RDP88-00904R000100130047-6 -3- It;VIBOTHIIO TIO.1 BeprUnWcb O0nytlei14IC peIlTre110BbuMVI lly4QMH rlpM ycnol3K)ix: 190 ICB, 15 Ma, cpVlnbxp 0,5-m. Cw-3 , j& A, pQCCTOSIHMe h,3 CAI. ,x'030 BO3,Il(A1CT13Vih1 13 OIIIITCX CUCTaBnflna 400 p . IViBOTUbie 6LIJII4 3Q611Tbl C1IYCTSI H CYTOIC w tiepe3 40 AHe I riocne OdnygeiiVifi. OA- IIOBpCL1eIIliO B ICQ AbIII 143 3TVIX CpO1COB 38OVIBQJ1I Cb Heo6)1ygeulllWe, KOIIT- ponbHble ICUBOT11110. Comet-mu w (j)iacwpoi3wim B KapHya C nocneuylmet1 OKlpaCKO0 a1A0TOxapMWIIOM. XapaKTep11cv1ILQ HopMarlbIIoro Hadopa xpOMOCOM, 000OOUIIOCTVI CTpyKTypbl M noBe,ueHH1fl XpoMOCOM B M0i3O3e y oOnytleliHbIX oOe3bAH XpOLIOCOMHb11 Ha6op y 06C3bf1H T,14tcaoa mulatta BaepBbie 6tdn O0caeA013311 B 1924 r. IIai1HTepoM. OH yCTaHOBNl, t?ITO B ICneTKax ceMemiCa 3TOrO B4AQ AMn11O14,iiHbIg XpOIAOCOMHu11 Hadop COCTOVIT 13 48 3neMeHTOB. HaulM 1CCneAOBEHMf1 10pI4OTVina B CeMeHII1dKaX Toro xe BVIAB oOe3b- Jill COBnaA@IOT C 3TVIMVI AaHHbIMM fl HTepa. 3TO noATBepxAaeTCfi TaK)ie nOAC4eTQMM B ranfOMAHOM Hadope B 3KBaTOpManbHbIX nFaCTKIIKaX II MegOT44eCKOrO AeneHVifi (pViC. -1 a, 6 ). B MOTac a3HbiX nnaCTVSHKaX cnepMaToroHVt41 donee ICpyliHble xpoMoc0?dbI BcerAa pacnonaraloTCfi no ne- pwiepMN Komnnexca, a donee 1de ame - B L(eHTpe. B nnaC T14HKax Mc9OTM- 4eCP:4X AeneHH9, n0-BI&IAVIMOMY, HaOnioAaeTC$I CTporasi ynOpflAO4eHHOCTb, npM ICOTOp09 IO4TM BCe XpOMOCOMh1 3aHMMa1OT nep1 epM4ecKoe nonozeHNe Bolcpyr BepeTeHa, oOpa3yfi c wrypbl AUBORBHO CTpO iHb1X Konen (puc.3e ). B npoBeAeHHoM payee ri1cTonorM4ecKoM 1ccneAoBaHMM (5) ceMeH- HMKOB OOnytleHHbIX 06e3bfiH ObITiO yCTaHOBneHO: I. Hanvl'uie donbujoro KonwgecTBa HHKHOTM4ecKVIx aAep H pa3py- uIeHHOro XpOMaTHHOBOro MaTepmana AereHep1poBaBIuMx KneTOK. 2. AcMHXpOHHOCTb B pa3BKTMVI OTAenbHHX CeMeHHWX KaHanbueB M donee McAneHHI 1 XOA cnepMaToreHe3a y oOe3b$IH, 06ny4eHHbIX B 2-neT. HAM Bo3paCTe. Approved For Release 2009/08/31: CIA-RDP88-00904R000100130047-6 Approved For Release 2009/08/31: CIA-RDP88-00904R000100130047-6 -4- Tedu4a I xKBOT- Horo Bo3pacT K MOMeH- Ty odny- qeHHA Bo3paCT it MOM@H'Ty r1deAM MAN 3adon u03a odny- ueHHH, P COOTOAHKe cnepMaTO- reHO3a npKqKHH rodent 2 2 roAa 4 roAa 450 AOKHXpOHHOCTb, 3adMT KH(J)aHTUIIbHOCTb 6 2 rOAa 4 roAa 300 CTepKnbHOCTb 4 3 roAa 5 neT 450 Heoxonbxo 3aMeA neHIIbl XOA criep MaToreHe3a 23 4 r.4Mec. 4r.4M.3lAH. 400 BneWHe HopManb- Hwwt CIIepMa To- reHeB 1 8 neT 10 neT 150 BHeWHe