PROPOSED SUPPLEMENT TO (DELETED) WITH (DELETED) FOR STUDIES ON MOTION SICKNESS.

• Document Type: SPECIALCOLLECTION
• Collection: General CIA Records
• Document Number (FOIA) /ESDN (CREST): 00184438
• Release Decision: RIPPUB
• Original Classification: U
• Document Page Count: 2
• Document Creation Date: January 21, 2025
• Document Release Date: January 15, 1983
• Publication Date: November 3, 1950

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Washington 25, D.
Subject: Proposed
with
ness:
Gentlemen:
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November 3, 1950
for studies of motion
after conferences with repre-
sentatives of presents for the consideration and support oil-1101V
a proposal for supplementation of its presej P ram of res ar on
otion sickness t. be ca ed'o t in_t
The proposed supplement requests an expansion of studies now
in progress on the effects of certain drugs for prevention of motion
sickness. The specific Purpose of the proposed supplement is the
development of methods for study of the side-effects of these drugs,
and of related substances, or of other drugs or agents, with special
attention to their actions on complex psychological functions and on
behavior followed by the evaluation of particular drugs. The in-
vestigation will have three main aspects:
1. A survey of present knowledge of methods for assessment
of the behavioral effects of chemical and environmental agents, such
as drugs, toxins, alcohol, high altitude, endocrines including pitui-
tary and adrenal cortical hormones, high temperature, sleep loss,
noise or vibrations, environmental stress, social stress, etc.. The
purpose will be the discovery of methods which will make it possible
to measure the specific nature of the effects of drugs on perception,
judgment, mood, impulsiveness, emotionality and other intellectual
and personality traits.
2. The development and testing of a sot of methods by which
such drug actions may be validly measured. For this purpose human
subjects will be used under the influence of such drugs as are now
known to.produce particular effects on intellectual, personality
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and,. conatiVe traits, in order to test the validity of the methods.
The three major approaches will probably be: a) day-book and
observational studies of the daily-life activities of subjects
under minimal dosages, b) laboratory investigations by physiologi-
cal and psychological t.ists under a variety of dosage levels, and
c) situational and interview procedures at various dosage levels.
Each of these three methods will be applied to subjects who differ
widely in intellectual, personality and character traits, so as
to find the interaction of the human factor and the drug factor.
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3. The testing, by means of whatever valid methods
have been developed by the study, of such drugs as seem likely
� to be in most widespread use.
It is hoped that the results of those studies may make
possible decisions on the limits of proper use of drugs in mili-
tary operations. Particularly, it is hoped to find which drugs
may safely be administered to officers and other critical person-
nel whose perception, judgment, discretion and decisions are
vitally important.
But the significance of such work, if it has a success-
ful outcome, may go far beyond such specific questions. It may
make contributions to each of the areas of investigation of the
effects of chemical and environmental agents mentioned in (1) above,
to problems of interest to the mental health authorities working
on the effects of endocrine:3 or an the use of drugs as an aid in
the psychotheraTeutic process, and to fundamental behavior theory.
It is obvious that this task is a difficult one, having
been the objective of many scientific workers for sixty years.
Because of its scope it will require the cooperative thinking and
efforts of a number of sciences. Furthermore, it is not now pos-
sible to foresee all of the specific needs for equipment, con-
sultation or personnel. For these reascns the budget must be rela-
tively large and the plans here presented and budget categories
shown should be regarded as subject to later revisions.