SCIENTIFIC ABSTRACT BOBRANSKI, B. - BOBRIK, I. P.

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• Collection: Scientific Abstracts
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• Document Creation Date: November 2, 2016
• Document Release Date: June 9, 2000
• Sequence Number: 14
• Publication Date: December 31, 1967
• Content Type: SCIENCEAB

~\- ~\~ ~,-) -
KULIGA, T;BOBRANSKI, B.
quantitative determination of thoobromine in thoobromine-
nodium salicylate. Act& poloniae pharm, 9 no,lil-11
1952,(CL14L 2212)
1. Of the Institute of Pharmaceutical Chemistry
(Head-Prof.
Boguslaw Bobranski. M. D.) of Wroclaw Medical AcadeaV.

BOMUSKI. B.
Studies on g -phenyl-sthylamineAerivatives;
2-amino-phanyl-alkanes.
Acto poloniae pharm. 9 no.3:165-172 1952- (CLML 23:2)
1. Of the Institute of Pharmaceutical
Ohemistry.(Head-Prof. Bogaslaw
Bobranski, H.D. ) of V'roclav Medical AcadezV.

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:.# 4AA ... M.L-A.t.1

%
1.10-bis~-Wuenthliudno)-
deeane.derliatliis. Aita Polonle;m ph&=. 12
n6.3..-129-134 '53.
1"..z
Zakladtx'.Ch ft. MilhWantycmej A'N.
we-.:Vrocl&wiu-'Kirownik:
Prof. di B. Bobrauski.
(MUSCIM FMAXAMS
1-10-bis-(dinetbrlsaino)-docana deriY4

WBRAI;3KI, B.
B. bOBIMSKI, T. JAKOBIEG, D. PRELIC,'-,: Investiptions ::,,i
cunrl-i-,orn nrlents.
SO: Acta Polonloo I'lisraincoutica (Fh*irr,,.lceutlc,-.1s) ,
Third -.,;U, rt-jr 195~.

I
1 1 7 ~ -
a
Z ., .
Wl~. ;~, .

BOBPANM, B.; JAKOBIM, T.; cz, D.
Now neurotropic barbituric acid derivatives. Acta,
Polonlao
pharm. 12 n0.4.-237-240 1955.
1. W Insty-tutit Immuologil I, Terapli
DoswIsAosaluej PAN i1n.
L.Hirsifelda. 2? Shka'du Chexii. 7arm autycsnej oras
II Iliniki
Chorob Vownetrmwch we Wroclaviue
(BARBITUIRATO,
pharmaool. of several barbituric acid deriv.)

77'7
MT
1 4
-w- toll
4~

fide, ip. dirhlixide 4
nualao VIA. uztki w. likIllmider of b1512 N.
nsetlv PerWJLio)dhy)) sWluxWc. in. 230~-40*, p-xy*u9i-
.1
methylp~j*ndiiw bromidc), D* all] '%]Ylc"ebt54 N
mehylpyrroMur tzami&) P.I. 22~-f~l awriound to tx,
1 .6, 0 ;t' 0-3% G.OB. jind 0 05

%~Ca=potxrids blockbg tb~ faactlaiit;, of tfic 4utamoraic
pagUit. G-Itishaw Rat~~Vi, -..deu-sa I Dk-.,:t.,-. ,i
D~i.,Uto FFMT.--DMOW;~ .r.Q 240--&-AWM)
On bcatinx (1j in ~k. s-,-Il~
w4h b0th terliVY adiPhatic Rmd hrt~yth, wni.~ trnr :--x
bk-uaternaty dibro=--Jr3 with PemiticyruLd
~Oxz 'tructure bave btcz3 obtabed. The folte.-minI comoi-
lmv-- hEC2 Pr4,d.: Pt from I and &-thylocittylumair, P,'
fram I and P- from I wild
Pauline, P~ Irm I And A'-clbylp~pclidinv, P, Imm I .d-
'pu f
The pbarm vol. inv--IlZaLt4m 0 thisv rompd2. sho~td that
solrcW tbm ban a =Dn favor3ble *mapxutk cm>~l ffiao
ptad~wmiLg. Tbis rdm espetiatly to P,, PT, and Pl..
come c4 tbm. vlx., P, zzd P, we free fro= Uxhyphyll!,v~,
............