HopManb- H1d9 cnepMa T0- reHe3 9 9 neT 10 neT 500 CTepKnbHOCTb IlorMd OT 06OCTpeHK$ xpoHnecxoN AK3eHTepKK B ceueuHux xaHanbltaX naTKneTHeg (N' 4) K AeUTKneTHem (lb 1) OdJIygeHHIIX Ode3bAH npOTexaeT BHeIHe HOpM8)LBHHR CnepMaToreHe3, Odpa33yeTCA MHOro CnepMaT030KA0B. BcTpetiaeTCA MHoro MKTOTK4eCICKX ( T&ryp K pC3HSe MANX Me903a. O, Hai o npn oonee AeTanbHOT-[ paCCMOT- peHKbi MaTepKana ykaeTCA yCTaHOBKTB paA xaeTO'IHLIX HapymeHxW, KOTO- p13e He BCTpemallaTOf B K0HTponbHOM MaTepKane, 3. PacnaA aAep Ha Hecxonbxo Menxux xapMOCOM KAM Ha donee icpynxne rAHdxa X OMa TKHa (pKc. 2 8 ) . 2. CninaHHe xpoMaTKHOBoro aAepHoro MaTepKana B decnopaAotI- Hiie rnxdxH, HanoMHHa Hil1e Krypii AKazKHe3a. 3. HenpaBdnbHoe pacxoxAeHize rpynn xpOMOCOM B Meflo3e, B pe- 3ynbT8Te uero x OAHOMy nO1IOCy BepeTeHa OTXOAKT donbmee KOfHgeCTBO XpoMocoMHOro MaTepKana (pKc. 2 a). 4. HanK ii a AByx-- K qeTxpexnAepHHx xneTOzc. 5. Ham ti ie Tpexnon cHbi: MHTO3OB B pe3ynbT8Te HapymeHKa an= napaTa BepeTexa (pMC.2 c0). 6. CTpyxTypHue HapymeHKA XpOMOCOM. AaHHaA KaTeropMfi K3MeHeHKYI 3acny'KiBaeT ocodorO BHKMaHMB, TaK Approved For Release 2009/08/31 : CIA-RDP88-00904R000100130047-6 Approved For Release 2009/08/31: CIA-RDP88-00904R000100130047-6 -5- ICax npe4CT813nf1eT CoOO1 IIe06pQTUMble 914 TOrolOTUq(GCICUe 1IepOCTpOHKu fl.epHoro Marepuane. K tluClly uaCTO BCTpetiaK0ll(MXCf1 OTKIIOH@HIR 1 3TOro Tuna CneAyeT OTHCCTU XpOMUCOMHWW MOCTI-1 D alla(')a3aX u TeJIO(j)03(0X MeftOTUtleCKOro )ielleumi, IIapyUuoilufl 11p114 J)UICXOI,L OIINU, 1IOABIIeHUe alieT- putleCKUX 4)parMeIIT0D XpOMOCOM U T.A. (TaOn. 2). llpu puccMOTpelIUU TQUll. 2, rAe npMBeACHH ,11raHIImme no TpeM 06e3biIIIaM, OTMetlaeTCA Cne,liyl0l eC 1iuTepecHoe fiBneHUO. B cebleliHUxax 06e3bRHbI } I, 0611ytIeuHOR A0309 150p u 3QUMT0M CIIyCTA 2 rue, 06Hapy uBaeTCA ,IjO 5% 143MeHeHHGIX aHa(ba3 (allacIla3u C OAHWM, J!BJMfI 14 tleTblpbMfl XpOMOCOMHMMU MOCTaMbI u aueHTputlecKNMU c)par:.19HTOMU). B C@MeU nax 06e3b$HbI. P 4, oOnytleHuo t 450P u 3001ITO9 TaK'Ke CnyCTA 2 roAa, 06114 IIpOI;U oxpoMaTM.WLe MOCTM. ABy :poMBTKAHble MOCTM MOryT BO3HKX&Tb B pe3yilbTaTe MHBepCKIl Ha OCHOBe xpoccKHro- Bepa B CMHafT14pyal4eL nape xpoMOCOM. O.]U1oXpOMaTKAHBe MOCTM (B CBA- 3K C HaAMqKeM AMiAeHTpM'4ecKMX xpoMocou) MOryT dblTI CneACTBMeM Kax KHBepCHiI, TOR M TpaHCJ1OKa9M2, B03HHKM1X 3Ha4HTenbHO pat;Lwe Aa HHoro AeReHKa KneTKK. Tait Kax c 1doMeHTa odnygeHHS AByX 0de3b$IH np0MA0 2 roAa H Bee KneTICM, oOny4eHHHe H8 donee n03I1HKX cTaAMnx pa3BKTKA, dbtuii AMdo 3JIIMMHMpOBaHU oTdopoM, AH60 BbldpomeHl3 B BKAe 3peJIUX cnepuaT03oM- AOB, To ecTeCTBeHHO, 'To HeodxoAKMbie Tenepb xpoMocolHHe nepeCTpo9- KM MorfH BO3HXKHYTb JIKmb B paHHHx reHepaLMax xaeTOK, T. e. cnepMaTO- romax. AdeppalKl1, oxa3aBl!MOCH donee ICH3HeCnocodHbNMM, K Tenepb 00HapyXKBaEOTC.fl Ha pa3HbIX CTaAKAX Mekio3a. CAeAOBaTellbHO, HeBepLo, tTO no YicTegeHNK A)MTeabHoro cpoKa nocne o J1p1eHMA paCXO,oBaHMe 3peJINx noJ1OBbiX KneTOE H rx6e1Ib xneTOIC c xpoMOCOMHbiMK nepecTpogxa- M11, B03HKXIUKM14 Ha pa 3HbIX cTaAtux raMeToreHe3a, noAHOCTbiO BoccTa- HaBJ1MBaIDT H0pMaJIbHytO nn0A0BMMT0CTb K CHKMaIOT uKToreneTHgec1 w 3 eICT odnyqeHxa. K3 npMBeAeHHbIX MaTepHanort BMAHO, .To xpoMOCOMHUe nepecTp09- xn, o6Hapy)eHHne B ceMeHHHriax ooe3b,9H H Bo3uw1cwKe n0A B03Ae9CT- BmeM Mould3MpyKI4ero V13Ay4eHKA, 01Ca3a/IMMCb aaanor 44HHMH TeM, KoTOpble Y -a 3P.a4HTeABHO paHBwe BbI3I BaAMCb peHTreHOBbIMM ny4aMn y Ap030t ZAU, paCTeHxg x MbimeL? OdpaigaeT Ha CeOSI BHMMaHHe TOT cpaKT, 4T0 y 06e3bHH OAHOxp8THOf1 Approved For Release 2009/08/31: CIA-RDP88-00904R000100130047-6 Approved For Release 2009/08/31: CIA-RDP88-00904R000100130047-6 -9 ll,O on 450p IJUJIIIJU()T cpu.,3y O'let(b OunbWOe K0J1144eCTBo XpOMOCOUIUX 110j)COTpOuiC H3 locax C1'U,lll1llX cuepMa TOrdile3a, B TOM 4i4Cne H B CnepMa- TOrollxiix. OpiluHNTUJII.JIbJU iI IIHIJ '011w1Jt;ICTa 130J,ALACT13K11 HOH143l1pyk19O1 pa,IlKL1iI,k1N iii) :3(] j)U) hIIllUBIIL K,JILTKM 0003b$H ki Mbiweg I1CCne,UUt3U tlk1U rollo-r'teCKorO 344xj)e1C'1'la B03,uel CTuNA K3ny4eUHH Ha rt)H(1,[jw MIIII1t3H 0W110 rlporie,I1cuo pnjiou aIJTOp)OB K AanO apeACTaBneHHe 0 BARRU i t 061tyI1o 1114i1 km p)I1',01011111do C'T 3,lNk1 cnepMaTorexe3a, He BO3HHK- HOBe:1Me rt3HHIAx M'T0U.I'1 A M XpOMOCUMHIIX IlepOCTpOOK, B gaCTHOCTH TpilIiC110KCcIANH (6-12). IIU OCUO i UIIKM nony41e11Hb[x ,II,aHHUX no 48CTOTe MyT01LU11 B CIICpMUTOI'JIIKSIX ulilueg 6un0 nponeAUHO CpaBHeHHe C ,aHHBM} n0 48CTOTC MYT049;1 y A(po3oti1U)lbl (13). AHanK3 n0Ka30n donee BUCOKyD raieTc4ueci-Cyio p)iAAilotlyl10'rD14T1;llbUUCTb MUWeN no epaBHeHxlp C Ap03O4 i- noK. McTO1 y'ieTLI XI)OMOCOMHIIX riepeCTpoeK no 4KCny aHa pUal bIX MOCTOB B pI33Hhle CpoKk1 nocne oOJly4uHKH n03iioAAOT Cy,l1,HTb 0 KOnH4eCTBe BO3Hk1Ka?:1d4iX [IOA BJK11LI1 M H3ny 4eHk1 3 K COXp8HIDU(KXC$3 Xp011000MHbtX nepeCTpoeK cpe,ir,K pa3MH0Ulnul1XCA 3ap0Ahluleai