far 09 do
rdutioll fte MUNN d SM a
A7.
-The varintion of presiiirv in the combustion tube
F-1.6duced by the combustion ef the ---I TA- is und
z
r
automatically regulating the rate of hexting.
i"he.
jndut -J
fr~ ncy P.,
__7 M r. ;Ito como-40 tlh~ V'waqh tinder c6nstant
juvJ therefore in an txcrp of oxygeri.
Preum
DILgrarns of the tordbustion-tube train, oxygen
--pressure Mulator, mavezueter, H. F electrodea and
betwe'en,a2c dyes and I Fairly
large amounts of barbiturates (00 Mg) Uwe ner~ded
zo give the reaction. Steam -distillation in acid.
alkaline~ and neutral media failed to Wit the
I - barbiturate complex t. tatkvcly. and it is
;ggested that column MMIt be used
We eflectivt sepwation of AV I-Positive;
compounds. D . FZLtX
M11 REM

.77
len
,v,
COMI
Mj wtj under

!,7:r --j
- gj4~J~O.J'

F'CL.'.-JD/0rganic Chemistry. Synthetic Organic Chemistry E-2
Abs Jour: Ref Zhur-Khimiya, No 6, 1957, 19217
'1004 is acidified with H2Cr j07b in 40 cc water (hoating
on a water bath 15 min.), an o tainod are 4-5 111, m-P.
200-2010 (doe.; from ale.); 2.4--dinitrophony1hydrazonc,
does not melt up to ~000. /~ g. I is dissolved in 25g.
cone. " S04 after 15 min. it is poured into water, and
obtainci arop 5 g.V, M.P. 188-190, (from ale.); benzoyl
derivntivo, m.p 173--175 (from othylacetate); acctyl
derivative, m.p: lIA-1450 (from benzono). /-2 g. III is
boiled 2.5 hours with 2g. Zn-dust and 100 cc water and
obtained arc 0.5 g. IV, m.p. 259-2610; 2,4.-dinitrophanyl-
hydrazone, docomp. P. 2600. 0. 5 g. V is oxidized in
the samo way as II, and is obtained 0.3 g. IV.
Card 3/3

POLAND G
C_-:-tC_at;rY:Organic Chemistry. Synthetic organic Chemistry!
is.
:Ref Zluw - XbU., Ho 5, 1-959) no. 15432
._1 ilit'hor
:Bobranski, B.; Jakobiec, T.; Prelicz, D.
Inati~))t.
:.-
Title
;on
the Action of Iodine on 5,5-Diallylbarbi-

turie Acid
Oris 7'u1-.
u
:Roczn. chem., 1956, 30, No 2, 483-492
r.i!Dstract
In
continuation of the work begun earlier, (see

report I, Ref
Zhur-]Khim, 1957, 19216), the

structure of the product which is
formed underi

the action of I in the absence of HI on 5,5

diallylbarbiturie acid (I), both in an acid

and in an alkaline
medium, was examined. The

product obtained differed In
composition from

the earlier-prepared I under the action of 12

on I in a weak alkaline medium, (Bougault, J.p

Guillou, J., 0.
r. Acad. sci., 1931, 193, 463)'
Gct rid: 1/9
G - 60

Catu-itry G
Aba. jour Ref Zhur Xh*ia-o No 5, 1959, MD. 15432
Aut, ho r
11-13titut.
T Itlo
Ork-, Pab.
Ab at re, r. 1.-and to this product the following structure
cont'd. was attributed: 2f,6'-bIs-(Iodmethy1)-2',3',
51,61-te~vrabydrospiro-(pyrano-41,5-barbiturie)
acid (II). The structure of II is confirmed by
the resistance of II to oxidants and by other
properties, as well an by the impossibility of
converting the ring of barbitairic acid into a
monolaotim form under conditions of an acid
medium, in which 11 is also formed. Tfte sub-
stance of II is also obtained under the action
C.z rd: 2/9

Couatry G
'"S' your '9ef ZhIIr No 5, 1959, No - 15432
Aut ho r
11-13 t ltuav
T It]" c.
Orl.~r, Pub.
Ab,3tract
conttd.
all7lbarbiturie acid (VI) into 5-acetonyl-5-
(P-oxy-r-iodopropyl)-barbituric acid (VII).
Under the action of K20r 0 VII is converted
"- 2vjP
into 5,5-di-(3-Iodoaoqton7 )-barbiturie acid
(VIII) and 515-diacetonylbarbituria acid (IX).1
The reduction of VIII with Zn powder leads to
TX- 7 9. of NaHC03 are added to 10 g. of I in
200 mi. of water, dissolved at about 80019 26
12 and 40 g. of KI in 60 ml, of water
ga;eo`add6d9 and after cooling the resinous massi
C,a rd 4/9