x xneTOK. Taal L(HTO- reHeTVI4eCKM i McTU,U f0313O11neT npoLieCTM CpaBHKTenbHH31 aHaJIM3 B OT- Hoiueu1uI 4aCTOTbI 14H,,kyLl4ipoi30HHUx xpoMacoMHblx nepecTpoex y pa3AXtlH6lx 1MBOTHbtX. rloJIyLleuuiAe CpaBUUMTenbHHC AaHHWe MoryT nOCTy%NTb KpidTe- pKeM ,gJir7 oueHxu i~KTOreHeTkiqecKOH paAK04yBCTBKTenbH0CTK pa3HbLX? >ItKBOTHb1X it 06JitygleEiIHIG. Cpe,qki KCCJ1e,11,OB8dHb1X o6npieHHHX OOe3bllil OAHa o6e3baH8 (*23) 61;?;ia 3acMTa Ha 11-H Will nocne 06JIytleHMa peHTreHOBhLMK JIygaMH AO_ loci 400p . Rpm COXj)aHCH4k[, n0 BO3M0XHOCTH, KAeHTKtIHbIX t K3H4e- CK14X yCJ10B16~ OTIUITU 0binld npoBeaeHbi 001jy4eHKf1 MHme TOH ze AO30 peHTreHOBbIX Jiygeg. LIBOTIHWe OUJIVi 3adMTbl C[1 CTfi 33 CYTOK H 40 AHeg1 nocne o011ygieHHfl. 00HapyzeHlible LMTOnorKt1ecKKe K3MexeHMH B 3ap0Abi- IueBblx KIICTKOX MHUIe i OMJIK allagOrZgHH K3MeHeHKiiM, Ha0 DAaBu1MMcfi B 3ap0AH1ueBux KJIeTKaX o0e3bu. Pa3ii MsI OTMeu)1MCb JIMIUB B OTHOuIe- 1 MM t 8CT0Tb? Toro 411M YIHOrO HapyiUIeHl4A (Ta5n. 3). M3 TaOn!4U,1 3 Bk111H0, '-IT0 y MbIlieli BCTpeual)TCfl 4ai4e oAKHapHBe Xp0M000MfIble MOCTUI, Ha H3-rrl AeHb OHM OOHapy) MBaDTCfi B 3,63% cny- ;4aC 3. ZpltleAv c e tIaCTOTO OTMetramTCii aHa{ a lbi c aL;efTpt1-? gec$4iMyi ilparMeHTca.M'r'i (4,65%). Meubuie B03H1KaeT aHacPa3 C ABYMf3 MOCTaMM (0,37%) ;4 e;le pee Bczpe'ieIDTCJI auatpa3bl c TpeMfl MOCT6MK Approved For Release 2009/08/31: CIA-RDP88-00904R000100130047-6 Approved For Release 2009/08/31: CIA-RDP88-00904R000100130047-6 _10_ (pt4c.5). B iineTKIaX cemeIIHNKOB KOHTpOnbHWX ZNBOTHbIX dbl1O o6Hapyt6HO TUnbKO ABa cnytlaa aHa(Pa3HbIX MOCTUB 10 851 I1pOCMOTPOHHOM 8Ba(a36i, '(TO COCTaBJIHeT 0,23%. OAHaKO CJCAyeT OTMeTNTb, RITO KapTVIHU 061ANX HapymeUM 4, odHa- pytKeHHUJC B ceMBHHKKaX o0e3b1H, OCTaeTCa aHa)IorINHOR N y MUIIeM. TaKKC HapyueHIIA, KIK I1O BneHKe MHOrOLAepHbuX KneTOK, HapymeHKe annapaTa BepeTeHa (TpeXIOAIOCIWe MKT03M). xapiopexcHc, GRI MMHKM XpoMOCOM w ApyrKe M3MeHeHKa, BCTpeyaDTCA KOK y oOe3bAH, TaK K y Mbimei (pic.5). IlpeACTaBna@T KHTepec npuBeCTK cpaBHKTenbHH9 aHa)IK3 4aCTOTU Bo3HKKHoBeHKa XpomocomHbIX peopraHN3auM9 y MHWeg K oOe3bBH npN OAKHaKOBo ,il>cewi KHBepCNM B CHH7nTNpYIOI4HX Xp0M000MaX Ha CTaANK np04)a3U B 3apOIuAuI8Bb1X K]IeTROX O6e3bAH. 4. B Me 1o3e y Ode3bBH O0HUpyaeH1A OAHUXpOMaTKAHNe N AByXpO- M8TK,1Hue aHaLP83Hbie MOCTbi. O,1(HN N3 HOX ABni1IOTCA cneACTBKeM Kpoe- CMH:'oBepa B KHBepCNAX, a pyre - pe3ynbTQTOM B03HMKWKX TpaHCnO- KauHn. 