Country G
Abs. Jour Hef Zhur - Mix., No 5, 1959, No. 1-5432
Author
1118titut.
T It "Lo%
Or kr 11-i i b
Abstract of Zn
I g. of 119 100 mi. of water and 1 g*'
oont'd. powder are boiled for two hours, and 0.3 g. of
I is separated out from the filtrate. 1.8 g.
of KI and 0.72 g. of KIOI in 30 ml. of water
are added to 2.3 9. of IV and 1 g. of KI in
5 ml. of hot water and 2 ml. of 16% H004.at
ko. washed with Na2820.3 solution after about
12 hours,oand 2..5 g. of V Is obtained, m.p,
210.5-211 (decomposition; from alcohol).
2.2 g. of IV, 0.75 9. of K103p 2 mi. of 16%
6/9

G
GZ t c 3 '.) ry
1 1
Alm. Jour Ref Zbur M21m., No 5, 195% No. 1%32
A'Lithor
lnstiLut.
Titlo
Ori!~ Pub.
Abstract t HpSO and 10 ml. o -f water are heated to 8001 1
cont'd. 1.11. of KI in 20 ml. of water age added, 2.21
g. of V is obtained, m,p. 211-212 (decomposi-I
tion; from water). 11 g. of VI, 3.6 g. of KI03'
200 ml. of w4ter and 50 ml. of 10% H23 are
O'J, 5-5 9. of KI in 70 ml. C~
heated to 8 0 water,
are addedo and after-2 hours IP g. of VII are
obtainedo m.p. 211-212 (deeomposition; from
Water); 24-dinitropbLenylhydrazone, M.P0 230-
2320. 6 g. of Vil in 25o ml. of 10% H2SOk are
7/9
G - 6

T
'~',o-iislau- T3obra-~s.M-, "?'a6eusz Jalcobirtc, I`reli
cz - cti un of, e on
Acid, H. lliocmii I-L C--;, i %'ol '10, "o 2,
Published from. the Rese.-:rch Laborator,,.., of
Pharna-.eiitical of
,?C-:,d4C4 -,L, 'N'rocl from. 'he Reonarch Laboratory o4"'
I Ii. ~, e%, and
Insti-Louta of inripftinolo,-17 an6 Zxporincntal Therepy
i:,:s. L. 'Hmzf'--Id of th-3 Polish
Acadc-'; of Sciences, 1 Jul 55-
.L

PCLAND/Organic Chemistry. Synthetic Organic Chemistry.
G-2
Abs Jour: Ref Zhur-Khim., No 24, 1958, 81526.
Author Debranski B., Jabobiec T., Prelicz D.
4, Inst
Title An Improved Method of Obtaining Methylated
Aliphatic
Diamines, A -lialide-Alkylamines and Bis-( /.~-Halide
Alkyl)-
Amine3.
Orig Pub: Roczn. chem., 1956, 30, No 2, 623-625.
Abstract: A modification of Leikart's method is
suggested,
which consists in rethylating aliphatic diamines,
haloalkyl amines and bis-( 4 -halcalkyl)-amines,
where the salts instead of the corresponding free
amines are used. one mole of dichlorohydrate of
diamine is"dissolved in 12 moles of 90% IfCOOH (I)
Card 1/3
LU,~ c 0 AP,
3

POLUM/Organic Chemistry, Synthetic Organic
Chemistry. G-2
Abs Jour: Ref Zhur-Xhim., No 24, 1958, 81526.
and.:in,6:raoles of 35~.CHO (II), the mixture is
heated.from-12_14,~hours_at 105-115 C., then is
eva-
porated:t.~ dryness-An.vacuun. is recrystallized
from
absolute"alcohbl or is dissolved in water, and is
converted to the base, is extracted with a solvent,
and the methylated amine is isolated. Given is the
compound, yield in ~', boiling point in-'C.:
(CH,)~N
(CHj,CN(CH;).;, 75, 157-158--c./17 mm.;
~CH,~N(dfl~)--
N(CH,.L,, 6o'-65, 112-113/25mm-, and 96-98/i5 mm.;
(Cq?)-N(CH,,,)~jN(CH3~N(CH3).~, 50-55, 192-194. One
mole of BrCHLCHZNH
.2-EBr in 6 moles of I Plus 3 moles
of II is heated to 10VC., 0the temperature is grad-
ually increased to 145-150 C., the mixture is kept
at this temperature for 5-6 hours, and upon
evapora-
Cara 2/3