5. Bo3HM1CWNe NHBepCNOHHUe N TpaHCJOKaLANOHHble MOCTH, BHOBb ,11;a14IQNe MOCTbI npM AaabHe IweM AeneHYIK KneTOK, npMBO,E aT, B KOHL O KOH90BO K 3)KMNHBi(NM K3 sApa uenux XpOMOCOMHHX 3neMeHTOB. 3T0 B CBOIO 04epeAb BIL3bIBaeT AereHepagmi oTAenbHbHX aAep Kn! KX reHeTK- 4ecxyD HenofHOueHHOCTb B COCTaBe 3penHx nOAOBUX KneTOK. 6. Odiuan oAl oxpaTHan Ao3a KoHK3Kpyoutero odnyaeHHA B 150-400 OCT3Bn$eT BpeAHbl uKTOreHeTKqecxN 3 )eIT B HeKOTOPUX pa3MHOZa10- u ixca KneTKax nOfOBO2 xene3bi TMBOTHOro, no xpakHei mepe B Teue- HNe 2 neT, a, BO3I4OTHO, M Ha BCiD ero nOCneAylDU.ya tK3Hb. 7. 3KCnepMMeHTanbHue AaHHbte no B/NAHNTO paAuaLINK Ha HaCAeA- CTBeHHH8 CTpYKTypH Ode3bRH K MUWeg nOK83anM donee BHCOKYK paAKO- 4yBCTBNTeAbH0CTb 3TNX CTpYKTyp y o6e3baa. 8. npeACTaBneuMe 0 TOM, LITO rNdenb KABTOK B raMeToreHe3e 3a C4eT B8C6anaHCNpOBaHHbIX HAep CIIyCTA p,JNTeAbHoe BpeMs nocne o6ny- 4eHKA npMBOAHT K CHATMID Ij4ToreHeTK4ecroro 3c eKTa npM BO3AeMCTBKH NoHM3MpyiDLI ero N3nygeHMA, OKa3aIIOCb aeBepHuM. 9. YCT3HoBneHHOe pa3JIT ie B paANO4yBCTBWTenbH0CTX 06e3b8H no Cp8BHeHNi) c MbimaMM Heo6XOANMO y4NTb1Ba Tb npf! coBpeMeHHblx pac- 4eTaX pa i oreHeTN4ecxorO 34x eKTa Ha 4eJOBexa. Approved For Release 2009/08/31: CIA-RDP88-00904R000100130047-6 Approved For Release 2009/08/31: CIA-RDP88-00904R000100130047-6 JIHTep0Typa 1. Proc.Int.Conf.Peuoeful Usos of Atomic 1N;riurL;y.Goneva,1955,2 2. Effect of radiation on human heredity. Chronicle Word Health Organiz,1 957,2,Ns8, 237-244 3. The responsibilities of the medical profe,sion in the use of X-rays and other ionizing radiation.United Nations Scientific Comittee on the Effect of atomic Radiation. Amer.J.Human Genetios, 1957, 9,N%2, 93-97 4. AydaHHu H.n. HOHH3Hpy01400 H3ny'O}II e H HaCneACTBeuHOCTb genOBe- xa, H3B. AH CCCP. Cep. t ioA. , 1957, lb 6. 5. THHaxoB r.r., ApceHbeBa M.A., bouapoB D.C. rKOTOnorL1 ecxaa CTpyK'Typa HOpMaJIbHUX Ode3bRH H 00ny4eHHUx peHTreHOBbtMH nygaMH (B riegaTH), 1957. 6. Russell ,Y.G. Genetic effect of radiation in mammals in Radiation Biology.Ed.by A.Iiollaender,1,825-859.M.C.Graw Hill,New-York,1954 7. Carter T.C., Lyon N. , Phillips R. Induction of mutations in mice by chronic gamma irradiation, Brit.J. Radiology, 1956, 29, 338, 106-109 8. Snell G.D. X-ray sterility in the male house mouse, J.Exptl. Zool., 1933, 65, 421-441 9. Russell W.G. X-ray induced mutations in mice,Cold Spr. Harb.Symp.quant.Biol.,1956, 16, 327 10. Auerbach C., Slizynski B. Sensitivity of the mouse teetis to the mutagenic action of X-rays, Nature,1956, 1779 N24504, 376-377 If. HyzAHH H.H., Manxpo H.N., HeTpoBa O.H. CTepHnM3ywuee Ae9CTBKe KoHH3MpyoWe1 paAHagNx as MnexonITa0u1&x, CO.padoT no paAKO- dxonorKu, 83-112. M., H3A-BO AH CCCP, 1955. 