& Ars^//~_Vj
POLAND/Organic Chemistry. Organic Synthosiso
as Jour Ref Zhur-Khiriiyal No 91 1959, 31383
Author Bobranski, Boguslaw; Jakubiec, Tadeusz;
tE -
rr-3 I re -z1- ura
Inst
Title Now Derivatives of Barbituric Acid.
Orig Pub Roczn. chern., 1957, 319 No 22 559-568
Abstract In order tu obtain new derivatives of
G-2
barbituric acid (I) active in the case of
neurovegotative illnesses 5-allyl-(11-
rithylbutyl)-I [sic] (II) ?Soconal) was trea-
ted with I in the presence of KIO I pro-
duct of adiition of HIO-5411.-:meth ib~tyl)-5-
-(21-hydroxY-31-iodopropyl)-I (IIIi was thus
obtained. Tho latter can be reduced back into
Card 1/6

POLIXD/Organic Chemistry. Organic Synthosise G-2
fibs Jour :Ref Zhur-Ehimiya, No 9, 1959, 31383
of KI in, 30 -a of water is added drop-by-
drop, tho mixture is heated for 30 mlin-0
and 15 g of crude III~ nolt. p, 192-194
(from 70 percent alcohol) is obtained. 2 g
of 1119 1 g of Zn dust anO 30 nl of alco-
hol are boiled for 2 hours, tho hot filtrate
is diluted with 150 n1 of viatorg and II, Lielt.
P. 78-790, is obtained. The solution of 0.5 g
of K Cr207 in 100 ml of viator is added to the
solu
Mon of 2 g of III in 400 ml of boiling
"5-)percaht"M2S04 anC; all.is hoated fo--., 45 min,
poured on 250 g of ice, and 1.6 g of 5411-
0 nethylbutyl)-5-(31-iodoacetonyl)-I (X), rielt.
-1470 (doe..), is obtained. 10 g of II
p. 145
is added to 30 g of H2S04; 30 min later it is
Card 3/6

POLIM/Organic Chouistry. organic Synthesis. G-2
Abs Jour t Rof Zhur-RhIrAya, No 99-19599 31383
rielt. PO 223-2250 (doe is obtained. VII
with Zn dust in 150.per~ont alcohol produces
1.0..2 t cotonyl)-I
VI. I , g~;of 5a-phenyl 543 -iodpa
(X11) * rialt. p, 220-2220 is obtained from
3zg -80 1 12 percont solution.
2 )f:vli$ 11- of
oi H 804 -arid 0*6 g;~-of K2Cr207 (boiling for
In) a, 3 _- g of
45 ri vi is dissolved in 10 g of
cone. TIDSOA and poured into water 10 min la-
ter: ot 5-phonyl-5-(21-hydroxypropyl)-l
(XIIA, McIg rielte po 228-21 is obtained.
5 g of XIII is oxidized wit
2 h K2Cr209 in
7:5 percent H 80, (20 min) and 2 g of VIII?
2
melt. P. 279-SO (dissoc.3 is obtained, 1 g
of XII and Zn dust in water produce 0e35 9
of VIII. 2 g of Na st-at of 5-phanyl-I, 1 n1
Card t 5/6

BOBRANSKI, B.
Professor Aleksander Koewa; his life and scientific work. P.
535.
WIADCHOSCI CHEKICZNE. (Polskie Towarzystwo Chericzne)
Wroclaw,, Poland.
Vol. 13, no. 10, 1959.
A
Monthly List of East European Accessions (EEAT) LC, Vol. 9,
no. 2,, Feb. 1960
Uncl.

BOBRANSKI, B.; POMORSKI, J.
Synthesis of sulfapyridine-N-oxide. Bal Ac Pol chim 7
no.4:203-203
'59. (EM 9:7)
1. The L.Hirszfeld Institute of Immunology and
Experimental Therapy,
Wroclaw, Polish Academy of Sciences. Laboratory of Drug
Synthesis, Warsaw. Presented by T.Urbanski.
(Oxides) (Sulfapyridine)

KONIEC M . Mieczyslaw; BOBRANSKIq Boguslaw
k new method of preparing O-t acetone. Rocz chemii
33 no.4/5:
1027-1030 #59. (EM 9:9)
1. Zaklad Chemii, Farmaceutycznej Akademli
Medycznej, Wroclaw.
(Tolylacetons) (Dinitropheny1hydrazone)