12. HyxABH H.H., IllariKpo H.K., neTpoBa O.H,, He4aeB H.A. CTepxnH- ay..ee AeRCTBxe xorn wpyioigeg pa1ZHeuHH H8 MJle1OnMTaiDu4Kx, Cd.paOOT no p3AKOOKOnorMH, 150-159. M., N3A-Bo AH CCCP, 1955 3. ApceHbeBa M.A., beabroncic i M.A. H Ap. PBAxarAOHHas reHeTKxa. HTor1 Hayn. EKOA. xaym. I. PagHo6Monor uB. 329-379, M. , KU-Bo AH CCU, 1957 Approved For Release 2009/08/31: CIA-RDP88-00904R000100130047-6 Approved For Release 2009/08/31: CIA-RDP88-00904R000100130047-6 0 ? w by -~c7 aC 0 ca ds J op a~ co 0 ~o )s Mxo m am C) Cr) o>Cco O >Qe 040x O 0 ca ~O O ~ Wok{ M acv 0 ona >4 m m Approved For Release 2009/08/31: CIA-RDP88-00904R000100130047-6 Approved For Release 2009/08/31: CIA-RDP88-00904R000100130047-6 ? W. ?0 mo C) M 0 0 H Approved For Release 2009/08/31: CIA-RDP88-00904R000100130047-6 Approved For Release 2009/08/31: CIA-RDP88-00904R000100130047-6 -I7- PKc.3. CTpyKTypHHe HapymeHH$ XpOMOCOM B Meg03e y O0e3bRH. 8-0 - a Haca3a C O, HMM X OMOCOMHMM MOCTOM x 600; B - aHa a3a c AByMR XpOMOCOMHUUMH MOCTaMK x 600; r - aHac)a3a c geTMpBMA MOCTaMK X 900 (T PH xpoMOCOM- HcIX, OAMH xpOMaTHAHAg) ; A - pHCyHOK aHacPa3U. H3O- dpa eHHOR Ha MHKpo oTO r ; e - axa~a3a c aL eHTpHUe- cKHM c)parMeHTOM x 900 ; I - PKCYHOK axac a.u, 1139- 6pateHHOM Ha MLiKpO(OTO e Approved For Release 2009/08/31: CIA-RDP88-00904R000100130047-6 Approved For Release 2009/08/31: CIA-RDP88-00904R000100130047-6 6 Pzc.4. ABe wHBepcoui B CMHanTwp 60tue 4 nape xpo- M000M. a - M~;KpOcfJOTO x 9MO ; 0 - pVICy- HOK OHBepCb161 14306pa9CHHUX Ha MNKpO- ()OTO a x 1356 Approved For Release 2009/08/31: CIA-RDP88-00904R000100130047-6 Approved For Release 2009/08/31: CIA-RDP88-00904R000100130047-6 _19_ PMc.5. CTpyxTyQHble HapyuieH>4a X OMOCOM B McMIO3e y MHmek. a - a Hacpa 3a c OAHMM XpoMaTUA- HbIM MOCTOM x 400 ; 0 - aHa~613a C AByMa XpOMOCOMHHMM MOCTaMJI x 400; B - aHacpa 3a C OAH14M X OMOCOMH}IM H OAHM1vi XpOMaTNAHb1M MOCTOM X X400 ; r - a Hac a3a C MOCTOM VI cppa rMeHTaMM x 400 ; A - a Hasa Oa c cppa r- M HTaMK x 400 ; e - TpexrlorlwcHblyl MMT03 x 400 Approved For Release 2009/08/31: CIA-RDP88-00904R000100130047-6