MiAF146p UIVen RaMOS
COuntM Poland
Academic Degree3l 5,ot given7
Affiliations
sources Warsaw I PostepX HiRieny -i -Medycyn-v Dosyladczalnei Vol
XV, No 41
19619 pp. 402-404.
Datas"Tho Hydration Products of Diallyl-Homophtalimide.11
Bnglish abstract of article originally published in Bull L'Aaad Polon
Sci,, Berie de's sci chim) 140, 105. b) Dissertationes Pharmaceu-
as 19609 129 19.
lAuthoTst
I,BOBagLKjj_D, ffresume,17 ludw It R-1-ro-hold-111stitute of
Immunology and
3x 7Terapii Doswiadozalnej
perimental Therapy ( S ut Iramunologii i
im. Ludwika Eirszfelda), Polish'Aaademy of Sciences (PAN--Polska
Akademia Nauk),.Wroalav; Directors Prof's Stefan SLOPEN, Dr.'
iWO.TTKOwSKII, R.
GPO 9416143

BOBRANSKI, B.; PRELICZ, D.; SYPER, L.; WOJ'TOWSKII R.
On the isomerisation of 5-a.1371-54 -bydroxypropyl)
barbitirric
1*1 1
aoid. Bul chim. PAN 8 n0.9:475-479 (I.
1. Department of Pharmaceutical Chemistry, School of
Medicine,
Wroclaw.
(Isomerism) ("i group) (Hydroxy group)
(Propyl) (Barbituric aoid)

- B913WSKIL Boguslav: EIANO. Jozef; GIMAIWOWSKI.
Jerzy; PRia rez, Danuta;
PR CZARSEA, Alicja; WILI)IOWSKI.Karian
On certain spiro-pyrano-barbiturate compounds.
Arch.imman.ter.
doew. 8 no.2:355-359 160.
1. Zakl9A Syntezy Srodkow Leasnicsych I 7Aklad
Yarmakologil,
Instytutu Immunologil. i Terapil, Doewladezalnej PAN
we Wroclaviu,
Zaklad Chemit Yarmaceutycznej Akademil Medycznej we
Wroclawlu.
(TIAR ITURAT39S Pharmacol)

j
C,
Jerzy
a

8/081/62/000/021/025/969
B1 1 7/-B101
AUTHORSi obrafieki, Bogualaw, Mleozko- Wanda
,=!o haki, Bogualaw,
TITLEi-. Synthbais 4nd properties of 1-p-iodophenyl-5,5-diallyl
barbituric acid
PERIODICALs Referativnyy zhurnal. Khimiyaj no. 21, 1962, 180,
abstract
21Zh179 (Arch. immunol. i terap. do6wiadez. v. 9f no. 4,
1961t-593 - 598 LEng.-; summaries-.in Pol. and Russ-3)
TEXTt 1-p-ioddphenyl-5,5-diallyl barbituric acid (I) was
synthesized and
pharmacologically examined. Experiments showed no sedative effect
of I -
on mice. 30 g of POCI 3 is added to a boiling mixture-of 10 g of CH
2(COOH)2
dried over F 0 26 g of p-iodophenyl urea*(II) dried at 1200C and
100 ml
2 5'
of absolute GHGl3 within 1 hr. Then the mixture~is boiled for 7 hrs,
Mcl 3 is distilled off in vacuo, the residue-is poured into ice
water, and
1-p-iod6phenyl barbituric acid (III) iB finally obtainedt C 10H7IN
203;
yield 89%j m.p., 230 - 2320C (from alcohol). 20 mmoles of III and
42mmoles
Card 1/2

S/081/62/000/021/025/069
Synthesis and properties of.., B117/B101
of alljl bromide are added to the C 2H5ON& solution
synthesized from 0.04 9-
atom of Na and 15 ml of absolute alcohol. Then the mixture is
kept at
55 - 600C for about 3 hrs until the alkaline reaction with
phenol phthaloin
ceases; it is subsequently poured into cold water, and
finally I is ob-
tained: C 16H15 IN2Op yield, 77%; m.p., 177 - 1780C (from
alcohol). A
mixture of 25 mmoles of dry diallyl malonic acid, 25 mmoles
of dry II,
30 mmoles of (CH 3C0)20 , and 50 ml of absolute CHCl5 is
boiled for 3 - 4 hm,
CHCl3 is distilled off in vacua, the residue is mixed with
alcohol, and
I is filtered off (yield, 50%)- When administered per as DL
50 of I is
3 g/kg. Doses of 1/5 DL 50 have no analgesia effect and do
not affect the
spontaneous mobility of mice. Doses of 1/3 DL 50 do not
influence the
blood pressure in five hours. LAbstracterls note: Complete
translationj
Card 2/2

1AM.j Given Nan. es
Countrys Poland
Academic Degreess,5ot five
ffreswneV LuEW 'k Hirszfeld Institute of IM''hunology and Experi-
AffiliatiOn: mental t-herapy-